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Journal Articles

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Geoffrey M. Matthews, PhD, Sara Gandolfi, MD, Johanna Bruggentheis, Ricardo De Matos Simoes, PhD, Dennis L Buckley, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Hayley Poarch, James E. Bradner, MD, Constantine S Mitsiades, MD PhD

Blood (2016) 128 (22): 1062.

https://doi.org/10.1182/blood.V128.22.1062.1062

Published: 2016

Journal Articles

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Geoffrey M. Matthews, PhD, Ricardo De Matos Simoes, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Paul J. Hengeveld, B.Sc., Megan A. Bariteau, BSc, Brian Glassner, PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Sara Gandolfi, MD, Pallavi Awate, MSc, Huihui Tang, PhD, Franciska Vazquez, PhD, Aedin Culhane, PhD, Constantine S Mitsiades, MD PhD

Blood (2016) 128 (22): 119.

https://doi.org/10.1182/blood.V128.22.119.119

Published: 2016

Journal Articles

Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology

Ricardo De Matos Simoes, PhD, Geoffrey M. Matthews, PhD, Yiguo Hu, MD PhD, Brian Glassner, PhD, Megan A. Bariteau, BSc, Michal Sheffer, PhD, Ryosuke Shirasaki, MD, Constantine S Mitsiades, MD PhD

Blood (2016) 128 (22): 486.

https://doi.org/10.1182/blood.V128.22.486.486

Published: 2016

Journal Articles

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Blood (2011) 118 (21): 883.

https://doi.org/10.1182/blood.V118.21.883.883

Published: 2011

Journal Articles

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

Diana Cirstea, MD, Teru Hideshima, MD, PhD, Loredana Santo, MD, Homare Eda, MD, PhD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Anuj K. Mahindra, MD, Gullu Gorgun, PhD, Yiguo Hu, MD, PhD, Naoya Mimura, MD, PhD, Claire Fabre, MD, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Kenneth C. Anderson, MD, Sylvie M Guichard, PharmD, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2916.

https://doi.org/10.1182/blood.V118.21.2916.2916

Published: 2011

Journal Articles

Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Naoya Mimura, MD, PhD, Diana Cirstea, M.D., Loredana Santo, MD, Yiguo Hu, MD, PhD, Claire Fabre, MD, Noopur Raje, MD, Nikhil C. Munshi, MD, Paul G Richardson, MD, Kenneth C. Anderson, MD

Blood (2010) 116 (21): 2996.

https://doi.org/10.1182/blood.V116.21.2996.2996

Published: 2010

Journal Articles

Immunomodulatory EFFECTS of Lenalidomide and Pomalidomide ON INTERACTION of TUMOR and BONE MARROW Accessory CELLS IN MULTIPLE MYELOMA.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Teru Hideshima, MD, PhD, Giulia Perrone, MD, Giada Bianchi, MD, Hiroshi Ikeda, MD, PhD, Mala Mani, PhD, Yiguo Hu, MD, PhD, Diana Cristea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Nikhil Munshi, MD, Paul Richardson, MD, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 950.

https://doi.org/10.1182/blood.V114.22.950.950

Published: 2009

Journal Articles

A NOVEL Aurora A Kinase INHIBITOR MLN8237 Induces Cytotoxicity and CELL Cycle Arrest IN MULTIPLE MYELOMA.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Teru Hideshima, MD, PhD, Jeffrey Ecsedy, PhD, Giada Bianchi, MD, Mala Mani, PhD, Madhavi Bandi, Hiroshi Ikeda, MD, PhD, Giulia Perrone, MD, Yiguo Hu, MD, PhD, Yu-Tzu Tai, PhD, Mei Zheng, Diana Cristea, MD, Loredana Santo, MD, Daniel R. Carrasco, MD, PhD, Nikhil Munshi, MD, Paul Richardson, MD, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 3830.

https://doi.org/10.1182/blood.V114.22.3830.3830

Published: 2009

Journal Articles

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma.

Diana Cirstea, MD, Teru Hideshima, MD, PhD, Loredana Santo, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Hiroshi Ikeda, MD, PhD, Hannes Loferer, PhD, Giulia Perrone, MD, Gullu Gorgun, PhD, Yiguo Hu, MD, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2009) 114 (22): 4915.

https://doi.org/10.1182/blood.V114.22.4915.4915

Published: 2009

Journal Articles

Inhibitory Effects of Homoharringtonine on Leukemic Stem Cells and BCR-ABL Induced Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Mice.

Yaoyu Chen, MD, Yiguo Hu, MD., PhD, Shawnya Michaels, PhD, Dennis Brown, PhD, Shaoguang Li, MD, PhD

Blood (2007) 110 (11): 2912.

https://doi.org/10.1182/blood.V110.11.2912.2912

Published: 2007

Journal Articles

Immunodominant Minor Histocompatibility Antigen-Specific T Lymphocytes Eradicate BCR-ABL-Induced B-ALL and CML without Causing Graft-Versus-Host Disease in Mice.

Yiguo Hu, MD, Thomas Sproule, BS, Cong Peng, MS, Linghong Kong, MD, PhD, Ami Goodrich, Derry Roopenian, PhD, Shaoguang Li, MD, PhD

Blood (2006) 108 (11): 3686.

https://doi.org/10.1182/blood.V108.11.3686.3686

Published: 2006

Journal Articles

Increase in Leukemic Stem Cells Is Associated with Acceleration of BCR-ABL-Induced CML in P-Selectin-Deficient Mice.

Linghong Kong, MD, PhD, Yiguo Hu, MD, Cong Peng, MS, Zhu Wang, Ted Duffy, PhD, Ami Goodrich, Shaoguang Li, MD, PhD

Blood (2006) 108 (11): 2129.

https://doi.org/10.1182/blood.V108.11.2129.2129

Published: 2006

Journal Articles

IPI-504, a Novel, Orally Active HSP90 Inhibitor, Prolongs Survival of Mice with BCR-ABL T315I CML and B-ALL.

Cong Peng, MS, Julia Brain, PhD, Yiguo Hu, MD, Linghong Kong, MD, PhD, David Grayzel, MD, Roger Pak, PhD, Margaret Read, PhD, Shaoguang Li, MD, PhD

Blood (2006) 108 (11): 2183.

https://doi.org/10.1182/blood.V108.11.2183.2183

Published: 2006

Journal Articles

Hsp-90 Inhibition Decreases Survival of BCR-ABL T315I Leukemic Stem Cells in Mice.

Cong Peng, MS, Julia Brain, PhD, Yiguo Hu, MD, Linghong Kong, MD, PhD, Ami Goodrich, David Grayzel, MD, Roger Pak, PhD, Margaret Read, PhD, Shaoguang Li, MD, PhD

Blood (2006) 108 (11): 2184.

https://doi.org/10.1182/blood.V108.11.2184.2184

Published: 2006

Journal Articles

Targeting Chronic Myeloid Leukemia (CML) Stem Cells by BMS-214662 in Mice.

Cong Peng, MS, Yiguo Hu, MD, Francis Y. Lee, PhD, Shaoguang Li, MD, PhD

Blood (2005) 106 (11): 2861.

https://doi.org/10.1182/blood.V106.11.2861.2861

Published: 2005

Journal Articles

A Critical Role of Blockade of Cell Differentiation in BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia (B-ALL): Basis for Superb Therapeutic Effect on B-ALL in Mice by Promotion of Pro-B Leukemic Cell Differentiation and Treatment with Imatinib.

Yiguo Hu, MD, Linghong Kong, MD, PhD, Kevin Staples, Kevin Mills, PhD, John G. Monroe, PhD, Shaoguang Li, MD, PhD

Blood (2005) 106 (11): 844.

https://doi.org/10.1182/blood.V106.11.844.844

Published: 2005

Journal Articles

Targeting BCR-ABL Kinase Activity-Independent Signaling Pathways and Leukemia Stem Cells Is Essential for Curative Therapy of Philadelphia Chromosome Positive (Ph+) Leukemia.

Shaoguang Li, MD, PhD, Yiguo Hu, MD, Sarah Swerdlow, BS, Theodore M. Duffy, MS, Roberto Weinmann, PhD, Francis Y. Lee, PhD

Blood (2005) 106 (11): 1990.

https://doi.org/10.1182/blood.V106.11.1990.1990

Published: 2005

NARROW

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma

Immunomodulatory EFFECTS of Lenalidomide and Pomalidomide ON INTERACTION of TUMOR and BONE MARROW Accessory CELLS IN MULTIPLE MYELOMA.

A NOVEL Aurora A Kinase INHIBITOR MLN8237 Induces Cytotoxicity and CELL Cycle Arrest IN MULTIPLE MYELOMA.

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma.

Inhibitory Effects of Homoharringtonine on Leukemic Stem Cells and BCR-ABL Induced Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Mice.

Immunodominant Minor Histocompatibility Antigen-Specific T Lymphocytes Eradicate BCR-ABL-Induced B-ALL and CML without Causing Graft-Versus-Host Disease in Mice.

Increase in Leukemic Stem Cells Is Associated with Acceleration of BCR-ABL-Induced CML in P-Selectin-Deficient Mice.

IPI-504, a Novel, Orally Active HSP90 Inhibitor, Prolongs Survival of Mice with BCR-ABL T315I CML and B-ALL.

Hsp-90 Inhibition Decreases Survival of BCR-ABL T315I Leukemic Stem Cells in Mice.

Targeting Chronic Myeloid Leukemia (CML) Stem Cells by BMS-214662 in Mice.

A Critical Role of Blockade of Cell Differentiation in BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia (B-ALL): Basis for Superb Therapeutic Effect on B-ALL in Mice by Promotion of Pro-B Leukemic Cell Differentiation and Treatment with Imatinib.

Targeting BCR-ABL Kinase Activity-Independent Signaling Pathways and Leukemia Stem Cells Is Essential for Curative Therapy of Philadelphia Chromosome Positive (Ph+) Leukemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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