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Journal Articles

Deferasirox Associated to Liver Failure and Death in a Sickle Cell Anemia Patient Homozygous for the -1774delG Polymorphism in the ABCC2 Gene Encoding Multidrug Resistance Protein 2 (MRP2)

Caroline Cordeiro Barroso Braga, Bruno Deltreggia Benites, MD, Dulcineia M de Albuquerque, Marisa Claudia Alvarez, Fernando F Costa, PhD MD, Simone C O Gilli, MD PhD, Sara T.O. Saad, MD PhD

Blood (2016) 128 (22): 4822.

https://doi.org/10.1182/blood.V128.22.4822.4822

Published: 2016

Journal Articles

Circulating Lipoprotein Concentrations Correlate with Total but Not Free Heme in Different Sickle Cell Disease Genotypes

Felipe Vendrame, M.Sc., Sara T.O. Saad, MD, PhD, Fernando F Costa, MD, PhD, Kleber Yotsumoto Fertrin, MD, PhD

Blood (2015) 126 (23): 4580.

https://doi.org/10.1182/blood.V126.23.4580.4580

Published: 2015

Journal Articles

Hypersegmented Neutrophil Percentage Using Automated Digital Cell Morphology: A Simple Laboratory Parameter to Monitor Hydroxyurea Therapy in Sickle Cell Disease Patients

Kleber Yotsumoto Fertrin, MD, PhD, Elza Miyuki Kimura, B.Sc., Fernanda Madureira de Oliveira Araujo, B.Sc., Maria de Fatima Pereira Gilberti, MD, Sara T.O. Saad, MD, PhD, Fernando F Costa, MD, PhD

Blood (2015) 126 (23): 2188.

https://doi.org/10.1182/blood.V126.23.2188.2188

Published: 2015

Journal Articles

Arhgap21 +/- Mice Show Impaired Adhesion, Migration, Homing and Short Term Reconstitution of Hematopoietic Progenitor Cells

Juliana M. Xavier, Ricon Lauremília, PhD, Vieira Karla, PhD, Longhini Ana Leda, PhD, Franchi Gilberto, Jr, Nowill Alexandre, MD PhD, Carolina Bigarella, PhD, Sara T.O Saad, MD, PhD

Blood (2014) 124 (21): 4333.

https://doi.org/10.1182/blood.V124.21.4333.4333

Published: 2014

Journal Articles

Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis

Mariana Lazarini, PhD, João Agostinho Machado-Neto, MSc, Adriana Silva Santos Duarte, PhD, Fernando V Pericole, MD, Karla Priscila Ferro, PhD, Paula de Melo Campos, MD, Fabiola Traina, MD PhD, Sara T.O. Saad, MD, PhD

Blood (2014) 124 (21): 3239.

https://doi.org/10.1182/blood.V124.21.3239.3239

Published: 2014

Journal Articles

MDM2 SNP309 and TP53 SNPArg72Pro Polymorphisms in Myelodysplastic Syndrome.

João Agostinho Machado Neto, BSci, Fabiola Traina, MD, PhD, Paula Melo Campos, BSci, Marilisia Andreoli, BSci, Irene Lorand Metze, Ph.D., Fernando Ferreira Costa, PhD, MD, Sara T.O. Saad, MD, PhD

Blood (2009) 114 (22): 1745.

https://doi.org/10.1182/blood.V114.22.1745.1745

Published: 2009

Journal Articles

Upregulation of the Anti-Apoptotic Protein, Survivin, in Hematopoietic Cells in Sickle Cell Anemia and Effects of Hydroxyurea Therapy.

Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Mariana R. B. Mello, B.Sc., M.Sc, Kleber Yotsumoto Fertrin, MD, Marcos André C Bezerra, Ph.D., Dulcinéia M. Albuquerque, B.Sc., M.Sc., Ph.D, Nicola Conran, Ph.D., Sara T.O. Saad, MD, PhD, Aderson S. Araujo, M.D., Ph.D., Fernando F. Costa, PhD, MD

Blood (2009) 114 (22): 1532.

https://doi.org/10.1182/blood.V114.22.1532.1532

Published: 2009

Journal Articles

ANKHD1, a New Ankyrin-Repeat Protein, Binds to SIVA and May Modulate ROS Generation, Cell Cycle and Apoptosis Signaling in Cancer Cells

Fabiola Traina, MD, PhD, Patrícia Cristina Rodrigues, M.Sc., Mariana Lazarini, M.Sc., Paulo Roberto Moura Lima, PhD, Fernando F. Costa, MD, PhD, Sara T.O. Saad, MD, PhD

Blood (2008) 112 (11): 5319.

https://doi.org/10.1182/blood.V112.11.5319.5319

Published: 2008

Journal Articles

Induction of Caspase-Independent Apoptosis by Sickle Cell Disease (SCD) Serum in Non-SCD Leukocytes

Camila B. Almeida, M.Sc., Fernanda Gonçalves Pereira, M.Sc., Irene Lorand Metze, MD, Ph.D., Sara T.O. Saad, MD, PhD, Fernando F. Costa, PhD, MD, Nicola Conran, Ph.D.

Blood (2008) 112 (11): 2475.

https://doi.org/10.1182/blood.V112.11.2475.2475

Published: 2008

Journal Articles

Simvastatin Reduces the in Vitro Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers

Andreia A Canalli, B.Sc., Ph.D., Renata P. Ferreira, B.Sc., Sara T.O. Saad, MD, PhD, Nicola Conran, B.Sc, PhD, Fernando F. Costa, M.D., Ph.D.

Blood (2008) 112 (11): 2489.

https://doi.org/10.1182/blood.V112.11.2489.2489

Published: 2008

Journal Articles

Production and Expression of Inflammatory Mediators in Leukocytes of Sickle Cell Anaemia Patients and Effects of Hydroxyurea Therapy on This Production

Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Dulcinéia M Albuquerque, B.Sc., M.Sc., Ph.D, Sara T.O. Saad, MD, PhD, Nicola Conran, B.Sc., Ph.D, Fernando F. Costa, PhD, MD

Blood (2008) 112 (11): 2490.

https://doi.org/10.1182/blood.V112.11.2490.2490

Published: 2008

Journal Articles

Increased Adhesive Properties and Reactive Oxygen Species of Red Cells, Platelets and Leukocytes and Neutrophil Chemotaxis in IVS-1-6 (T → C) Homozygous β-Thalassemia Intermedia.

Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Marcos André Cavalcanti Bezerra, B.Sc., M.Sc, Mariana R. B. Mello, B.Sc., M.Sc, Sheley Gambero, B.Sc., M.Sc, Dulcinéia M Albuquerque, B.Sc., M.Sc., Ph.D, Carolina Lanaro, B.Sc., Ph.D, Sara T.O. Saad, MD, PhD, Aderson S. Araújo, M.D., Ph.D., Fernando F. Costa, PhD, MD

Blood (2008) 112 (11): 1873.

https://doi.org/10.1182/blood.V112.11.1873.1873

Published: 2008

Journal Articles

Expression of High Levels of Human γ-Globin in Adult Mice Carrying a Transgene of the Brazilian Type of Hereditary Persistence of Fetal Hemoglobin.

Anderson F. Cunha, PhD, Ana F. Brugnerotto, Monica B. Melo, PhD, Marcus A.F. Corat, PhD, Ana P. Gimenes, Luiz A.C. Passos, PhD, Emily E. Devlin, PhD, David M. Bodine, PhD, Sara T.O. Saad, MD, PhD, Fernando F. Costa, MD, PhD

Blood (2007) 110 (11): 3831.

https://doi.org/10.1182/blood.V110.11.3831.3831

Published: 2007

Journal Articles

Identification of Intronic RNA Expression in CD34+ Cells of Patients with Myelodysplatic Syndrome by RNA Microarray Analysis.

Mariana O. Baratti, BSc, Yuri B. Moreira, BSc, Fabiola Traina, MD, PhD, Luciene Borges, PhD, Fernando F. Costa, MD, PhD, Sergio Verjovski-Almeida, MD, PhD, Sara T.O. Saad, MD, PhD

Blood (2007) 110 (11): 2423.

https://doi.org/10.1182/blood.V110.11.2423.2423

Published: 2007

Journal Articles

Defective Expression of ANKHD1 Transcript Variant 3 in Myelodysplastic Cells and Its Role in Apoptosis.

Adriana S.S. Duarte, MsD, Fabiola Traina, MD, PhD, Fernando F. Costa, MD, PhD, Sara T.O. Saad, MD, PhD

Blood (2007) 110 (11): 2432.

https://doi.org/10.1182/blood.V110.11.2432.2432

Published: 2007

Journal Articles

Glucocorticoid Action upon SIRPa and SHP-1 mRNA Expression in Autoimmune Hemolytic Anemia (AIHA).

Ana Carolina Almeida, Sara T.O. Saad, MD, PhD, Maria de Lourdes R.B. Castro, MD, PhD, Antonio Condino Neto, MD, PhD

Blood (2007) 110 (11): 3843.

https://doi.org/10.1182/blood.V110.11.3843.3843

Published: 2007

Journal Articles

Global Gene Expression Revealed a Set of Genes Involved in the Modification of Cells during Erythropoiesis.

Anderson F. Cunha, PhD, Ana F. Brugnerotto, Adriana S.S. Duarte, M.Sc, Gustavo G.L. Costa, Sara T.O. Saad, MD,PhD, Fernando F. Costa, MD,PhD

Blood (2007) 110 (11): 4074.

https://doi.org/10.1182/blood.V110.11.4074.4074

Published: 2007

Journal Articles

Altered Red Cell and Platelet Adhesion in the Hemolytic Diseases: Hereditary Spherocytosis, Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Anemia.

Andreia A. Canalli, BSc, MSc, Carla F. Franco-Penteado, BSc, PhD, Fabiola Traina, MD, Nicola Conran, BSc, PhD, Rafael Morgante, BSc, MSc, Sheley Gambero, BSc, MSc, Sara T.O. Saad, MD, PhD, Fernando F. Costa, MD, PhD

Blood (2006) 108 (11): 1238.

https://doi.org/10.1182/blood.V108.11.1238.1238

Published: 2006

Journal Articles

HbA Is More Effective Than HbF for Improving the Clinical Course in Sickle Cell Disease.

Marcos A.C. Bezerra, BSc, Andre Fattori, MD; PhD, Magnum N. Santos, B.Sc, Dulcineia M. Albuquerque, B.Sc; PhD, Maria F. Sonati, B.Sc; PhD, Sara T.O. Saad, MD; PhD, Aderson S. Araujo, MD.; PhD, Fernando F. Costa, MD; PhD

Blood (2006) 108 (11): 3776.

https://doi.org/10.1182/blood.V108.11.3776.3776

Published: 2006

Journal Articles

The Overexpression of ANKHD1 in Acute Leukemia Cells and Its Association with SIVA-1, a Proapoptotic Protein.

Fabiola Traina, MD, Patricia M.B. Favaro, PhD, Adriana S.S. Duarte, MS, Sheila M.B. Winnschofe, PhD, Fernando F. Costa, MD,PhD, Sara T.O. Saad, MD, PhD

Blood (2006) 108 (11): 4290.

https://doi.org/10.1182/blood.V108.11.4290.4290

Published: 2006

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Deferasirox Associated to Liver Failure and Death in a Sickle Cell Anemia Patient Homozygous for the -1774delG Polymorphism in the ABCC2 Gene Encoding Multidrug Resistance Protein 2 (MRP2)

Circulating Lipoprotein Concentrations Correlate with Total but Not Free Heme in Different Sickle Cell Disease Genotypes

Hypersegmented Neutrophil Percentage Using Automated Digital Cell Morphology: A Simple Laboratory Parameter to Monitor Hydroxyurea Therapy in Sickle Cell Disease Patients

Arhgap21 +/- Mice Show Impaired Adhesion, Migration, Homing and Short Term Reconstitution of Hematopoietic Progenitor Cells

Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis

MDM2 SNP309 and TP53 SNPArg72Pro Polymorphisms in Myelodysplastic Syndrome.

Upregulation of the Anti-Apoptotic Protein, Survivin, in Hematopoietic Cells in Sickle Cell Anemia and Effects of Hydroxyurea Therapy.

ANKHD1, a New Ankyrin-Repeat Protein, Binds to SIVA and May Modulate ROS Generation, Cell Cycle and Apoptosis Signaling in Cancer Cells

Induction of Caspase-Independent Apoptosis by Sickle Cell Disease (SCD) Serum in Non-SCD Leukocytes

Simvastatin Reduces the in Vitro Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers

Production and Expression of Inflammatory Mediators in Leukocytes of Sickle Cell Anaemia Patients and Effects of Hydroxyurea Therapy on This Production

Increased Adhesive Properties and Reactive Oxygen Species of Red Cells, Platelets and Leukocytes and Neutrophil Chemotaxis in IVS-1-6 (T → C) Homozygous β-Thalassemia Intermedia.

Expression of High Levels of Human γ-Globin in Adult Mice Carrying a Transgene of the Brazilian Type of Hereditary Persistence of Fetal Hemoglobin.

Identification of Intronic RNA Expression in CD34+ Cells of Patients with Myelodysplatic Syndrome by RNA Microarray Analysis.

Defective Expression of ANKHD1 Transcript Variant 3 in Myelodysplastic Cells and Its Role in Apoptosis.

Glucocorticoid Action upon SIRPa and SHP-1 mRNA Expression in Autoimmune Hemolytic Anemia (AIHA).

Global Gene Expression Revealed a Set of Genes Involved in the Modification of Cells during Erythropoiesis.

Altered Red Cell and Platelet Adhesion in the Hemolytic Diseases: Hereditary Spherocytosis, Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Anemia.

HbA Is More Effective Than HbF for Improving the Clinical Course in Sickle Cell Disease.

The Overexpression of ANKHD1 in Acute Leukemia Cells and Its Association with SIVA-1, a Proapoptotic Protein.

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