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Journal Articles

Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress

Guangyan C Sun, PhD, Anna C Shvab, Bin C Li, PhD, Felipe C Beckedorff, Guy Jacques Leclerc, PhD, Ramin Shiekhattar, PhD, Julio C Barredo, MD

Blood (2018) 132 (Supplement 1): 1321.

https://doi.org/10.1182/blood-2018-99-112678

Published: 2018

Journal Articles

Evaluation Of Acadesine, a Drug Stimulating Cell Autophagy, In Azacitidine(AZA)-Resistant Myelodysplastic Syndromes (MDS)

Thomas Cluzeau, MD, PhD, Guillaume Robert, PhD, Jean Michel Karsenti, MD, Frederic Luciano, PhD, Nicolas Mounier, MD, PhD, Jill Patrice Cassuto, MD, PhD, Lionel Ades, Sophie Raynaud, MD, PhD, Pierre Fenaux, MD, PhD, Patrick Auberger, PhD

Blood (2013) 122 (21): 1568.

https://doi.org/10.1182/blood.V122.21.1568.1568

Published: 2013

Journal Articles

The Nucleoside Analogue Acadesine Exerts Antitumoral Activity and Cooperates with Conventional Agents In In Vitro and In Vivo Models of Mantle Cell Lymphoma

Arnau Montraveta, MS, Mercè de Frías, PhD, Clara Campàs, PhD, Elias Campo, MD, PhD, Gael Roue, PhD, Dolors Colomer, PhD

Blood (2010) 116 (21): 3918.

https://doi.org/10.1182/blood.V116.21.3918.3918

Published: 2010

Journal Articles

Acadesine for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL): A Multicentre Phase I/II Study

Eric Van den Neste, Bruno Cazin, Ann Janssens, M.D., Eva González-Barca, María José Terol, Vincent Levy, Jaime Pérez de Oteyza, Pierre Zachee, Andrew Saunders, Mercè de Frias, Clara Campàs

Blood (2010) 116 (21): 4625.

https://doi.org/10.1182/blood.V116.21.4625.4625

Published: 2010

Journal Articles

Acadesine-Induced Citotoxicy In Chronic Lymphocytic Leukemia Is Independent of Immunoglobulin Mutational Status and Zap70 Expression

Silvia Pairet, Ana Ferrer, Eugenia Abella, MariCarmen Vela, Raquel Longarón, Clara Campàs, Mercè de Frías, Aina Pons, Blanca Espinet, Sergi Serrano, Carlos Besses, Beatriz Bellosillo

Blood (2010) 116 (21): 4631.

https://doi.org/10.1182/blood.V116.21.4631.4631

Published: 2010

Journal Articles

AICAR Induces Apoptosis In B Lymphocytes From Balb/c Mice and Its Effect In Chronic Lymphocytic Leukemia Cells Is Synergic or Additive with Current Chemotherapy

Diana M González-Gironès, Antonio F Santidrián, Daniel Iglesias-Serret, Ana M Cosialls, Alba Pérez-Perarnau, Camila Rubio-Patiño, Mercè de Frias, Alberto Fernandez de Sevilla, MD, PhD, Eva González-Barca, Esmeralda de la Banda, Gabriel Pons, Clara Campàs, Joan Gil

Blood (2010) 116 (21): 1815.

https://doi.org/10.1182/blood.V116.21.1815.1815

Published: 2010

Journal Articles

Induction of Autophagic Cell Death Circumvents Azacitidine-Resistance In Myelodysplastic Syndrome-Derived Cell Lines

Thomas Cluzeau, Guillaume Robert, Jean-Michel Karsenti, Frederic Luciano, Alexandre Puissant, S. Dominique Raynaud, MD, Lionel Mannone, Jill-Patrice Cassuto, Nicolas Mounier, Patrick Auberger

Blood (2010) 116 (21): 1817.

https://doi.org/10.1182/blood.V116.21.1817.1817

Published: 2010

Journal Articles

Acadesine Inhibits Proliferation and Induces Apoptosis In Multiple Myeloma Cells, and Synergizes with Standard of Care Antimyeloma Agents

Susana Hernández-García, Mercè de Frias, Clara Campàs, Bruno Paiva, Enrique M. Ocio, Jesús F. San Miguel, Sr., MD, PhD, Atanasio Pandiella, Sr., MD, PhD

Blood (2010) 116 (21): 5023.

https://doi.org/10.1182/blood.V116.21.5023.5023

Published: 2010

Journal Articles

AICAR Induces Apoptosis in Chronic Lymphocytic Leukemia Cells through the Mitochondrial Pathway and Independently of p53 Pathway and AMPK Activation.

Joan Gil, PhD, Antonio F Santidrián, PhD, Diana M González-Gironès, PhD, Daniel Iglesias-Serret, PhD, Llorenç Coll-Mulet, PhD, Ana M Cosialls, PhD, Mercè de Frias, PhD, Clara Campàs, PhD, Eva González-Barca, MD, PhD, Esther Alonso, MD, Alberto Fernandez de Sevilla, MD, PhD, Benoit Viollet, PhD, Gabriel Pons, MD, PhD

Blood (2009) 114 (22): 4819.

https://doi.org/10.1182/blood.V114.22.4819.4819

Published: 2009

Journal Articles

Acadesine (Acadra‘) for Patients with Resistant/Relapsed Chronic B-Cell Lymphocytic Leukemia (B-CLL): A Multicentre Phase I/II Study.

Eric W Van Den Neste, MD, PhD, Eva Gonzalez-Barca, M.D., Ann Janssens, MD, Bruno Cazin, M.D., J. Pérez de Oteyza, M.D., Maria Jose Terol, MD, T. Auton, PhD, Andrew Saunders, M.D., Clara Campas, PhD

Blood (2009) 114 (22): 4405.

https://doi.org/10.1182/blood.V114.22.4405.4405

Published: 2009

Journal Articles

Mechanism of Acadesine-Induced Apoptosis in B-Cell Neoplasms.

Antonio F. Santidrián, BD, Clara Campàs, PhD, Llorenç Coll-Mulet, BD, Daniel Iglesias-Serret, PhD, Ana M. Cosialls, BD, Mercé Defrias, BD, Alicia Domindo, MD, Alberto Fernandez de Sevilla, MD, PhD, Gabriel Pons, MD, PhD, Joan Gil, PhD

Blood (2005) 106 (11): 4822.

https://doi.org/10.1182/blood.V106.11.4822.4822

Published: 2005

Journal Articles

MDM2 Antagonists Activate p53 and Synergize with Genotoxic Drugs To Induce Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells but Not in T Cells.

Joan Gil, PhD, Llorenç Coll-Mulet, BD, Daniel Iglesias-Serret, PhD, Antonio F. Santidrián, BD, Esther Castaño, PhD, Clara Campàs, PhD, Montserrat Barragán, PhD, Ana M. Cosialls, BD, Mercé De Frias, BD, Alberto Fernández de Sevilla, MD, PhD, Alicia Domingo, MD, Lyubomir T. Vassilev, PhD, Gabriel Pons, MD, PhD

Blood (2005) 106 (11): 5040.

https://doi.org/10.1182/blood.V106.11.5040.5040

Published: 2005

Journal Articles

Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes

Clara Campàs, José Manuel López, Antonio F. Santidrián, Montserrat Barragán, Beatriz Bellosillo, Dolors Colomer, Joan Gil

Blood (2003) 101 (9): 3674–3680.

https://doi.org/10.1182/blood-2002-07-2339

Published: 2003

NARROW

Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress

Evaluation Of Acadesine, a Drug Stimulating Cell Autophagy, In Azacitidine(AZA)-Resistant Myelodysplastic Syndromes (MDS)

The Nucleoside Analogue Acadesine Exerts Antitumoral Activity and Cooperates with Conventional Agents In In Vitro and In Vivo Models of Mantle Cell Lymphoma

Acadesine for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL): A Multicentre Phase I/II Study

Acadesine-Induced Citotoxicy In Chronic Lymphocytic Leukemia Is Independent of Immunoglobulin Mutational Status and Zap70 Expression

AICAR Induces Apoptosis In B Lymphocytes From Balb/c Mice and Its Effect In Chronic Lymphocytic Leukemia Cells Is Synergic or Additive with Current Chemotherapy

Induction of Autophagic Cell Death Circumvents Azacitidine-Resistance In Myelodysplastic Syndrome-Derived Cell Lines

Acadesine Inhibits Proliferation and Induces Apoptosis In Multiple Myeloma Cells, and Synergizes with Standard of Care Antimyeloma Agents

AICAR Induces Apoptosis in Chronic Lymphocytic Leukemia Cells through the Mitochondrial Pathway and Independently of p53 Pathway and AMPK Activation.

Acadesine (Acadra‘) for Patients with Resistant/Relapsed Chronic B-Cell Lymphocytic Leukemia (B-CLL): A Multicentre Phase I/II Study.

Mechanism of Acadesine-Induced Apoptosis in B-Cell Neoplasms.

MDM2 Antagonists Activate p53 and Synergize with Genotoxic Drugs To Induce Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells but Not in T Cells.

Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes

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American Society of Hematology

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American Society of Hematology

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