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Journal Articles

The CXCL12/CXCR4 and VEGF165/Nrp1 Pathways Have Differential Effects on Pathological Neo-Angiogenesis and Vascular Remodeling in Hemophilic Arthropathy

Tine L. Wyseure, PhD, Esther J. Cooke, PhD, Annette von Drygalski, MD, Laurent O. Mosnier, PhD

Blood (2017) 130 (Supplement 1): 180.

https://doi.org/10.1182/blood.V130.Suppl_1.180.180

Published: 2017

Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

Journal Articles

Defective TAFI Activation in Hemophilia Worsens Joint Bleeding

Tine L Wyseure, PhD, Esther J Cooke, PhD, Paul J Declerck, PhD, Joost CM Meijers, PhD, Annette von Drygalski, MD PharmD, Laurent O Mosnier, PhD

Blood (2016) 128 (22): 3752.

https://doi.org/10.1182/blood.V128.22.3752.3752

Published: 2016

Journal Articles

Effects of Joint Blood Volume and Hemostasis Correction on Vascular Changes in the Joint after Induced Hemarthrosis in Hypocoagulable Mice

Esther J Cooke, PhD, Tine L Wyseure, PhD, Jenny Y Zhou, MD, Laurent O Mosnier, PhD, Annette von Drygalski, MD PharmD

Blood (2016) 128 (22): 2578.

https://doi.org/10.1182/blood.V128.22.2578.2578

Published: 2016

Journal Articles

Defective TAFI Activation in Hemophilia Exacerbates Vascular Remodeling in Hemophilic Arthropathy

Tine L Wyseure, PhD, Esther J Cooke, PhD, Paul J Declerck, PhD, Joost CM Meijers, PhD, Annette von Drygalski, MD PharmD, Laurent O Mosnier, PhD

Blood (2016) 128 (22): 82.

https://doi.org/10.1182/blood.V128.22.82.82

Published: 2016

Journal Articles

Vascular Remodeling Underlies Re-Bleeding in Hemophilic Arthropathy

Annette Von Drygalski, MD PharmD, Vikas Bhat, PhD, Merissa Olmer, MS, Shweta Joshi, PhD, Donald Durden, MD, Thomas J Cramer, PhD, Richard FW Barnes, PhD MPH, Scott T Ball, MD, Tudor H Hughes, MD, Mauricio Silva, MD, James V Luck, MD, Randy Moore, DC,RDMS, Laurent O. Mosnier, PhD

Blood (2015) 126 (23): 1038.

https://doi.org/10.1182/blood.V126.23.1038.1038

Published: 2015

Journal Articles

Non-Canonical PAR3 Activation Induces Tie2-Dependent Endothelial Barrier Protective Effects

Fabian Stavenuiter, PhD, Laurent O. Mosnier, PhD

Blood (2014) 124 (21): 2802.

https://doi.org/10.1182/blood.V124.21.2802.2802

Published: 2014

Journal Articles

Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)

Ranjeet Kumar Sinha, PhD, Laurent Burnier, PhD, Naveen Gupta, MD, Xiao Xu, MS, Sergey Kupriyanov, PhD, Greg Martin, MS, Laurent O. Mosnier, PhD, John H. Griffin, PhD

Blood (2014) 124 (21): 99.

https://doi.org/10.1182/blood.V124.21.99.99

Published: 2014

Journal Articles

Disruption of EPCR-Dependent Functions By Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Can be Rescued By a Soluble EPCR Variant

Jens E.V. Petersen, Eveline A. Bouwens, PhD, Ibai Tamayo, PhD, Louis Turner, PhD, Christian Wang, PhD, Monique Stins, PhD, Thor G. Theander, PhD, José Hermida, PhD, Thomas Lavstsen, PhD, Laurent O. Mosnier, PhD

Blood (2014) 124 (21): 577.

https://doi.org/10.1182/blood.V124.21.577.577

Published: 2014

Journal Articles

Synergistic Effect in Bleed Reduction By super fva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

Vikas Bhat, PhD, Annette von Drygalski, MD PharmD, Andrew J. Gale, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2014) 124 (21): 692.

https://doi.org/10.1182/blood.V124.21.692.692

Published: 2014

Journal Articles

Prevention of Premature Fibrinolysis and Reduction of Bleeding in Vivo in Hemophilia with Inhibitors By a Stabilized TAFI Variant

Maarten L.V. Hendrickx, PhD, Vikas Bhat, PhD, Ann Gills, PhD, Paul J. Declerck, PhD, Annette von Drygalski, MD PharmD, Laurent O. Mosnier, PhD

Blood (2014) 124 (21): 694.

https://doi.org/10.1182/blood.V124.21.694.694

Published: 2014

Journal Articles

Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered super factor Va

Vikas Bhat, PhD, Andrew J. Gale, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD, Annette von Drygalski, MD PharmD

Blood (2014) 124 (21): 695.

https://doi.org/10.1182/blood.V124.21.695.695

Published: 2014

Journal Articles

An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C

Annette Von Drygalski, MD, PharmD, Andrew J. Gale, PhD, Laurent Burnier, PhD, Thomas J. Cramer, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2013) 122 (21): 203.

https://doi.org/10.1182/blood.V122.21.203.203

Published: 2013

Journal Articles

Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice

Annette Von Drygalski, MD, PharmD, Thomas J. Cramer, PhD, John H. Griffin, PhD, Andrew J. Gale, PhD, Laurent O. Mosnier, PhD

Blood (2012) 120 (21): 17.

https://doi.org/10.1182/blood.V120.21.17.17

Published: 2012

Journal Articles

Activated Protein C Cytoprotective Signaling in Endothelial Cells Involves apoER2 and Disabled-1

Ranjeet Kumar Sinha, PhD, Xia Yang, PhD, Laurent O. Mosnier, PhD, John H. Griffin, PhD

Blood (2012) 120 (21): 1102.

https://doi.org/10.1182/blood.V120.21.1102.1102

Published: 2012

Journal Articles

Protection Against Vascular Leakage in Vivo by a Peptide Mimetic of the Novel Tethered Ligand Generated by Non-Canonical Cleavage of Protease Activated Receptor 1 by Activated Protein C

Laurent Burnier, PhD, Ranjeet Kumar Sinha, PhD, Eveline A. Bouwens, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2012) 120 (21): 497.

https://doi.org/10.1182/blood.V120.21.497.497

Published: 2012

Journal Articles

Activated Protein C Cellular Pathways Regulating Thrombosis

John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2011) 118 (21): SCI-44.

https://doi.org/10.1182/blood.V118.21.SCI-44.SCI-44

Published: 2011

Journal Articles

Non-Canonical Cleavage of Protease Activated Receptor 1 (PAR1) by Activated Protein C Provides Novel Insights Into the Repertoire of Cytoprotective and Proinflammatory PAR1 Signaling

Laurent O. Mosnier, PhD, John H. Griffin, PhD

Blood (2011) 118 (21): 534.

https://doi.org/10.1182/blood.V118.21.534.534

Published: 2011

Journal Articles

Novel Infrared Fluorescence Methodology Defines An Essential Role for Endothelial Protein C Receptor (EPCR) for Protection Against Vascular Leakage In Inflammation

Annette Von Drygalski, MD, PharmD, Christian Furlan-Freguia, PhD, Laurent O. Mosnier, PhD, Wolfram Ruf, MD, John H. Griffin, PhD

Blood (2010) 116 (21): 653.

https://doi.org/10.1182/blood.V116.21.653.653

Published: 2010

Journal Articles

Modulation of Substrate Specificity of the Thrombin-Thrombomodulin Complex for Protein C Versus TAFI Activation by Platelet Factor 4 and Non-Anticoagulant Heparin-Derivatives.

Laurent O. Mosnier, PhD

Blood (2009) 114 (22): 3181.

https://doi.org/10.1182/blood.V114.22.3181.3181

Published: 2009

NARROW

The CXCL12/CXCR4 and VEGF165/Nrp1 Pathways Have Differential Effects on Pathological Neo-Angiogenesis and Vascular Remodeling in Hemophilic Arthropathy

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Defective TAFI Activation in Hemophilia Worsens Joint Bleeding

Effects of Joint Blood Volume and Hemostasis Correction on Vascular Changes in the Joint after Induced Hemarthrosis in Hypocoagulable Mice

Defective TAFI Activation in Hemophilia Exacerbates Vascular Remodeling in Hemophilic Arthropathy

Vascular Remodeling Underlies Re-Bleeding in Hemophilic Arthropathy

Non-Canonical PAR3 Activation Induces Tie2-Dependent Endothelial Barrier Protective Effects

Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)

Disruption of EPCR-Dependent Functions By Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Can be Rescued By a Soluble EPCR Variant

Synergistic Effect in Bleed Reduction By super fva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

Prevention of Premature Fibrinolysis and Reduction of Bleeding in Vivo in Hemophilia with Inhibitors By a Stabilized TAFI Variant

Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered super factor Va

An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C

Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice

Activated Protein C Cytoprotective Signaling in Endothelial Cells Involves apoER2 and Disabled-1

Protection Against Vascular Leakage in Vivo by a Peptide Mimetic of the Novel Tethered Ligand Generated by Non-Canonical Cleavage of Protease Activated Receptor 1 by Activated Protein C

Activated Protein C Cellular Pathways Regulating Thrombosis

Non-Canonical Cleavage of Protease Activated Receptor 1 (PAR1) by Activated Protein C Provides Novel Insights Into the Repertoire of Cytoprotective and Proinflammatory PAR1 Signaling

Novel Infrared Fluorescence Methodology Defines An Essential Role for Endothelial Protein C Receptor (EPCR) for Protection Against Vascular Leakage In Inflammation

Modulation of Substrate Specificity of the Thrombin-Thrombomodulin Complex for Protein C Versus TAFI Activation by Platelet Factor 4 and Non-Anticoagulant Heparin-Derivatives.

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American Society of Hematology

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American Society of Hematology

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