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Journal Articles

Broad Activity of Apto-253 in AML and Other Hematologic Malignancies Correlates with KLF4 Expression Level

Stephen E. Kurtz, PhD, Daniel Bottomly, MS, Beth Wilmot, PhD, Shannon K. McWeeney, PhD, William Rice, PhD, Stephen B Howell, MD, Avanish Vellanki, Brian J. Druker, MD, Jeffrey W. Tyner, PhD
Journal: Blood
Blood (2015) 126 (23): 1358.
https://doi.org/10.1182/blood.V126.23.1358.1358
Published: 2015
Journal Articles

APTO-253 Induces KLF4 to Promote Potent in Vitro Pro-Apoptotic Activity in Hematologic Cancer Cell Lines and Antitumor Efficacy As a Single Agent and in Combination with Azacitidine in Animal Models of Acute Myelogenous Leukemia (AML)

William G Rice, PhD, Avanish Vellanki, MBS, MBA, Yoon Lee, PhD, Jeff Lightfoot, PhD, Robert Peralta, MSc, DVM, Mona Jamerlan, MSc, Hongnan Jin, Ronnie Lum, PhD, Tiffany Cheng, MSc
Journal: Blood
Blood (2014) 124 (21): 4813.
https://doi.org/10.1182/blood.V124.21.4813.4813
Published: 2014
Journal Articles

The Leukemogenic Potential of Cdx2 Is Dependent on Its N-Terminal Serine Sites and Can Be Counteracted by MAPK Inhibitors

Vijay P.S. Rawat, PhD, Vegi M. Naidu, MSc, Deepak Bararia, PhD, Silvia Thoene, MSc, Farid Ahmed, PhD, Leticia Quintanilla-Martinez, MD, Wolfgang Hiddemann, Stefan Bohlander, Michaela Feuring-Buske, MD, Christian Buske, MD
Journal: Blood
Blood (2008) 112 (11): 3784.
https://doi.org/10.1182/blood.V112.11.3784.3784
Published: 2008
Journal Articles

The Transforming Potential of the Homeobox Gene Cdx2 Is Depending on Its N-Terminal Transactivation Domain In Vivo and Can Be Antagonized by the MEK1/2 Inhibitor in a Mouse Model of t(12;13) Positive AML.

Vijay P.S. Rawat, MSc, Natalia Arseni Arseni, Ph.D., Vegi M. Naidu, M.Sc, John P. Lynch, Ph.D, Wolfgang Hiddemann, MD, Michaela Feuring-Buske, MD, Christian Buske, MD
Journal: Blood
Blood (2006) 108 (11): 7.
https://doi.org/10.1182/blood.V108.11.7.7
Published: 2006