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Yun Chen, PhD
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Journal Articles

FLT3 Inhibitors Induce Instability of p53 By Mir-181 Mediated Downregulation of Deubiquitinase YOD1 in Acute Myeloid Leukemia

Han Zhong Pei, Yao Guo, PhD, Bo Lu, MD, Zhiguang Chang, PhD, Dengyang Zhang, PhD, Liuting Yu, Yuming Zhao, Suk-Hwan Baek, PhD, Yun Chen, PhD, Zhizhuang Joe Zhao, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-139002
Published: 2020
Journal Articles

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

Dengyang Zhang, PhD, Yao Guo, PhD, Yuming Zhao, MD, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Junbin Huang, MDPhD, Chun Chen, MDPhD, Hongman Xue, MDPhD, Yihang Pan, MD, Ningning Li, PhD, Chengming Zhu, PhD, Zhizhuang Joe Zhao, PhD, Jian Yu, PhD, Yun Chen, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-140200
Published: 2020
Journal Articles

Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

Yao Guo, PhD, Junbin Huang, MDPhD, Dengyang Zhang, PhD, Liqin Zhang, Yuming Zhao, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Chun Chen, MDPhD, Hongman Xue, MDPhD, Xiaojun Xu, MDPhD, Zhizhuang Joe Zhao, PhD, Yun Chen, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36–37.
https://doi.org/10.1182/blood-2020-142093
Published: 2020
Journal Articles

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Michael Y. Choi, MD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Emanuela M. Ghia, PhD, Elsa Sanchez-Lopez, PhD, George F. Widhopf II, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4415.
https://doi.org/10.1182/blood-2018-99-111996
Published: 2018
Journal Articles

Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1

Elsa Sanchez-Lopez, PhD, Emanuela M. Ghia, PhD, Laura Antonucci, PhD, Laura Z. Rassenti, PhD, Yun Chen, PhD, Thomas J. Kipps, MD PhD, Michael Karin, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3122.
https://doi.org/10.1182/blood-2018-99-115564
Published: 2018
Journal Articles

Wnt5a Induces Association of ROR1 with Ca 2+ /Calmodulin-Dependent Protein Kinase II and ROR1-Dependent Calcium Influx in Chronic Lymphocytic Leukemia

Liguang Chen, PhD, Yun Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1846.
https://doi.org/10.1182/blood-2018-99-119811
Published: 2018
Journal Articles

Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway

Jian Yu, PhD, Yun Chen, PhD, Liguang Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf II, PhD, Thomas J. Kipps, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4019.
https://doi.org/10.1182/blood.V130.Suppl_1.4019.4019
Published: 2017
Journal Articles

Wnt5a Induces Interleukin-6 Via a ROR1-Dependent Pathway in Chronic Lymphocytic Leukemia, Leading to Leukemia-Cell Activation of STAT3

Yun Chen, PhD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4282.
https://doi.org/10.1182/blood.V130.Suppl_1.4282.4282
Published: 2017
Journal Articles

Nurse-like Cells Express High-Levels of Wnt5a, Which Induces ROR1-Dependent Signaling That Promotes Migration and Survival of Neoplastic Cells in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3007.
https://doi.org/10.1182/blood.V130.Suppl_1.3007.3007
Published: 2017
Journal Articles

Wnt5a Induces Association of ROR1 with 14-3-3ΞΆ to Enhance Chemotaxis and Proliferation in Chronic Lymphocytic Leukemia

Jian Yu, PhD, Liguang Chen, PhD, Yun Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf, II, PhD, Zhouxin Shen, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 349.
https://doi.org/10.1182/blood.V128.22.349.349
Published: 2016
Journal Articles

Cirmtuzumab Targets ROR1 to Inhibit Ibrutinib-Resistant, Wnt5a-Induced Rac1 Activation in Chronic Lymphocytic Leukemia

Jian Yu, PhD, Liguang Chen, PhD, Bing Cui, PhD, Christina Wu, PhD, Michael Y. Choi, MD, Yun Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf, II, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 2034.
https://doi.org/10.1182/blood.V128.22.2034.2034
Published: 2016