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Jay Y. Spiegel, MDFRCPC
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Journal Articles

Bleeding and Thrombosis Are Associated with Endothelial Dysfunction in CAR-T Cell Therapy and Are Increased in Patients Experiencing Neurologic Toxicity

Andrew Johnsrud, MD, Juliana Craig, BA, John H. Baird, MD, Jay Y. Spiegel, MDFRCPC, Lori S. Muffly, MD MS, James Zehnder, MD, Robert S. Negrin, MD, Laura J. Johnston, MD, Sally Arai, MD MS, Judith A Shizuru, MD PhD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Wen-Kai Weng, MD PhD, Parveen Shiraz, MD, Andrew R. Rezvani, MD, Theresa Latchford, RN, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Matthew J. Frank, MD PhD, Surbhi Sidana, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-142218
Published: 2020
Journal Articles

Molecular Imaging of Chimeric Antigen Receptor T Cells By ICOS-Immunopet

Federico Simonetta, MD PhD, Israt S. Alam, PhD, Juliane K. Lohmeyer, MD, Bita Sahaf, PhD, Zinaida Good, PhD, Weiyu Chen, PhD, Zunyu Xiao, MD PhD, Toshihito Hirai, MD PhD, Lukas Scheller, MD, Pujan Engels, M.Sc., Ophir Vermesh, MD PhD, Elise Robinson, Tom Haywood, PhD, Ataya Sathirachindra, Jeanette Baker, Meena B. Malipatlolla, Liora M. Schultz, MD, Jay Y. Spiegel, MDFRCPC, Jason T. Lee, PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD, Sanjiv S. Gambhir, MD PhD, Robert S. Negrin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136331
Published: 2020
Journal Articles

Monitoring Measurable Residual Disease Using Peripheral Blood in Acute Lymphoblastic Leukemia: Results of a Prospective, Observational Study

Lori S. Muffly, MD MS, Vandana Sundaram, MPH, Connie Chen, Ilana Yurkiewicz, MD BS, Eric Kuo, Sarah Burnash, Jay Y. Spiegel, MDFRCPC, Kelly Chyan, Sally Arai, MD MS, Matthew J. Frank, MD PhD, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Surbhi Sidana, MD, Parveen Shiraz, MD, Judith A Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Michaela Liedtke, MD, Hyma T. Vempaty, MD, David B. Miklos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-138988
Published: 2020
Journal Articles

CD22-Directed CAR T-Cell Therapy Mediates Durable Complete Responses in Adults with Relapsed or Refractory Large B-Cell Lymphoma after Failure of CD19-Directed CAR T-Cell Therapy and High Response Rates in Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

John H. Baird, MD, Matthew J. Frank, MD PhD, Juliana Craig, BA, Shabnum Patel, PhD, Jay Y. Spiegel, MDFRCPC, Bita Sahaf, PhD, Sheren F. Younes, MD PhD, Jean S. Oak, MD PhD, Yasodha Natkunam, MD PhD, Zachary Ehlinger, MS, Warren D. Reynolds, BS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Parveen Shiraz, MD, Surbhi Sidana, MD, Wen-Kai Weng, MD PhD, Liora M. Schultz, MD, Sneha Ramakrishna, MD, Kara L Davis, DO, Steven A. Feldman, PhD, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Lori S. Muffly, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-139087
Published: 2020
Journal Articles

CD58 Aberrations Limit Durable Responses to CD19 CAR in Large B Cell Lymphoma Patients Treated with Axicabtagene Ciloleucel but Can be Overcome through Novel CAR Engineering

Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Christopher Mount, MD PhD, Aidan Tousley, David M. Kurtz, MDPhD, Brian Sworder, MD PhD, Katherine A Murphy, Antigoni Manousopoulou, Kennedy Kohler, Maria Caterina Rotiroti, PhD, Jay Y. Spiegel, MDFRCPC, Yasodha Natkunam, MD PhD, Sheren F. Younes, MD PhD, Elena Sotillo, PhD, Vandon Duong, Charles Macaulay, MSc, BA, Zinaida Good, PhD, Peng Xu, MD, Louai Labanieh, Leo D Wang, MD PhD, Ash A. Alizadeh, MD PhD, Michelle Monje, MD PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-139605
Published: 2020
Journal Articles

Detectable Circulating Tumor DNA 28 Days after the CD19 CAR T-Cell Therapy, Axicabtagene Ciloleucel, Is Associated with Poor Outcomes in Patients with Diffuse Large B-Cell Lymphoma

Matthew J. Frank, MD PhD, Nasheed Hossain, MD, Ali Bukhari, MD, Erin Dean, MD, Jay Y. Spiegel, MDFRCPC, Gursharan K. Claire, MPH, Ilan M. Kirsch, Allison P. Jacob, Chelsea D Mullins, BS, Lik Wee Lee, PhD, Katherine A. Kong, Juliana Craig, BA, Crystal L. Mackall, MD, Aaron P. Rapoport, Saurabh Dahiya, MD, Frederick L. Locke, MD, David B Miklos, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 884.
https://doi.org/10.1182/blood-2019-132057
Published: 2019
Journal Articles

Circulating DNA for Molecular Response Prediction, Characterization of Resistance Mechanisms and Quantification of CAR T-Cells during Axicabtagene Ciloleucel Therapy

Brian Sworder, MD PhD, David M. Kurtz, MD PhD, Charles Macaulay, MSc, BA, Matthew J. Frank, MD PhD, Stefan Alig, MD, Andrea Garofalo, BS, BA, Bita Sahaf, PhD, Mohammad Shahrokh Esfahani, Jay Y. Spiegel, MDFRCPC, Jean Oak, MD PhD, Sara Beygi, MD, Michael C. Jin, BS, Jacob J Chabon, Michael S. Khodadoust, MD PhD, Robbie G. Majzner, MD, Crystal L. Mackall, MD, Maximilian Diehn, MD PhD, David B Miklos, MD PhD, Ash A. Alizadeh, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 550.
https://doi.org/10.1182/blood-2019-129015
Published: 2019
Journal Articles

Characteristics and Outcomes of Patients Receiving Bridging Therapy While Awaiting Manufacture of Standard of Care Axicabtagene Ciloleucel CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymphoma CAR-T Consortium

Michael D. Jain, MD PhD, Miriam T. Jacobs, MD, Loretta J. Nastoupil, MD MSc, Jay Y. Spiegel, MDFRCPC, Gao Feng, Yi Lin, MD PhD, Matthew A. Lunning, DO, FACP, Saurabh Dahiya, MD, Lazaros J Lekakis, MD, Patrick M Reagan, MD, Olalekan O. Oluwole, MBBS, MPH, Joseph P. McGuirk, DO, Abhinav Deol, MD, Andre Goy, MD, Brian T. Hill, MD, Javier Munoz, MD, Julio Chavez, Aaron P. Rapoport, Julie M Vose, MDMBA, David B Miklos, MD PhD, Sattva S Neelapu, MD, N. Nora Bennani, MD, Charalambos Andreadis, MD MSCE, Alison R. Sehgal, MD, Armin Ghobadi, MD, Frederick L. Locke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 245.
https://doi.org/10.1182/blood-2019-129624
Published: 2019
Journal Articles

Characteristics and Outcomes of Patients Who Did Not Develop CRS after Axicabtagene Ciloleucel for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymphoma CAR-T Consortium

Miriam T. Jacobs, MD, Michael D. Jain, MD PhD, Jay Y. Spiegel, MDFRCPC, Loretta J. Nastoupil, MD MSc, Yibo Li, MD, Gao Feng, Matthew A. Lunning, DO, FACP, Lazaros J Lekakis, MD, Saurabh Dahiya, MD, Patrick M Reagan, MD, Olalekan O. Oluwole, MBBS, MPH, Joseph P. McGuirk, DO, Abhinav Deol, MD, Alison R. Sehgal, MD, Andre Goy, MD, Brian T. Hill, MD, Charalambos Andreadis, MD MSCE, Javier Munoz, MD, Julio Chavez, N. Nora Bennani, MD, Aaron P. Rapoport, Julie M Vose, MDMBA, David B Miklos, MD PhD, Sattva S Neelapu, MD, Armin Ghobadi, MD, Frederick L. Locke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1583.
https://doi.org/10.1182/blood-2019-131168
Published: 2019
Journal Articles

Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)

Liora M Schultz, MD, Lori S Muffly, MD, Jay Y. Spiegel, MDFRCPC, Sneha Ramakrishna, MD, Nasheed Hossain, MD, Christina Baggott, RN, PhD, Bita Sahaf, PhD, Shabnum Patel, PhD, Juliana Craig, BA, Jenny Yoon, Meena Kadapakkam, MD, Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Courtney Erickson, Anne Cunniffe Marcy, MSBH, Michelle Fujimoto, Neehar Bhatia, Everett H Meyer, MD PhD, Katherine A. Kong, Emily Egeler, Sharon Mavroukakis, Haiying Qin, MS, Terry J. Fry, MD, Steven A Feldman, PhD, David B Miklos, MD PhD, Crystal L. Mackall, MD, Kara L. Davis, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 744.
https://doi.org/10.1182/blood-2019-129411
Published: 2019
Journal Articles

Identification of Two CAR T-Cell Populations Associated with Complete Response or Progressive Disease in Adult Lymphoma Patients Treated with Axi-Cel

Zinaida Good, PhD, Jay Y. Spiegel, MDFRCPC, Bita Sahaf, PhD, Meena B. Malipatlolla, Matthew J. Frank, MD PhD, John Baird, MD, Lori S Muffly, MD, Gursharan K. Claire, MPH, Juliana Craig, BA, Katherine A. Kong, Sean Bendall, PhD, David B Miklos, MD PhD, Crystal L. Mackall, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 779.
https://doi.org/10.1182/blood-2019-130815
Published: 2019