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S Haihua Chu, PhD
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Journal Articles

Adenine Base Editing of the Sickle Allele in CD34 + Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S

S. Haihua Chu, PhD, Daisy Lam, Michael S. Packer, PhD, Jennifer Olins, Alexander Liquori, Jeffrey Marshall, PhD, Calvin Lee, Bo Yan, PhD, Jeremy Decker, Bob Gantzer, M.S., Scott J. Haskett, M.S., Tanggis Bohnuud, PhD, David Born, PhD, Luis Barrera, PhD, Ian Slaymaker, PhD, Nicole M. Gaudelli, PhD, Adam J. Hartigan, PhD, Giuseppe Ciaramella, PhD, B.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 47.
https://doi.org/10.1182/blood-2020-141805
Published: 2020
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan Chabon, BS, Janna Minehart, BS, Chloe N Matovina, BS, Jian Zhang, Bo-Ruei Chen, PhD, Elsa Callen-Moreu, PhD, Putzer J Hung, Zhaohui Feng, BM, BS, Richard Koche, PhD, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, PhD, Barry Sleckman, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 511.
https://doi.org/10.1182/blood-2018-99-111952
Published: 2018
Journal Articles

Targeting the DNA Damage Response Pathway in MLL- rearranged B-Acute Lymphoblastic Leukemias

S. Haihua Chu, PhD, Evelyn Junyao Song, BS, Jonathan Chabon, BS, Janna Minehart, BS, Zhaohui Feng, BM, BS, Kenneth Ross, PhD, Richard Koche, PhD, Andrei V. Krivtsov, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3880.
https://doi.org/10.1182/blood.V130.Suppl_1.3880.3880
Published: 2017
Journal Articles

Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations

Evelyn J Song, BS, S. Haihua Chu, PhD, Janna Minehart, BS, Jonathan Chabon, BS, Richard Koche, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1511.
https://doi.org/10.1182/blood.V128.22.1511.1511
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan R Chabon, BS, Janna Minehart, BS, Richard Koche, PhD, Katie Li, BS, Matthew Witkin, BS, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 423.
https://doi.org/10.1182/blood.V128.22.423.423
Published: 2016
Journal Articles

Genetic and Pharmacologic Notch4 Inhibition Synergizes with FLT3 Tyrosine Kinase Inhibition in Vitro to More Effectively Eliminate FLT3/ITD-Positive Leukemia Cells

Courtney M. Shirley, PhD, S. Haihua Chu, PhD, Yandan Yang, PhD, George W. Wright, PhD, Louis M. Staudt, MD PhD, Donald Small, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3583.
https://doi.org/10.1182/blood.V124.21.3583.3583
Published: 2014