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Journal Articles

PML-RAR Binds to the +7kb Enhancer of CEBPE and Inhibits Its Expression

Pavithra Shyamsunder, Shree Pooja Sridharan, Pushkar Dakle, Zeya Cao, Vikas Madan, PhD, Sin Tiong Ong, MD, H. Phillip Koeffler, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43.
https://doi.org/10.1182/blood-2020-136230
Published: 2020
Journal Articles

The Genomic and Epigenomic Landscapes of Blast Crisis Transformation in Chronic Myeloid Leukemia

S. Tiong Ong, MD, Thushangi Pathiraja, PhD, Asif Javed, PhD, Xin Xuan Sheila Soh, Simeen Malik, PhD, Joanna H.J. Tan, Tun Kiat Ko, PhD, Charles Chuah, Naoto Takahashi, MD, PhD, Ravi Bhatia, MD, King Pan Ng, PhD, Wee Joo Chng, MD PhD, Chandana Tennakoon, PhD, Qiangze Hoi, Peiyong Guan, Audrey S.M. Teo, Wah Heng Lee, PhD, Patrick Tan, MD PhD, Win Kin Sung, PhD, Pauline Ng, PhD, Axel Hillmer, PhD
Journal: Blood
Blood (2015) 126 (23): 3737.
https://doi.org/10.1182/blood.V126.23.3737.3737
Published: 2015
Journal Articles

Functional Analysis of the CML Blast Crisis Transcriptome and Epigenome Using Crispr-CAS9 and Pharmacologic Approaches

Tun Kiat Ko, PhD, Xin Xuan Sheila Soh, Willie Yu, PhD, Peter S. Winter, Thushangi Pathiraja, PhD, Asif Javed, PhD, Simeen Malik, PhD, Joanna H.J. Tan, Charles Chuah, MD PhD, Naoto Takahashi, MD, PhD, Ravi Bhatia, MD, Wee Joo Chng, MD PhD, Peter Valent, MD, Sabine Cerny-Reiterer, DVM, King Pan Ng, PhD, Chandana Tennakoon, PhD, Qiangze Hoi, Peiyong Guan, Audrey S.M. Teo, Wah Heng Lee, PhD, Patrick Tan, MD PhD, Win Kin Sung, PhD, Pauline Ng, PhD, Axel Hillmer, PhD, Kris C. Wood, PhD, Steve Rozen, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2015) 126 (23): 2764.
https://doi.org/10.1182/blood.V126.23.2764.2764
Published: 2015
Journal Articles

The BIM Deletion Polymorphism: A Paradigm Of a Permissive Interaction Between Germline and Acquired TKI Resistance Factors In Chronic Myeloid Leukemia

Tun Kiat Ko, PhD, Charles Chuah, MD, John W.J. Huang, King-Pan Ng, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2013) 122 (21): 3977.
https://doi.org/10.1182/blood.V122.21.3977.3977
Published: 2013
Journal Articles

The BCL-2 Inhibitor ABT-199 Enhances Imatinib-Induced Cell Death In Chronic Phase CML Progenitors

Tun Kiat Ko, PhD, Charles Chuah, MD, John Huang, King-Pan Ng, PhD, S. Tiong Ong, MD
Journal: Blood
Blood (2013) 122 (21): 3978.
https://doi.org/10.1182/blood.V122.21.3978.3978
Published: 2013
Journal Articles

Targeting of a Novel MNK-eIF4E-b-Catenin Axis in Blast Crisis Chronic Myelogenous Leukemia Inhibits Leukemia Stem Cell Function

Sharon Lim, PhD, Tzuen Yih Saw, Sandy Chang, Min Zhang, MD, Matthew Robert Janes, MPH, David A Fruman, PhD, David A. Rizzieri, MD, Soo-Yong Tan, MBBS, FRCPath, DPhil, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2011) 118 (21): 963.
https://doi.org/10.1182/blood.V118.21.963.963
Published: 2011
Journal Articles

Physiologic Hypoxia Protects Chronic Myelogenous Leukemia Progenitors From Elimination by Imatinib Mesylate.

King-Pan Ng, PhD, Tuang Yeow Poh, PhD, Wen Tian Sun, PhD, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2009) 114 (22): 2181.
https://doi.org/10.1182/blood.V114.22.2181.2181
Published: 2009
Journal Articles

Overexpression and Phosphorylation of eIF4E Is Required for Beta-Catenin Activation in Blast Crisis Chronic Myelogenous Leukemia.

Sharon Lim, PhD, T. Yih Saw, MSc, Charles Chuah, MD, S. Tiong Ong, MD
Journal: Blood
Blood (2009) 114 (22): 41.
https://doi.org/10.1182/blood.V114.22.41.41
Published: 2009
Journal Articles

Bcr-Abl Regulates IRES-Dependent Translation of Lymphoid Enhancer Factor-1 in Chronic Myelogenous Leukemia.

Judy Jimenez, PhD, Min Zhang, M.D., Marian L. Waterman, Ph.D., Tiong Ong, MD
Journal: Blood
Blood (2006) 108 (11): 2124.
https://doi.org/10.1182/blood.V108.11.2124.2124
Published: 2006
Journal Articles

Increased eIF4E Expression and Phosphorylation in Late Phase Chronic Myelogenous Leukemia Occurs in a Bcr-Abl-Dependent Manner, and Can Be Targeted by a Novel Mnk Kinase Inhibitor, CGP57380, To Overcome Imatinib-Resistance.

Min Zhang, MD, James C. Moore, M.D., Je Ko, Wuxia Fu, M.D., Sharmila Prabhu, John P. Fruehauf, M.D., Ph.D., Tiong Ong, MD
Journal: Blood
Blood (2006) 108 (11): 2193.
https://doi.org/10.1182/blood.V108.11.2193.2193
Published: 2006