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Journal Articles

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Erica M.F. Gotardo, PhD, Pamela L. Brito, M.Sc., Hanan Chweih, M.Sc., Flavia C. Leonardo, PhD, Fernando Ferreira Costa, MD PhD, Nicola Conran, PhD

Blood (2019) 134 (Supplement_1): 2263.

https://doi.org/10.1182/blood-2019-131741

Published: 2019

Journal Articles

Safe Use of Hydroxyurea in Sickle Cell Disease Patients Hospitalized for Painful Vaso-Occlusive Episodes: Results of the Randomized, Open-Label Helps Study

Nicola Conran, PhD, Kleber Yotsumoto Fertrin, MD PhD, Claudia de Alvarenga Maximo, MD, Thais Oliveira, B.Sc., Clarisse Lobo, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2019) 134 (Supplement_1): 2303.

https://doi.org/10.1182/blood-2019-130106

Published: 2019

Journal Articles

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Hanan Chweih, M.Sc., Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Pamela L. Brito, B.Sc, Guilherme G.O. Barbosa, PhD, Flavia Garcia, PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2354.

https://doi.org/10.1182/blood-2018-99-118633

Published: 2018

Journal Articles

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Mariana Gonçalves Oliveira, M.Sc., Edson Antunes, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2362.

https://doi.org/10.1182/blood-2018-99-118813

Published: 2018

Journal Articles

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Lidiane S. Torres, PhD, Lediana I. Miguel, M.Sc., Merav E. Shaul, PhD, Zvi G. Fridlender, MD PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Sara T. Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2366.

https://doi.org/10.1182/blood-2018-99-118960

Published: 2018

Journal Articles

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Pamela L. Brito, B.Sc, Flavia C. Leonardo, PhD, Raquel Costa, PhD, Raquel Soares, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3608.

https://doi.org/10.1182/blood-2018-99-118416

Published: 2018

Journal Articles

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

Lediana I. Miguel, M.Sc., Lidiane S. Torres, PhD, Wilson A. Ferreira, Jr., PhD, Fernanda C. Z. Fabris, B.Sc., Flavia C. Leonardo, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3610.

https://doi.org/10.1182/blood-2018-99-118974

Published: 2018

Journal Articles

The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis

Nicola Conran, PhD, Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Lediana I. Miguel, M.Sc., Flávia Costa Leonardo, PhD, Wilson A. Ferreira, Jr., PhD, Bo E. Hedlund, PhD, Howard L. Elford, PhD, Fernando F. Costa, MD, PhD

Blood (2018) 132 (Supplement 1): 1034.

https://doi.org/10.1182/blood-2018-99-119224

Published: 2018

Journal Articles

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Juliete A.F. Silva, PhD, Hanan Chweih, BSc, Erica M.F. Gotardo, PhD, Wilson A. Ferreira, Jr., PhD, Carla F. Franco-Penteado, B.Sc. PhD, Camila B. Almeida, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 3514.

https://doi.org/10.1182/blood.V130.Suppl_1.3514.3514

Published: 2017

Journal Articles

Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia

Hanan Chweih, BSc, Juliete A.F. Silva, PhD, Wilson A. Ferreira, Jr., PhD, Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Flavia C. Leonardo, PhD, Carla F Franco-Penteado, B.Sc. PhD, Fernando Ferreira Costa, PhD,MD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 540.

https://doi.org/10.1182/blood.V130.Suppl_1.540.540

Published: 2017

Journal Articles

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Rafaela Mendonça, BS, Karla P.V Ferro, PhD, Flávia Costa Leonardo, PhD, Juliete A.F. Silva, PhD, Fernando Vieira Pericole, MD PhD, Sara T Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 2233.

https://doi.org/10.1182/blood.V130.Suppl_1.2233.2233

Published: 2017

Journal Articles

Rock Inhibitor Fasudil Reduces Leukocyte-Endothelium Interactions in the Microvasculature of a Sickle Cell Mouse Model of Allergic Inflammation

Athos Rodrigues Moraes, Hanan Chweih, BSc, Nicola Conran, PhD, Kleber Yotsumoto Fertrin, MD PhD, Fernando Ferreira Costa, MD PhD, Carla Fernanda Franco-Penteado, BSc, PhD

Blood (2017) 130 (Supplement 1): 961.

https://doi.org/10.1182/blood.V130.Suppl_1.961.961

Published: 2017

Journal Articles

Heme Induces NLRP3 Inflammasome Formation in Primary Human Macrophages and May Propagate Hemolytic Inflammatory Processes By Inducing S100A8 Expression

Angelica A. Silveira, M.Sc., Clare Cunningham, PhD, Emma Corr, B.Sc., Wilson Alves Ferreira, Jr., PhD, Fernando F. Costa, MD, PhD, Camila B. Almeida, PhD, Nicola Conran, PhD, Aisling Dunne, PhD

Blood (2016) 128 (22): 1256.

https://doi.org/10.1182/blood.V128.22.1256.1256

Published: 2016

Journal Articles

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

Fernanda F.C. Fabris, Flavia C. Leonardo, PhD, Rodolfo Cancado, MD, PhD, Rafaela Mendonça, B.Sc., Angelica A. Silveira, M.Sc., Kleber Yotsumoto Fertrin, MD, PhD, Sara Teresinha Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD, Camila B. Almeida, PhD

Blood (2016) 128 (22): 1257.

https://doi.org/10.1182/blood.V128.22.1257.1257

Published: 2016

Journal Articles

Inflammasome-Dependent IL-1β Release from Neutrophils in Human Sickle Cell Anemia

Rafaela Mendonça, B.Sc., Angelica A. Silveira, M.Sc., Fernando Vieira Pericole, MD, Cecilia Seguin, B.Sc., Flavia C. Leonardo, PhD, Sara T Olalla Saad, MD, PhD, Fernando F. Costa, MD PhD, Nicola Conran, PhD

Blood (2016) 128 (22): 854.

https://doi.org/10.1182/blood.V128.22.854.854

Published: 2016

Journal Articles

Inhibition Of the Rho/Rho-Kinase Pathway Reduces In Vitro Adhesion Of Sickle Cell Anemia Eosinophils To Human Endothelial Cells

Flavia Rubia Pallis, BSc, MSc, Daiana Morelli Vital, B.Sc., Kleber Yotsumoto Fertrin, MD, PhD, Sara T O Saad, MD, PhD, Nicola Conran, PhD, Fernando Ferreira Costa, MD, PhD, Carla Fernanda Franco-Penteado, PhD

Blood (2013) 122 (21): 2219.

https://doi.org/10.1182/blood.V122.21.2219.2219

Published: 2013

Journal Articles

Imaging Flow Cytometry and Microfluidic Flow Assays Demonstrate Heterocellular Aggregation Of Immature Sickle Erythrocytes To Neutrophils Via Mac-1/VLA-4 Interactions

Venina Marcela Dominical, M.Sc., Leigh Samsel, MS, Daiana Morelli Vital, B.Sc., James S Nichols, RN, Vanessa Tonin Garrido, Sara T O Saad, MD, PhD, Fernando Ferreira Costa, MD, PhD, J. Philip McCoy, PhD, Nicola Conran, PhD, Gregory J. Kato, M.D.

Blood (2013) 122 (21): 318.

https://doi.org/10.1182/blood.V122.21.318.318

Published: 2013

Journal Articles

Hydroxyurea Therapy Reduces The Hypercoagulability State In a Sickle Cell Mouse Model

Marina Pereira Colella, MD, Camila Bononi Almeida, Ph.D., Nicola Conran, PhD, Flavia Rubia Pallis, BSc, MSc, Carla Fernanda Franco-Penteado, Ph.D, Joyce Maria Annichino-Bizzacchi, MD, PhD, Fernando Ferreira Costa, MD, PhD, Erich Vinicius de Paula, MD, PhD, Sara Terezinha Olalla-Saad, M.D., Ph.D., Fabiola Traina, MD, PhD

Blood (2013) 122 (21): 2234.

https://doi.org/10.1182/blood.V122.21.2234.2234

Published: 2013

Journal Articles

Acute Inflammatory Processes Are Induced By Hemolysis and Reversed By Hydroxyurea

Camila Bononi Almeida, Ph.D., Lucas Eduardo Botelho Souza, M.Sc., Fabio Trindade Maranhão Costa, PhD, Claudio Werneck, Ph.D., Dimas T. Covas, MD, PhD, Fernando Ferreira Costa, MD, PhD, Nicola Conran, PhD

Blood (2013) 122 (21): 951.

https://doi.org/10.1182/blood.V122.21.951.951

Published: 2013

Journal Articles

Increased Inflammatory Markers and Their Correlations To Clinical Complications In Hemoglobin SC Disease

Marina Pereira Colella, MD, Erich Vinicius de Paula, MD, PhD, Nicola Conran, PhD, Joao Machado-Neto, MSc, Susan K.P. Quaino, Joyce M. Annichino-Bizzacchi, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara Terezinha Olalla-Saad, M.D., Ph.D., Fabiola Traina, MD, PhD

Blood (2013) 122 (21): 973.

https://doi.org/10.1182/blood.V122.21.973.973

Published: 2013

NARROW

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Safe Use of Hydroxyurea in Sickle Cell Disease Patients Hospitalized for Painful Vaso-Occlusive Episodes: Results of the Randomized, Open-Label Helps Study

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Rock Inhibitor Fasudil Reduces Leukocyte-Endothelium Interactions in the Microvasculature of a Sickle Cell Mouse Model of Allergic Inflammation

Heme Induces NLRP3 Inflammasome Formation in Primary Human Macrophages and May Propagate Hemolytic Inflammatory Processes By Inducing S100A8 Expression

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

Inflammasome-Dependent IL-1β Release from Neutrophils in Human Sickle Cell Anemia

Inhibition Of the Rho/Rho-Kinase Pathway Reduces In Vitro Adhesion Of Sickle Cell Anemia Eosinophils To Human Endothelial Cells

Imaging Flow Cytometry and Microfluidic Flow Assays Demonstrate Heterocellular Aggregation Of Immature Sickle Erythrocytes To Neutrophils Via Mac-1/VLA-4 Interactions

Hydroxyurea Therapy Reduces The Hypercoagulability State In a Sickle Cell Mouse Model

Acute Inflammatory Processes Are Induced By Hemolysis and Reversed By Hydroxyurea

Increased Inflammatory Markers and Their Correlations To Clinical Complications In Hemoglobin SC Disease

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American Society of Hematology

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