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Journal Articles

ASPP2 Attenuation Is an Early Step in Leukemogenesis Facilitating Acquisition of Mutations

Kerstin M Kampa-Schittenhelm, Dr., MD, Figen Akmut, Barbara Illing, Charles Lopez, Marcus M Schittenhelm, Dr., MD

Blood (2014) 124 (21): 2221.

https://doi.org/10.1182/blood.V124.21.2221.2221

Published: 2014

Journal Articles

Gain-of-Function KIT Mutations Sensitize the Mutant Isoform to the Type I Tyrosine Kinase Inhibitor Crenolanib: A Rationale for the Therapeutic Use in Systemic Mastocytosis (SM) and Core Binding Factor Leukemias (CBFL)

Marcus M Schittenhelm, Dr., MD, Figen Akmut, Barbara Illing, Julia Frey, Katja Schuster, PhD, Abhijit Ramachandran, Lothar Kanz, MD, Kerstin M Kampa-Schittenhelm, Dr., MD

Blood (2014) 124 (21): 2230.

https://doi.org/10.1182/blood.V124.21.2230.2230

Published: 2014

Journal Articles

Methylation Of The 5’UTR Of Apoptosis Stimulating Protein Of p53-2 (ASPP2) Impairs Gene Expression and Associates With Aggressive Disease and Therapy Failure In Acute Leukemia

Marcus M Schittenhelm, Dr., MD, Barbara Illing, Figen Akmut, Gunnar Blumenstock, Konstanze Döhner, MD, Charles D Lopez, MD, PhD, Kerstin M Kampa-Schittenhelm, Dr., MD

Blood (2013) 122 (21): 3770.

https://doi.org/10.1182/blood.V122.21.3770.3770

Published: 2013

Journal Articles

Identification Of C-Terminal Truncated Splice Variants Of The Apoptosis-Stimulating Protein Of p53-2 (ASPP2) In Acute Leukemia Lacking The p53-Binding Site

Kerstin M Kampa-Schittenhelm, Dr.,, Barbara Illing, Figen Akmut, Michael Walter, PhD, Charles D Lopez, MD, PhD, Marcus M Schittenhelm, Dr.,

Blood (2013) 122 (21): 1270.

https://doi.org/10.1182/blood.V122.21.1270.1270

Published: 2013

Journal Articles

Heatshockproteins-60 and 90 Are Overexpressed In Leukemia Stem Cells and Stabilize Oncogene Signaling

Kerstin M Kampa-Schittenhelm, Dr., MD, Tanja Grandl, Figen Akmut, Barbara Illing, Marcus M Schittenhelm, Dr., MD

Blood (2013) 122 (21): 3952.

https://doi.org/10.1182/blood.V122.21.3952.3952

Published: 2013

Journal Articles

Induction Of Apoptosis By The Dual PI3K/Mtor Inhibitor NVP-BEZ235 Is Impaired By a Profound G1/G0 Arrest In Acute Leukemia Which Can Be Overcome By Combination Approaches

Kerstin M Kampa-Schittenhelm, Dr., MD, Figen Akmut, Barbara Illing, Marcus M Schittenhelm, Dr., MD

Blood (2013) 122 (21): 3856.

https://doi.org/10.1182/blood.V122.21.3856.3856

Published: 2013

Journal Articles

Attenuation of Apoptosis-Stimulating Protein of p53 2 (ASPP2 or TP53BP2) Associates with High Risk Disease and Therapy Failure in Acute Leukemia

Marcus M Schittenhelm, Dr., MD, Charles D Lopez, MD, PhD, Lothar Kanz, MD, Kerstin M Kampa-Schittenhelm, Dr., MD

Blood (2012) 120 (21): 1416.

https://doi.org/10.1182/blood.V120.21.1416.1416

Published: 2012

Journal Articles

Heatshockprotein-60/90 Are Overexpressed in Leukemia Stem Cells and Stabilize Oncogene Signaling.

Kerstin M Kampa-Schittenhelm, Dr., MD, Lothar Kanz, MD, Marcus M Schittenhelm, Dr., MD

Blood (2012) 120 (21): 2472.

https://doi.org/10.1182/blood.V120.21.2472.2472

Published: 2012

Journal Articles

Efficacy Analysis of the Novel Dual PI3K-MTORC1/2 Inhibitors NVP-BGT226 and NVP-BEZ235 in Acute Leukemia.

Marcus M Schittenhelm, Dr., MD, Hartmut Doehner, MD, PhD, Konstanze Doehner, Lothar Kanz, MD, Michael C. Heinrich, MD, Kerstin M Kampa-Schittenhelm, Dr., MD

Blood (2012) 120 (21): 2474.

https://doi.org/10.1182/blood.V120.21.2474.2474

Published: 2012

Journal Articles

Identification of Three Tyrosine Phosphorylation Sites in the p53 Binding Domain of Apoptosis-Stimulating p53 Protein 2 (ASPP2) That Are Differentially Phosphorylated in Response to Chemotherapy in Patient Derived AML Blasts

Kerstin M Kampa-Schittenhelm, Dr., MD, Charles D Lopez, MD, PhD, Marcus M Schittenhelm, Dr., MD

Blood (2011) 118 (21): 1396.

https://doi.org/10.1182/blood.V118.21.1396.1396

Published: 2011

Journal Articles

ASPP2 Expression In Acute Leukemia Modulates Response to Therapy

Kerstin M Kampa-Schittenhelm, Dr., MD, Charles D Lopez, Md, PhD, Marcus Schittenhelm, Dr., MD

Blood (2010) 116 (21): 3143.

https://doi.org/10.1182/blood.V116.21.3143.3143

Published: 2010

Journal Articles

The Heatshockprotein-90 Inhibitor IPI-504 Potently Overcomes Tyrosinekinase Inhibitor-Induced Activation of Cell Protection Mechanisms and Degrades HSP-Client Proteins KIT and FLT3 In Acute Leukemia Models

Marcus Schittenhelm, Dr., MD, Tanja Grandl, Emmanuel Normant, PharmD, PhD, Helmut R. Salih, MD, Kerstin M Kampa-Schittenhelm, Dr., MD

Blood (2010) 116 (21): 3982.

https://doi.org/10.1182/blood.V116.21.3982.3982

Published: 2010

NARROW

ASPP2 Attenuation Is an Early Step in Leukemogenesis Facilitating Acquisition of Mutations

Gain-of-Function KIT Mutations Sensitize the Mutant Isoform to the Type I Tyrosine Kinase Inhibitor Crenolanib: A Rationale for the Therapeutic Use in Systemic Mastocytosis (SM) and Core Binding Factor Leukemias (CBFL)

Methylation Of The 5’UTR Of Apoptosis Stimulating Protein Of p53-2 (ASPP2) Impairs Gene Expression and Associates With Aggressive Disease and Therapy Failure In Acute Leukemia

Identification Of C-Terminal Truncated Splice Variants Of The Apoptosis-Stimulating Protein Of p53-2 (ASPP2) In Acute Leukemia Lacking The p53-Binding Site

Heatshockproteins-60 and 90 Are Overexpressed In Leukemia Stem Cells and Stabilize Oncogene Signaling

Induction Of Apoptosis By The Dual PI3K/Mtor Inhibitor NVP-BEZ235 Is Impaired By a Profound G1/G0 Arrest In Acute Leukemia Which Can Be Overcome By Combination Approaches

Attenuation of Apoptosis-Stimulating Protein of p53 2 (ASPP2 or TP53BP2) Associates with High Risk Disease and Therapy Failure in Acute Leukemia

Heatshockprotein-60/90 Are Overexpressed in Leukemia Stem Cells and Stabilize Oncogene Signaling.

Efficacy Analysis of the Novel Dual PI3K-MTORC1/2 Inhibitors NVP-BGT226 and NVP-BEZ235 in Acute Leukemia.

Identification of Three Tyrosine Phosphorylation Sites in the p53 Binding Domain of Apoptosis-Stimulating p53 Protein 2 (ASPP2) That Are Differentially Phosphorylated in Response to Chemotherapy in Patient Derived AML Blasts

ASPP2 Expression In Acute Leukemia Modulates Response to Therapy

The Heatshockprotein-90 Inhibitor IPI-504 Potently Overcomes Tyrosinekinase Inhibitor-Induced Activation of Cell Protection Mechanisms and Degrades HSP-Client Proteins KIT and FLT3 In Acute Leukemia Models

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American Society of Hematology

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ASH Publications

American Society of Hematology

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