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Klaus-Michael Debatin, MD, PhD
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Journal Articles

Lysosomal Cell Death and Apoptosis Crosstalk - Synergistic Role in Bcl-2 Inhibitor (ABT-263) Mediated Cell Death in B-Cell Precursor Acute Lymphoblastic Leukemia

Stefanie Enzenmüller, PhD, Qian Sun, PhD, Klaus-Michael Debatin, MD PhD, Lüder-Hinrich Meyer, MD
Journal: Blood
Blood (2016) 128 (22): 1584.
https://doi.org/10.1182/blood.V128.22.1584.1584
Published: 2016
Journal Articles

Anti-Leukemia Activity of the Selective BCL-2 Inhibitor ABT-199 in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia Is Characterized By MCL-1/BCL-2 Expression Serving As Biomarker for Treatment Response

Felix Seyfried, MD, Salih Demir, MSc, Rebecca Hörl, Stefan Köhrer, Annika Scheffold, Stephan Stilgenbauer, Klaus-Michael Debatin, MD PhD, Lüder Hinrich Meyer, MD
Journal: Blood
Blood (2016) 128 (22): 1081.
https://doi.org/10.1182/blood.V128.22.1081.1081
Published: 2016
Journal Articles

FOXO1 Is Involved in the Regulation of B-Cell Precursor Acute Lymphoblastic Leukemia Survival and Serves As a Novel Target for Directed Therapy

Salih Demir, MSc, Fan Wang, Franziska Gehringer, Clarissa Weitzer, Klaus-Michael Debatin, MD PhD, Thomas Wirth, Prof. Dr., Lüder Hinrich Meyer, MD, Alexey Ushmorov, Dr.
Journal: Blood
Blood (2016) 128 (22): 4020.
https://doi.org/10.1182/blood.V128.22.4020.4020
Published: 2016
Journal Articles

Leukemia Initiating Cells In Acute Lymphoblastic Leukemia Are Characterized By Low Metabolic Activity and Enriched In Early Cell Cycle

Luca Trentin, PhD, Manon Queudeville, MD, Sarah M Eckhoff, MD, Manuel Herrmann, Simone Miller, Sandra Lutz, Nabiul Hasan, Klaus-Michael Debatin, MD PhD, Lueder H Meyer, MD PhD
Journal: Blood
Blood (2013) 122 (21): 4197.
https://doi.org/10.1182/blood.V122.21.4197.4197
Published: 2013
Journal Articles

Overcoming Apoptosis Resistance In High Risk Acute Lymphoblastic Leukemia By Smac Mimetics In a Preclinical ALL Xenograft Model In Vivo

Melanie Schirmer, MD, Manon Queudeville, MD, Luca Trentin, PhD, Sarah M Eckhoff, MD, Lueder H Meyer, MD, PhD, Klaus-Michael Debatin, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1433.
https://doi.org/10.1182/blood.V122.21.1433.1433
Published: 2013
Journal Articles

CRLF2 Rearrangement Is Not Associated with Activated mTOR Pathway in NOD/SCID/huALL Xenograft Mouse Model.

Md. Nabiul Hasan, MSc, Silvia Bresolin, PhD, Ilaria Bronzini, PhD, Chiara Palmi, PhD, Manon Queudeville, MD, Sarah Mirjam Eckhoff, MD, Luca Trentin, PhD, Giovanni Cazzaniga, PhD, Geertury te Kronnie, PhD, Klaus-Michael Debatin, MD, PhD, Lüder-Hinrich Meyer, MD
Journal: Blood
Blood (2012) 120 (21): 2518.
https://doi.org/10.1182/blood.V120.21.2518.2518
Published: 2012
Journal Articles

Rapid BCP-ALL Engraftment in NOD/SCID Mice Is Characterized by a High Leukemia Initiating Cell (LIC) Frequency.

Luca Trentin, PhD, Manon Queudeville, MD, Sarah M. Eckhoff, MD, Felix Seyfried, Manuel Herrmann, Simone Miller, Nabiul Hasan, Klaus-Michael Debatin, MD, PhD, Lueder H. Meyer, MD
Journal: Blood
Blood (2012) 120 (21): 2985.
https://doi.org/10.1182/blood.V120.21.2985.2985
Published: 2012
Journal Articles

APG101 - a Novel Inhibitor of CD95/CD95L Signaling Prevents Graft-Versus-Host Disease without Disabling T Cell Effector Function and Anti-Tumor Activity,

Gudrun Strauss, PhD, Natalie Hartmann, PhD, Michael Kluge, PhD, Harald Fricke, MD, PhD, Klaus-Michael Debatin, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4019.
https://doi.org/10.1182/blood.V118.21.4019.4019
Published: 2011
Journal Articles

Hyperactivated mTOR Signaling Is a Characteristic Feature of High Risk Acute Lymphoblastic Leukemia and Can Be Effectively Targeted in a Preclinical NOD/SCID/huALL Xenograft Mouse Model

Md. Nabiul Hasan, MSc, Manon Queudeville, MD, Sarah Mirjam Eckhoff, MD, Manuel Herrmann, Simone Miller, Luca Trentin, PhD, Klaus-Michael Debatin, MD PhD, Lueder Hinrich Meyer, MD
Journal: Blood
Blood (2011) 118 (21): 2572.
https://doi.org/10.1182/blood.V118.21.2572.2572
Published: 2011
Journal Articles

High Risk Acute Lymphoblastic Leukemia with Rapid NOD/SCID Engraftment Is Characterized by High Protein Expression of CYCLIN B, Beta-CATENIN, ANNEXIN I and Decreased PKC Alpha Activation

Felix Seyfried, Benedetta Accordi, PhD, Manon Queudeville, MD, Sarah Mirjam Eckhoff, MD, Gloria Milani, Luisa Galla, Marco Giordan, PhD, Johann M Kraus, Giuseppe Basso, MD PhD, Hans Armin Kestler, PhD, Geertruy te Kronnie, PhD, Klaus-Michael Debatin, MD, PhD, Lueder Hinrich Meyer, MD
Journal: Blood
Blood (2011) 118 (21): 1457.
https://doi.org/10.1182/blood.V118.21.1457.1457
Published: 2011