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Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 731.
https://doi.org/10.1182/blood-2019-125959
Published: 2019
Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 821.
https://doi.org/10.1182/blood-2019-127904
Published: 2019
Journal Articles

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

Shuhei Asada, MD, Susumu Goyama, MD PhD, Daichi Inoue, MD PhD, Reina Takeda, MD, Masahito Kawazu, Hiroyuki Mano, MDPhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 562.
https://doi.org/10.1182/blood.V130.Suppl_1.562.562
Published: 2017
Journal Articles

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoietic Stem and Progenitor Cells

Susan Hilgendorf, MSc, Hendrik Folkerts, MSc, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4107.
https://doi.org/10.1182/blood.V126.23.4107.4107
Published: 2015
Journal Articles

BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes

Lindsay M LaFave, PhD, Wendy Béguelin, PhD, Richard Koche, PhD, Matt Teater, Efthymia Papalexi, Barbara Spitzer, MD, Sarah Knutson, PhD, John Campbell, PhD, Heike Keilhack, PhD, Paul M Thomas, PhD, Neil L Kelleher, PhD, Omar Abdel-Wahab, Ari M. Melnick, MD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 713.
https://doi.org/10.1182/blood.V126.23.713.713
Published: 2015
Journal Articles

Downregulation of BAP1 in Chronic Myelomonocytic Leukemia: Correlated with a Post-Translational Reduction of BRCA1 Levels and Independent of Promoter Methylation

Ana María Hurtado, Gines Luengo-Gil, Laura Palomo, MSc, Eva Lumbreras, Eva Caparrós, Tzu Hua Chen-Liang, Bartlomiej Przychodzen, MSc, Maria Luz Amigo, María Díez-Campelo, MD PhD, Lurdes Zamora, PhD, Francisco José Ortuño, Raul Teruel Montoya, PhD, Jaroslaw P. Maciejewski, MD PhD, Consuelo Del Cañizo, MD PhD, Francesc Sole, PhD, Francisca Ferrer-Marin, Andres Jerez
Journal: Blood
Blood (2015) 126 (23): 1648.
https://doi.org/10.1182/blood.V126.23.1648.1648
Published: 2015
Journal Articles

Deubiquitnase BAP1 Downregulation in Myeloid Malignances: A New Pathogenic Mechanism, Dominant in Chronic Myelomonocytic Leukemia

Ana Maria Hurtado, Eva Caparrós, Jose Miguel Torregrosa, Ginés Luengo, Mara Toderici, María Eugenia De la Morena, Begoña Muiña, Maria Luisa Lozano, Constant Martinez, Mari Luz Amigo, Felipe De Arriba, Francisco Ortuño, Raul Teruel Montoya, PhD, Francisca Ferrer-Marin, MD, PhD, Vicente Vicente, MD PhD, Andres Jerez, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5594.
https://doi.org/10.1182/blood.V124.21.5594.5594
Published: 2014
Journal Articles

BRCA1-Down-Regulation In Chronic Myeloid Leukemia (CML) Occurs Via The Deubiquitinase / Tumor Suppressor BRCA1-Associated Protein 1 (BAP1)

Fatima Dkhissi, PhD, Djamel Aggoune, Julien Pontis, Marie Laure Bonnet, Marie Claude Meunier, Nathalie Sorel, PhD, Clémentine Bouneau, Annelise Bennaceur-Griscelli, MD, PhD, François Guilhot, MD, Jean-Claude Chomel, PharmD, PhD, Slimane Ait-Si-Ali, PhD, Ali G Turhan, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3813.
https://doi.org/10.1182/blood.V122.21.3813.3813
Published: 2013
Journal Articles

ASXL1 Mutations Promote Myeloid Transformation Through Inhibition of PRC2-Mediated Gene Repression

Omar Abdel-Wahab, MD, Mazhar Adli, PhD, Lindsay Saunders, B.Sc., Jie Gao, PhD, Alan H. Shih, MD, PhD, Suveg Pandey, B.Sc., Jake Jaffe, PhD, Xinyang Zhao, PhD, Fabiana Perna, MD, Martin Carroll, MD, Ari Melnick, MD, Stephen D. Nimer, MD, Iannis Aifantis, PhD, Bradley Bernstein, Ross L Levine, MD
Journal: Blood
Blood (2011) 118 (21): 405.
https://doi.org/10.1182/blood.V118.21.405.405
Published: 2011