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Journal Articles

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Christine R. Keenan, Nadia Iannarella, Gaetano Naselli, Naiara G. Bediaga, Timothy M. Johanson, Leonard C. Harrison, Rhys S. Allan

Blood (2020) 135 (23): 2049–2058.

https://doi.org/10.1182/blood.2019002990

Published: 2020

Includes: Supplemental data

Journal Articles

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Sudip Kumar Paul, MSc, Masamitsu Sone, PhD, Hisaya Kato, MD PhD, Yoshiro Maezawa, MD PhD, Yasuo Ouchi, PhD, Koutaro Yokote, MD PhD, Koji Eto, MD, Naoya Takayama, MD PhD

Blood (2019) 134 (Supplement_1): 3615.

https://doi.org/10.1182/blood-2019-123919

Published: 2019

Journal Articles

CLL Increases the Frequency of CD4 + HLADR + PD1 + T Cells That Demonstrate an Exhaustion Gene Signature and Potential Prognostic Value for Disease Progression

Peter M Henley, BMedSc, Christopher Fegan, MB, MD FRCP, FRCPath, Stephen Man, PhD

Blood (2019) 134 (Supplement_1): 3033.

https://doi.org/10.1182/blood-2019-128546

Published: 2019

Journal Articles

Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms

Blood (2018) 132 (Supplement 1): 3842.

https://doi.org/10.1182/blood-2018-99-116015

Published: 2018

Journal Articles

Inhibition of Endothelial mTOR Drives Hematopoietic Stem Cell Aging

Jason M. Butler, PhD, Pradeep Ramalingam, MD

Blood (2018) 132 (Supplement 1): 1289.

https://doi.org/10.1182/blood-2018-99-117710

Published: 2018

Journal Articles

The Netrin-1 - Neogenin Axis Regulates Hematopoietic Stem Cell Dormancy and Function with Implications for Stem Cell Ageing

Simon Renders, Pia Sommerkamp, Jasper Panten, Luisa Ladel, Katharina Schönberger, Daniel Klimmeck, PhD, Nina Cabezas-Wallscheid, PhD, Andreas Trumpp, Prof, PhD

Blood (2018) 132 (Supplement 1): 637.

https://doi.org/10.1182/blood-2018-99-118152

Published: 2018

Journal Articles

TGF-β1 Production By Bone Marrow Mesenchymal Stem Cells of FANCD2 Differs from Other Fanconi Anemia Complementation Groups

Ilgın Cagnan, MSc, Aysen Gunel-Ozcan, MD PhD, Fatima Aerts-Kaya, MD PhD, Najim Ameziane, PhD, Baris Kuskonmaz, MD, Josephine Dorsman, PhD, Fatma Gumruk, MD, Duygu Cetinkaya, MD

Blood (2017) 130 (Supplement 1): 2464.

https://doi.org/10.1182/blood.V130.Suppl_1.2464.2464

Published: 2017

Journal Articles

High Mobility Group A1 Chromatin Remodeling Protein Regulates Self-Renewal, Niche Formation, and Regenerative Function in Adult Stem Cells through Wnt/β-Catenin Signaling

Linda Resar, MD, Lingling Xian, MD PhD, Tait Huso, Amy Belton, PhDBSc, Leslie Cope, PhDBSc, David Huso, DVM, PhD

Blood (2016) 128 (22): 2647.

https://doi.org/10.1182/blood.V128.22.2647.2647

Published: 2016

Journal Articles

Analysis of Molecular-Cellular Responses to Proteasome Inhibitors in Multiple Myeloma Patients; A Translational Approach of Proteasome Inhibitors In Vivo Effects from the Drosophila Experimental Model to Humans

Eleni-Dimitra Papanagnou, Tina Bagratuni, Efstathios Kastritis, Issidora Papassideri, Evangelos Terpos, MD, Meletios A. Dimopoulos, Ioannis P. Trougakos

Blood (2015) 126 (23): 3250.

https://doi.org/10.1182/blood.V126.23.3250.3250

Published: 2015

Journal Articles

Animal Models of Aging Research

Marc F. Hoylaerts, PhD

Blood (2015) 126 (23): SCI-4.

https://doi.org/10.1182/blood.V126.23.SCI-4.SCI-4

Published: 2015

Journal Articles

Physiologic Frailty Among Hematopoietic Cell Transplantation (HCT) Survivors Suggests Accelerated Aging and Is a Predictor for Premature Mortality: A Report from the Bone Marrow Transplant Survivor Study (BMTSS)

Mukta Arora, MD MS, Can-Lan Sun, PhD, Kirsten K. Ness, PhD, Jennifer Berano Teh, MD, Jessica Wu, Liton F. Francisco, BS, Saro Armenian, DO, MPH, Amy Schad, MPH, CCRP, Golnaz Namdar, MPH, Alysia Bosworth, Linus Kuo, Daniel Weisdorf, MD, Stephen J. Forman, MD, Smita Bhatia, MD MPH

Blood (2015) 126 (23): 739.

https://doi.org/10.1182/blood.V126.23.739.739

Published: 2015

Journal Articles

Extrahematopoietic Manifestations of Telomere Syndromes

Mary Armanios, MD

Blood (2015) 126 (23): SCI-51.

https://doi.org/10.1182/blood.V126.23.SCI-51.SCI-51

Published: 2015

Journal Articles

Consistent Upregulation of Oxidative Stress and DNA Damage Amongst Dyskeratosis Congenita Genotypes: Ameliorative Effects of Antioxidants

Larisa Pereboeva, MD PhD, Erik Westin, PhD, Meredith Hubbard, BS, Frederick D Goldman, MD

Blood (2014) 124 (21): 1603.

https://doi.org/10.1182/blood.V124.21.1603.1603

Published: 2014

Journal Articles

Evidence for Premature Aging of (Clonal but also) Non-Clonal Hematopoietic Stem Cells in Patients with Acute Myeloid Leukemia (AML)

Martina Crysandt, MD, Monica S.V. Ferreira, PhD, Patrick Ziegler, PhD, Sebastian Hummel, Julian Kaufmann, Stefan Wilop, MD, Edgar Jost, MD, Wolfgang Wagner, MD PhD, Tim H. Brummendorf, MD PhD, Fabian Beier, MD

Blood (2014) 124 (21): 1048.

https://doi.org/10.1182/blood.V124.21.1048.1048

Published: 2014

Journal Articles

Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency

Serine Avagyan, Michael Churchill, Kenta Yamamoto, Jennifer L. Crowe, Chen Li, Brian J. Lee, Tian Zheng, Siddhartha Mukherjee, Shan Zha

Blood (2014) 124 (10): 1622–1625.

https://doi.org/10.1182/blood-2014-05-574863

Published: 2014

Includes: Supplemental data

Journal Articles

Age-Associated DNA Methylation Signature Reveals Premature Aging In Patients With Aplastic Anemia and Dyskeratosis Congenita Which Correlates With Telomere Shortening

Fabian Beier, MD, Carola I. Weidner, Qiong Lin, Patrick Ziegler, PhD, Martin Zenke, Tim H. Brümmendorf, MD, Wolfgang Wagner, MD, PhD

Blood (2013) 122 (21): 1223.

https://doi.org/10.1182/blood.V122.21.1223.1223

Published: 2013

Journal Articles

Increased Thrombin Generation and Fibrin Formation In Premature Aging BMAL1 Deficient Mice

Marisa Ninivaggi, Hilde Kelchtermans, PhD, Marijke Kuipers, PhD, Bianca Hemmeryckx, PhD, Johan Heemskerk, PhD, Theo Lindhout, PhD, Marc F. Hoylaerts, PhD, Bas De Laat, PhD

Blood (2013) 122 (21): 3575.

https://doi.org/10.1182/blood.V122.21.3575.3575

Published: 2013

Journal Articles

A Mouse Model Of Rothmund-Thomson Syndrome Reveals An Essential Role For Recql4 In Maintenance Of Hematopoiesis

Elisabetta DeLuca, Monique Smeets, Meaghan Wall, MBBS (Hons), FRACP, FRCPA, PhD, Julie Quach, Andrew Deans, Jorg Heierhorst, Louise E Purton, PhD, David Izon, Carl R Walkley, PhD, BPharm

Blood (2013) 122 (21): 591.

https://doi.org/10.1182/blood.V122.21.591.591

Published: 2013

Journal Articles

DNA Damage Responses and Oxidative Stress in Dyskeratosis Congenita.

Larisa Pereboeva, MD, PhD, Erik Westin, PhD, Toral Patel, Ian Flaniken, Lawrence S. Lamb, Jr., PhD, Aloysius Klingelhutz, PhD, Frederick D Goldman, MD

Blood (2012) 120 (21): 2359.

https://doi.org/10.1182/blood.V120.21.2359.2359

Published: 2012

Journal Articles

Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging

Jasmine C. Wong, PhD, Kelley Weinfurtner, BA, Yan Zhang, Ph.D., Pilar Alzamora, Eugene Hwang, BA, Scott C. Kogan, MD, Kevin M. Shannon, MD

Blood (2011) 118 (21): 2340.

https://doi.org/10.1182/blood.V118.21.2340.2340

Published: 2011

NARROW

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

CLL Increases the Frequency of CD4 + HLADR + PD1 + T Cells That Demonstrate an Exhaustion Gene Signature and Potential Prognostic Value for Disease Progression

Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms

Inhibition of Endothelial mTOR Drives Hematopoietic Stem Cell Aging

The Netrin-1 - Neogenin Axis Regulates Hematopoietic Stem Cell Dormancy and Function with Implications for Stem Cell Ageing

TGF-β1 Production By Bone Marrow Mesenchymal Stem Cells of FANCD2 Differs from Other Fanconi Anemia Complementation Groups

High Mobility Group A1 Chromatin Remodeling Protein Regulates Self-Renewal, Niche Formation, and Regenerative Function in Adult Stem Cells through Wnt/β-Catenin Signaling

Analysis of Molecular-Cellular Responses to Proteasome Inhibitors in Multiple Myeloma Patients; A Translational Approach of Proteasome Inhibitors In Vivo Effects from the Drosophila Experimental Model to Humans

Animal Models of Aging Research

Physiologic Frailty Among Hematopoietic Cell Transplantation (HCT) Survivors Suggests Accelerated Aging and Is a Predictor for Premature Mortality: A Report from the Bone Marrow Transplant Survivor Study (BMTSS)

Extrahematopoietic Manifestations of Telomere Syndromes

Consistent Upregulation of Oxidative Stress and DNA Damage Amongst Dyskeratosis Congenita Genotypes: Ameliorative Effects of Antioxidants

Evidence for Premature Aging of (Clonal but also) Non-Clonal Hematopoietic Stem Cells in Patients with Acute Myeloid Leukemia (AML)

Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency

Age-Associated DNA Methylation Signature Reveals Premature Aging In Patients With Aplastic Anemia and Dyskeratosis Congenita Which Correlates With Telomere Shortening

Increased Thrombin Generation and Fibrin Formation In Premature Aging BMAL1 Deficient Mice

A Mouse Model Of Rothmund-Thomson Syndrome Reveals An Essential Role For Recql4 In Maintenance Of Hematopoiesis

DNA Damage Responses and Oxidative Stress in Dyskeratosis Congenita.

Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging

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American Society of Hematology

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American Society of Hematology

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