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Journal Articles

A Novel Non-Covalent Modulator of Hemoglobin Improves Anemia and Reduces Sickling in a Mouse Model of Sickle Cell Disease

Kelly M. Knee, PhD, Reema Jasuja, PhD, Amey Barakat, MS, Dharani Rao, Zane Wenzel, MS, Parag Sahasrabudhe, Jatin Narula, PhD, Jay Jasti, Jeanne S. Chang, Kevin Beaumont, David W. Piotrowski, Jay M. Janz, PhD

Blood (2019) 134 (Supplement_1): 207.

https://doi.org/10.1182/blood-2019-128270

Published: 2019

Journal Articles

LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

Benjamin Vieira, Vu P. Hong, Kunal Desai, Martin K. Safo, David R. Light

Blood (2018) 132 (Supplement 1): 1074.

https://doi.org/10.1182/blood-2018-99-116319

Published: 2018

Journal Articles

Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice

Kelly Marie Knee, Reema Jasuja, Amey Barakat, John J. Kelly, Joseph C. Nneji, Pratap Singh, Jay M. Janz

Blood (2016) 128 (22): 3644.

https://doi.org/10.1182/blood.V128.22.3644.3644

Published: 2016

Journal Articles

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Athiwat Hutchaleelaha, PhD, Mira Patel, PhD, Abel Silva, Donna Oksenberg, PhD, Brian Metcalf, PhD

Blood (2015) 126 (23): 2172.

https://doi.org/10.1182/blood.V126.23.2172.2172

Published: 2015

Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD

Blood (2014) 124 (21): 218.

https://doi.org/10.1182/blood.V124.21.218.218

Published: 2014

Journal Articles

GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O 2 Affinity

Mira Patel, PhD, Pedro Cabrales, PhD, Kobina Dufu, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2014) 124 (21): 1370.

https://doi.org/10.1182/blood.V124.21.1370.1370

Published: 2014

Journal Articles

A Long Acting Polymeric Iron Chelator for the Treatment of Transfusion Associated Iron Overload

Jasmine La Juanie Hamilton, PhD Candidate, Muhammad Imran ul-haq, PhD, Benjamin Lai, MSc, Jayachandran N. Kizhakkedathu, PhD

Blood (2012) 120 (21): 486.

https://doi.org/10.1182/blood.V120.21.486.486

Published: 2012

Journal Articles

Modification of rVWF with Polysialic Acid: Biochemical and Functional Characterization in Mice with VWD.

Peter L. Turecek, PhD, Juergen Siekmann, PhD, Alfred Weber, PhD, Herbert Gritsch, PhD, Katalin Váradi, PhD, H. Peter Matthiessen, PhD, Eva-Maria Muchitsch, DVM, Bernhard Baumgartner, DVM, Hans Peter Schwarz, MD

Blood (2006) 108 (11): 1001.

https://doi.org/10.1182/blood.V108.11.1001.1001

Published: 2006

Journal Articles

New Approach for Finding Novel Antisickling Agents at the NIH NHLBI Sickle Cell Disease Reference Laboratory.

Toshio Asakura, MD, PhD, Jisheng Yang, Qiukan Chen, MD, Greg Evans, PhD, Osheiza Abdulmalik, DVM

Blood (2006) 108 (11): 1219.

https://doi.org/10.1182/blood.V108.11.1219.1219

Published: 2006

Journal Articles

In Vitro Antisickling Effects of Novel Pyridyl Derivatives with Enhanced Potency.

Osheiza Y. Abdulmalik, DVM, Martin K. Safo, PhD, Gajanan Joshi, PhD, Jisheng Yang, Qiukan Chen, Daniel Obeng, Donald J. Abraham, PhD, Toshio Asakura, MD, PhD

Blood (2005) 106 (11): 2347.

https://doi.org/10.1182/blood.V106.11.2347.2347

Published: 2005

Journal Articles

MSDD1, a Prodrug of 5-Hydroxymethyl-2-Furfural (5HMF), Prolongs the Antisickling Effect of 5HMF in Transgenic Sickle Mice.

Osheiza Abdulmalik, DVM, Martin K. Safo, PhD, Richmond Danso-Danquah, PhD, Jisheng Yang, Qiukan Chen, MD, Carlo Brugnara, MD, Donald J. Abraham, PhD, Toshio Asakura, MD, PhD

Blood (2004) 104 (11): 3576.

https://doi.org/10.1182/blood.V104.11.3576.3576

Published: 2004

Journal Articles

Finding of 8 New Therapeutic Agents by the Use of New High-Throughput Drug Screening Methods Established by the Nhlbi Sicke Cell Disease Reference Laboratory.

Toshio Asakura, MD, PhD, Osheiza Abdulmalik, DVM, Efe Iyamu, PhD, Qiukan Chen, MD, Jisheng Yang, Carlo Brugnara, MD, Greg Evans, PhD

Blood (2004) 104 (11): 3751.

https://doi.org/10.1182/blood.V104.11.3751.3751

Published: 2004

NARROW

A Novel Non-Covalent Modulator of Hemoglobin Improves Anemia and Reduces Sickling in a Mouse Model of Sickle Cell Disease

LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O 2 Affinity

A Long Acting Polymeric Iron Chelator for the Treatment of Transfusion Associated Iron Overload

Modification of rVWF with Polysialic Acid: Biochemical and Functional Characterization in Mice with VWD.

New Approach for Finding Novel Antisickling Agents at the NIH NHLBI Sickle Cell Disease Reference Laboratory.

In Vitro Antisickling Effects of Novel Pyridyl Derivatives with Enhanced Potency.

MSDD1, a Prodrug of 5-Hydroxymethyl-2-Furfural (5HMF), Prolongs the Antisickling Effect of 5HMF in Transgenic Sickle Mice.

Finding of 8 New Therapeutic Agents by the Use of New High-Throughput Drug Screening Methods Established by the Nhlbi Sicke Cell Disease Reference Laboratory.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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