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Takehisa Kitazawa, DVM
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Journal Articles

Pharmacology and Pharmacokinetics of NXT007; Emicizumab-Based Engineered Fixa/Fx Bispecific Antibody with Improved Properties

Kazuki Yamaguchi, Tetsuhiro Soeda, PhD, Motohiko Sato, Norihito Shibahara, PhD, Hikaru Koga, Mina Ichiki, Eri Joyashiki, Yuri Teranishi, Kei Nishimura, Hirotake Shiraiwa, Hidetomo Kitamura, PhD DVM, Tomoyuki Igawa, PhD, Hiroko Konishi, Takehisa Kitazawa, DVM
Journal: Blood
Blood (2020) 136 (Supplement 1): 19.
https://doi.org/10.1182/blood-2020-138958
Published: 2020
Journal Articles

Assessment of Emicizumab-Driven Clot Stability in Hemophilia a Model

Kenichi Ogiwara, MD PhD, Hiroki Horiuchi, Keiji Nogami, MD PhD, Takehisa Kitazawa, DVM, Midori Shima, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2478.
https://doi.org/10.1182/blood-2018-99-118379
Published: 2018
Journal Articles

SKY59: A Long-Lasting Engineered Anti-C5 Antibody for Subcutaneously Injectable Anti-Complement Therapy

Kenta Haraya, PhD, Zenjiro Sampei, PhD, Tatsuhiko Tachibana, PhD, Taku Fukuzawa, PhD, Siok Wan Gan, PhD, Meiri Shida-Kawazoe, PhD, Yuichiro Shimizu, PhD, Masaru Muraoka, PhD, Tomoyuki Igawa, PhD, Takehisa Kitazawa, DVM, Junichi Nezu, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3611.
https://doi.org/10.1182/blood-2018-99-110145
Published: 2018
Journal Articles

Increasing of Ternary Complex Formation By Predominant Accumulation of Factor (F)X Accompanied By Increase of Fixa Contributes to Enhancement of Clotting Function By Apcc in Combination with Emicizumab

Koji Yada, MD PhD, Keiji Nogami, MDPhD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Midori Shima, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3658.
https://doi.org/10.1182/blood.V130.Suppl_1.3658.3658
Published: 2017
Journal Articles

Anti-Factor IXa/Factor X Antibody (ACE910) Improves the Coagulation Function in Acquired Hemophilia A ex vivo

Masahiro Takeyama, MD PhD, Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3565.
https://doi.org/10.1182/blood.V126.23.3565.3565
Published: 2015
Journal Articles

ACE910 Facilitates Its Hemostatic Effect with the Lower Concentration of Factor X Than That Required for Factor VIIa-Driven Coagulation

Koji Yada, MD PhD, Keiji Nogami, MD PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1077.
https://doi.org/10.1182/blood.V126.23.1077.1077
Published: 2015
Journal Articles

Activated Protein C-Catalyzed Factor Va Inactivation Predominantly Contributes to the Downregulation of Coagulation Rather Than Factor VIIIa Inactivation

Koji Yada, MD PhD, Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4222.
https://doi.org/10.1182/blood.V124.21.4222.4222
Published: 2014
Journal Articles

FVIII Heavy Chain Enhances Tenase Activity Induced By FVIIIa Mimicking Bispesific Antibody, ACE910

Hiroaki Minami, MD, Keiji Nogami, MD PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1481.
https://doi.org/10.1182/blood.V124.21.1481.1481
Published: 2014
Journal Articles

Distinct Localization of Coagulation Factor VIII, Von Willebrand Factor and Factor VIIIa-Mimetic Bispecific Antibody Contributing to Thrombus Formation Under Whole Blood Flow Conditions

Yasuaki Shida, MD PhD, Keiji Nogami, MD PhD, Hiroaki Minami, MD, Hiroaki Yaoi, MD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1483.
https://doi.org/10.1182/blood.V124.21.1483.1483
Published: 2014
Journal Articles

Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model

Atsushi Muto, Takehisa Kitazawa, DVM, Kazutaka Yoshihasi, DVM, PhD, Minako Takeda, DVM, Tetsuhiro Soeda, PhD, Tomoyuki Igawa, PhD, Zenjiro Sampei, Yuichiro Sakamoto, Yukiko Okuyama-Nishida, PhD, Hiroyuki Saito, Yoshiki Kawabe, PhD, Midori Shima, MD, PhD, Akira Yoshioka, MD, PhD, Kunihiro Hattori, PhD
Journal: Blood
Blood (2012) 120 (21): 42.
https://doi.org/10.1182/blood.V120.21.42.42
Published: 2012
Journal Articles

Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity

Tomoyuki Igawa, PhD, Zenjiro Sampei, Tetsuhiro Soeda, PhD, Yukiko Okuyama-Nishida, PhD, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, PhD, Takehisa Kitazawa, DVM, Kazutaka Yoshihashi, DVM, PhD, Aya Harada, Miho Funaki, Kenta Haraya, Tachibana Tatsuhiko, PhD, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi, PhD, Kunihiro Hattori, PhD
Journal: Blood
Blood (2012) 120 (21): 1126.
https://doi.org/10.1182/blood.V120.21.1126.1126
Published: 2012