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Journal Articles

Cross Priming of Transgene Product-Specific CD8 + T Cells in Hepatic AAV Gene Transfer Depends on IL-1 Receptor and XCR1 + Dendritic Cells but Not TLR9

Sandeep Kumar, PhD, Moanaro Biswas, PhD, Annie R Pineros, PhD, Ype P De Jong, MD, Roland W Herzog, PhD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-142926

Published: 2020

Journal Articles

AAV Vector Dose Determines TLR9 Dependence of CD8+ T Cell Response to Transgene Product

Ning Li, Thais Bertolini, Roland W Herzog, PhD

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-141054

Published: 2020

Journal Articles

Alternative Approaches to Oral Tolerance Induction to Factor FVIII

Thais Bertolini, Moanaro Biswas, PhD, Radoslaw Kaczmarek, PhD, Henry Daniell, PhD, Roland W Herzog, PhD

Blood (2020) 136 (Supplement 1): 8–9.

https://doi.org/10.1182/blood-2020-142661

Published: 2020

Journal Articles

Revisiting the "Danger Theory": Toll-like Receptor 9 Stimulation Triggers Activation of Conventional CD8α + and Plasmacytoid Dendritic Cells En Route to Enhancing FVIII Inhibitor Formation

Radoslaw Kaczmarek, PhD, Thais Bertolini, Roland W Herzog, PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-143259

Published: 2020

Journal Articles

Toll-like Receptor 9 Activation Accelerates Inhibitor Formation in Response to Factor VIII

Radoslaw Kaczmarek, Alexandra Sherman, DVM, Moanaro Biswas, PhD, Roland W Herzog, PhD

Blood (2019) 134 (Supplement_1): 1113.

https://doi.org/10.1182/blood-2019-125348

Published: 2019

Journal Articles

Innate Immune Activation Via TLR9 May Enhance Antibody Formation Against Factors VIII and IX in Protein and Gene Therapy

Roland W Herzog, PhD, Alexandra Sherman, DVM, Brad E. Hoffman, PhD

Blood (2017) 130 (Supplement 1): 3651.

https://doi.org/10.1182/blood.V130.Suppl_1.3651.3651

Published: 2017

Journal Articles

Lettuce Plants Expressing High Levels of Factor VIII Antigen in the Chloroplast for Oral Tolerance in Hemophilia a

Roland W Herzog, PhD, Alexandra Sherman, DVM, Kwang-Chul Kwon, PhD, Wan-Jung Chang, MS, Henry Daniell, PhD

Blood (2017) 130 (Supplement 1): 362.

https://doi.org/10.1182/blood.V130.Suppl_1.362.362

Published: 2017

Journal Articles

Reprogrammed CD4 + T Cells That Express FoxP3 + Effectively Control Inhibitory Antibody Development in Hemophilic Mice

Moanaro Biswas, PhD, Veronica Kuteyeva, Roland W Herzog, PhD

Blood (2017) 130 (Supplement 1): 175.

https://doi.org/10.1182/blood.V130.Suppl_1.175.175

Published: 2017

Journal Articles

Generation of FVIII-Specific Tregs Expressing a Chimeric Antigen Receptor (CAR) to Suppress Inhibitor Development in Hemophilia a Mice

Moanaro Biswas, PhD, Todd M Brusko, PhD, Roland W Herzog, PhD

Blood (2017) 130 (Supplement 1): 176.

https://doi.org/10.1182/blood.V130.Suppl_1.176.176

Published: 2017

Journal Articles

Hepatic AAV Gene Transfer of Cytoplasmic Transgene Induces Transgene Product-Specific T Cell Activation Initially in the Liver and Celiac Lymph Node Preceding Treg Induction

Roland W. Herzog, PhD, George Q. Perrin, PhD

Blood (2015) 126 (23): 3241.

https://doi.org/10.1182/blood.V126.23.3241.3241

Published: 2015

Journal Articles

Factor IX Expressed in Lettuce Chloroplasts Induces Oral Tolerance in Hemophilia B Mice

Roland W. Herzog, PhD, Jin Su, PhD, Liqing Zhu, BS, Xiaomei Wang, PhD, Shina Lin, BS, Aditya Kamesh, BS, Henry Daniell, PhD

Blood (2015) 126 (23): 292.

https://doi.org/10.1182/blood.V126.23.292.292

Published: 2015

Journal Articles

AAV3 Capsid Is Superior for In Vivo Gene Transfer to Human Hepatocytes Compared to Serotypes 5 and 8 in a Mouse/Human Chimeric Model

Roland W. Herzog, PhD, Brad E. Hoffman, PhD, Irene Zolotukhin, MS, Katherine A. High, MD, Arun Srivastava, PhD, Ype P. de Jong, MD PhD, Koen Vercauteren, PhD, Jing Xiao

Blood (2015) 126 (23): 4418.

https://doi.org/10.1182/blood.V126.23.4418.4418

Published: 2015

Journal Articles

TLR9 and Dendritic Cells Are Required for CD8 + T Cell Responses to the AAV Capsid

Geoffrey L. Rogers, BS, Roland W Herzog, PhD

Blood (2014) 124 (21): 552.

https://doi.org/10.1182/blood.V124.21.552.552

Published: 2014

Journal Articles

Self-Complementary AAV Vectors Delivered Intramuscularly Do Not Break Tolerance In a Partial Knockout Model Of Hemophilia B

Geoffrey L. Rogers, BS, Roland W Herzog, PhD

Blood (2013) 122 (21): 4209.

https://doi.org/10.1182/blood.V122.21.4209.4209

Published: 2013

Journal Articles

Mechanism Of Oral Tolerance Induced By Bioencapsulated Coagulation Factor IX In Hemophilia B Mice

Xiaomei Wang, PhD, Alexandra Sherman, DVM, Jin Su, PhD, Henry Daniell, PhD, Roland W Herzog, PhD

Blood (2013) 122 (21): 30.

https://doi.org/10.1182/blood.V122.21.30.30

Published: 2013

Journal Articles

Suppression of Inhibitor Formation Against Factor VIII in Hemophilia A Mice by Oral Delivery of Bioencapsulated Antigen

Roland W Herzog, PhD, Dheeraj Verma, PhD, Xiaomei Wang, PhD, Alexandra Sherman, DVM, Shina Lin, BS, Henry Daniell, PhD

Blood (2012) 120 (21): 14.

https://doi.org/10.1182/blood.V120.21.14.14

Published: 2012

Journal Articles

Immune Tolerance Induction to Factor IX Through B Cell Gene Transfer – Delineating Between Tolerogenic and Immunogenic B Cells.

Xiaomei Wang, PhD, Babak Moghimi, MD, Irene Zolotukhin, M.S., Ou Cao, MD, PhD, Roland W Herzog, PhD

Blood (2012) 120 (21): 3156.

https://doi.org/10.1182/blood.V120.21.3156.3156

Published: 2012

Journal Articles

Synergistic Effect of Flt3L and Rapamycin On Immune Tolerance Induction Via Plasmacytoid Dendritic Cells and Treg.

Debalina Sarkar, PhD, Gongxian Liao, PhD, Cox Terhorst, PhD, Roland W Herzog, PhD

Blood (2012) 120 (21): 2209.

https://doi.org/10.1182/blood.V120.21.2209.2209

Published: 2012

Journal Articles

In Vivo Model to Evaluate Loss of Liver-Derived Factor IX Expression Caused by AAV Capsid-Specific CD8+ T Cells

David M Markusic, PhD, Ashley T Martino, Ph.D., Federico Mingozzi, PhD., Katherine A. High, MD, Roland W Herzog, PhD

Blood (2012) 120 (21): 2046.

https://doi.org/10.1182/blood.V120.21.2046.2046

Published: 2012

Journal Articles

Suppression of Inhibitor Formation in Protein and Gene Therapy for Hemophilia Using Ex Vivo Expanded Treg

Debalina Sarkar, PhD, David M Markusic, PhD, Cox Terhorst, PhD, Todd Brusko, PhD, Roland W Herzog, PhD

Blood (2012) 120 (21): 13.

https://doi.org/10.1182/blood.V120.21.13.13

Published: 2012

NARROW

Cross Priming of Transgene Product-Specific CD8 + T Cells in Hepatic AAV Gene Transfer Depends on IL-1 Receptor and XCR1 + Dendritic Cells but Not TLR9

AAV Vector Dose Determines TLR9 Dependence of CD8+ T Cell Response to Transgene Product

Alternative Approaches to Oral Tolerance Induction to Factor FVIII

Revisiting the "Danger Theory": Toll-like Receptor 9 Stimulation Triggers Activation of Conventional CD8α + and Plasmacytoid Dendritic Cells En Route to Enhancing FVIII Inhibitor Formation

Toll-like Receptor 9 Activation Accelerates Inhibitor Formation in Response to Factor VIII

Innate Immune Activation Via TLR9 May Enhance Antibody Formation Against Factors VIII and IX in Protein and Gene Therapy

Lettuce Plants Expressing High Levels of Factor VIII Antigen in the Chloroplast for Oral Tolerance in Hemophilia a

Reprogrammed CD4 + T Cells That Express FoxP3 + Effectively Control Inhibitory Antibody Development in Hemophilic Mice

Generation of FVIII-Specific Tregs Expressing a Chimeric Antigen Receptor (CAR) to Suppress Inhibitor Development in Hemophilia a Mice

Hepatic AAV Gene Transfer of Cytoplasmic Transgene Induces Transgene Product-Specific T Cell Activation Initially in the Liver and Celiac Lymph Node Preceding Treg Induction

Factor IX Expressed in Lettuce Chloroplasts Induces Oral Tolerance in Hemophilia B Mice

AAV3 Capsid Is Superior for In Vivo Gene Transfer to Human Hepatocytes Compared to Serotypes 5 and 8 in a Mouse/Human Chimeric Model

TLR9 and Dendritic Cells Are Required for CD8 + T Cell Responses to the AAV Capsid

Self-Complementary AAV Vectors Delivered Intramuscularly Do Not Break Tolerance In a Partial Knockout Model Of Hemophilia B

Mechanism Of Oral Tolerance Induced By Bioencapsulated Coagulation Factor IX In Hemophilia B Mice

Suppression of Inhibitor Formation Against Factor VIII in Hemophilia A Mice by Oral Delivery of Bioencapsulated Antigen

Immune Tolerance Induction to Factor IX Through B Cell Gene Transfer – Delineating Between Tolerogenic and Immunogenic B Cells.

Synergistic Effect of Flt3L and Rapamycin On Immune Tolerance Induction Via Plasmacytoid Dendritic Cells and Treg.

In Vivo Model to Evaluate Loss of Liver-Derived Factor IX Expression Caused by AAV Capsid-Specific CD8+ T Cells

Suppression of Inhibitor Formation in Protein and Gene Therapy for Hemophilia Using Ex Vivo Expanded Treg

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American Society of Hematology

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American Society of Hematology

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