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Journal Articles

Short-Term Fasting Induces Cell Cycle Arrest of Immature Hematopoietic Cells and Increases the Number of Naive T Cells in the Bone Marrow of Mice

Teruhito Takakuwa, MD, Yasuhiro Nakashima, MD, PhD, Hideo Koh, MD,PhD, Takahiko Nakane, MD, PhD, Hirohisa Nakamae, MD PhD, Masayuki Hino, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 5047.
https://doi.org/10.1182/blood.V128.22.5047.5047
Published: 2016
Journal Articles

Inhibition of the Histone Demethylase LSD1 Combined with Caloric Restriction or IGF1/Insulin Inhibition Leads to Durable Responses in a Preclinical Model of Acute Myeloid Leukemia

Luca Mazzarella, MD PhD, Tiphanie Durfort, Rani Pallavi, Elena Mylonas, Paolo Falvo, Anna Giulia Sanarico, Massimo Stendardo, Luciano Giaco', Anna Russo, Lucilla Luzi, Massimiliano Mazza, Giulia De Conti, Paola Vianello, Pier Luigi Rossi, Elena Ceccacci, Mohamed Elgendy, Marco Giorgio, Ciro Mercurio, Saverio Minucci, Pier Giuseppe Pelicci
Journal: Blood
Blood (2015) 126 (23): 459.
https://doi.org/10.1182/blood.V126.23.459.459
Published: 2015
Journal Articles

Microrna Mediated Regulation of Hematopoietic Stem Cell Aging

Safak Yalcin, PhD, Mark Carty, Joseph Yusup Shin, Richard A Miller, PhD, Christina Leslie, PhD, Christopher Y. Park, MD PhD
Journal: Blood
Blood (2014) 124 (21): 602.
https://doi.org/10.1182/blood.V124.21.602.602
Published: 2014
Journal Articles

Longevity Promoting Interventions Inhibit Molecular and Functional Changes In Aging Hematopoietic Stem Cells

Safak Yalcin, PhD, Wenhuo Hu, PhD, Richard A Miller, PhD, Yusup Shin, Christopher Y. Park, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1168.
https://doi.org/10.1182/blood.V122.21.1168.1168
Published: 2013
Journal Articles

Modelling The Influence Of Diet On APL Identifies Insulin-Growth Factor 1 As A Central Mediator and Provides A Mechanistic Rationale For Therapeutic Weight Loss

Luca Mazzarella, MD. PhD, Tiphanie Durfort, PhD, Pier Giuseppe Pelicci
Journal: Blood
Blood (2013) 122 (21): 833.
https://doi.org/10.1182/blood.V122.21.833.833
Published: 2013
Journal Articles

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Ophélie Meynet, Barbara Zunino, Lina Happo, Ludivine A. Pradelli, Johanna Chiche, Marie A. Jacquin, Laura Mondragón, Jean-François Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-François Michiels, Ewa M. Michalak, Michel Carles, Clare L. Scott, Jean-Ehrland Ricci
Journal: Blood
Blood (2013) 122 (14): 2402–2411.
https://doi.org/10.1182/blood-2013-01-478651
Published: 2013
Includes: Supplemental data
Journal Articles

A Novel Perspective on Stem Cells, Tissue Senescence and Aging: Pluripotent Very Small Embryonic-Like Stem Cells (VSELs) and Hematopoietic Stem Cells (HSCs) Are Prematurely Depleted in Adult Bone Marrow (BM) in Response to Prolonged Growth Hormone/Insulin-Like Growth Factor-1 Signaling (IIS) and Chronic Increase in Caloric Uptake

Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Dong-Myung Shin, PhD, Rui Liu, Ph.D., Michal Masternak, Ph.D., Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 4818.
https://doi.org/10.1182/blood.V118.21.4818.4818
Published: 2011
Journal Articles

Novel View on Stem Cell Compartment and Aging - a Number of Pluripotent Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells in Murine Bone Marrow Is High in Several Long-Living and Reduced in Short-Living Murine Strains and Unexpectedly Inversely Correlates in These Animals with Plasma Growth Hormone/Insulin-Like Growth Factor-1 Level

Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Rui Liu, MB, BS, Dong-Myung Shin, PhD, Michal Masternak, PhD, Andrzej Bartke, PhD, Mariusz Z Ratajczak, MD, PhD
Journal: Blood
Blood (2011) 118 (21): LBA-5–LAB-5.
https://doi.org/10.1182/blood.V118.21.LBA-5.LBA-5
Published: 2011
Journal Articles

Calorie Restriction and Aging

Rafael de Cabo, PhD
Journal: Blood
Blood (2010) 116 (21): SCI-2.
https://doi.org/10.1182/blood.V116.21.SCI-2.SCI-2
Published: 2010
Journal Articles

Unexpected Evidence That Chronic IGF-1 Deficiency In Laron Dwarf Mice Maintains High Levels of Hematopoietic Stem Cells (HSCs) In BM - Are HSCs Gradually Depleted From BM with Age In An IGF-1–dependent Manner? Implications for the Novel Effect of Caloric Restriction on the Hematopoietic Stem Cell Compartment and Longevity.

Janina Ratajczak, MD, PhD, Wu Wan, MS, Rui Liu, MB, BS, Dong-Myung Shin, Ph.D., Magdalena Kucia, PhD, Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, MD, PhD, DSc
Journal: Blood
Blood (2010) 116 (21): 1551.
https://doi.org/10.1182/blood.V116.21.1551.1551
Published: 2010
Journal Articles

The Number of Very Small Embryonic Like Stem Cells (VSELs) Decreases During Aging In An IGF-1-Dependent Manner - a Novel Link Between Aging, Caloric Restriction, and the Size of the Stem Cell Pool

Dong-Myung Shin, Ph.D., Wu Wan, BS, Rui Liu, MB, BS, Janina Ratajczak, MD, PhD, Andrzej Bartke, Ph.D., Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD, PhD, DSc
Journal: Blood
Blood (2010) 116 (21): 4796.
https://doi.org/10.1182/blood.V116.21.4796.4796
Published: 2010
Journal Articles

SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.

Tomohiro Kozako, PhD, Teruhisa Shoji, Akiyoshi Aikawa, Satoru Hayashida, Yukako Kuramoto, PhD, Rie Mononagare, Shinichiro Honda, PhD, Hiroshi Shimeno, PhD, Shinji Soeda, PhD, Makoto Yoshimitsu, MD, Yohann White, MD, Naomichi Arima, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3684.
https://doi.org/10.1182/blood.V114.22.3684.3684
Published: 2009
Journal Articles

NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.

Sachiko Ezoe, MD, PhD, Itaru Matsumura, MD.PhD, Hirokazu Tanaka, MD.PhD, Hirohiko Shibayama, MD.PhD, Masao Mizuki, MD.PhD, Yuzuru Kanakura, MD.PhD
Journal: Blood
Blood (2006) 108 (11): 1320.
https://doi.org/10.1182/blood.V108.11.1320.1320
Published: 2006