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Journal Articles

BCL2A1 : A Novel Target in Refractory Acute Myeloid Leukemia with FLT3 -ITD/D835 Dual Mutations

Kotoko Yamatani, MD, Tomohiko Ai, MDPhD, Kaori Saito, Haeun Yang, Vivian Ruvolo, MS, Po Yee Mak, Sonoko Kinjo, PhD, Kazuho Ikeo, PhD, Hironori Harada, MD PhD, Kazuhiro Katayama, PhD, Takashi Miida, MD PhD, Marina Konopleva, MD PhD, Weiguo Zhang, MD PhD, Bing Z Carter, PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD, Yoko Tabe, MD PhD

Blood (2020) 136 (Supplement 1): 32–33.

https://doi.org/10.1182/blood-2020-136587

Published: 2020

Journal Articles

Dual Targeting of Mitochondrial Vulnerability Using Complex I Inhibitor Iacs-010759 with Bcl-2 Inhibitor Venetoclax and Azacitidine in Pre-Clinical Acute Myeloid Leukemia (AML) Models

Qi Zhang, PhD, Lina Han, PhD, Alessia Lodi, PhD, Connie Weng, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, MSc, Helen Ma, MS, Abhishek Maiti, Yoko Tabe, MD PhD, Joseph R Marszalek, PhD, Stefano Tiziani, Marina Konopleva, MD PhD

Blood (2020) 136 (Supplement 1): 13–14.

https://doi.org/10.1182/blood-2020-142547

Published: 2020

Journal Articles

The Direct Interactions with Bone Marrow Microenvironment Confer Resistance to the Inhibition of Oxidative Phosphorylation in AML

Yoko Tabe, MD PhD, Kaori Saito, Kotoko Yamatani, MD, Haeun Yang, Rodrigo Jacamo, PhD, Helen Ma, MS, Vivian Ruvolo, MS, Qi Zhang, PhD, Vinitha Mary Kuruvilla, MSc, Natalia Baran, PhDMD, Junichi Imoto, Kazuho Ikeo, PhD, Koya Suzuki, PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Christopher P Vellano, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD

Blood (2020) 136 (Supplement 1): 11.

https://doi.org/10.1182/blood-2020-137366

Published: 2020

Journal Articles

Oxphos Inhibition Induces Formation of Tunneling Nanotubes in AML Cells and Facilitates Mitochondrial Transfer from BM Stroma to AML That Contributes to Microenvironment-Mediated Drug-Resistance of AML

Blood (2019) 134 (Supplement_1): 911.

https://doi.org/10.1182/blood-2019-125007

Published: 2019

Journal Articles

Inhibiting Mitochondria Function By Bcl-2 Inhibitor Venetoclax and Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells in Pre-Clinical AML Models

Qi Zhang, PhD, Alessia Lodi, PhD, Shannon Renee Sweeney, PhD, Lina Han, PhD, Tianyu Cai, PhD, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, Helen Ma, MS, Yoko Tabe, MD PhD, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y Konopleva, MD PhD

Blood (2019) 134 (Supplement_1): 3927.

https://doi.org/10.1182/blood-2019-124494

Published: 2019

Journal Articles

Cage Transcriptome Analysis Reveals BCL2A1 Upregulation in FLT3 -ITD/D835 Dual Mutated AML Cells Harboring Complex Co-Mutations

Kotoko Yamatani, MD, Tomohiko Ai, MD PhD, Kaori Saito, Haeun Yang, Koya Suzuki, PhD, Atsushi Hori, PhD, Yuko Murakami-Tonami, MD PhD, Weiguo Zhang, MD PhD, Bing Z Carter, PhD, Sonoko Kinjo, PhD, Kazuho Ikeo, PhD, Katayama Kazuhiro, Hironori Harada, MD PhD, Takashi Miida, MD PhD, Neil P. Shah, MD PhD, Marina Y Konopleva, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD, Yoko Tabe, MD PhD

Blood (2019) 134 (Supplement_1): 1264.

https://doi.org/10.1182/blood-2019-124685

Published: 2019

Journal Articles

A Novel Automated Image Analysis System Using Deep Convolutional Neural Networks to Diagnose MDS

Konobu Kimura, Yoko Tabe, MD PhD, Tomohiko Ai, MD PhD, Akihiko Matsuzaki, Kumiko Nishibe, Miki Ebihara, Kimiko Kaniyu, Ikki Takehara, PhD, Kinya Uchihashi, PhD, Akimichi Ohsaka, MD PhD

Blood (2019) 134 (Supplement_1): 4670.

https://doi.org/10.1182/blood-2019-129524

Published: 2019

Journal Articles

Upregulation of Bcl-2 Confers Resistance to FLT3 Inhibition in FLT3 -ITD AML with Secondary Acquired Mutations

Kotoko Yamatani, MD, Yoko Tabe, MD PhD, Kaori Saito, Haeun Yang, Yuko Murakami-Tonami, MD PhD, Koya Suzuki, PhD, Weiguo Zhang, MD PhD, Sonoko Kinjo, PhD, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, PhD, Shigeo Yamaguchi, MD PhD, Hironori Harada, MD PhD, Takashi Miida, MD PhD, Neil P. Shah, MD PhD, Marina Y. Konopleva, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 3944.

https://doi.org/10.1182/blood-2018-99-109957

Published: 2018

Journal Articles

Contribution of Amino Acid Metabolism to Hematologic Malignancies

Marina Y. Konopleva, MD PhD, Philip L Lorenzi, PhD, Sanaz Ghotbaldini, Yoko Tabe, MD PhD, Tianyu Cai, PhD, Stefano Tiziani, PhD

Blood (2018) 132 (Supplement 1): SCI-10.

https://doi.org/10.1182/blood-2018-99-109469

Published: 2018

Journal Articles

Mitochondrial Transfer Confers Microenvironment-Mediated Resistance to Oxphos Inhibition in AML

Haeun Yang, Yoko Tabe, MD PhD, Kaori Saito, Rodrigo Jacamo, PhD, Helen Ma, MS, Vivian Ruvolo, MS, Junichi Imoto, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, PhD, Shigeo Yamaguchi, Kotoko Yamatani, MD, Yuko Murakami-Tonami, MD, Koya Suzuki, PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Marina Y. Konopleva, MD PhD

Blood (2018) 132 (Supplement 1): 430.

https://doi.org/10.1182/blood-2018-99-112933

Published: 2018

Journal Articles

Combined Targeting of Bcl-2 and XPO1 Overcomes Acquired Resistance to Tyrosine Kinase Inhibitors in the FLT3-ITD/TKD Double Mutant AML

Yoko Tabe, MD PhD, Kotoko Yamatani, MD, Haeun Yang, Kaori Saito, Yuko Murakami-Tonami, MD, Koya Suzuki, PhD, Weiguo Zhang, MD PhD, Sonoko Kinjo, PhD, Kazuho Ikeo, PhD, Masaki Hosoya, PhD, Kaoru Mogushi, PhD, Shigeo Yamaguchi, Hironori Harada, MD PhD, Takashi Miida, MD PhD, Neil Shah, MD, Marina Y. Konopleva, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 2640.

https://doi.org/10.1182/blood-2018-99-113195

Published: 2018

Journal Articles

BCL-2 Antagonist ABT-199 Combined with Complex I Inhibitor IACS-010759 Blocks Mitochondrial Respiration and Facilitates Anti-Leukemia Efficacy in Pre-Clinical AML Models

Qi Zhang, PhD MD, Lina Han, PhD, Tianyu Cai, PhD, Vinitha Mary Kuruvilla, Antonio Cavazos, MSc, Helen Ma, MS, Venkata Lokesh Battula, PhD, Natalia Baran, PhD MD, Karine Harutyunyan, PhD, Michael Andreeff, MD PhD, Yoko Tabe, MD PhD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD

Blood (2017) 130 (Supplement 1): 1362.

https://doi.org/10.1182/blood.V130.Suppl_1.1362.1362

Published: 2017

Journal Articles

XPO1 Inhibition Targets Transcriptional Vulnerability of FLT3-ITD+D835 Double Mutant AML through p53 Accumulation and Inhibition of Oncogenic Transcription Factors: Lesson Learned from Cage Sequencing of Primary AML Cells

Kotoko Yamatani, MD PhD, Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Haeun Yang, Kaori Saito, Weiguo Zhang, MD PhD, Kazuho Ikeo, PhD, Sonoko Kinjo, Kaoru Mogushi, PhD, Masaki Hosoya, Yoshihide Hayashizaki, MD PhD, Yasunari Yamanaka, MD PhD, Hironori Harada, Takashi Miida, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 1244.

https://doi.org/10.1182/blood.V130.Suppl_1.1244.1244

Published: 2017

Journal Articles

Novel Oxidative Phosphorylation Inhibitor IACS-010759 Induces AMPK-Dependent Apoptosis of AML Cells

Haeun Yang, Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Kaori Saito, Helen Ma, MS, Vivian Ruvolo, PhD, Junichi Imoto, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, Yoshihide Hayashizaki, MD PhD, Yasunari Yamanaka, MD PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD

Blood (2017) 130 (Supplement 1): 1245.

https://doi.org/10.1182/blood.V130.Suppl_1.1245.1245

Published: 2017

Journal Articles

Inhibition of FAO in AML Co-Cultured with BM Adipocytes: Mechanisms of Survival and Chemosensitization to Cytarabine

Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Haeun Yang, Kaori Saito, Vivian Ruvolo, PhD, Hikari Taka, Naoko Kaga, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Paul A. Spagnuolo, PhD, Marina Konopleva, MD PhD

Blood (2017) 130 (Supplement 1): 3832.

https://doi.org/10.1182/blood.V130.Suppl_1.3832.3832

Published: 2017

Journal Articles

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcriptional Signatures of FLT3-ITD with Secondary D835 TKD Mutations in Acute Myeloid Leukemia

Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Kaori Saitoh, Norikazu Monma, PhD, Kazuho Ikeo, PhD, Bogumil Kaczkowski, Weiguo Zhang, MD, PhD, Yasunari Yamanaka, MD PhD, Takashi Miida, MDPhD, Neil P. Shah, MD PhD, Hironori Harada, MD PhD, Yoshihide Hayashizaki, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 1530.

https://doi.org/10.1182/blood.V128.22.1530.1530

Published: 2016

Journal Articles

Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach

Jo Ishizawa, MD PhD, Rodrigo Omar Jacamo, PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Vivian Ruvolo, MS, Peter Ruvolo, PhD, Weiguo Zang, PhD, Yoko Tabe, MD PhD, Marina Konopleva, MD PhD, William Devine, PhD, Susan Lindquist, PhD, John A Porco, Jr., Luke Whitesell, MD PhD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 2548.

https://doi.org/10.1182/blood.V126.23.2548.2548

Published: 2015

Journal Articles

Combined Targeting of JAK2 with a Type II JAK2 Inhibitor and mTOR with a TOR Kinase Inhibitor Constitutes Synthetic Activity in JAK2-Driven Ph-like Acute Lymphoblastic Leukemia

Blood (2015) 126 (23): 2529.

https://doi.org/10.1182/blood.V126.23.2529.2529

Published: 2015

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Blood (2015) 126 (23): 2051.

https://doi.org/10.1182/blood.V126.23.2051.2051

Published: 2015

Journal Articles

Novel Flowcytometry-Based Approach for Detection of Tumor Cells in Body Fluid Using Automated Hematology Analyzer

Yoko Tabe, MD PhD, Hiroyuki Takemura, Konobu Kimura, Aya Konishi, Takashi Horii, Takashi Miida, MDPhD, Akimichi Ohsaka, MD PhD

Blood (2015) 126 (23): 5600.

https://doi.org/10.1182/blood.V126.23.5600.5600

Published: 2015

NARROW

BCL2A1 : A Novel Target in Refractory Acute Myeloid Leukemia with FLT3 -ITD/D835 Dual Mutations

Dual Targeting of Mitochondrial Vulnerability Using Complex I Inhibitor Iacs-010759 with Bcl-2 Inhibitor Venetoclax and Azacitidine in Pre-Clinical Acute Myeloid Leukemia (AML) Models

The Direct Interactions with Bone Marrow Microenvironment Confer Resistance to the Inhibition of Oxidative Phosphorylation in AML

Oxphos Inhibition Induces Formation of Tunneling Nanotubes in AML Cells and Facilitates Mitochondrial Transfer from BM Stroma to AML That Contributes to Microenvironment-Mediated Drug-Resistance of AML

Inhibiting Mitochondria Function By Bcl-2 Inhibitor Venetoclax and Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells in Pre-Clinical AML Models

Cage Transcriptome Analysis Reveals BCL2A1 Upregulation in FLT3 -ITD/D835 Dual Mutated AML Cells Harboring Complex Co-Mutations

A Novel Automated Image Analysis System Using Deep Convolutional Neural Networks to Diagnose MDS

Upregulation of Bcl-2 Confers Resistance to FLT3 Inhibition in FLT3 -ITD AML with Secondary Acquired Mutations

Contribution of Amino Acid Metabolism to Hematologic Malignancies

Mitochondrial Transfer Confers Microenvironment-Mediated Resistance to Oxphos Inhibition in AML

Combined Targeting of Bcl-2 and XPO1 Overcomes Acquired Resistance to Tyrosine Kinase Inhibitors in the FLT3-ITD/TKD Double Mutant AML

BCL-2 Antagonist ABT-199 Combined with Complex I Inhibitor IACS-010759 Blocks Mitochondrial Respiration and Facilitates Anti-Leukemia Efficacy in Pre-Clinical AML Models

XPO1 Inhibition Targets Transcriptional Vulnerability of FLT3-ITD+D835 Double Mutant AML through p53 Accumulation and Inhibition of Oncogenic Transcription Factors: Lesson Learned from Cage Sequencing of Primary AML Cells

Novel Oxidative Phosphorylation Inhibitor IACS-010759 Induces AMPK-Dependent Apoptosis of AML Cells

Inhibition of FAO in AML Co-Cultured with BM Adipocytes: Mechanisms of Survival and Chemosensitization to Cytarabine

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcriptional Signatures of FLT3-ITD with Secondary D835 TKD Mutations in Acute Myeloid Leukemia

Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach

Combined Targeting of JAK2 with a Type II JAK2 Inhibitor and mTOR with a TOR Kinase Inhibitor Constitutes Synthetic Activity in JAK2-Driven Ph-like Acute Lymphoblastic Leukemia

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Novel Flowcytometry-Based Approach for Detection of Tumor Cells in Body Fluid Using Automated Hematology Analyzer

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American Society of Hematology

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American Society of Hematology

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