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Journal Articles

Elevation of Hypercoagulability Markers in Hemoglobin SC Disease

Marina P Colella, MD, Erich V De Paula, MD, PhD, Nicola Conran, Ph.D., João Machado-Neto, MSc, Susan K.P. Quaino, Joyce M Annichino-Bizzacchi, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara T Olalla Saad, MD, PhD, Fabiola Traina, MD, PhD

Blood (2012) 120 (21): 3227.

https://doi.org/10.1182/blood.V120.21.3227.3227

Published: 2012

Journal Articles

Platelets From Sickle Cell Disease Individuals Induce Endothelial Activation, Demonstrating ICAM-1 and E-Selectin Adhesion Molecule Expression, Inflammatory Cytokine Production and Activation of NFκB Transcription Factor Gene Expression.

Renata Proença-Ferreira, M.Sc., Ana Flavia Brugnerotto, M.Sc., Vanessa Tonin Garrido, B.Sc., Marilene de Fatima Reis Ribeiro, Fabiola Traina, MD, PhD, Sara T Olalla Saad, MD, PhD, Fernando Ferreira Costa, MD, PhD, Nicola Conran, Ph.D.

Blood (2012) 120 (21): 2114.

https://doi.org/10.1182/blood.V120.21.2114.2114

Published: 2012

Journal Articles

Proangiogenic Effects of Plasma From Sickle Cell Disease Patients and Antiangiogenic Effects of Hydroxyurea: Evaluation of Invasion and Proliferation of Human Endothelial Cells and Effects of Hydroxyurea in a Mouse Matrigel Plug Neovascularization Assay

Fláavia Cristine Mascia Lopes, M.Sc., Ph.D., Raquel Costa, Sara T Olalla Saad, MD, PhD, Raquel Soares, Fernando Ferreira Costa, MD, PhD, Nicola Conran, Ph.D.

Blood (2012) 120 (21): 377.

https://doi.org/10.1182/blood.V120.21.377.377

Published: 2012

Journal Articles

European Chromosome 6 Haplotypes Significantly Augment Fetal Hemoglobin Levels in Brazilian Sickle Cell Anemia Patients: Influence of Four HBS1L-MYB Intergenic Region SNPs

Flávia Costa Leonardo, Ph.D., Stephan Menzel, MD, Ana Flavia Brugnerotto, Kleber Yotsumoto Fertrin, MD, PhD, Marcos André Cavalcanti Bezerra, MSc, PhD, Aderson S Araujo, MD, PhD, Fernando Ferreira Costa, MD, PhD, Swee Lay Thein, MD, FRCP, FRCPath, DSc, Nicola Conran, Ph.D.

Blood (2012) 120 (21): 1002.

https://doi.org/10.1182/blood.V120.21.1002.1002

Published: 2012

Journal Articles

Increased Neutrophil Adhesive Properties In Patients with Venous Thromboembolism and Residual Vein Thrombosis and High D-Dimer Levels

kiara Cristina Senger Zapponi, Luis Fernando Bittar, Bruna m Mazetto, Fernanda Dutra Santiago-Bassora, MD, Fernanda A. Orsi, MD, Erich V de Paula, MD, PhD, Nicola Conran, Ph.D., Joyce M Annichino-Bizzacchi, MD, PhD

Blood (2011) 118 (21): 2301.

https://doi.org/10.1182/blood.V118.21.2301.2301

Published: 2011

Journal Articles

Adhesive and Inflammatory Properties Are Increased in Blood Outgrowth Endothelial Cells From Patients with Sickle Cell Anemia

Tatiana M. Sakamoto, M.Sc., Carolina Lanaro, B.Sc., Ph, D, Vanessa Tonin Garrido, B.Sc., Margareth C. Ozelo, M.D., Ph.D., Sara T. Olalla-Saad, M.D., Ph.D., Nicola Conran, Ph.D., Fernando Ferreira Costa, MD, PhD

Blood (2011) 118 (21): 2133.

https://doi.org/10.1182/blood.V118.21.2133.2133

Published: 2011

Journal Articles

Increased Angiogenic Activity of Plasma From Sickle Cell Disease Patients and Anti-Angiogenic Effects of Hydroxyurea: Evaluation of Capillary-Like Structure Formation of Human Umbilical Vein Endothelial Cells on Matrigel

Flávia Cristine Mascia Lopes, M.Sc., Ph.D., Kleber Yotsumoto Fertrin, M.D., Sara T. Olalla-Saad, M.D., Ph.D., Fernando Ferreira Costa, MD, PhD, Nicola Conran, Ph.D.

Blood (2011) 118 (21): 899.

https://doi.org/10.1182/blood.V118.21.899.899

Published: 2011

Journal Articles

Hydroxyurea Reduces the Hypercoagulable State In Sickle Cell Anemia

Marina P Colella, MD, Joao Machado-Neto, MSc, Susan K.P. Quaino, Nicola Conran, Ph.D., Joyce M Annichino-Bizzacchi, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara Olalla Saad, MD, PhD, Erich V de Paula, MD, PhD, Fabiola Traina, MD, PhD

Blood (2011) 118 (21): 1068.

https://doi.org/10.1182/blood.V118.21.1068.1068

Published: 2011

Journal Articles

Elevated Plasma Levels and Platelet-Associated Expression of the Pro-Thrombotic and Pro-Inflammatory Protein, LIGHT (TNFSF14), In Sickle Cell Anemia (SCA)

Vanessa T. Garrido, Venina M. Dominical, M.Sc., Renata Proença-Ferreira, M.Sc., Marcos André Cavalcanti Bezerra, Ph.D., Mariana R. B. Mello, B.Sc., M.Sc., Aderson S Araujo, M.D., Ph.D., Sara T. Olalla-Saad, M.D., Ph.D., Fernando Ferreira Costa, M.D., Ph.D., Nicola Conran, Ph.D.

Blood (2010) 116 (21): 2651.

https://doi.org/10.1182/blood.V116.21.2651.2651

Published: 2010

Journal Articles

Inhibition of Phosphodiesterase 9A (PDE9A) Significantly Reduces Cytokine-Stimulated Adhesion of Neutrophils From Sickle Cell Disease Individuals, in Vitro , but Not Red Cell Adhesion.

Lediana I Miguel, B.Sc., Camila B. Almeida, M.Sc., Carla F Franco-Penteado, Ph.D, Marcos André C Bezerra, Ph.D., Fabiola Traina, M.D., Ph.D., Venina M Dominical, B.Sc., Aderson S Araujo, M.D., Ph.D., Sara T.O. Saad, M.D, Ph.D., Fernando F. Costa, Ph.D., M.D., Nicola Conran, Ph.D.

Blood (2009) 114 (22): 1520.

https://doi.org/10.1182/blood.V114.22.1520.1520

Published: 2009

Journal Articles

Upregulation of the Anti-Apoptotic Protein, Survivin, in Hematopoietic Cells in Sickle Cell Anemia and Effects of Hydroxyurea Therapy.

Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Mariana R. B. Mello, B.Sc., M.Sc, Kleber Yotsumoto Fertrin, MD, Marcos André C Bezerra, Ph.D., Dulcinéia M. Albuquerque, B.Sc., M.Sc., Ph.D, Nicola Conran, Ph.D., Sara T.O. Saad, MD, PhD, Aderson S. Araujo, M.D., Ph.D., Fernando F. Costa, PhD, MD

Blood (2009) 114 (22): 1532.

https://doi.org/10.1182/blood.V114.22.1532.1532

Published: 2009

Journal Articles

Hydroxyurea Therapy Is Associated with Decreased Platelet Aggregation Responses and Activation in Sickle Cell Disease.

Renata Proença-Ferreira, M.Sc., Tania F.G.S. Machado, Fabiola Traina, M.D., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando Ferreira Costa, Ph.D., M.D., Nicola Conran, Ph.D.

Blood (2009) 114 (22): 2565.

https://doi.org/10.1182/blood.V114.22.2565.2565

Published: 2009

Journal Articles

Induction of Caspase-Independent Apoptosis by Sickle Cell Disease (SCD) Serum in Non-SCD Leukocytes

Camila B. Almeida, M.Sc., Fernanda Gonçalves Pereira, M.Sc., Irene Lorand Metze, MD, Ph.D., Sara T.O. Saad, MD, PhD, Fernando F. Costa, PhD, MD, Nicola Conran, Ph.D.

Blood (2008) 112 (11): 2475.

https://doi.org/10.1182/blood.V112.11.2475.2475

Published: 2008

Journal Articles

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

Renata P. Ferreira, B.Sc., Carla F. Franco-Penteado, Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, Ph.D.

Blood (2008) 112 (11): 2472.

https://doi.org/10.1182/blood.V112.11.2472.2472

Published: 2008

Journal Articles

The Cyclic GMP-Dependent Pathway Is Involved in the Mechanisms of Action of Hydroxyurea.

Yusuke Suzuki, PhD, Lakiea Bailey, M.S., Abdullah Kutlar, M.D., Nicola Conran, Ph.D., Fernando F. Costa, M.D., Karin M. Gaensler, M.D., Tohru Ikuta, M.D., Ph.D.

Blood (2007) 110 (11): 2256.

https://doi.org/10.1182/blood.V110.11.2256.2256

Published: 2007

Journal Articles

The Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers, In Vitro , Is Mediated by the Mac-1, LFA-1 and VLA-4 Integrins.

Andreia A. Canalli, MSc, Renata F. Proenca, B.Sc., Sara T.O. Saad, M.D., Ph.D., Nicola Conran, Ph.D., Fernando F. Costa, M.D., Ph.D.

Blood (2007) 110 (11): 2264.

https://doi.org/10.1182/blood.V110.11.2264.2264

Published: 2007

Journal Articles

A Constitutive Increase in Gamma Globin Gene Production during the Erythroid Differentiation of CD34 + Cells from Sickle Cell Disease Patients and Alterations in Cyclic Nucleotide Levels during This Differentiation.

Carolina Lanaro, Ph.D., Adriana S.S Duarte, M.Sc., Dulcineia M. Albuquerque, Ph.D., Nicola Conran, Ph.D., Sara T.O Saad, M.D., Ph.D., Fernando F. Costa, MD, PhD

Blood (2007) 110 (11): 3790.

https://doi.org/10.1182/blood.V110.11.3790.3790

Published: 2007

Journal Articles

Increased GM-CSF Levels in Sickle Cell Disease Are Associated with Increased Leukocyte Counts and Are Reversed by Hydroxyurea.

Nicola Conran, Ph.D, Tohru Ikuta, M.D., Ph.D., Sara T.O. Saad, M.D., PhD, Fernando F. Costa, M.D., Ph.D.

Blood (2004) 104 (11): 3573.

https://doi.org/10.1182/blood.V104.11.3573.3573

Published: 2004

NARROW

Elevation of Hypercoagulability Markers in Hemoglobin SC Disease

Platelets From Sickle Cell Disease Individuals Induce Endothelial Activation, Demonstrating ICAM-1 and E-Selectin Adhesion Molecule Expression, Inflammatory Cytokine Production and Activation of NFκB Transcription Factor Gene Expression.

Proangiogenic Effects of Plasma From Sickle Cell Disease Patients and Antiangiogenic Effects of Hydroxyurea: Evaluation of Invasion and Proliferation of Human Endothelial Cells and Effects of Hydroxyurea in a Mouse Matrigel Plug Neovascularization Assay

European Chromosome 6 Haplotypes Significantly Augment Fetal Hemoglobin Levels in Brazilian Sickle Cell Anemia Patients: Influence of Four HBS1L-MYB Intergenic Region SNPs

Increased Neutrophil Adhesive Properties In Patients with Venous Thromboembolism and Residual Vein Thrombosis and High D-Dimer Levels

Adhesive and Inflammatory Properties Are Increased in Blood Outgrowth Endothelial Cells From Patients with Sickle Cell Anemia

Increased Angiogenic Activity of Plasma From Sickle Cell Disease Patients and Anti-Angiogenic Effects of Hydroxyurea: Evaluation of Capillary-Like Structure Formation of Human Umbilical Vein Endothelial Cells on Matrigel

Hydroxyurea Reduces the Hypercoagulable State In Sickle Cell Anemia

Elevated Plasma Levels and Platelet-Associated Expression of the Pro-Thrombotic and Pro-Inflammatory Protein, LIGHT (TNFSF14), In Sickle Cell Anemia (SCA)

Inhibition of Phosphodiesterase 9A (PDE9A) Significantly Reduces Cytokine-Stimulated Adhesion of Neutrophils From Sickle Cell Disease Individuals, in Vitro , but Not Red Cell Adhesion.

Upregulation of the Anti-Apoptotic Protein, Survivin, in Hematopoietic Cells in Sickle Cell Anemia and Effects of Hydroxyurea Therapy.

Hydroxyurea Therapy Is Associated with Decreased Platelet Aggregation Responses and Activation in Sickle Cell Disease.

Induction of Caspase-Independent Apoptosis by Sickle Cell Disease (SCD) Serum in Non-SCD Leukocytes

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

The Cyclic GMP-Dependent Pathway Is Involved in the Mechanisms of Action of Hydroxyurea.

The Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers, In Vitro , Is Mediated by the Mac-1, LFA-1 and VLA-4 Integrins.

A Constitutive Increase in Gamma Globin Gene Production during the Erythroid Differentiation of CD34 + Cells from Sickle Cell Disease Patients and Alterations in Cyclic Nucleotide Levels during This Differentiation.

Increased GM-CSF Levels in Sickle Cell Disease Are Associated with Increased Leukocyte Counts and Are Reversed by Hydroxyurea.

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American Society of Hematology

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American Society of Hematology

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