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Journal Articles

Clonal Architecture of TET2 Mutations Influences the Clinical Phenotype of Patients with Myeloid Neoplasms

Cassandra M. Hirsch, BS, Aziz Nazha, MD, Kneen Kassy, Manja Meggendorfer, PhD, Bartlomiej P. Przychodzen, MSc, Niroshan Nadarajah, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Valeria Visconte, PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Ryszard Ólinski, Professor, Sudipto Mukherjee, MD PhD MPH, Babal K Jha, PhD, Thomas Laframboise, PhD, Tomas Radivoyevitch, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 4228.

https://doi.org/10.1182/blood.V130.Suppl_1.4228.4228

Published: 2017

Journal Articles

Activation of Autophagy in Models of SF3B1 Mutant MDS

Blood (2017) 130 (Supplement 1): 4230.

https://doi.org/10.1182/blood.V130.Suppl_1.4230.4230

Published: 2017

Journal Articles

PPM1D Mutations and up Modulation Phenocopy TP53 Lesions in Myeloid Neoplasms

Reem Elagooz, MS, MD, Mai Aly, MD MS, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, Teodora Kuzmanovic, BA, Tomas Radivoyevitch, Valeria Visconte, PhD, Sudipto Mukherjee, MD PhD MPH, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Aziz Nazha, MD, Jaroslaw P. Maciejewski, PhD MD FACP, Yasunobu Nagata, MD PhD

Blood (2017) 130 (Supplement 1): 4233.

https://doi.org/10.1182/blood.V130.Suppl_1.4233.4233

Published: 2017

Journal Articles

Mutational Signatures Associated with Intensity and Duration of Smoking in Myelodysplastic Syndromes (MDS)

Yazan F. Madanat, MD, Tomas Radivoyevitch, PhD, Aziz Nazha, MD, Yazeed Sawalha, MD, Karam Al-Issa, MD, Nour Abuhadra, MD, Teodora Kuzmanovic, BA, Bartlomiej Przychodzen, Cassandra M. Hirsch, BS, Bhumika J. Patel, MD, David Seastone, PhDDO, Yogenthiran Saunthararajah, MD, Sudipto Mukherjee, MD PhD MPH, Anjali S. Advani, MD, Hetty E. Carraway, MD MBA, Aaron T. Gerds, MDMS, Jaroslaw P. Maciejewski, PhD MD FACP, Mikkael A. Sekeres, MD MS

Blood (2017) 130 (Supplement 1): 424.

https://doi.org/10.1182/blood.V130.Suppl_1.424.424

Published: 2017

Journal Articles

Distinct Genomic Associations to Predict Acute Myeloid Leukemia (AML) Progression from Myelodysplastic Syndromes (MDS)

Yazan F. Madanat, MD, Mikkael A. Sekeres, MD MS, Karam Al-Issa, MD, Cassandra M. Hirsch, BS, Sudipto Mukherjee, MD PhD MPH, Aaron T. Gerds, MDMS, Nour Abuhadra, MD, Babal K Jha, PhD, Vera Adema, PhD, Anjali S. Advani, MD, Yasunobu Nagata, MD PhD, Teodora Kuzmanovic, BA, Bartlomiej P. Przychodzen, MSc, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Aziz Nazha, MD

Blood (2017) 130 (Supplement 1): 4245.

https://doi.org/10.1182/blood.V130.Suppl_1.4245.4245

Published: 2017

Journal Articles

Model Heterogeneity in Predicting Outcomes in Patients with Chronic Myelomonocytic Leukemia (CMML): An Overestimation of Survival in Lower-Risk Group

Aziz Nazha, MD, Mrinal M. Patnaik, MDMBBS, Rami S. Komrokji, MD, Karam Al-Issa, MD, Naval Daver, MD, Guillermo Garcia-Manero, MD, Jaroslaw P. Maciejewski, PhD MD FACP, Alan F. List, MD, Michael R. Savona, MD, Raphael Itzykson, MD PhD, Pierre Fenaux, MD PhD, Valeria Santini, MD, Ayalew Tefferi, MD, Mikkael A. Sekeres, MD MS, Eric Padron, MD

Blood (2017) 130 (Supplement 1): 4255.

https://doi.org/10.1182/blood.V130.Suppl_1.4255.4255

Published: 2017

Journal Articles

High Rates of Atherosclerotic Disease-Related Mortality in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia Patients Associated with TET2-Mutations

Remco J Molenaar, Tomas Radivoyevitch, PhD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MD PhD MPH, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 421.

https://doi.org/10.1182/blood.V130.Suppl_1.421.421

Published: 2017

Journal Articles

Clinical and Molecular Characteristics of Therapy-Related Acute Lymphoblastic Leukemia

Blood (2017) 130 (Supplement 1): 3993.

https://doi.org/10.1182/blood.V130.Suppl_1.3993.3993

Published: 2017

Journal Articles

Extent and Clinical Implications of Subclonal Diversity in Paroxysmal Nocturnal Hemoglobinuria

Mohammad Fahad B Asad, MD MBBS, Abhinav Goyal, MD, Hassan Awada, MD, Mai Aly, Cassandra Hirsch, Michael J. Clemente, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD MPH, Yasunobu Nagata, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 779.

https://doi.org/10.1182/blood.V130.Suppl_1.779.779

Published: 2017

Journal Articles

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Xiaorong Gu, PhD, Quteba Ebrahem, MD, Reda Z. Mahfouz, MD PhD, Metis Hasipek, PhD, Francis Enane, PhD, Tomas Radivoyevitch, Nicolas Rapin, PhDMSc, Bartlomiej P. Przychodzen, MSc, Ramesh Balusu, PhD, Claudiu V Cotta, David Wald, MD PhD, Zhenbo Hu, MD PhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD, Yogenthiran Saunthararajah, MD

Blood (2017) 130 (Supplement 1): 878.

https://doi.org/10.1182/blood.V130.Suppl_1.878.878

Published: 2017

Journal Articles

Modulation of TET2 Activity with Ascorbic Acid in Myeloid Neoplasia: Diagnostic and Therapeutic Implications

Edward F Greenberg, MD, Cassandra M. Hirsch, BS, Shi Chen, Xiaochen Liiu, Babal K Jha, PhD, Valeria Visconte, PhD, Dewen You, PhD, Bartlomiej P. Przychodzen, MSc, Thomas Laframboise, PhD, Hideki Makishima, MD PhD, Aziz Nazha, MD, Mingjiang Xu, MDPhD, Daniel Gackowski, PhD, Mridul Mukherji, D.Phil., Mikkael A. Sekeres, MD MS, Ryszard Ólinski, Professor, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1205.

https://doi.org/10.1182/blood.V130.Suppl_1.1205.1205

Published: 2017

Journal Articles

IDH1/2 -Mutated Acute Myeloid Leukemia Has Impaired DNA Damage Response and Is Sensitive to Monotherapy with the PARP Inhibitior Olaparib

Remco J Molenaar, Tomas Radivoyevitch, PhD, Yasunobu Nagata, MD PhD, Bartlomiej P. Przychodzen, MSc, Hideki Makishima, MD PhD, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD MPH, Mikkael A. Sekeres, MD MS, Cornelis van Noorden, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 568.

https://doi.org/10.1182/blood.V130.Suppl_1.568.568

Published: 2017

Journal Articles

Acquired Somatic Mutations in T Cells in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndromes

Sofie Lundgren, Mikko Keränen, MD PhD, Kari Nousiainen, Samuli Eldfors, Sari Hannula, Tiina Hannunen, Pekka Ellonen, Gunilla Walldin, Michael Clemente, Freja Ebeling, MD PhD, Hanna Rajala, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP, Harri Lähdesmäki, PhD, Eva Hellstrom-Lindberg, MD PhD, Satu Mustjoki, MDPhD

Blood (2017) 130 (Supplement 1): 1169.

https://doi.org/10.1182/blood.V130.Suppl_1.1169.1169

Published: 2017

Journal Articles

High Frequency of Subclonal Myeloid Mutations Can be Found in Large Granular Lymphocyte Leukemia

Elise LeMelle, Cassandra M. Hirsch, BS, Michael Clemente, MS, Srinivasa Reddy Sanikommu, MD, Vera Adema, PhD, Hassan Awada, MD, Bartlomiej P. Przychodzen, MSc, Hetty E. Carraway, MD MBA, Alan Lichtin, MD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MD PhD MPH, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1171.

https://doi.org/10.1182/blood.V130.Suppl_1.1171.1171

Published: 2017

Journal Articles

Paroxysmal Nocturnal Hemoglobinuria Results from Initial Clonal PIG-a Mosaicism

Michael J. Clemente, Bartlomiej Przychodzen, Cassandra M. Hirsch, BS, Bhumika J. Patel, MD, Taha Bat, Yasunobu Nagata, MD PhD, Marcin W. Wlodarski, MD PhD, Hideki Makishima, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1179.

https://doi.org/10.1182/blood.V130.Suppl_1.1179.1179

Published: 2017

Journal Articles

Novel Therapeutic Targets for DNMT3A Mutant Myeloid Neoplasms

Vera Adema, PhD, Suresh K. Balasubramanian, MD, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, James G Phillips, PhD, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, Sudipto Mukherjee, MD PhD MPH, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Francesc Sole, PhD, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 106.

https://doi.org/10.1182/blood.V130.Suppl_1.106.106

Published: 2017

Journal Articles

A Personalized Prediction Model to Risk Stratify Patients with Acute Myeloid Leukemia (AML)

Aziz Nazha, MD, Sudipto Mukherjee, MD PhD MPH, Karam Al-Issa, MD, Ahed Makhoul, MD, Vera Adema, PhD, Cassandra M. Hirsch, BS, Anjali S. Advani, MD, Aaron T. Gerds, MDMS, Matt Kalaycio, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Mikkael A. Sekeres, MD MS

Blood (2017) 130 (Supplement 1): 1408.

https://doi.org/10.1182/blood.V130.Suppl_1.1408.1408

Published: 2017

Journal Articles

Patterns of Genomic Associations Can Define Acute Myeloid Leukemia (AML) Phenotype

Aziz Nazha, MD, Mikkael A. Sekeres, MD MS, Karam Al-Issa, MD, Ahed Makhoul, MD, Vera Adema, PhD, Cassandra M. Hirsch, BS, Anjali S. Advani, MD, Bartlomiej P. Przychodzen, MSc, Teodora Kuzmanovic, BA, Babal K Jha, PhD, Aaron T. Gerds, MDMS, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD MPH, Matt Kalaycio, MD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1409.

https://doi.org/10.1182/blood.V130.Suppl_1.1409.1409

Published: 2017

Journal Articles

BCOR Mutations in Myelodysplastic Syndromes (MDS): Mutation Characteristics Impact Clinical Outcomes

Nour Abuhadra, MD, Karam Al-Issa, MD, Sudipto Mukherjee, MD PhD MPH, Cassandra M. Hirsch, BS, Aaron T. Gerds, MDMS, Babal K Jha, PhD, Vera Adema, PhD, Hassan Awada, MD, Mohammad Fahad B Asad, MD MBBS, Abhinav Goyal, MD, Anjali S. Advani, MD, Yasunobu Nagata, MD PhD, Bartlomiej P. Przychodzen, MSc, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Mikkael A. Sekeres, MD MS, Aziz Nazha, MD

Blood (2017) 130 (Supplement 1): 5304.

https://doi.org/10.1182/blood.V130.Suppl_1.5304.5304

Published: 2017

Journal Articles

Non-Random Interactions between Founder and Subclonal Mutations Shape the Clinical and Morphological Features of MDS

Blood (2017) 130 (Supplement 1): 583.

https://doi.org/10.1182/blood.V130.Suppl_1.583.583

Published: 2017

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Clonal Architecture of TET2 Mutations Influences the Clinical Phenotype of Patients with Myeloid Neoplasms

Activation of Autophagy in Models of SF3B1 Mutant MDS

PPM1D Mutations and up Modulation Phenocopy TP53 Lesions in Myeloid Neoplasms

Mutational Signatures Associated with Intensity and Duration of Smoking in Myelodysplastic Syndromes (MDS)

Distinct Genomic Associations to Predict Acute Myeloid Leukemia (AML) Progression from Myelodysplastic Syndromes (MDS)

Model Heterogeneity in Predicting Outcomes in Patients with Chronic Myelomonocytic Leukemia (CMML): An Overestimation of Survival in Lower-Risk Group

High Rates of Atherosclerotic Disease-Related Mortality in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia Patients Associated with TET2-Mutations

Clinical and Molecular Characteristics of Therapy-Related Acute Lymphoblastic Leukemia

Extent and Clinical Implications of Subclonal Diversity in Paroxysmal Nocturnal Hemoglobinuria

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Modulation of TET2 Activity with Ascorbic Acid in Myeloid Neoplasia: Diagnostic and Therapeutic Implications

IDH1/2 -Mutated Acute Myeloid Leukemia Has Impaired DNA Damage Response and Is Sensitive to Monotherapy with the PARP Inhibitior Olaparib

Acquired Somatic Mutations in T Cells in Patients with Aplastic Anemia and Hypoplastic Myelodysplastic Syndromes

High Frequency of Subclonal Myeloid Mutations Can be Found in Large Granular Lymphocyte Leukemia

Paroxysmal Nocturnal Hemoglobinuria Results from Initial Clonal PIG-a Mosaicism

Novel Therapeutic Targets for DNMT3A Mutant Myeloid Neoplasms

A Personalized Prediction Model to Risk Stratify Patients with Acute Myeloid Leukemia (AML)

Patterns of Genomic Associations Can Define Acute Myeloid Leukemia (AML) Phenotype

BCOR Mutations in Myelodysplastic Syndromes (MDS): Mutation Characteristics Impact Clinical Outcomes

Non-Random Interactions between Founder and Subclonal Mutations Shape the Clinical and Morphological Features of MDS

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