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Journal Articles

Combination of the MEK Inhibitor Trametinib and Pyrvinium Pamoate Efficiently Targets RAS Pathway-Mutated Acute Myeloid Leukemia in Preclinical Models

Blood (2019) 134 (Supplement_1): 2671.

https://doi.org/10.1182/blood-2019-123418

Published: 2019

Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD

Blood (2019) 134 (Supplement_1): 2552.

https://doi.org/10.1182/blood-2019-123364

Published: 2019

Journal Articles

Extracellular ATP and CD39 Regulates Mitochondrial Function and Cytarabine Resistance through Intrinsic PKA-ATF-PGC1a Pathway in Acute Myeloid Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Nesrine Aroua, PhD

Blood (2018) 132 (Supplement 1): 2737.

https://doi.org/10.1182/blood-2018-99-112534

Published: 2018

Journal Articles

Catabolic Flexibility Enhances Drug Resistance but Induces Selective Vulnerability to New Mitochondrial-Targeted Therapeutic Combinations in IDH Mutant Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Lucille Stuani, PhD, Jean-Charles Portais, PhD

Blood (2018) 132 (Supplement 1): 5238.

https://doi.org/10.1182/blood-2018-99-112523

Published: 2018

Journal Articles

Adrenomedullin Receptor Calcrl Drives Drug Resistance of Leukemic Stem Cells in Acute Myeloid Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Clément Larrue, PhD

Blood (2018) 132 (Supplement 1): 1449.

https://doi.org/10.1182/blood-2018-99-112503

Published: 2018

Journal Articles

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

Lucille Stuani, PhD, Christian Recher, MD PhD, Jean-Charles Portais, PhD, Jean-Emmanuel Sarry, PhD

Blood (2017) 130 (Supplement 1): 5080.

https://doi.org/10.1182/blood.V130.Suppl_1.5080.5080

Published: 2017

Journal Articles

Dexamethasone Reduces Incidence of Relapse and Improves Overall Survival in Hyperleucocytic Acute Myeloid Leukemia

Christian Récher, MD PhD, Sarah Bertoli, MD PhD, Muriel Picard, MD, Emilie Bérard, MD PhD, Clément Larrue, PhD, Suzanne Tavitian, MD, Francois Vergez, DVM, PhD, Edwige Yon, Jean Ruiz, MD, Eric Delabesse, PharmD, PhD, Isabelle Luquet, MD, Laetitia Linares, PhD, Martin Carroll, MD, Audrey Sarry, Françoise Huguet, MD, Jean-Emmanuel Sarry, PhD

Blood (2016) 128 (22): 1636.

https://doi.org/10.1182/blood.V128.22.1636.1636

Published: 2016

Journal Articles

Immunophenotypic-Defined Stage of Leukemia Differentiation Arrest Identifies Oncogenic and Metabolic Signatures in AML

Francois Vergez, DVM, PhD, Sarah Bertoli, MD PhD, Marina Bousquet, PhD, Marie-Laure Nicolau-Travers, Michael Peres, PharmD, Estelle Saland, Françoise Huguet, MD, Isabelle Luquet, MD, Veronique Mansat-de Mas, PharmD, PhD, Cecile Demur, MD, Eric Delabesse, MD PhD, Gwenn Danet-Desnoyers, PhD, Jean-Emmanuel Sarry, PhD, Christian Récher, MDPhD

Blood (2015) 126 (23): 90.

https://doi.org/10.1182/blood.V126.23.90.90

Published: 2015

Journal Articles

In Vivo Response to Cytarabine Chemotherapy Uncovers the Role of the Oxidative and Energetic Metabolism in the Chemoresistance of Human Primary AML Stem Cells

Nesrine Aroua, PhD, Jean-Emmanuel Sarry, PhD, Fabienne De Toni, PhD, Robin Carson, MD BA, Francois Vergez, VD PhD, Estelle Saland, Mayumi Sugita, MD, Martin Carroll, MD, Christian Recher, MDPhD, Gwenn Danet, PhD

Blood (2015) 126 (23): 4269.

https://doi.org/10.1182/blood.V126.23.4269.4269

Published: 2015

Journal Articles

The Combination of ATRA and Dasatinib for Differentiation Therapy in Acute Myeloid Leukemias with IDH Mutations

Helena Boutzen, PharmD PhD, Estelle Saland, Mathilde Cathebras, Clément Larrue, PhD, Thomas Farge, Nizar Serhan, PhD, Fabienne De Toni, PhD, Marion David, PhD, Lara Gales, Florence Castelli, Christophe Junot, PhD, Eric Delabesse, PharmD PhD, Demas Veronique, PharmD PhD, Jean-Charles Portais, PhD, Ouathek Ouerfelli, PhD, Yang Guangli, PhD, Francois Vergez, VD PhD, Christian Recher, MDPhD, Jean-Emmanuel Sarry, PhD

Blood (2015) 126 (23): 2542.

https://doi.org/10.1182/blood.V126.23.2542.2542

Published: 2015

Journal Articles

Dendrogenin_A : A Natural Liver X Receptor Modulator for the Treatment of Acute Myeloid Leukemia

Christian Recher, MDPhD, Marion David, PhD, Philippe de Medina, PhD, Cécile Bize, PhD, Nizar Serhan, PhD, Michael R Paillasse, PhD, Estelle Saland, Emmanuel Noguer, Julia Cherier, PhD, Cécile Demur, MDPhD, Clément Larrue, Fabienne de Toni, PhD, François Vergez, VMD-PhD, Jean-emmanuel Sarry, PhD, Sandrine Silvente-Poirot, PhD, Marc Poirot, PhD

Blood (2014) 124 (21): 3767.

https://doi.org/10.1182/blood.V124.21.3767.3767

Published: 2014

Journal Articles

A Novel Path for ATRA Differentiation Therapy in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations

Jean-Emmanuel Sarry, PhD, Helena Boutzen, PharmD. PhD, Christian Récher, MDPhD

Blood (2014) 124 (21): 3727.

https://doi.org/10.1182/blood.V124.21.3727.3727

Published: 2014

Journal Articles

Cytosine Arabinoside Chemotherapy Does Not Enrich For Leukemic Stem Cells In Xenotransplantation Model Of Human Acute Myeloid Leukemia

Fabienne de Toni, PhD, Robin L. Perry, MD, Estelle Saland, Mayumi Sugita, MD, Marion David, PhD, François Vergez, VMD, Eric Delabesse, MD, PhD, Véronique De Mas Mansat, PharmD PhD, Cécile Demur, MD, Jason Iacovoni, PhD, Stéphane Manenti, PhD, Gwenn Danet-Desnoyers, Christian Recher, MD PhD, Martin Carroll, MD, Jean-Emmanuel Sarry, PhD

Blood (2013) 122 (21): 1651.

https://doi.org/10.1182/blood.V122.21.1651.1651

Published: 2013

Journal Articles

Metabolic Capability to Induce the Pasteur Effect Mediates Sensitivity of Human Leukemic Cells to Metformin

Sarah Scotland, Estelle Saland, Lindsay Peyriga, Rémi Peyraud, Elizabeth Micklow, Gwenn Danet-Desnoyers, Stéphane Manenti, Christian Récher, Jean-Charles Portais, Mary Selak, Martin Carroll, MD, Jean-Emmanuel Sarry, PhD

Blood (2011) 118 (21): 2601.

https://doi.org/10.1182/blood.V118.21.2601.2601

Published: 2011

Journal Articles

Acute Myeloid Leukemia Stem Cells Cells Are Rare and Heterogeneous in Human Acute Myeloid Leukemia.

Jean-Emmanuel Sarry, PHD, Kathleen Murphy, Gwenn-ael Danet-Desnoyers, Ph.D., Martin Carroll, MD

Blood (2009) 114 (22): 390.

https://doi.org/10.1182/blood.V114.22.390.390

Published: 2009

Journal Articles

A Robust Xenotransplantation Model for Acute Myeloid Leukemia

Robin L. Perry, MD, Patricia Vanessa Sanchez, PHD, Jean-Emmanuel Sarry, PHD, Alexander Perl, MD, Adam Bagg, MD, Vivianna van Deerlin, Jacklyn Biegel, Gwenn-ael Danet-Desnoyers, Martin Carroll, MD

Blood (2008) 112 (11): 2939.

https://doi.org/10.1182/blood.V112.11.2939.2939

Published: 2008

Journal Articles

Mitochondrial Proteome from Human Peripheral Blood Cells.

Jean-Emmanuel Sarry, PhD, Gwenn-ael Danet-Desnoyers, PhD, Martin Carroll, MD, Stephen G. Emerson, MD PhD, Fevzi Daldal, PhD, Andrew Dancis, MD

Blood (2006) 108 (11): 4193.

https://doi.org/10.1182/blood.V108.11.4193.4193

Published: 2006

NARROW

Combination of the MEK Inhibitor Trametinib and Pyrvinium Pamoate Efficiently Targets RAS Pathway-Mutated Acute Myeloid Leukemia in Preclinical Models

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Extracellular ATP and CD39 Regulates Mitochondrial Function and Cytarabine Resistance through Intrinsic PKA-ATF-PGC1a Pathway in Acute Myeloid Leukemia

Catabolic Flexibility Enhances Drug Resistance but Induces Selective Vulnerability to New Mitochondrial-Targeted Therapeutic Combinations in IDH Mutant Leukemia

Adrenomedullin Receptor Calcrl Drives Drug Resistance of Leukemic Stem Cells in Acute Myeloid Leukemia

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

Dexamethasone Reduces Incidence of Relapse and Improves Overall Survival in Hyperleucocytic Acute Myeloid Leukemia

Immunophenotypic-Defined Stage of Leukemia Differentiation Arrest Identifies Oncogenic and Metabolic Signatures in AML

In Vivo Response to Cytarabine Chemotherapy Uncovers the Role of the Oxidative and Energetic Metabolism in the Chemoresistance of Human Primary AML Stem Cells

The Combination of ATRA and Dasatinib for Differentiation Therapy in Acute Myeloid Leukemias with IDH Mutations

Dendrogenin_A : A Natural Liver X Receptor Modulator for the Treatment of Acute Myeloid Leukemia

A Novel Path for ATRA Differentiation Therapy in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations

Cytosine Arabinoside Chemotherapy Does Not Enrich For Leukemic Stem Cells In Xenotransplantation Model Of Human Acute Myeloid Leukemia

Metabolic Capability to Induce the Pasteur Effect Mediates Sensitivity of Human Leukemic Cells to Metformin

Acute Myeloid Leukemia Stem Cells Cells Are Rare and Heterogeneous in Human Acute Myeloid Leukemia.

A Robust Xenotransplantation Model for Acute Myeloid Leukemia

Mitochondrial Proteome from Human Peripheral Blood Cells.

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American Society of Hematology

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American Society of Hematology

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