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Klaus Podar, M.D., Ph.D
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Journal Articles

Targeting MEK1/2 Signaling Cascade by AS703026, a Novel Selective MEK1/2 Inhibitor, Induces Pleiotropic Anti-Myeloma Activity in Vitro and In Vivo.

Yu-Tzu Tai, Ph.D., Kihyun Kim, M.D., Xian-Feng Li, M.S., Mariateresa Fulciniti, Ph.D., Weihua Song, M.D., Sabikun Nahar, B.S., Peter Burger, B.S., Mathew J. Rumizen, Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D, Teru Hideshima, M.D., Ph.D., Robert L Schlossman, M.D., Ph.D., Nikhil C. Munshi, Paul Richardson, M.D., Ph.D., Ann Clark, Ph.D., Janet Ogden, Ph.D., Goutopoulos Andreas, Ph.D., Luca Rastelli, Ph.D., Kenneth C. Anderson, MD
Journal: Blood
Blood (2009) 114 (22): 3848.
https://doi.org/10.1182/blood.V114.22.3848.3848
Published: 2009
Journal Articles

Activation of B-Cell Maturation Antigen (BCMA) on Human Multiple Myeloma Cells by a Proliferation-Inducing Ligand (APRIL) Promotes Myeloma Cell Function in the Bone Marrow Microenvironment.

Merav Leiba, M.D., Jiangchun Xu, M.D., Ph.D., Weihua Song, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Jennifer Kordich, M.S., Linda Cassiano, B.A., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Teru Hideshima, M.D., Ph.D., Nikhil C. Munshi, M.D., Paul Richardson, M.D., Kenneth C. Anderson, M.D., Yu-Tzu Tai, PhD
Journal: Blood
Blood (2007) 110 (11): 1503.
https://doi.org/10.1182/blood.V110.11.1503.1503
Published: 2007
Journal Articles

CS1, a New Surface Target on Multiple Myeloma (MM) Cells, Protects Myeloma Cells from Apoptosis Via Regulation of ERK1/2, AKT and STAT3 Signaling Cascades.

Yu-Tzu Tai, PhD, Giovanni Tonon, M.D., Ph.D., Merav Leiba, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Weihua Song, M.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Nihkil Munshi, M.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2007) 110 (11): 109.
https://doi.org/10.1182/blood.V110.11.109.109
Published: 2007
Journal Articles

The Jak2 V617F Oncogene Associated with Polycythemia Vera Requires a Functional FERM Domain for Transformation and for Expression of the Myc and Pim Proto-Oncogenes.

Martin Sattler, PhD, Brian J. Crowley, Jeffrey R. Gonneville, Jeremy Ho, Heidi H. Hudon, Klaus Podar, M.D., Ph.D., Yohan Royer, Stefan N. Constantinescu, M.D., Ph.D., James D. Griffin, M.D.
Journal: Blood
Blood (2006) 108 (11): 3611.
https://doi.org/10.1182/blood.V108.11.3611.3611
Published: 2006
Journal Articles

The BAFF Inhibitor AMG523 Blocks Adhesion and Survival of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment: Clinical Implication.

Yu-Tzu Tai, PhD, Jiangchun Xu, M.D., Xian-Feng Li, M.S., Iris Breitkreutz, M.D., Klaus Podar, M.D. Ph.D., Teru Hideshima, M.D. Ph.D., Robert Schlossman, M.D., Paul Richardson, M.D., Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 3452.
https://doi.org/10.1182/blood.V108.11.3452.3452
Published: 2006
Journal Articles

Inhibition of ERK1/2 Activity by the MEK1/2 Inhibitor AZD6244 (ARRY-142886) Induces Human Multiple Myeloma Cell Apoptosis in the Bone Marrow Microenvironment: A New Therapeutic Strategy for MM.

Yu-Tzu Tai, PhD, Xian-Feng Li, M.S., Iris Breitkreutz, M.D., Weihua Song, M.D., Peter Burger, B.S., Matthew Rumizen, Teru Hideshima, M.D. Ph.D., Klaus Podar, M.D. Ph.D., Irene Ghobrial, M.D., Robert Schlossman, M.D., Paul Richardson, M.D., Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 3460.
https://doi.org/10.1182/blood.V108.11.3460.3460
Published: 2006
Journal Articles

BIRB796 Inhibits p38 MAPK/Hsp27 Pathway and Enhances Cytotoxicity Triggered by Bortezomib, Hsp90 Inhibitor, and Dexamethasone in Multiple Myeloma.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Janice Jin, M.D., Enrique M. Ocio, D., Ph.D., Tanyel Kiziltepe, Ph.D, Yutaka Okawa, M.D., Ph.D., Sonia Vallet, M.D., Ph.D., Shweta Chhetri, Kenji Ishitsuka, M.D., Ph.D., Yu-Tzu Tai, Ph.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Chris Pargellis, Ph.D., Neil Moss, Ph.D., Noopur Raje, M.D., Ph.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 3440.
https://doi.org/10.1182/blood.V108.11.3440.3440
Published: 2006
Journal Articles

p38MAPK Inhibitor LSN2322600 Modulates the Bone Marrow Microenvironment and Inhibits Osteoclastogenesis in Multiple Myeloma.

Kenji Ishitsuka, MD, PhD, Teru Hideshima, M.D., Ph.D., Paola Neri, M.D., Ph.D., Sonia Vallet, M.D., Ph.D., Norihiko Shiraishi, Ph.D., Noopur Raje, M.D., Zhenxin Shen, M.D., Ph.D., Tanyel Kiziltepe, Ph.D., Enrique M. Ocio, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Nikhil Munshi, M.D., Robert M. Campbell, Ph.D., Alfonso De Dios, Ph.D., Chuan Shih, Ph.D., James J. Starling, Ph.D., Kazuo Tamura, M.D., Ph.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 5042.
https://doi.org/10.1182/blood.V108.11.5042.5042
Published: 2006
Journal Articles

Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway.

Hiroshi Yasui, MD, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, M.D., Ph.D., Enrique M. Ocio, M.D., Ph.D., Tanyel Kiziltepe, Ph.D., Sonia Vallet, M.D., Ph.D., Yutaka Okawa, M.D., Ph.D., Shweta Chhetri, Kumar Sukhdeo, Kenji Ishitsuka, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Noopur Raje, M.D., Ph.D., Dharminder Chauhan, Ph.D., Daniel R. Cattasco, M.D., Ph.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2006) 108 (11): 5005.
https://doi.org/10.1182/blood.V108.11.5005.5005
Published: 2006
Journal Articles

A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment.

Kenji Ishitsuka, M.D., Ph.D, Teru Hideshima, M.D., Ph.D, Makoto Hamasaki, M.D., Ph.D, Raje Noopur, M.D., Ph.D, Kumar Shaji, M.D., Ph.D, Hiroshi Yasui, M.D., Ph.D, Aldo M. Roccaro, M.D., Dharminder Chauhan, Ph.D, Klaus Podar, M.D., Ph.D, Yu-Zu Tai, Ph.D, Jugnu Jain, Ph.D, Kenneth C. Anderson, M.D., Ph.D
Journal: Blood
Blood (2004) 104 (11): 2468.
https://doi.org/10.1182/blood.V104.11.2468.2468
Published: 2004
Journal Articles

Pim Kinases Mediate Viability Signals Downstream of the Tyrosine Kinase Oncogenes BCR-ABL and FLT3-ITD.

Martin Sattler, Ph.D., Emily Babendreier, Stephanie C. Chu, Jessica L. Gramlich, Klaus Podar, M.D., Ph.D., James D. Griffin, M.D.
Journal: Blood
Blood (2004) 104 (11): 557.
https://doi.org/10.1182/blood.V104.11.557.557
Published: 2004
Journal Articles

Enhanced Cytotoxicity of Monoclonal Antibody SGN-40 and Immunomodulatory Drug IMiD3 Against Human Multiple Myeloma.

Yu-Tzu Tai, Ph.D., Laurence Catley, M.D., Xian-Feng Li, M.S., Makoto Hamasaki, M.D., Ph.D., Klaus Podar, M.D., Ph.D., Teru Hideshima, M.D., Ph.D., Dharminder Chauhan, Ph.D., Robert Schlossman, M.D., Paul Richardson, M.D., Steven P. Streon, M.D., Ph.D., Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2004) 104 (11): 1498.
https://doi.org/10.1182/blood.V104.11.1498.1498
Published: 2004