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Matthew D Blunt, PhD
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Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

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Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4290.
https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290
Published: 2017
Journal Articles

Regulation and Impact of BCR Induced Autophagy in Chronic Lymphocytic Leukemia

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Lindsay D Smith, PhD, Laura I Karydis, PhD, Margaret Ashton-Key, MD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Graham Packham, PhD, Mark Cragg, PhD, David A Tumbarello, PhD, Matthew D Blunt, PhD, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1717.
https://doi.org/10.1182/blood.V130.Suppl_1.1717.1717
Published: 2017
Journal Articles

Regulation of B-Cell Receptor Signalling By the Tumour Microenvironment in Chronic Lymphocytic Leukemia (CLL) and Its Impact on Adhesion and miRNA Expression

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Matthew D Blunt, PhD, Rachel Dobson, BSc(Hons), Lindsay D Smith, PhD, Jonathan C. Strefford, Pamela B. Conley, PhD, Anjali Pandey, PhD, Andrew J Davies, FRCP PhD, Peter M Johnson, MA, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Greg P Coffey, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2016) 128 (22): 351.
https://doi.org/10.1182/blood.V128.22.351.351
Published: 2016
Journal Articles

Biological Significance of B Cell Receptor Mediated Regulation of Autophagy in Chronic Lymphocytic Leukemia

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Lindsay Smith, PhD, Elizabeth Hogg, BSc(Hons), Angus Haynes, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Freda K Stevenson, DPhil, Graham Packham, PhD, Mark S Cragg, PhD, David Tumbarello, Matthew D Blunt, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 4130.
https://doi.org/10.1182/blood.V126.23.4130.4130
Published: 2015
Journal Articles

The Syk\Jak Inhibitor Cerdulatinib (PRT062070) Shows Promising Preclinical Activity in Chronic Lymphocytic Leukemia By Antagonising B Cell Receptor and Microenvironmental Signalling

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Matthew D Blunt, PhD, Jack Parnell, BSc(hons), Marta Larrayoz, PhD, Lindsay Smith, PhD, Rachel Dobson, BSc(Hons), Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Davies, MRCP, Peter W Johnson, MD, Graham Packham, PhD, Greg P. Coffey, PhD, Mark S Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 1716.
https://doi.org/10.1182/blood.V126.23.1716.1716
Published: 2015
Journal Articles

The Dual PI3K/mTOR Inhibitor PF-04691502 Induces Substantial Apoptosis in Chronic Lymphocytic Leukemia Cells in Vitro and Prolongs Survival in the Eµ-TCL1 Mouse Model

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Matthew D Blunt, PhD, Matthew J Carter, PhD, Marta Larrayoz, PhD, Maria Montserrat Aguilar, PhD, Sarah Murphy, Mark Reynolds, Thomas Tipton, Kerry Cox, Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, Graham Packham, PhD, Mark Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 832.
https://doi.org/10.1182/blood.V124.21.832.832
Published: 2014
Journal Articles

IL-4 Exerts Opposing Effects on Surface-IgM and CXCR4 Mediated Signalling in Chronic Lymphocytic Leukaemia

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Maria Montserrat Aguilar, PhD, Matthew D Blunt, PhD, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Mark Cragg, PhD, Freda K Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 3299.
https://doi.org/10.1182/blood.V124.21.3299.3299
Published: 2014
Journal Articles

Modulation of B Cell Receptor Signalling By IL-4 In Chronic Lymphocytic Leukaemia

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Maria Aguilar-Hernandez, PhD, Matthew D Blunt, PhD, Jonathan C Strefford, Andrew Duncombe, MD, Francesco Forconi, MD, PhD, Freda K. Stevenson, DPhil, Graham K Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2013) 122 (21): 4125.
https://doi.org/10.1182/blood.V122.21.4125.4125
Published: 2013