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Jean-Philippe Defour, BPharm,
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Journal Articles

JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils

Cristina Mambet, MD, Jean-Philippe Defour, BPharm, PhD, Olga Babosova, M.Sc., Emilie Leroy, Laura Necula, PhD, Oana Stanca, MD, Aurelia Tatic, MD, Daniel Coriu, MD, Monika Belickova, PhD, Barbora Kralova, MSc, Lucie Lanikova, PhD, Pascale Saussoy, Violaine Havelange, Carmen C. Diaconu, PhD, Vladimir Divoky, PhD, Stefan N Constantinescu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3066.
https://doi.org/10.1182/blood-2018-99-117019
Published: 2018
Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Christian Pecquet, PhD, Thomas Balligand, MD, Ilyas Chachoua, PhD, Anita Roy, PhD, Gaelle Vertenoeil, MD, Didier Colau, PhD, Emanuel Fertig, MD, Caroline Marty, PhD, Harini Nivarthi, PhD, Jean-Philippe Defour, BPharm, PhD, Erica Xu, Eva Hug, PhD, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, MSc, Ilaria Carola Casetti, MD, Elisa Rumi, MD, Daniela Pietra, PhD, Chiara Cavalloni, MD, Luca Arcaini, MD, Mario Cazzola, Norio Komatsu, MD PhD, Yoshihiko Kihara, PhD, Yoshitaka Sunami, MD PhD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Isabelle Plo, PhD, William Vainchenker, MD PhD, Robert Kralovics, PhD, Stefan N Constantinescu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4.
https://doi.org/10.1182/blood-2018-99-118348
Published: 2018
Journal Articles

Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis

Thomas Balligand, MD, Younes Achouri, PhD, Ilyas Chachoua, MSc, Christian Pecquet, PhD, Jean-Philippe Defour, BPharm,, Stefan N. Constantinescu
Journal: Blood
Blood (2016) 128 (22): 4274.
https://doi.org/10.1182/blood.V128.22.4274.4274
Published: 2016
Journal Articles

Thrombopoietin Activates STAT2 Inducing Type I Interferon Effects and Gene Expression: Implications for in Vivo Tpo Treatment and for Myeloproliferative Neoplasms

Stefan N Constantinescu, MD PhD Prof., Jean-Philippe Defour, BPharm,, Celine Mouton, Isabelle Plo, William Vainchenker, MD PhD, Jean-Luc Villeval, PhD, Thomas Michiels, MD PhD, Judith Staerk, Christian Pecquet, PhD
Journal: Blood
Blood (2014) 124 (21): 820.
https://doi.org/10.1182/blood.V124.21.820.820
Published: 2014
Journal Articles

Differential Association of Calreticulin Type 1 and Type 2 Mutations with Myelofibrosis and Essential Thrombocytemia: Relevance for Disease Evolution

Xenia Cabagnols, undegraduate, Jean-Philippe Defour, BPharm,, Valérie Ugo, MD PhD, Jean Christophe Ianotto, Pascal Mossuz, Julie Mondet, Francois Girodon, MD PhD, Alexandre Ji-Hye, MD, Olivier Mansier, MD, Jean François Viallard, MD, Eric Lippert, Anne Murati, MD, MJ Mozziconacci, Ollivier Legrand, MD PhD, Pascale Saussoy, Marie-Christianne Vekemans, MD, Laurent Knoops, Florence Pasquier, Vincent Ribrag, Eric Solary, Isabelle Plo, Stefan N. Constantinescu, MD PhD, Nicole Casadevall, MD, William Vainchenker, MD, PhD, Christophe Marzac, MD, Olivier Bluteau, PhD
Journal: Blood
Blood (2014) 124 (21): 1823.
https://doi.org/10.1182/blood.V124.21.1823.1823
Published: 2014
Journal Articles

Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515

Jean-Philippe Defour, BPharm, Miki Itaya, MSc., Vitalina Gryshkova, PhD, Ian Brett, MSc., Christian Pecquet, PhD, Takeshi Sato, PhD, Steven O. Smith, PhD, Stefan N. Constantinescu, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3449.
https://doi.org/10.1182/blood.V120.21.3449.3449
Published: 2012
Journal Articles

Combination Treatment with JAK2 and PI3K Inhibitors in Myeloproliferative Neoplasms

Meng Ling Choong, PhD, Christian Pecquet, PhD, Shi Jing Tai, Jacklyn WY Yong, PhD, Vishal Pendharkar, SiFang Wang, Jean-Philippe Defour, BPharm, Carmen C. Diaconu, PhD, Kanda Sangthongpitag, PhD, Jean-Luc Villeval, PhD, William Vainchenker, MD, PhD, Stefan N. Constantinescu, MD, PhD, May Ann Lee, PhD
Journal: Blood
Blood (2012) 120 (21): 180.
https://doi.org/10.1182/blood.V120.21.180.180
Published: 2012