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Karthika Natarajan, PhD
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Journal Articles

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

Patrick R. Baldwin, PhD, Shivani Kapoor, B.S., Karthika Natarajan, PhD, Rossana Trotta, PhD, Adriana Tron, PhD, Dennis Huszar, PhD, Eduardo Davila, PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD
Journal: Blood
Blood (2016) 128 (22): 35.
https://doi.org/10.1182/blood.V128.22.35.35
Published: 2016
Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Kshama A. Doshi, M.S., Karthika Natarajan, PhD, Feyruz V. Rassool, PhD, Dennis Huszar, PhD, Maria R. Baer, MD
Journal: Blood
Blood (2015) 126 (23): 1268.
https://doi.org/10.1182/blood.V126.23.1268.1268
Published: 2015
Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Apoptosis Induction By Clinically Active FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and in Vivo through Synergistic Downregulation of Mcl-1 and of Bcl-xL

Karthika Natarajan, PhD, Trevor J Mathias, MS, Kshama A Doshi, MS, Adriana E Tron, PhD, Manfred Kraus, PhD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD, Dennis Huszar, PhD, Maria R Baer, MD
Journal: Blood
Blood (2014) 124 (21): 3601.
https://doi.org/10.1182/blood.V124.21.3601.3601
Published: 2014
Journal Articles

The Pim Kinase Inhibitor SGI-1776 Chemosensitizes Multidrug Resistant Cells by Both Inhibiting Drug Transport by ABCB1 and ABCG2 and Decreasing ABCB1 and ABCG2 Surface Expression On Cells That Overexpress Pim-1.

Karthika Natarajan, PhD, Jasjeet Bhullar, PhD, Suneet Shukla, PhD, Mehmet Burcu, BS, Suresh V. Ambudkar, PhD, Maria R. Baer, M.D.
Journal: Blood
Blood (2012) 120 (21): 2462.
https://doi.org/10.1182/blood.V120.21.2462.2462
Published: 2012