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Richard A. Morgan, PhD
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Journal Articles

Preclinical Development of Edit-201, a Multigene Edited Healthy Donor NK Cell with Enhanced Anti-Tumor Function and Superior Serial Killing Activity in an Immunosuppressive Environment

Christopher M Borges, PhD BS, Kevin Wasko, Jared M Nasser, Kelly Donahue, Amanda Pfautz, Lincy P Antony, Glenn Leary, Steven Sexton, Richard A. Morgan, PhD, Karrie K Wong, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33.
https://doi.org/10.1182/blood-2020-139988
Published: 2020
Journal Articles

Generation of Natural Killer Cells with Enhanced Function from a CRISPR/Cas12a-Edited Induced Pluripotent Stem Cell Line

Jung-Il Moon, PhD, Melissa S Chin, BS, Andrew T Burden, BS, Steven Sexton, Kevin Wasko, Jared M Nasser, Lincy P Antony, Karrie K Wong, PhD, Christopher M Borges, PhD BS, Richard A. Morgan, PhD, G. Grant Welstead, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8.
https://doi.org/10.1182/blood-2020-139471
Published: 2020
Journal Articles

Knockout of CBLB Greatly Enhances Anti-Tumor Activity of CAR T Cells

Kathryn Hooper, PhD, Kyle Havens, PhD, Anne-Rachel Krostag, BS, Michael S Magee, PhD, Unja Martin, Ankit Gupta, PhD, Yegor Smurnyy, PhD, Lisa Pechilis, Amanda Rode, Andrew Chavkin, MS, Shannon Grande, PhD, Richard A. Morgan, PhD, Jordan Jarjour, PhD, Alexander Astrakhan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 338.
https://doi.org/10.1182/blood-2018-99-119247
Published: 2018
Journal Articles

Durable Clinical Responses in Heavily Pretreated Patients with Relapsed/Refractory Multiple Myeloma: Updated Results from a Multicenter Study of bb2121 Anti-Bcma CAR T Cell Therapy

Jesus G. Berdeja, MD, Yi Lin, MD PhD, Noopur Raje, MD, Nikhil Munshi, MD, David Siegel, MD PhD, Michaela Liedtke, MD, Sundar Jagannath, MD, Marcela V. Maus, MD PhD, Ashley Turka, Lyh Ping Lam, PharmD, RPh, Kristen Hege, MD, Richard A. Morgan, PhD, Michael Travis Quigley, James N. Kochenderfer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 740.
https://doi.org/10.1182/blood.V130.Suppl_1.740.740
Published: 2017
Journal Articles

ROR1-Directed Chimeric Antigen Receptor T Cell Recognition of Self-Antigen Is Associated with Acute Toxicity, T Cell Dysfunction, and Poor Tumor Control.

James B Rottman, DVM, PhD DACVP, Kenneth Ganley, BS, Brenna Daly, BS, Holly M. Horton, PhD, Kevin M. Friedman, Molly Perkins, PhD, Shannon Grande, PhD, Claire J Rhodes, BS, Richard A. Morgan, PhD, Christopher J. Horvath, DVM, MS, DACVP
Journal: Blood
Blood (2017) 130 (Supplement 1): 4450.
https://doi.org/10.1182/blood.V130.Suppl_1.4450.4450
Published: 2017
Journal Articles

Gene Editing of TRAC Locus Utilizing Megatal Nucleases Increases Expression of Transgenic TCRs Delivered Via Lentiviral Vector-Mediated Gene Transfer

Michael S Magee, PhD, Iulia Diaconu, PhD, Mark Pogson, PhD, Ankit Gupta, PhD, Amy Jensen-Smith, PhD, Brian Collette, BS, Andrew Chavkin, MS, Eli Pasackow, BS, Aaron Edwards, MS, Kevin M. Friedman, Alexander Astrakhan, PhD, Michael T Certo, PhD, Jordan Jarjour, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1906.
https://doi.org/10.1182/blood.V130.Suppl_1.1906.1906
Published: 2017
Journal Articles

A Novel TGF-β 2 /Interleukin Receptor Signal Conversion Platform That Protects CAR/TCR T Cells from TGF-β 2 -Mediated Immune Suppression and Induces T Cell Supportive Signaling Networks

Benjamin Boyerinas, Sara M. Miller, Ryan C. Murray, John W. Evans, Geoffrey B. Parsons, Katherine J. Seidl, Kevin M. Friedman, Richard A. Morgan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1911.
https://doi.org/10.1182/blood.V130.Suppl_1.1911.1911
Published: 2017
Journal Articles

A Novel and Highly Potent CAR T Cell Drug Product for Treatment of BCMA-Expressing Hematological Malignances

Alena A. Chekmasova, PhD, Holly M. Horton, PhD, Tracy E. Garrett, BA, John W. Evans, PhD, Johanna Griecci, BS, Amanda Hamel, BS, Howard J. Latimer, IV, BS, Stacie L. Seidel, MA, Byoung Y. Ryu, PhD, Michael Kuczewski, MS, Christopher J. Horvath, DVM, MS, DACVP, Kevin M. Friedman, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2015) 126 (23): 3094.
https://doi.org/10.1182/blood.V126.23.3094.3094
Published: 2015
Journal Articles

Characterization of Lentiviral Vector Derived Anti-Bcma CAR T Cells Reveals Key Parameters for Robust Manufacturing of Cell-Based Gene Therapies for Multiple Myeloma

Graham Lilley, M.S., Alden Ladd, Daniel Cossette, Laura Viggiano, Gregory Hopkins, John W. Evans, PhD, Mingli Li, M.S., Howard J. Latimer, IV, BS, Sara M. Miller, Michael Kuczewski, MS, Wendy Bakeman, Kayla MacLeod, Kevin M. Friedman, PhD, Dawn A Maier, M.S., Michael Paglia, M.S., Richard A. Morgan, PhD, Mark D Angelino, PhD
Journal: Blood
Blood (2015) 126 (23): 3243.
https://doi.org/10.1182/blood.V126.23.3243.3243
Published: 2015
Journal Articles

Manufacturing an Enhanced CAR T Cell Product By Inhibition of the PI3K/Akt Pathway During T Cell Expansion Results in Improved In Vivo Efficacy of Anti-BCMA CAR T Cells

Molly R. Perkins, D.Phil., Shannon Grande, PhD, Amanda Hamel, BS, Holly M. Horton, PhD, Tracy E. Garrett, BA, Sara M. Miller, Howard J. Latimer, IV, BS, Christopher J. Horvath, DVM, MS, DACVP, Michael Kuczewski, MS, Kevin M. Friedman, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2015) 126 (23): 1893.
https://doi.org/10.1182/blood.V126.23.1893.1893
Published: 2015