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Journal Articles

Pre Clinical mTOR-Inhibition of Acute Lymphoblastic Leukemia Cells Synergizes with Pro-Apoptotic Target Therapy Through Mcl-1 Down-Regulation,

Stefano Iacovelli, Maria Rosaria Ricciardi, PhD, Paola Bergamo, Cinzia Rinaldo, PhD, Roberto Licchetta, Antonella Vitale, Anna Testi, MD, Maria Teresa Petrucci, MD, Marina Konopleva, MD, PhD, Michele Milella, MD, Robin Foà, Agostino Tafuri

Blood (2011) 118 (21): 3581.

https://doi.org/10.1182/blood.V118.21.3581.3581

Published: 2011

Journal Articles

Bcl-2 and mTOR as Effective Targets for Molecular Therapy of Acute Lymphoblastic Leukemia

Stefano Iacovelli, Maria Rosaria Ricciardi, PhD, Andrea Miele, Paola Bergamo, Roberto Licchetta, Antonella Vitale, MD, Anna Testi, MD, Maria Teresa Petrucci, MD, Michele Milella, MD, Robin Foà, MD, Agostino Tafuri, MD

Blood (2010) 116 (21): 3228.

https://doi.org/10.1182/blood.V116.21.3228.3228

Published: 2010

Journal Articles

Novel Histone Deacetilase (HDAC) Inhibitors: In Vitro Effects on Leukemic Cells

Maria Rosaria Ricciardi, PhD, Roberto Licchetta, Paola Bergamo, Stefano Iacovelli, Andrea Miele, Maria Teresa Petrucci, MD, Michele Milella, MD, Claudio Pisano, PhD, Agostino Tafuri, MD

Blood (2010) 116 (21): 4946.

https://doi.org/10.1182/blood.V116.21.4946.4946

Published: 2010

Journal Articles

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Maria Rosaria Ricciardi, PhD, Twee Tsao, PhD, Stephen Lee Abrams, PhD, Paola Bergamo, MS, Linda S Steelman, BS., MS, Samantha Decandia, PhD, Lara Felicioni, PhD, Ludovica Ciuffreda, PhD, Cristina Di Sanza, PhD, Antonio Marchetti, MD, PhD, Francesco Cognetti, MD, James McCubrey, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Agostino Tafuri, MD, Michele Milella, MD

Blood (2009) 114 (22): 594.

https://doi.org/10.1182/blood.V114.22.594.594

Published: 2009

Journal Articles

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Marina Konopleva, MD, PhD, Michele Milella, MD, Julie C Watts, PhD, Maria Rosaria Ricciardi, PhD, Borys Korchin, PhD, Twee Tsao, PhD, Paola Bergamo, MS, Duncan H. Mak, PhD, Samantha Decandia, PhD, James McCubrey, PhD, Agostino Tafuri, MD, Michael Andreeff, MD, PhD

Blood (2009) 114 (22): 2757.

https://doi.org/10.1182/blood.V114.22.2757.2757

Published: 2009

Journal Articles

Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

Michele Milella, MD, Maria Rosaria Ricciardi, Paola Bergamo, MS, Maria Cristina Scerpa, PhD, Jacopo Gervasoni, MS, Maria Teresa Petrucci, MD, Sabina Chiaretti, MD, Simona Tavolaro, MS, Ludovica Ciuffreda, PhD, Samantha Decandia, Francesco Libotte, Stephen Lee Abrams, Linda S Steelman, BS., MS, Marina Konopleva, MD, PhD, Francesco Cognetti, MD, Robert Foa, Michael Andreeff, MD, PhD, James McCubrey, PhD, Agostino Tafuri

Blood (2008) 112 (11): 860.

https://doi.org/10.1182/blood.V112.11.860.860

Published: 2008

Journal Articles

Comparative Gene Profiling of Acute Myeloid Leukemia (AML) and Malignant Melanoma (MEL) Cell Lines Exposed to the MEK Inhibitor PD0325901 Reveals Common Effectors of the MEK/ERK Kinase Module.

Michele Milella, MD, Sabina Chiaretti, MD, PhD, Maria R. Ricciardi, PhD, Simona Tavolaro, BSc, Ludovica Ciuffreda, PhD, Barbara Benassi, PhD, Alfonso Bellacosa, MD, PhD, Gianfranco Peluso, PhD, Paola Bergamo, MS, James A. McCubrey, PhD, Francesco Cognetti, MD, Gabriella Zupi, PhD, Robert Foà, MD, Agostino Tafuri, MD

Blood (2007) 110 (11): 3470.

https://doi.org/10.1182/blood.V110.11.3470.3470

Published: 2007

Journal Articles

The BCL-2 Antagonist ABT-737 Is Highly Effective on Primary Acute Lymphoblastic Leukemia Cells.

Maria Rosaria Ricciardi, PhD, Chiara Gregorj, PhD, Fabiana De Cave, MS, Paola Bergamo, Samantha Decandia, MS, Sara Santinelli, Antonella Vitale, MD, Maria Teresa Petrucci, MD, Michele Milella, MD, Robert Foa, MD, Agostino Tafuri, MD

Blood (2007) 110 (11): 155.

https://doi.org/10.1182/blood.V110.11.155.155

Published: 2007

Journal Articles

Functional Effects of the Bcl-2/Bcl-xL Inhibitor ABT-737 on Primary Cells from Smoldering Multiple Myeloma.

Maria Rosaria Ricciardi, PhD, Elisabetta Calabrese, MD, Fabiana De Cave, PhD, Sara Santinelli, Paola Bergamo, Samantha Decandia, PhD, Chiara Gregorj, PhD, Vincenzo Federico, MD, Michele Milella, MD, Robert Foa, MD, Agostino Tafuri, MD, Maria Teresa Petrucci, MD

Blood (2007) 110 (11): 4782.

https://doi.org/10.1182/blood.V110.11.4782.4782

Published: 2007

Journal Articles

Dominant Role of Raf/MEK/ERK Signaling in Hematopoietic Cell Cycle Progression, Prevention of Apoptosis and Drug Resistance.

James A. McCubrey, PhD, Steven L. Abrams, BS, Linda S. Steelman, MS, Ellis W.T. Wong, BS, William H. Chappell, MS, Jorg Basecke, MD, Franca Stivala, MD, Massimo Libra, MD, PhD, Michele Milella, MD, Agostino Tafuri, MD, Jacob Troppmair, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Camilla Evangelisti, BS, Alberto M. Martelli, MD, PhD

Blood (2006) 108 (11): 1116.

https://doi.org/10.1182/blood.V108.11.1116.1116

Published: 2006

Journal Articles

Molecular and Functional Effects of the Novel MEK Inhibitor PD0325901 in Preclinical Models of Human Leukemias.

Michele Milella, MD, Maria Rosaria Ricciardi, PhD, Chiara Gregorj, PhD, Fabiana De Cave, PhD, Steven L. Abrams, BS, Linda S. Steelman, MS, Sabina Chiaretti, PhD, Marina Konopleva, MD, PhD, Maria Teresa Petrucci, MD, Francesco Cognetti, MD, Robert Foa, MD, PhD, Michael Andreeff, MD, PhD, James McCubrey, PhD, Agostino Tafuri, MD

Blood (2006) 108 (11): 254.

https://doi.org/10.1182/blood.V108.11.254.254

Published: 2006

Journal Articles

Effective Targeting of MEK/ERK Signalling at Nanomolar Concentrations by the Novel Small Molecule Inhibitor PD0325901 in Hematopoietic and Solid Tumors.

Maria R. Ricciardi, PhD, Maria C. Scerpa, PhD, Ludovica Ciuffreda, PhD, Sabina Chiaretti, MD, PhD, Simona Tavolaro, PhD, Jacopo Gervasoni, Fabiana De Cave, PhD, Chiara Gregorj, PhD, Maria T. Petrucci, MD, Francesco Cognetti, MD, Michael Andreeff, MD, PhD, Gabriella Zupi, MD, Robin Foà, MD, Agostino Tafuri, MD, Michele Milella, MD

Blood (2005) 106 (11): 3370.

https://doi.org/10.1182/blood.V106.11.3370.3370

Published: 2005

Journal Articles

Role of Extracellular Signal-Regulated Kinase-1/2 (ERK) on Complete Remission Achievement of Primary Adult Acute Lymphoblastic Leukemia Patients Enrolled in the GIMEMA Protocol LAL 2000: In Vitro Activity of the MEK Inhibithor PD98059.

Blood (2005) 106 (11): 853.

https://doi.org/10.1182/blood.V106.11.853.853

Published: 2005

NARROW

Pre Clinical mTOR-Inhibition of Acute Lymphoblastic Leukemia Cells Synergizes with Pro-Apoptotic Target Therapy Through Mcl-1 Down-Regulation,

Bcl-2 and mTOR as Effective Targets for Molecular Therapy of Acute Lymphoblastic Leukemia

Novel Histone Deacetilase (HDAC) Inhibitors: In Vitro Effects on Leukemic Cells

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

Comparative Gene Profiling of Acute Myeloid Leukemia (AML) and Malignant Melanoma (MEL) Cell Lines Exposed to the MEK Inhibitor PD0325901 Reveals Common Effectors of the MEK/ERK Kinase Module.

The BCL-2 Antagonist ABT-737 Is Highly Effective on Primary Acute Lymphoblastic Leukemia Cells.

Functional Effects of the Bcl-2/Bcl-xL Inhibitor ABT-737 on Primary Cells from Smoldering Multiple Myeloma.

Dominant Role of Raf/MEK/ERK Signaling in Hematopoietic Cell Cycle Progression, Prevention of Apoptosis and Drug Resistance.

Molecular and Functional Effects of the Novel MEK Inhibitor PD0325901 in Preclinical Models of Human Leukemias.

Effective Targeting of MEK/ERK Signalling at Nanomolar Concentrations by the Novel Small Molecule Inhibitor PD0325901 in Hematopoietic and Solid Tumors.

Role of Extracellular Signal-Regulated Kinase-1/2 (ERK) on Complete Remission Achievement of Primary Adult Acute Lymphoblastic Leukemia Patients Enrolled in the GIMEMA Protocol LAL 2000: In Vitro Activity of the MEK Inhibithor PD98059.

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American Society of Hematology

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American Society of Hematology

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