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Jan G. J. van de Winkel, PhD
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Journal Articles

Recombinant Dimeric IgA Antibodies as Tumor-Specific Agents.

Michael Dechant, MD, Stefan Lohse, PhD, Stefanie Derer, PhD, Thomas Beyer, PhD, Katja Klausz, PhD, Matthias Peipp, PhD, Jeanette H. W. Leusen, PhD, Jan G. J. van de Winkel, PhD, Thomas Valerius, MD
Journal: Blood
Blood (2010) 116 (21): 1488.
https://doi.org/10.1182/blood.V116.21.1488.1488
Published: 2010
Journal Articles

Daratumumab, a Novel Potent Human Anti-CD38 Monoclonal Antibody, Induces Significant Killing of Human Multiple Myeloma Cells: Therapeutic Implication.

Yu-Tzu Tai, Ph.D., Michel de Weers, Ph.D., Xian-Feng Li, MS, Weihua Song, MD, Sabikun Nahar, B.S., Joost M Bakker, Tom Vink, Danièˆlle Jacobs, Lukas Oomen, Wim K Bleeker, Nikhil C. Munshi, MD, Jan G. J. van de Winkel, PhD, Paul W. H. I. Parren, PhD, Paul Richardson, M.D., Ph.D., Kenneth C. Anderson, MD
Journal: Blood
Blood (2009) 114 (22): 608.
https://doi.org/10.1182/blood.V114.22.608.608
Published: 2009
Journal Articles

Ofatumumab, a Human Mab Targeting a Membrane-Proximal Small-Loop Epitope On CD20, Induces Potent NK Cell-Mediated ADCC.

Jenny L Craigen, PhD, Wendy J.M. Mackus, PhD, Patrick Engleberts, Sam R Miller, Sue Speller, Louise C Chamberlain, Bill G Davis, PhD, Simon M McHugh, PhD, Ed Bullmore, PhD, Charles J Cox, PhD, Sally Wetten, Gerrard Perdock, Joost M Bakker, PhD, Jan G. J. van de Winkel, PhD, Paul W. H. I. Parren, PhD
Journal: Blood
Blood (2009) 114 (22): 1725.
https://doi.org/10.1182/blood.V114.22.1725.1725
Published: 2009
Journal Articles

Complement (C) Activation Followed by Penetration of the Membrane Attack Complex (MAC) on B Cells Opsonized with CD20 Mabs Allows for Calcium Influx Which Induces Streamers. Generalization of Streaming to Include other Mabs and Target Cells.

Ronald P. Taylor, PhD, Paul V. Beum, PhD, P. Todd Stukenberg, PhD, Andrew W. Pawluczkowycz, MS, Margaret A. Lindorfer, PhD, Frank J. Beurskens, PhD, Paul W. H. I. Parren, PhD, Jan G. J. van de Winkel, PhD
Journal: Blood
Blood (2008) 112 (11): 1577.
https://doi.org/10.1182/blood.V112.11.1577.1577
Published: 2008
Journal Articles

Binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab (OFA) or Rituximab (RTX) Promotes Complement Dependent Cytotoxicity (CDC), and Considerably Higher Levels of CDC Are Induced by OFA Than by RTX.

Ronald P. Taylor, PhD, Andrew W. Pawluczkowycz, MS, Margaret A. Lindorfer, PhD, Jan G. J. van de Winkel, PhD, Frank J. Beurskens, PhD, Paul W. H. I. Parren, PhD
Journal: Blood
Blood (2008) 112 (11): 1578.
https://doi.org/10.1182/blood.V112.11.1578.1578
Published: 2008