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Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 2782.

https://doi.org/10.1182/blood-2019-127615

Published: 2019

Journal Articles

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Teresa Sadras, PhD, Mickaël Martin, MD PhD, Lauren Kim-Sing, Jevon Cutler, PhD, Gal Lenz, PhD, Anne Marie Knapp, Dana Ghergus, MD PhD, Fabien Delmotte, Cédric Schleiss, Anne-Sophie Korganow, MD PhD, Pauline Soulas-Sprauel, PharmD, PhD, Zhengshan Chen, MD PhD, Akhilesh Pandey, MD PhD, David M. Weinstock, MD, Hassan Jumaa, PhD, Eric Meffre, PhD, Thierry Martin, MD PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 295.

https://doi.org/10.1182/blood-2019-128999

Published: 2019

Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Blood (2019) 134 (Supplement_1): 393.

https://doi.org/10.1182/blood-2019-131270

Published: 2019

Journal Articles

Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies

Teresa Sadras, PhD, Jevon Cutler, Julia Aguade-Gorgorio, PhD, Zhengshan Chen, MD PhD, Kadriye Nehir Cosgun, PhD, Akhilesh Pandey, MD PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 3922.

https://doi.org/10.1182/blood-2018-99-116954

Published: 2018

Journal Articles

PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia

Gang Xiao, PhD, Zhengshan Chen, MD PhD, Brass Daniel, PhD, Lai N Chan, PhD, Huimin Geng, PhD, Xiaoyan Jiang, MD PhD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 1056.

https://doi.org/10.1182/blood.V128.22.1056.1056

Published: 2016

Journal Articles

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

Zhengshan Chen, MD PhD, Huimin Geng, PhD, Lars Klemm, BSc, MSc, Lai N Chan, PhD, Brass Daniel, PhD, Warren S. Alexander, PhD, Cheryl L. Willman, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4069.

https://doi.org/10.1182/blood.V128.22.4069.4069

Published: 2016

Journal Articles

Transcriptional Control of Glucose and Energy Supply Prevents Oncogenic Signaling and B Cell Transformation

Lai N Chan, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Jaewoong Lee, PhD, Huimin Geng, PhD, Hurtz Christian, PhD, Valeria Cazzaniga, PhD, Giovanni Cazzaniga, PhD, Ross A Dickins, PhD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 437.

https://doi.org/10.1182/blood.V128.22.437.437

Published: 2016

Journal Articles

Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia

Lai N Chan, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Gang Xiao, PhD, Zhengshan Chen, MD PhD, Thomas Ernst, MD, Andreas Hochhaus, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 2771.

https://doi.org/10.1182/blood.V128.22.2771.2771

Published: 2016

Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD

Blood (2016) 128 (22): 2738.

https://doi.org/10.1182/blood.V128.22.2738.2738

Published: 2016

Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4088.

https://doi.org/10.1182/blood.V128.22.4088.4088

Published: 2016

Journal Articles

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Blood (2014) 124 (21): 284.

https://doi.org/10.1182/blood.V124.21.284.284

Published: 2014

Journal Articles

Divergent Lineage-Specific Functions of PP2A in Chronic Phase CML and Lymphoid Blast Crisis

Gang Xiao, PhD, Huimin Geng, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Markus Muschen, MD PhD

Blood (2014) 124 (21): 3128.

https://doi.org/10.1182/blood.V124.21.3128.3128

Published: 2014

Journal Articles

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Zhengshan Chen, MD PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jae-Woong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, OC, PhD DSc, FRSC, FRS, Markus Muschen, MDPhD

Blood (2014) 124 (21): 792.

https://doi.org/10.1182/blood.V124.21.792.792

Published: 2014

Journal Articles

Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

Shojaee Seyedmehdi, PhD, Zhengshan Chen, MD PhD, Maike Buchner, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Hilde Schjerven, PhD, Lai N Chan, PhD, Phillip Koeffler, MD, Cheryl L. Willman, MD, Stephen Hunger, MD, Sinisa Dovat, MD,PhD, Elisabeth Paietta, PhD, Wolf-Karsten Hofmann, Ari M Melnick, MD, Warren S. Alexander, Steven M. Kornblau, MD, Markus Muschen, MDPhD

Blood (2014) 124 (21): 787.

https://doi.org/10.1182/blood.V124.21.787.787

Published: 2014

Journal Articles

IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Jae-Woong Lee, PhD, Zhengshan Chen, MD PhD, Behzad Kharabi Masouleh, MD, Christian Hurtz, PhD, Eugene Park, Gang Xiao, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD

Blood (2014) 124 (21): 788.

https://doi.org/10.1182/blood.V124.21.788.788

Published: 2014

Journal Articles

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Eugene Park, Angela Park, Lars Klemm, Charles Bailey, Markus Muschen, MDPhD

Blood (2014) 124 (21): 1070.

https://doi.org/10.1182/blood.V124.21.1070.1070

Published: 2014

Journal Articles

Ifitm3 (CD225) Mediates CD19-Dependent Survival and Proliferation During Normal B Cell Development and In Ph + ALL

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD, PhD, Eugene Park, Lars Klemm, Charles C Bailey, Markus Muschen, MD, PhD

Blood (2013) 122 (21): 2505.

https://doi.org/10.1182/blood.V122.21.2505.2505

Published: 2013

Journal Articles

Targeting Pre-B Cell Receptor and BCL6 In TCF3-PBX1 B-Lineage Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Christian Hurtz, PhD, Zhengshan Chen, MD, PhD, Wei-Yi Chen, PhD, Erica Ballabio, PhD, Gang Xiao, PhD, Soo-mi Kweon, PhD, Rahul Nahar, PhD, Seyedmehdi Sojaee, PhD, Lai N. Chan, PhD, Behzad Kharabi Masouleh, MD, David B. Sykes, MD, PhD, Ari Melnick, MD, Robert Roeder, PhD, Thomas Milne, PhD, Markus Muschen, MD

Blood (2013) 122 (21): 349.

https://doi.org/10.1182/blood.V122.21.349.349

Published: 2013

Journal Articles

Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia

Zhengshan Chen, MD, PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jaewoong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD, PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari M. Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, Markus Muschen, MD, PhD

Blood (2013) 122 (21): 229.

https://doi.org/10.1182/blood.V122.21.229.229

Published: 2013

Journal Articles

Negative Feedback Signaling Enables Leukemic Transformation by Oncogenic Tyrosine Kinases

Seyedmehdi Shojaee, M.Sc., Maike Buchner, PhD, Srividya Swaminathan, B Tech, Huimin Geng, PhD, Linda Chan, PhD, Marle Bothe, Zhengshan Chen, MD, PhD, Ari Melnick, MD, Jeffery Molkentin, PhD, Gail Martin, PhD, H. Phillip Koeffler, MD, Markus Muschen, MD, PhD

Blood (2012) 120 (21): 1352.

https://doi.org/10.1182/blood.V120.21.1352.1352

Published: 2012

NARROW

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies

PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

Transcriptional Control of Glucose and Energy Supply Prevents Oncogenic Signaling and B Cell Transformation

Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Divergent Lineage-Specific Functions of PP2A in Chronic Phase CML and Lymphoid Blast Crisis

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia

IFITM3 (CD225) Regulates CD19 Surface Expression and CD19-Mediated Activation of PI3K Signaling in Pre-B Acute Lymphoblastic Leukemia Cells

Ifitm3 (CD225) Mediates CD19-Dependent Survival and Proliferation During Normal B Cell Development and In Ph + ALL

Targeting Pre-B Cell Receptor and BCL6 In TCF3-PBX1 B-Lineage Acute Lymphoblastic Leukemia

Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia

Negative Feedback Signaling Enables Leukemic Transformation by Oncogenic Tyrosine Kinases

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American Society of Hematology

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ASH Publications

American Society of Hematology

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