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Journal Articles

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Daniela Nicoleta Petrusca, PhD, Evgeny Berdyshev, PhD, Colin D. Crean, BS, Judith L Anderson, BS, G. David Roodman, MD PhD

Blood (2019) 134 (Supplement_1): 4387.

https://doi.org/10.1182/blood-2019-131106

Published: 2019

Journal Articles

Protein Phosphatase 2A Activation Dependent Down Regulation of PGC1-Alpha and FOXO1 Phosphorylation with OSU-2S in Human Lymphoma Cells

Sohaila Mohamed Khalil, Swagata Goswami, MSc, Xiaokui Mo, PhD MAS, Natarajan Muthusamy, DVM,PhD

Blood (2019) 134 (Supplement_1): 3977.

https://doi.org/10.1182/blood-2019-129224

Published: 2019

Journal Articles

Agonist-Induced Signaling and Integrin-Mediated Function in Murine Platelets Is Distinctly Regulated By the α Isoform of the Catalytic Subunit of Protein Phosphatase 1

Tanvir Khatlani, PhD, Subhashree Pradhan, PhD, Qi Da, PhD, K. Vinod Vijayan, PhD

Blood (2017) 130 (Supplement 1): 1023.

https://doi.org/10.1182/blood.V130.Suppl_1.1023.1023

Published: 2017

Journal Articles

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

Christopher B Ryder, Goutham Narla, MD PhD

Blood (2017) 130 (Supplement 1): 2517.

https://doi.org/10.1182/blood.V130.Suppl_1.2517.2517

Published: 2017

Journal Articles

The Impact of Chemotherapeutic Agents on Signaling and Epigenetics in Vascular Endothelial Cells

Srila Gopal, MD, Amanda Creech, Adam Officer, Shawn Egri, Desiree Davison, Jacob D Jaffe, PhD, Iris Z Jaffe, MD PhD

Blood (2016) 128 (22): 1353.

https://doi.org/10.1182/blood.V128.22.1353.1353

Published: 2016

Journal Articles

GATA Factor-Dependent Positive-Feedback Circuit Controls Acute Myeloid Leukemia Cell Proliferation: Mechanisms and Targets for Therapeutic Intervention

Koichi Ricardo Katsumura, MD PhD, Irene M Ong, PhD, Andrew W DeVilbiss, PhD, Rajendran Sanalkumar, PhD, Emery H Bresnick, PhD

Blood (2016) 128 (22): 1706.

https://doi.org/10.1182/blood.V128.22.1706.1706

Published: 2016

Journal Articles

The High Expression of CFTR in Ph+ Acute Leukemia Regulates the BCR-ABL and Wnt/ -Catenin Signaling Pathway Via Interaction with PP2A Protein

Xi Yang, Yuping Gong, MDPhD

Blood (2015) 126 (23): 1252.

https://doi.org/10.1182/blood.V126.23.1252.1252

Published: 2015

Journal Articles

OP449, a Novel SET Antagonist, Is Cytotoxic To Leukemia Cells and Enhances Efficacy Of Tyrosine Kinase Inhibitors In Drug-Resistant Myeloid Leukemias

Anupriya Agarwal, Ryan J. Meckenzie, B.S., Raffaella Pippa, Ph.D., Christopher A. Eide, Jessica Oddo, B.S., Jeffrey W. Tyner, Rosalie Sears, Ph.D., Michael P. Vitek, Ph.D., Maria D. Odero, M.D., Ph.D., Dale J. Christensen, Ph.D., Brian J. Druker

Blood (2013) 122 (21): 2511.

https://doi.org/10.1182/blood.V122.21.2511.2511

Published: 2013

Journal Articles

The PP2A Subunit B55α Suppresses Survival Signaling in Acute Myeloid Leukemia Cells

Peter P. Ruvolo, PhD, Vivian Ruvolo, Zhihong Zeng, YiHua Qui, MD, Liran Zhou, PhD, Kelly E Gallagher, Marina Konopleva, M.D., Ph.D., Steven M. Kornblau, MD, Michael Andreeff, M.D., Ph.D.

Blood (2011) 118 (21): 396.

https://doi.org/10.1182/blood.V118.21.396.396

Published: 2011

Journal Articles

A Novel SET Antagonist (OP449) Is Cytotoxic to CML Cells, Including the Highly-Resistant BCR-ABL T315I Mutant, and Demonstrates Enhanced Efficacy in Combination with ABL Tyrosine Kinase Inhibitors,

Anupriya Agarwal, PhD, Ryan MacKenzie, BS, Jessica Oddo, B.S., Michael P Vitek, PhD, Dale J. Christensen, PhD, Brian J. Druker

Blood (2011) 118 (21): 3757.

https://doi.org/10.1182/blood.V118.21.3757.3757

Published: 2011

Journal Articles

Discovery of Critical Functions of Histone Demethylase, PHF8, in Mediating ATRA Response in APL

Maria Francisca Arteaga, PhD, Jan-Henrik Mikesch, MD, Chi Wai Eric So, PhD

Blood (2011) 118 (21): 226.

https://doi.org/10.1182/blood.V118.21.226.226

Published: 2011

Journal Articles

FTY720 Has Potent Anti-Leukemic Effects on Acute Lymphoblastic Leukemia Cells and Results In Caspase Independent Cell Death

Craig T. Wallington-Beddoe, BSc, MBBS, John Hewson, MBBS, Kenneth Francis Bradstock, MB, PhD, Linda J. Bendall, BSc, PhD

Blood (2010) 116 (21): 3260.

https://doi.org/10.1182/blood.V116.21.3260.3260

Published: 2010

Journal Articles

Obligatory Asymmetric Cell Division Regulates Self-Renewal In Hematopoietic Progenitor/Stem Cells

William T. Tse, MD, PhD, Livana Soetedjo, BS, Timothy Lax, MD, Lei Wang, BA, MBA, Patrick J. Kennedy, BA, DDS

Blood (2010) 116 (21): 571.

https://doi.org/10.1182/blood.V116.21.571.571

Published: 2010

Journal Articles

Impact of Protein Phosphatase PP2A on ATRA-Induced Activation of FoxO3a In Acute Promyelocytic Leukemia Cells

Yasuhiko Sakoe, Kumi Sakoe, Haruo Shimazaki, Keita Kirito, MD, Norio Komatsu

Blood (2010) 116 (21): 2492.

https://doi.org/10.1182/blood.V116.21.2492.2492

Published: 2010

Journal Articles

Non-Competitive Protein Phosphatase-1 Inhibitors Prevent Sickling of SS RBCs.

Jerod Hairston, Keon Combi, Altreisha Foster, Bak Kim, Victor R. Gordeuk, MD, Sergei Nekhai, PhD

Blood (2009) 114 (22): 4038.

https://doi.org/10.1182/blood.V114.22.4038.4038

Published: 2009

Journal Articles

Erucylphosphohomocholine, the First Intravenously Applicable Alkylphosphocholine, Induces Cell Cycle Arrest, Apoptosis, and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia.

Veronica Papa, BS, PierLuigi Tazzari, MD, Francesca Chiarini, BS, Francesca Ricci, BS, Giovanni Martinelli, MD, Andrea Bontadini, MD, James McCubrey, PhD, Lars H Lindner, MD, Hansjoerg Eibl, PhD, Alberto M. Martelli, MD

Blood (2008) 112 (11): 1330.

https://doi.org/10.1182/blood.V112.11.1330.1330

Published: 2008

Journal Articles

BCL-2 Phosphorylation Modulates Sensitivity to the BH3-Mimetic GX15-070 (Obatoclax) and Reduces Its Synergistic Interaction with Bortezomib in Chronic Lymphocytic Leukemia Cells.

Patricia Perez Galan, PhD, Gael Roue, PhD, Monica Lopez Guerra, BS, Neus Villamor, MD, PhD, Emili Montserrat, MD, PhD, Elias Campo, MD, PhD, Dolors Colomer, PhD

Blood (2007) 110 (11): 3464.

https://doi.org/10.1182/blood.V110.11.3464.3464

Published: 2007

Journal Articles

The B56α PP2A B Regulatory Subunit Promotes Mitochondrial PP2A Activity and Supports Etoposide-Induced Cell Death in Human ALL Derived REH Cells.

Peter P. Ruvolo, PhD, Vivian R. Ruvolo, MA, Svitlana M. Kurinna, MS

Blood (2007) 110 (11): 3358.

https://doi.org/10.1182/blood.V110.11.3358.3358

Published: 2007

Journal Articles

A Study of the Protein Phosphatase 2A Involved in the Induction of NB4 and MR2 Cell Differentiation by ATRA.

Jian Ouyang, MD, Xihui Xu, De Pei Wu, MD

Blood (2007) 110 (11): 4309.

https://doi.org/10.1182/blood.V110.11.4309.4309

Published: 2007

Journal Articles

Protein Phosphatase 2A Inactivates Bcl2’s Antiapoptotic Function by Dephosphorylation and Up-Regulation of Bcl2-p53 Binding.

Xingming Deng, MD, Fengqin Gao, Tammy Flagg, W. Stratford May, M.D., Ph.D.

Blood (2006) 108 (11): 1436.

https://doi.org/10.1182/blood.V108.11.1436.1436

Published: 2006

NARROW

GFI1-Dependent SGPP1 Repression Promotes Growth and Survival of Myeloma Cells

Protein Phosphatase 2A Activation Dependent Down Regulation of PGC1-Alpha and FOXO1 Phosphorylation with OSU-2S in Human Lymphoma Cells

Agonist-Induced Signaling and Integrin-Mediated Function in Murine Platelets Is Distinctly Regulated By the α Isoform of the Catalytic Subunit of Protein Phosphatase 1

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

The Impact of Chemotherapeutic Agents on Signaling and Epigenetics in Vascular Endothelial Cells

GATA Factor-Dependent Positive-Feedback Circuit Controls Acute Myeloid Leukemia Cell Proliferation: Mechanisms and Targets for Therapeutic Intervention

The High Expression of CFTR in Ph+ Acute Leukemia Regulates the BCR-ABL and Wnt/ -Catenin Signaling Pathway Via Interaction with PP2A Protein

OP449, a Novel SET Antagonist, Is Cytotoxic To Leukemia Cells and Enhances Efficacy Of Tyrosine Kinase Inhibitors In Drug-Resistant Myeloid Leukemias

The PP2A Subunit B55α Suppresses Survival Signaling in Acute Myeloid Leukemia Cells

A Novel SET Antagonist (OP449) Is Cytotoxic to CML Cells, Including the Highly-Resistant BCR-ABL T315I Mutant, and Demonstrates Enhanced Efficacy in Combination with ABL Tyrosine Kinase Inhibitors,

Discovery of Critical Functions of Histone Demethylase, PHF8, in Mediating ATRA Response in APL

FTY720 Has Potent Anti-Leukemic Effects on Acute Lymphoblastic Leukemia Cells and Results In Caspase Independent Cell Death

Obligatory Asymmetric Cell Division Regulates Self-Renewal In Hematopoietic Progenitor/Stem Cells

Impact of Protein Phosphatase PP2A on ATRA-Induced Activation of FoxO3a In Acute Promyelocytic Leukemia Cells

Non-Competitive Protein Phosphatase-1 Inhibitors Prevent Sickling of SS RBCs.

Erucylphosphohomocholine, the First Intravenously Applicable Alkylphosphocholine, Induces Cell Cycle Arrest, Apoptosis, and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia.

BCL-2 Phosphorylation Modulates Sensitivity to the BH3-Mimetic GX15-070 (Obatoclax) and Reduces Its Synergistic Interaction with Bortezomib in Chronic Lymphocytic Leukemia Cells.

The B56α PP2A B Regulatory Subunit Promotes Mitochondrial PP2A Activity and Supports Etoposide-Induced Cell Death in Human ALL Derived REH Cells.

A Study of the Protein Phosphatase 2A Involved in the Induction of NB4 and MR2 Cell Differentiation by ATRA.

Protein Phosphatase 2A Inactivates Bcl2’s Antiapoptotic Function by Dephosphorylation and Up-Regulation of Bcl2-p53 Binding.

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American Society of Hematology

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American Society of Hematology

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