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Sean O'Brien, PhD
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Journal Articles

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Hans Lee, MD, Hua Wang, PhD, Heather Lin, M.S., Veera Baladandayuthapani, PhD, Jin He, Richard Julian Jones, PhD, Isere Kuiatse, PhD, Dongmin Gu, MD, PhD, Zhiqiang Wang, PhD, Sean O'Brien, PhD, Jonathan J Keats, PhD, Jing Yang, PhD, Richard Eric Davis, MD, Robert Z. Orlowski, PhD, MD
Journal: Blood
Blood (2015) 126 (23): 3010.
https://doi.org/10.1182/blood.V126.23.3010.3010
Published: 2015
Journal Articles

CX-4945, a Selective and Orally Bioavailable Inhibitor of Protein Kinase CK2 Inhibits PI3K/Akt, JAK-STAT and NF-κB Signaling and Induces Apoptosis In Multiple Myeloma Cells

Caroline Ho, MS, Rachel Rice, BS, Denis Drygin, PhD, Josh Bliesath, BS, Nicole Streiner, BS, Adam Siddiqui-Jain, PhD, Chris Proffitt, BS, Sean O'Brien, PhD, Kenna Anderes, PhD
Journal: Blood
Blood (2010) 116 (21): 787.
https://doi.org/10.1182/blood.V116.21.787.787
Published: 2010
Journal Articles

Discovery of Selective Small Molecule Pan-Pim Kinase Inhibitors with Potent Oral Efficacy in Murine Xenograft Models.

Sean O'Brien, PhD, Mustapha Haddach, PhD, Cosmin Borsan, Jerome Michaux, Pauline Kerdoncuff, Mike Schwaebe, Fabrice Pierre, PhD, Eric Stefan, PhD, Anne Sophie Nedellec, Adam Siddiqui-Jain, PhD, Nicole Streiner, BS, Diwata Macalino, BS, Denis Drygin, Phd, Caroline Ho, MS, Josh Bliesath, BS, May Omori, Ryan Stansfield, BS, Jennifer Phung, David Ryckman, PhD, William Rice, PhD, Kenna Anderes, PhD
Journal: Blood
Blood (2009) 114 (22): 1726.
https://doi.org/10.1182/blood.V114.22.1726.1726
Published: 2009