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Journal Articles

RAS-MPAK Pathway Signaling in Health and Disease

Qing Li, MD PhD

Blood (2018) 132 (Supplement 1): SCI-40.

https://doi.org/10.1182/blood-2018-99-109378

Published: 2018

Journal Articles

RGL4 over Expression Correlates with Variation in Midostaurin Response in FLT3-ITD Mutant AML Samples

Mara Rosenberg, BS, Cristina E. Tognon, PhD, Kevin M Watanabe-Smith, PhD, Uma Borate, MD

Blood (2018) 132 (Supplement 1): 1365.

https://doi.org/10.1182/blood-2018-99-120296

Published: 2018

Journal Articles

RGL2 Deficiency Impairs Human Erythropoiesis By Altering Terminal Erythroid Differentiation and Apoptosis

Harry Lesmana, MD, Georgios E Christakopoulos, MD, Mary Risinger, Haripriya Sakthivel, Omar Niss, MD, Theodosia A. Kalfa, MD PhD

Blood (2017) 130 (Supplement 1): 8.

https://doi.org/10.1182/blood.V130.Suppl_1.8.8

Published: 2017

Journal Articles

Comprehensive Analysis of Safety: Rigosertib in 557 Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Guillermo Garcia-Manero, MD, Pierre Fenaux, MD PhD, Aref Al-Kali, MD, Shyamala C. Navada, MD, Maria R. Baer, MD, Azra Raza, MD, Peter Greenberg, MD, Karl-Anton Kreuzer, MD, Devendra K Hiwase, MBBS, MD FRACP, FRCPA, PhD, Gail J. Roboz, Valeria Santini, MD, Uwe Platzbecker, MD, Michael E. Petrone, MD MPH, Bernard Brownstein, MD, Patrick Simon Zbyszewski, MBA, Manoj Maniar, PhD, Lewis R. Silverman, MD

Blood (2016) 128 (22): 2011.

https://doi.org/10.1182/blood.V128.22.2011.2011

Published: 2016

Journal Articles

Downregulation of DLEU1 Significantly Shortened Survival in a Rituximab-Treated DLEU1 Knockout Human Burkitt Lymphoma (BL) Xenograft NSG Mouse Model: DLEU1 May Act As a Tumor Suppressor Gene in Pediatric BL

Sanghoon Lee, PhD MSc, Changhong Yin, MD MS, Janet Ayello, MS, Erin Morris, RN, Carmella van de Ven, MA, Mitchell S. Cairo, MD

Blood (2015) 126 (23): 3656.

https://doi.org/10.1182/blood.V126.23.3656.3656

Published: 2015

Journal Articles

Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins

E. Premkumar Reddy, PhD, Sai Krishna Divakar, PhD, Rodrigo Vasquez-Del Carpio, PhD, Kaushik Dutta, PhD, Stacey J Baker, PhD, Ramana Reddy, PhD, Aneel K Aggarwal, PhD

Blood (2014) 124 (21): 5616.

https://doi.org/10.1182/blood.V124.21.5616.5616

Published: 2014

Journal Articles

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Jon Akutagawa, B.S., Monique Dail, PhD, Lori S Friedman, PhD, Kevin M. Shannon, MD, Deepak Sampath, PhD, Benjamin S. Braun, MD, PhD

Blood (2012) 120 (21): 2862.

https://doi.org/10.1182/blood.V120.21.2862.2862

Published: 2012

Journal Articles

Treatment of Chronic Lymphocytic Leukemia Patients with Lenalidomide Induces Down-Regulation of miR342-3p Associated with Over-Expression of Tumor Suppressor RASSF4,

Emanuela M. Ghia, PhD, Lillian Werner, Danelle F. James, M.D., Donna Neuberg, ScD, Laura G Corral, Senior, Scientist, Laura Z. Rassenti, Ph.D., Carlo M. Croce, MD, Thomas J. Kipps, M.D., Ph.D

Blood (2011) 118 (21): 3885.

https://doi.org/10.1182/blood.V118.21.3885.3885

Published: 2011

Journal Articles

Differential Gene Expression Associated with Chronic Myeloid Leukemia (CML) Progression Predicts Relapse and Survival Prior to Allogeneic Transplantation In Chronic Phase CML Patients

Vivian G. Oehler, MD, KaYee Yeung, PhD, Ailin Zhang, PhD, Theodore A. Gooley, PhD, Jerald P. Radich, MD

Blood (2010) 116 (21): 3507.

https://doi.org/10.1182/blood.V116.21.3507.3507

Published: 2010

Journal Articles

S-Nitrosylation of Rap1 and Relationship to Rap1 Activity and Disease Status In SCD

Victoria Tutaeva, MD, PhD, J. Will Thompson, PhD, Matthew W. Foster, PhD, M. Arthur Moseley, PhD, Stephen P. Holly, PhD, Martha Delahunty, PhD, Leslie Parise V., PhD, Marilyn J. Telen, MD

Blood (2010) 116 (21): 2662.

https://doi.org/10.1182/blood.V116.21.2662.2662

Published: 2010

Journal Articles

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Michaela Liedtke, Paul M. Ayton, Tim C. P. Somervaille, Kevin S. Smith, Michael L. Cleary

Blood (2010) 116 (1): 63–70.

https://doi.org/10.1182/blood-2009-09-243386

Published: 2010

Includes: Supplemental data

Journal Articles

Treatment with a MEK Inhibitor Improves Myeloproliferation, Anemia and Survival in a Mouse Model of CMML and JMML.

Natalya Lyubynska, Jennifer Lauchle, MD, Kevin Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2009) 114 (22): 966.

https://doi.org/10.1182/blood.V114.22.966.966

Published: 2009

Journal Articles

The RALGEF Pathway Contributes to the Pathogenesis of Chronic Myelogenous Leukemia by BCR/ABL

Jessica Fredericks, Ph.D., Chaitali Parikh, Ph.D., Ramesh Subrahmanyam, Ph.D., Ruibao Ren, M.D., Ph.D.

Blood (2008) 112 (11): 3208.

https://doi.org/10.1182/blood.V112.11.3208.3208

Published: 2008

Journal Articles

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells

Mariska G. Rondaij, Ruben Bierings, Ellen L. van Agtmaal, Karina A. Gijzen, Erica Sellink, Astrid Kragt, Stephen S. G. Ferguson, Koen Mertens, Matthew J. Hannah, Jan A. van Mourik, Mar Fernandez-Borja, Jan Voorberg

Blood (2008) 112 (1): 56–63.

https://doi.org/10.1182/blood-2007-07-099309

Published: 2008

Includes: Supplemental data

Journal Articles

Thrombopoietin Stimulates the Formation of Endothelial Cell-Cell Contacts and Activates the Small GTPase Rap1.

Marloes R. Tijssen, Franca di Summa, Anne-Marieke van Stalborch, C. Ellen Van der Schoot, MD, PhD, Jaap D. van Buul, PhD, Peter L. Hordijk, PhD, Carlijn Voermans, PhD

Blood (2007) 110 (11): 3713.

https://doi.org/10.1182/blood.V110.11.3713.3713

Published: 2007

Journal Articles

Intracellular Signals as Molecular Biomarkers for Therapeutic Responses in Kras Mutant Myeloid Cells.

Ernesto Diaz-Flores, PhD, Margaret VanMeter, BS, Jennifer O. Lauchle, M.D., Benjamin S. Braun, M.D.-Ph.D, Kevin M. Shannon, M.D.

Blood (2007) 110 (11): 2196.

https://doi.org/10.1182/blood.V110.11.2196.2196

Published: 2007

Journal Articles

Role of Downstream Effectors in Kras-Driven Myeloproliferative Disease.

Angell C. Shieh, BS, Kevin M. Shannon, M.D.

Blood (2007) 110 (11): 1617.

https://doi.org/10.1182/blood.V110.11.1617.1617

Published: 2007

Journal Articles

The Guanine Exchange Factor RalGDS Is Involved in Regulated Exocytosis of Weibel-Palade Bodies from Endothelial Cells.

Jan Voorberg, PhD, Mariska G. Rondaij, Karina A. Gijzen, Ruben Bierings, Erica Sellink, Mar Fernandez-Borja, PhD, Jan A. van Mourik, PhD

Blood (2005) 106 (11): 3688.

https://doi.org/10.1182/blood.V106.11.3688.3688

Published: 2005

Journal Articles

Multiparameter Flow Cytometric Analysis Reveals Aberrant Phosphorylation of a Network of Effector Molecules in Defined Populations of Kras Mutant Bone Marrow.

Margaret E.M. Van Meter, BA, Ernesto Diaz-Flores, PhD, Joehleen A. Archard, BS, Nikesh Kotecha, BS, Amit J. Sabnis, BS, Jonathan M. Irish, PhD, Garry P. Nolan, PhD, Kevin M. Shannon, MD, Benjamin S. Braun, MD, PhD

Blood (2005) 106 (11): 239.

https://doi.org/10.1182/blood.V106.11.239.239

Published: 2005

Journal Articles

RIAM, a New Rap1 Effector, Functions Downstream of Rap1 and Regulates Rap1 Localization at the Plasma Membrane and Rap1-Induced Adhesion.

Esther M. Lafuente, PhD, Christopher V. Carman, PhD, Matthias Krause, PhD, Timothy A. Springer, PhD, Frank B. Gertler, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2004) 104 (11): 510.

https://doi.org/10.1182/blood.V104.11.510.510

Published: 2004

NARROW

RAS-MPAK Pathway Signaling in Health and Disease

RGL4 over Expression Correlates with Variation in Midostaurin Response in FLT3-ITD Mutant AML Samples

RGL2 Deficiency Impairs Human Erythropoiesis By Altering Terminal Erythroid Differentiation and Apoptosis

Comprehensive Analysis of Safety: Rigosertib in 557 Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Downregulation of DLEU1 Significantly Shortened Survival in a Rituximab-Treated DLEU1 Knockout Human Burkitt Lymphoma (BL) Xenograft NSG Mouse Model: DLEU1 May Act As a Tumor Suppressor Gene in Pediatric BL

Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Treatment of Chronic Lymphocytic Leukemia Patients with Lenalidomide Induces Down-Regulation of miR342-3p Associated with Over-Expression of Tumor Suppressor RASSF4,

Differential Gene Expression Associated with Chronic Myeloid Leukemia (CML) Progression Predicts Relapse and Survival Prior to Allogeneic Transplantation In Chronic Phase CML Patients

S-Nitrosylation of Rap1 and Relationship to Rap1 Activity and Disease Status In SCD

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Treatment with a MEK Inhibitor Improves Myeloproliferation, Anemia and Survival in a Mouse Model of CMML and JMML.

The RALGEF Pathway Contributes to the Pathogenesis of Chronic Myelogenous Leukemia by BCR/ABL

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells

Thrombopoietin Stimulates the Formation of Endothelial Cell-Cell Contacts and Activates the Small GTPase Rap1.

Intracellular Signals as Molecular Biomarkers for Therapeutic Responses in Kras Mutant Myeloid Cells.

Role of Downstream Effectors in Kras-Driven Myeloproliferative Disease.

The Guanine Exchange Factor RalGDS Is Involved in Regulated Exocytosis of Weibel-Palade Bodies from Endothelial Cells.

Multiparameter Flow Cytometric Analysis Reveals Aberrant Phosphorylation of a Network of Effector Molecules in Defined Populations of Kras Mutant Bone Marrow.

RIAM, a New Rap1 Effector, Functions Downstream of Rap1 and Regulates Rap1 Localization at the Plasma Membrane and Rap1-Induced Adhesion.

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American Society of Hematology

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American Society of Hematology

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