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Journal Articles

Impact of Factor × Mutations on the Activity of Edoxaban

Kengo Noguchi, Shin-ichi Takahashi, PhD, Hiroaki Ishihara, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD, Yasuo Ikeda, MD, PhD, Mitsuru Murata, MD, PhD

Blood (2010) 116 (21): 3321.

https://doi.org/10.1182/blood.V116.21.3321.3321

Published: 2010

Journal Articles

GSK-3β Negatively Regulates Megakaryocyte and Platelet Production in an In Vitro Human Bone Marrow Mononuclear Cell-Derived Differentiation System.

Yumiko Matsubara, PhD, Mitsuru Murata, MD, Hidenori Suzuki, PhD, Kenji Yokoyama, MD, Hiroaki Ishihara, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD, Yasuo Ikeda, MD

Blood (2007) 110 (11): 4036.

https://doi.org/10.1182/blood.V110.11.4036.4036

Published: 2007

Journal Articles

Enhancing Effect of Collagen Receptor Polymorphisms on In Vitro Platelet Reactivity to Aspirin in Healthy Subjects.

Miho Ushida, Yumiko Matsubara, PhD, Shinichi Takahashi, Hiroaki Ishihara, PhD, Toshiro Shibano, PhD, Gentaro Watanabe, MD, Yasuo Ikeda, MD, Mitsuru Murata, MD

Blood (2006) 108 (11): 1099.

https://doi.org/10.1182/blood.V108.11.1099.1099

Published: 2006

Journal Articles

Identification of ADRA2A Polymorphisms Related to Shear-Mediated Platelet Function by the PFA-100® System.

Mariko Yabe, MD, Yumiko Matsubara, PhD, Shinichi Takahashi, Hiroaki Ishihara, PhD, Toshiro Shibano, PhD, Koichi Miyaki, MD, Kazuyuki Omae, MD, Gentaro Watanabe, MD, Mitsuru Murata, MD, Yasuo Ikeda, MD

Blood (2006) 108 (11): 3913.

https://doi.org/10.1182/blood.V108.11.3913.3913

Published: 2006

Journal Articles

The Genotype Combination of the P2Y12 Gene Might Confer Greater Risk for Coronary Artery Disease.

Koji Isobe, Yumiko Matsubara, PhD, Shinichi Takahashi, Toshihiro Uchida, Hiroaki Ishihara, PhD, Toshiro Shibano, PhD, Mie Ishikawa, MD, Kenichi Matsushita, MD, Shiro Iwanaga, MD, Satosh Ogawa, MD, Gentaro Watanabe, MD, Yasuo Ikeda, MD PhD, Mitsuru Murata, MD PhD

Blood (2006) 108 (11): 1468.

https://doi.org/10.1182/blood.V108.11.1468.1468

Published: 2006

Journal Articles

Antithrombin-Independent Thrombin Inhibitors, but Not Factor Xa Inhibitors, Enhance Thrombin Generation in Human Plasma Via Inhibition of Thrombin-Thrombomodulin-Protein C System.

Yoshiyuki Morishima, PhD, Taketoshi Furugohri, Yoko Shiozaki, Nobutoshi Sugiyama, PhD, Toshiro Shibano, PhD

Blood (2006) 108 (11): 914.

https://doi.org/10.1182/blood.V108.11.914.914

Published: 2006

Journal Articles

Anti-Thrombotic Action of DZ-697b, a Novel Anti-Platelet Agent, on Photochemically Induced Thrombosis with Lower Bleeding Risk in Guinea Pigs.

Tomoko Shibutani, PhD, Takako Iijima, Yuki Kaneda, Sumie Muramatsu, Yoshiyasu Ogihara, PhD, Toshiro Shibano, PhD

Blood (2005) 106 (11): 1870.

https://doi.org/10.1182/blood.V106.11.1870.1870

Published: 2005

Journal Articles

Impact of Antithrombin Deficiency on Efficacies of DU-176b, a Novel Orally Active Direct Factor Xa Inhibitor, and Antithrombin Dependent Anticoagulants, Fondaparinux and Heparin.

Toshio Fukuda, Yuko Honda, Chikako Matsumoto, Nobutoshi Sugiyama, PhD, Tadashi Matsushita, PhD, Masamitsu Yanada, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD

Blood (2005) 106 (11): 1874.

https://doi.org/10.1182/blood.V106.11.1874.1874

Published: 2005

Journal Articles

Pharmacological Profile of DZ-697b, a Novel Anti-Platelet Agent -Selective Inhibitor of vWF- and Collagen-Induced Platelet Aggregation.

Yoshiyasu Ogihara, PhD, Sumie Muramatsu, Yuki Kaneda, Takako Iijima, Tomoko Shibutani, PhD, Toshiro Shibano, PhD

Blood (2005) 106 (11): 1875.

https://doi.org/10.1182/blood.V106.11.1875.1875

Published: 2005

Journal Articles

A Thrombin Inhibitor, but Not a Factor Xa Inhibitor, DU-176b, Aggravates Tissue Factor-Induced Hypercoagulation in Rats.

Yoshiyuki Morishima, PhD, Toshio Fukuda, Naoki Tsuji, PhD, Yuko Honda, Chikako Matsumoto, Taketoshi Furugohri, Toshiro Shibano, PhD

Blood (2005) 106 (11): 1878.

https://doi.org/10.1182/blood.V106.11.1878.1878

Published: 2005

Journal Articles

The Genotypic Combination of Homozygous Carriers of Both H1 Haplotype and 34C Shows a Significantly Lower Responsiveness to ADP-Induced Platelet Aggregation Than Others in Healthy Volunteers.

Koji Isobe, Yumiko Matsubara, MD, Shinichi Takahashi, Miho Iwashita, Risa Komine, Aya Shimizu, Toshihiro Uchida, Hiroaki Ishihara, PhD, Toshiro Shibano, PhD, Gentaro Watanabe, MD, Yasuo Ikeda, MD, Mitsuru Murata, MD

Blood (2005) 106 (11): 3560.

https://doi.org/10.1182/blood.V106.11.3560.3560

Published: 2005

Journal Articles

In Vitro Characteristics, Anticoagulant Effects and In Vivo Antithrombotic Efficacy of a Novel, Potent and Orally Active Direct Factor Xa Inhibitor, DU-176b.

Yoshiyuki Morishima, PhD, Taketoshi Furugohri, Koji Isobe, Yuko Honda, Chikako Matsumoto, Yoko Shiozaki, Sumie Muramatsu, Nobutoshi Sugiyama, PhD, Toshiro Shibano, PhD

Blood (2004) 104 (11): 1862.

https://doi.org/10.1182/blood.V104.11.1862.1862

Published: 2004

Journal Articles

Antithrombotic and Hemorrhagic Effects of DU-176b, a Novel, Potent and Orally Active Direct Factor Xa Inhibitor: A Wider Safety Margin Compared to Heparins and Warfarin.

Taketoshi Furugohri, Yuko Honda, Chikako Matsumoto, Koji Isobe, Nobutoshi Sugiyama, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD

Blood (2004) 104 (11): 1851.

https://doi.org/10.1182/blood.V104.11.1851.1851

Published: 2004

Journal Articles

Antithrombotic Properties of DU-176b, a Novel, Potent and Orally Active Direct Factor Xa Inhibitor in Rat Models of Arterial and Venous Thrombosis: Comparison with Fondaparinux, an Antithrombin Dependent Factor Xa Inhibitor.

Toshio Fukuda, Chikako Matsumoto, Yuko Honda, Nobutoshi Sugiyama, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD

Blood (2004) 104 (11): 1852.

https://doi.org/10.1182/blood.V104.11.1852.1852

Published: 2004

NARROW

Impact of Factor × Mutations on the Activity of Edoxaban

GSK-3β Negatively Regulates Megakaryocyte and Platelet Production in an In Vitro Human Bone Marrow Mononuclear Cell-Derived Differentiation System.

Enhancing Effect of Collagen Receptor Polymorphisms on In Vitro Platelet Reactivity to Aspirin in Healthy Subjects.

Identification of ADRA2A Polymorphisms Related to Shear-Mediated Platelet Function by the PFA-100® System.

The Genotype Combination of the P2Y12 Gene Might Confer Greater Risk for Coronary Artery Disease.

Antithrombin-Independent Thrombin Inhibitors, but Not Factor Xa Inhibitors, Enhance Thrombin Generation in Human Plasma Via Inhibition of Thrombin-Thrombomodulin-Protein C System.

Anti-Thrombotic Action of DZ-697b, a Novel Anti-Platelet Agent, on Photochemically Induced Thrombosis with Lower Bleeding Risk in Guinea Pigs.

Impact of Antithrombin Deficiency on Efficacies of DU-176b, a Novel Orally Active Direct Factor Xa Inhibitor, and Antithrombin Dependent Anticoagulants, Fondaparinux and Heparin.

Pharmacological Profile of DZ-697b, a Novel Anti-Platelet Agent -Selective Inhibitor of vWF- and Collagen-Induced Platelet Aggregation.

A Thrombin Inhibitor, but Not a Factor Xa Inhibitor, DU-176b, Aggravates Tissue Factor-Induced Hypercoagulation in Rats.

The Genotypic Combination of Homozygous Carriers of Both H1 Haplotype and 34C Shows a Significantly Lower Responsiveness to ADP-Induced Platelet Aggregation Than Others in Healthy Volunteers.

In Vitro Characteristics, Anticoagulant Effects and In Vivo Antithrombotic Efficacy of a Novel, Potent and Orally Active Direct Factor Xa Inhibitor, DU-176b.

Antithrombotic and Hemorrhagic Effects of DU-176b, a Novel, Potent and Orally Active Direct Factor Xa Inhibitor: A Wider Safety Margin Compared to Heparins and Warfarin.

Antithrombotic Properties of DU-176b, a Novel, Potent and Orally Active Direct Factor Xa Inhibitor in Rat Models of Arterial and Venous Thrombosis: Comparison with Fondaparinux, an Antithrombin Dependent Factor Xa Inhibitor.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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