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Journal Articles

Identification of Thrombospondin-1 As a Novel Substrate of Cereblon Responsible for IMiDs-Induced Venous Thromboembolism

Kiwamu Hatakeyama, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 631.

https://doi.org/10.1182/blood-2019-125670

Published: 2019

Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2516.

https://doi.org/10.1182/blood-2019-129372

Published: 2019

Journal Articles

Evaluation of TIM-3-Positive LSCs Post Allo-SCT Is a Highly Sensitive Strategy to Predict AML Relapses

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Takuya Harada, MD, Hidetoshi Irifune, MD, Masayasu Hayashi, MD PhD, Goichi Yoshimoto, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2702.

https://doi.org/10.1182/blood-2019-127779

Published: 2019

Journal Articles

Somatic Mutations Potentiating RAS-MAPK Signaling Confer Resistant Potential Against FLT3-Inhibitors to Acute Myelogenous Leukemia

Masayasu Hayashi, MD PhD, Yoshikane Kikushige, MD PhD, Takuya Harada, MD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 910.

https://doi.org/10.1182/blood-2019-130694

Published: 2019

Journal Articles

Identification of GPAT1 As a Novel Therapeutic Target for Acute Leukemia By Inhibiting Leukemia Specific Metabolism

Hidetoshi Irifune, MD, Yu Kochi, MD, Masayasu Hayashi, MD PhD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 1384.

https://doi.org/10.1182/blood-2019-125661

Published: 2019

Journal Articles

Identification of TIM-3/Gal-9 Autocrine Loop As a Novel Wnt-Ligands Independent Machinery for the Constitutive Activation of Canonical Wnt Pathway in AML-LSCs

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2018) 132 (Supplement 1): 1460.

https://doi.org/10.1182/blood-2018-99-116897

Published: 2018

Journal Articles

Evaluation of TIM-3+ LSCs Is a Highly Sensitive MRD Monitoring Strategy to Predict AML Relapse after Allogenic Stem Cell Transplantation

Masayasu Hayashi, MD PhD, Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Hidetoshi Irifune, MD, Goichi Yoshimoto, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2018) 132 (Supplement 1): 1390.

https://doi.org/10.1182/blood-2018-99-116640

Published: 2018

Journal Articles

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 3919.

https://doi.org/10.1182/blood.V130.Suppl_1.3919.3919

Published: 2017

Journal Articles

PML-RARa of the Short but Not the Long/Variant Isoform Initiate from CD34 + TIM-3 + LSCs with Hierarchical Leukemic Organization

Mariko Minami, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 3967.

https://doi.org/10.1182/blood.V130.Suppl_1.3967.3967

Published: 2017

Journal Articles

Introduction of Macrophage Tolerance By Human SIRPA Knock-in Enhances Peripheral Reconstitution of Human Hematopoiesis in Xenotransplantation Model

Fumiaki Jinnouchi, MD, Katsuto Takenaka, MD PhD, Chika Iwamoto, PhD, Takuji Yamauchi, MD PhD, Ayano Yurino, MD, Takuya Nunomura, MD, Yoshikane Kikushige, MD PhD, Koji Kato, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 29.

https://doi.org/10.1182/blood.V128.22.29.29

Published: 2016

Journal Articles

TIM-3/Gal-9 Signaling Enhances Self-Renewal Capacity of AML-LSCs through Mimicking Canonical Wnt Signaling

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 1673.

https://doi.org/10.1182/blood.V128.22.1673.1673

Published: 2016

Journal Articles

Identification of ASCT1 As a Candidate Molecule Enhancing Antioxidant Activity in Primary Human AML Cells

Yu Kochi, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 1674.

https://doi.org/10.1182/blood.V128.22.1674.1674

Published: 2016

Journal Articles

IMiDs Cause Thrombocytopenia By the Inhibition of Proplatelet Formation, through Blocking Estradiol Autocrine Loop in Human Megakaryocytes

Taro Tochigi, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 894.

https://doi.org/10.1182/blood.V128.22.894.894

Published: 2016

Journal Articles

First Preclinical Report of the Efficacy and PD Results of KHK2823, a Non-Fucosylated Fully Human Monoclonal Antibody Against IL-3Rα

Tadakazu Akiyama, PhD, Shin-ichiro Takayanagi, PhD, Yoshimi Maekawa, Kohta Miyawaki, MD, Fumiaki Jinnouchi, MD, Takashi Jiromaru, MD, Takeshi Sugio, MD, Shinya Daitoku, MD, Hirotake Kusumoto, MD, Munetake Shimabe, PhD, Satoshi Nishikawa, Kengo Yamawaki, Kousuke Iijima, Masanori Hiura, Takeshi Takahashi, PhD, Yoshikane Kikushige, MD PhD, Hiromi Iwasaki, MD PhD, Koichi Akashi, MD PhD, Tomonori Tawara, PhD

Blood (2015) 126 (23): 1349.

https://doi.org/10.1182/blood.V126.23.1349.1349

Published: 2015

Journal Articles

Mobilization of Human Immature Hematopoietic Progenitors after Combinatory Use of Bortezomib and Immunomodulatory Drugs

Taro Tochigi, Takatoshi Aoki, MD, Yoshikane Kikushige, MD PhD, Tomohiko Kamimura, MD PhD, Takuji Yamauchi, MD PhD, Koji Kato, MD PhD, Katsuto Takenaka, MDPhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2015) 126 (23): 316.

https://doi.org/10.1182/blood.V126.23.316.316

Published: 2015

Journal Articles

Comparative Analysis of Tyrosine Kinase Inhibitors-Related Pulmonary Hypertension in the Patients Treated By Imatinib, Dasatinib and Nilotinib

Mariko Minami, MD, Toshihiro Miyamoto, MD PhD, Takeshi Arita, MD PhD, Tomohiko Kamimura, MD PhD, Junichiro Yuda, MD, Yoshikane Kikushige, MD PhD, Yasuo Mori, MDPhD, Goichi Yoshimoto, MD PhD, Kenjiro Kamezaki, MD PhD, Koji Kato, MD PhD, Motoaki Shiratsuchi, MDPhD, Katsuto Takenaka, MD PhD, Hiromi Iwasaki, MDPhD, Satoshi Yamasaki, MD PhD, Tsuyoshi Muta, MD PhD, Kazuki Tanimoto, MD PhD, Ryosuke Ogawa, MD PhD, Tetsuya Eto, MD PhD, Koichi Akashi, MD PhD

Blood (2015) 126 (23): 1583.

https://doi.org/10.1182/blood.V126.23.1583.1583

Published: 2015

Journal Articles

TIM-3 and Its Ligand, Galectin-9 Constitute a Pan-Myeloid Autocrine Loop to Develop and Maintain Malignant Stem Cells in Most Human Myeloid Leukemia

Yoshikane Kikushige, MD PhD, Junichiro Yuda, MD, Takahiro Shima, MD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2014) 124 (21): 835.

https://doi.org/10.1182/blood.V124.21.835.835

Published: 2014

Journal Articles

Persistence of Abnormally-Spliced, Functionally-Dead BCR-ABL Variants Is a Critical Obstacle to Achieve Sustained Complete Molecular Response in CML Patients: Results of a Quantitative, Highly-Sensitive, Deep Sequencing Study

Junichiro Yuda, MD, Toshihiro Miyamoto, MD PhD, Jun Odawara, MD PhD, Yoshikane Kikushige, MD PhD, Yasuyuki Ohkawa, PhD, Koichi Akashi, MD PhD

Blood (2014) 124 (21): 4525.

https://doi.org/10.1182/blood.V124.21.4525.4525

Published: 2014

Journal Articles

TIM-3, a Leukemia Stem Cell Marker, Plays a Role In Leukemic Transformation Through Autocrine Stimulatory Signaling By Its Ligand, Galectin-9

Yoshikane Kikushige, MD PhD, Junichiro Yuda, MD, Takahiro Shima, MD, Toshihiro Miyamoto, MD, Koichi Akashi, MD, PhD

Blood (2013) 122 (21): 4196.

https://doi.org/10.1182/blood.V122.21.4196.4196

Published: 2013

Journal Articles

Visualization Of Normal and Malignant Epigenetic Regulation In Hematopoiesis Utilizing Newly-Developed Histone Variant H3.3 Chipseq Analysis

Jun Odawara, MD, PhD, Kohta Miyawaki, MD, Junichiro Yuda, MD, Masayasu Hayashi, MD, Kazumitsu Maehara, PhD, Takahiro Shima, MD, Yoshikane Kikushige, MD, PhD, Yasuyuki Ohkawa, PhD, Koichi Akashi, MD, PhD

Blood (2013) 122 (21): 1189.

https://doi.org/10.1182/blood.V122.21.1189.1189

Published: 2013

NARROW

Identification of Thrombospondin-1 As a Novel Substrate of Cereblon Responsible for IMiDs-Induced Venous Thromboembolism

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Evaluation of TIM-3-Positive LSCs Post Allo-SCT Is a Highly Sensitive Strategy to Predict AML Relapses

Somatic Mutations Potentiating RAS-MAPK Signaling Confer Resistant Potential Against FLT3-Inhibitors to Acute Myelogenous Leukemia

Identification of GPAT1 As a Novel Therapeutic Target for Acute Leukemia By Inhibiting Leukemia Specific Metabolism

Identification of TIM-3/Gal-9 Autocrine Loop As a Novel Wnt-Ligands Independent Machinery for the Constitutive Activation of Canonical Wnt Pathway in AML-LSCs

Evaluation of TIM-3+ LSCs Is a Highly Sensitive MRD Monitoring Strategy to Predict AML Relapse after Allogenic Stem Cell Transplantation

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

PML-RARa of the Short but Not the Long/Variant Isoform Initiate from CD34 + TIM-3 + LSCs with Hierarchical Leukemic Organization

Introduction of Macrophage Tolerance By Human SIRPA Knock-in Enhances Peripheral Reconstitution of Human Hematopoiesis in Xenotransplantation Model

TIM-3/Gal-9 Signaling Enhances Self-Renewal Capacity of AML-LSCs through Mimicking Canonical Wnt Signaling

Identification of ASCT1 As a Candidate Molecule Enhancing Antioxidant Activity in Primary Human AML Cells

IMiDs Cause Thrombocytopenia By the Inhibition of Proplatelet Formation, through Blocking Estradiol Autocrine Loop in Human Megakaryocytes

First Preclinical Report of the Efficacy and PD Results of KHK2823, a Non-Fucosylated Fully Human Monoclonal Antibody Against IL-3Rα

Mobilization of Human Immature Hematopoietic Progenitors after Combinatory Use of Bortezomib and Immunomodulatory Drugs

Comparative Analysis of Tyrosine Kinase Inhibitors-Related Pulmonary Hypertension in the Patients Treated By Imatinib, Dasatinib and Nilotinib

TIM-3 and Its Ligand, Galectin-9 Constitute a Pan-Myeloid Autocrine Loop to Develop and Maintain Malignant Stem Cells in Most Human Myeloid Leukemia

Persistence of Abnormally-Spliced, Functionally-Dead BCR-ABL Variants Is a Critical Obstacle to Achieve Sustained Complete Molecular Response in CML Patients: Results of a Quantitative, Highly-Sensitive, Deep Sequencing Study

TIM-3, a Leukemia Stem Cell Marker, Plays a Role In Leukemic Transformation Through Autocrine Stimulatory Signaling By Its Ligand, Galectin-9

Visualization Of Normal and Malignant Epigenetic Regulation In Hematopoiesis Utilizing Newly-Developed Histone Variant H3.3 Chipseq Analysis

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American Society of Hematology

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American Society of Hematology

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