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Journal Articles

Microrna-138 Regulates Osteogenic Differentiation and Its Inhibition Presents a Novel Therapeutic Line to Prevent Bone Lytic Lesions in Multiple Myeloma

Shokichi Tsukamoto, MD PhD, Karma Salem, MD, Salomon Manier, MD, Michaela R. Reagan, PhD, Daisy Huynh, BS, MS, Adriana Perilla-Glen, MBA, Antonio Sacco, BS, Oksana Zavidij, PhD, Mahshid Rahmat, PhD, Satoshi Takagi, PhD, Yawara Kawano, MD PhD, Katsutoshi Kokubun, PhD, Charlotte Albæk Thrue, MSc, Andreas Petri, PhD MSc, David M. Dorfman, MD PhD, Aldo M. Roccaro, MD PhD, Marzia Capelletti, PhD MMSc, Sakari Kauppinen, PhD, Irene M. Ghobrial, MD

Blood (2016) 128 (22): 4483.

https://doi.org/10.1182/blood.V128.22.4483.4483

Published: 2016

Journal Articles

Anti-Sclerostin Treatment Prevents Multiple Myeloma Induced Bone Loss and Reduces Tumor Burden

Michaela R. Reagan, PhD, Michelle McDonald, PhD, Rachael Terry, PhD, Jessica Pettitt, Lawrence Le, Sindhu Mohanty, PhD, Michaela Kneissel, PhD, Ina Kramer, PhD, Daniel Brooks, Mary Bouxsein, PhD, Clifford J. Rosen, MD, Irene M. Ghobrial, MD, Peter Croucher, BSc, PhD

Blood (2015) 126 (23): 119.

https://doi.org/10.1182/blood.V126.23.119.119

Published: 2015

Journal Articles

Characterization of the Role of Regulatory T Cells (Tregs) in Inducing Progression of Multiple Myeloma

Yawara Kawano, MDPhD, Michele Moschetta, MD, Katsutoshi Kokubun, PhD, Pavlo Lukyanchykov, MD, Esilida Sula Karreci, MD, Salomon Manier, MD, Shokichi Tsukamoto, MD PhD, Satoshi Takagi, PhD, Jiantao Shi, Michaela R. Reagan, PhD, Daisy Huynh, BS, MS, Antonio Sacco, BS, David M. Dorfman, MD PhD, Marta Chesi, PhD, Peter Leif Bergsagel, MD PhD, Aldo M Roccaro, MD PhD, Jamil Azzi, MD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 502.

https://doi.org/10.1182/blood.V126.23.502.502

Published: 2015

Journal Articles

MYC Regulation Via the LIN28B/Let-7 Axis in Multiple Myeloma

Salomon Manier, MD, John Powers, PhD, Antonio Sacco, BS, Siobhan Glavey, MD, Daisy Huynh, BS, MS, Michaela R. Reagan, PhD, Karma Salem, MD, Michele Moschetta, MD, Yuji Mishima, PhD, Xavier Leleu, MD PhD, Aldo M Roccaro, MD PhD, George Q. Daley, MD PhD, Irene M. Ghobrial, MD

Blood (2015) 126 (23): 1755.

https://doi.org/10.1182/blood.V126.23.1755.1755

Published: 2015

Journal Articles

Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix

Siobhan Glavey, MD, Alexandra Naba, PhD, Salomon Manier, MD, Manuela Gambella, Alberto Rocci, MD, Antonio Sacco, BS, John M. Asara, PhD, Michele Moschetta, MD, Michaela R. Reagan, PhD, Yuji Mishima, PhD, Yawara Kawano, MD PhD, Aldo M Roccaro, MD PhD, Antonio Palumbo, MD, Richard O. Hynes, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 2051.

https://doi.org/10.1182/blood.V124.21.2051.2051

Published: 2014

Journal Articles

Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression in Multiple Myeloma (MM) and Represents a Novel Target for Therapy in MM

Yu Zhang, MD, Yong Zhang, PhD, Yuji Mishima, PhD, Michele Moschetta, MD, Wenjing Zhang, MD, Patricia Maiso, PhD, Antonio Sacco, BS, Yosra Aljawai, MS, Ilyas Sahin, MD, Michaela R. Reagan, PhD, Jennifer E. Ring, Winnie F. Tam, PhD, Qunli Xu, PhD, Jonathan A. Pachter, PhD, Aldo M Roccaro, MD PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 2101.

https://doi.org/10.1182/blood.V124.21.2101.2101

Published: 2014

Journal Articles

Prognostic Value of Circulating Exosomal microRNAs in 112 Patients with Multiple Myeloma

Salomon Manier, MD, Herve Avet-Loiseau, Federico Campigotto, MS, Siobhan Glavey, MD, Karma Salem, MD, Daisy Huynh, MPS, Erica N Boswell, BS, Antonio Sacco, BS, Yuji Mishima, PhD, Michele Moschetta, MD, Michaela R. Reagan, PhD, Yawara Kawano, MDPhD, Kenneth C. Anderson, MD, Aldo M Roccaro, MD PhD, Philippe Moreau, MD, Thierry Facon, MD, Xavier Leleu, MD PhD, Edie A. Weller, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 2056.

https://doi.org/10.1182/blood.V124.21.2056.2056

Published: 2014

Journal Articles

Early Trafficking of Bone Marrow Derived-Endothelial Progenitor Cells Promotes Multiple Myeloma Progression

Michele Moschetta, MD, Yuji Mishima, PhD, Yawara Kawano, MD PhD, Yosra Aljawai, MS, Bruno Paiva, PhD, Luis Palomera, MD, Arianna Calcinotto, Unitt L. Christine, BSc, Ilyas Sahin, MD, Antonio Sacco, BS, Siobhan Glavey, MD, Michaela R. Reagan, PhD, Salomon Manier, MD, Peter Leif Bergsagel, MD PhD, Marta Chesi, PhD, Matteo Bellone, MD, Aldo M Roccaro, MD PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 4719.

https://doi.org/10.1182/blood.V124.21.4719.4719

Published: 2014

Journal Articles

Clonal-Heterogeneity and Propensity for Bone Metastasis in Multiple Myeloma

Yuji Mishima, PhD, Michele Moschetta, MD, Jiantao Shi, PhD, Francois Mercier, MD, Salomon Manier, MD, Siobhan Glavey, MD, Michaela R. Reagan, PhD, Yawara Kawano, MD PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Aldo M Roccaro, MD PhD, Winston Hide, PhD, David T. Scadden, MD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 3370.

https://doi.org/10.1182/blood.V124.21.3370.3370

Published: 2014

Journal Articles

Bone Marrow Stroma Protects Myeloma Cells from Cytotoxic Damage Via Induction of the Oncoprotein MUC1

Michal Bar-Natan, MD, Katarina Luptakova, MD, Maxwell Douglas Coll, Dina Stroopinsky, PhD, Hasan Rajabi, PhD, Athalia Rachel Pyzer, MD, Kristen A Palmer, Michaela R. Reagan, PhD, Poorvi Somaiya, MSc, Salvia Jain, MD, Jon Arnason, MD, Irene M. Ghobrial, MD, Jacalyn Rosenblatt, MD, Kenneth C. Anderson, MD, Donald Kufe, MD, David Avigan, MD

Blood (2014) 124 (21): 3378.

https://doi.org/10.1182/blood.V124.21.3378.3378

Published: 2014

Journal Articles

CXCR4 Is a Regulator Of Disease Involvement Of Extramedullary Myeloma Confirmed By a Novel Mouse Model For Extramedullary Disease

Yuji Mishima, Ph. D., Michele Moschetta, MD, Michaela R Reagan, PhD, Yong Zhang, PhD, Ilyas Sahin, MD, Niraj Maulkhan, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 5320.

https://doi.org/10.1182/blood.V122.21.5320.5320

Published: 2013

Journal Articles

Nanoparticle Design For Bone-Specific Chemotherapy and Microenvironmental Targeting In Multiple Myeloma

Michaela R Reagan, PhD, Archana Swami, PhD, Pamela A Basto, Yuji Mishima, PhD, Jinhe Liu, Siobhan Glavey, MD, Grace B O'Callaghan, PhD, Michele Moschetta, MD, Kenichi Nagano, DDS, Ph.D, Roland Baron, DDS, PhD, Aldo M Roccaro, MD, PhD, Omid Farokhzad, MD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 881.

https://doi.org/10.1182/blood.V122.21.881.881

Published: 2013

Journal Articles

Mirna Expression Profiling and Proteomic Analysis Of Circulating Exosomes From Multiple Myeloma Patients

Salomon Manier, MD, Erica N Boswell, BS, Siobhan Glavey, MD, Antonio Sacco, BS, Patricia Maiso, PhD, Yuji Mishima, PhD, Yosra Aljaway, BS, Ranjit Banwait, MA, Wenjing Zhang, MD, Yu Zhang, MD, Ilyas Sahin, MD, Michele Moschetta, MD, Yong Zhang, PhD, Michaela R Reagan, PhD, John M. Asara, PhD, Xavier Leleu, MD, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 3086.

https://doi.org/10.1182/blood.V122.21.3086.3086

Published: 2013

Journal Articles

Microrna-Dependent Modulation Of Osteogenesis In a 3D In Vitro Bone Marrow Model System Of Multiple Myeloma

Michaela R Reagan, PhD, Yuji Mishima, PhD, Yong Zhang, PhD, Patricia Maiso, PhD, Salomon Manier, MD, Yu-Tzu Tai, PhD, Priya Dhir, Zhi Ning Lu, Masoumeh Memarzadeh, Antonio Sacco, BS, Yosra Aljawai, MS, Susanna Santos, PA-C, John Ready, MD, David L. Kaplan, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 3093.

https://doi.org/10.1182/blood.V122.21.3093.3093

Published: 2013

Journal Articles

Silencing The Sialyltransferase Gene ST3GAL6 Inhibits Adhesion and Migration Of Myeloma Cells In Vitro and Reduces The Homing and Proliferation Of Tumor Cells In Vivo

Siobhan Glavey, MD, Salomon Manier, MD, Antonio Sacco, BS, Michaela R Reagan, PhD, Yuji Mishima, PhD, Yong Zhang, PhD, Ilyas Sahin, MD, Yu Zhang, MD, Wenjing Zhang, MD, Laura S Murillo, PhD, Catherine Loughrey, MSc, Alessandro Natoni, PhD, Katarzyna Kazlowska, Lokesh Joshi, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD, Michael E O'Dwyer, MD, FRCPI, FRCPath

Blood (2013) 122 (21): 275.

https://doi.org/10.1182/blood.V122.21.275.275

Published: 2013

Journal Articles

Lin28B/Let-7 Axis Regulates Multiple Myeloma Proliferation By Enhancing c-Myc and Ras Survival Pathways

Salomon Manier, MD, John T Powers, PhD, Antonio Sacco, BS, Michaela R Reagan, PhD, Michele Moschetta, MD, Siobhan Glavey, MD, Patricia Maiso, PhD, Ilyas Sahin, MD, Yuji Mishima, PhD, Yosra Aljaway, BS, Xavier Leleu, MD, PhD, Aldo M Roccaro, MD, PhD, George Q. Daley, MD, PhD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 273.

https://doi.org/10.1182/blood.V122.21.273.273

Published: 2013

Journal Articles

CXCR4 Monoclonal Antibody, BMS-936564 (MDX-1338), Modulates Epithelial to Mesenchymal Transition (EMT) in Multiple Myeloma Cells

Aldo M Roccaro, MD, PhD, Antonio Sacco, BS, Michelle R. Kuhne, PhD, Abdel Kareem Azab, PhD, BSPharm, Patricia Maiso, PhD, Feda Azab, BPharm, Salomon Manier, MD, Yosra Aljaway, BS, Michaela R Reagan, PhD, Lewis Cohen, MD, MS, Pina M Cardarelli, Ph.D., Irene M. Ghobrial, MD

Blood (2012) 120 (21): 4009.

https://doi.org/10.1182/blood.V120.21.4009.4009

Published: 2012

Journal Articles

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Chirag Acharya, MD, Mike Y Zhong, B.S., Yolanda Calle, PhD, Stephen Schey, MD, Michelle Chen, Daniel Tannenbaum, B.S., Michaela R Reagan, PhD, Irene M. Ghobrial, MD, Yosef Landesman, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD

Blood (2012) 120 (21): 1835.

https://doi.org/10.1182/blood.V120.21.1835.1835

Published: 2012

Journal Articles

Multiple Myeloma-Derived Bone-Marrow Mesenchymal Stem Cells: Microrna-, Gene Expression-Profiling and Functional Characterization

Michaela R Reagan, PhD, Aldo M Roccaro, MD, PhD, AbdelKareem Azab, PhD, Yong Zhang, PhD, Grace B O'Callaghan, PhD, Patricia Maiso, PhD, Salomon Manier, MD, David L. Kaplan, PhD, Irene M. Ghobrial, MD

Blood (2012) 120 (21): 1837.

https://doi.org/10.1182/blood.V120.21.1837.1837

Published: 2012

NARROW

Microrna-138 Regulates Osteogenic Differentiation and Its Inhibition Presents a Novel Therapeutic Line to Prevent Bone Lytic Lesions in Multiple Myeloma

Anti-Sclerostin Treatment Prevents Multiple Myeloma Induced Bone Loss and Reduces Tumor Burden

Characterization of the Role of Regulatory T Cells (Tregs) in Inducing Progression of Multiple Myeloma

MYC Regulation Via the LIN28B/Let-7 Axis in Multiple Myeloma

Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix

Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression in Multiple Myeloma (MM) and Represents a Novel Target for Therapy in MM

Prognostic Value of Circulating Exosomal microRNAs in 112 Patients with Multiple Myeloma

Early Trafficking of Bone Marrow Derived-Endothelial Progenitor Cells Promotes Multiple Myeloma Progression

Clonal-Heterogeneity and Propensity for Bone Metastasis in Multiple Myeloma

Bone Marrow Stroma Protects Myeloma Cells from Cytotoxic Damage Via Induction of the Oncoprotein MUC1

CXCR4 Is a Regulator Of Disease Involvement Of Extramedullary Myeloma Confirmed By a Novel Mouse Model For Extramedullary Disease

Nanoparticle Design For Bone-Specific Chemotherapy and Microenvironmental Targeting In Multiple Myeloma

Mirna Expression Profiling and Proteomic Analysis Of Circulating Exosomes From Multiple Myeloma Patients

Microrna-Dependent Modulation Of Osteogenesis In a 3D In Vitro Bone Marrow Model System Of Multiple Myeloma

Silencing The Sialyltransferase Gene ST3GAL6 Inhibits Adhesion and Migration Of Myeloma Cells In Vitro and Reduces The Homing and Proliferation Of Tumor Cells In Vivo

Lin28B/Let-7 Axis Regulates Multiple Myeloma Proliferation By Enhancing c-Myc and Ras Survival Pathways

CXCR4 Monoclonal Antibody, BMS-936564 (MDX-1338), Modulates Epithelial to Mesenchymal Transition (EMT) in Multiple Myeloma Cells

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Multiple Myeloma-Derived Bone-Marrow Mesenchymal Stem Cells: Microrna-, Gene Expression-Profiling and Functional Characterization

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American Society of Hematology

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American Society of Hematology

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