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Journal Articles

AMP-Dependent Kinase/mTOR Complex 1 Signaling In T-Cell Acute Lymphoblastic Leukemia: Therapeutical Implications

Cecilia Grimaldi, BS, Francesca Chiarini, PhD, Francesca Ricci, BS, Pierluigi Tazzari, MD, Michela Battistelli, PhD, Elisabetta Falcieri, MD, Andrea Pession, MD, PhD, James McCubrey, PhD, Alberto M. Martelli, MD

Blood (2010) 116 (21): 3225.

https://doi.org/10.1182/blood.V116.21.3225.3225

Published: 2010

Journal Articles

Dual Inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin with NVP-BEZ235 as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia.

Francesca Chiarini, BS, Cecilia Grimaldi, BS, Francesca Ricci, BS, Pierluigi Tazzari, MD, Camilla Evangelisti, PhD, Andrea Pession, MD, PhD, Pasqualepaolo Pagliaro, MD, James McCubrey, PhD, Alberto M. Martelli, MD

Blood (2009) 114 (22): 2025.

https://doi.org/10.1182/blood.V114.22.2025.2025

Published: 2009

Journal Articles

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Maria Rosaria Ricciardi, PhD, Twee Tsao, PhD, Stephen Lee Abrams, PhD, Paola Bergamo, MS, Linda S Steelman, BS., MS, Samantha Decandia, PhD, Lara Felicioni, PhD, Ludovica Ciuffreda, PhD, Cristina Di Sanza, PhD, Antonio Marchetti, MD, PhD, Francesco Cognetti, MD, James McCubrey, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Agostino Tafuri, MD, Michele Milella, MD

Blood (2009) 114 (22): 594.

https://doi.org/10.1182/blood.V114.22.594.594

Published: 2009

Journal Articles

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Marina Konopleva, MD, PhD, Michele Milella, MD, Julie C Watts, PhD, Maria Rosaria Ricciardi, PhD, Borys Korchin, PhD, Twee Tsao, PhD, Paola Bergamo, MS, Duncan H. Mak, PhD, Samantha Decandia, PhD, James McCubrey, PhD, Agostino Tafuri, MD, Michael Andreeff, MD, PhD

Blood (2009) 114 (22): 2757.

https://doi.org/10.1182/blood.V114.22.2757.2757

Published: 2009

Journal Articles

The Glycogensynthase Kinase 3b (GSK-3β) Is Involved in Leukemic Transformation

Jörg Bäsecke, Anneke Lehmann, Ulla Bergholz, James McCubrey, PhD, Lorenz Trümper, Carol Stocking, Stefan Horn

Blood (2008) 112 (11): 4489.

https://doi.org/10.1182/blood.V112.11.4489.4489

Published: 2008

Journal Articles

Erucylphosphohomocholine, the First Intravenously Applicable Alkylphosphocholine, Induces Cell Cycle Arrest, Apoptosis, and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia.

Veronica Papa, BS, PierLuigi Tazzari, MD, Francesca Chiarini, BS, Francesca Ricci, BS, Giovanni Martinelli, MD, Andrea Bontadini, MD, James McCubrey, PhD, Lars H Lindner, MD, Hansjoerg Eibl, PhD, Alberto M. Martelli, MD

Blood (2008) 112 (11): 1330.

https://doi.org/10.1182/blood.V112.11.1330.1330

Published: 2008

Journal Articles

PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic Leukemia Cells: A New Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia.

Francesca Chiarini, BS, Federica Fala, PhD, Francesca Ricci, BS, PierLuigi Tazzari, MD, Annalisa Astolfi, PhD, Andrea Pession, MD, PhD, James McCubrey, PhD, Alberto M. Martelli, MD

Blood (2008) 112 (11): 1921.

https://doi.org/10.1182/blood.V112.11.1921.1921

Published: 2008

Journal Articles

Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

Michele Milella, MD, Maria Rosaria Ricciardi, Paola Bergamo, MS, Maria Cristina Scerpa, PhD, Jacopo Gervasoni, MS, Maria Teresa Petrucci, MD, Sabina Chiaretti, MD, Simona Tavolaro, MS, Ludovica Ciuffreda, PhD, Samantha Decandia, Francesco Libotte, Stephen Lee Abrams, Linda S Steelman, BS., MS, Marina Konopleva, MD, PhD, Francesco Cognetti, MD, Robert Foa, Michael Andreeff, MD, PhD, James McCubrey, PhD, Agostino Tafuri

Blood (2008) 112 (11): 860.

https://doi.org/10.1182/blood.V112.11.860.860

Published: 2008

Journal Articles

Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia Displaying Elevated Akt Signaling.

PierLuigi Tazzari, MD, Veronica Papa, BS, Francesca Ricci, BS, Francesca Chiarini, BS, Camilla Evangelisti, PhD, Giovanni Martinelli, MD, Andrea Bontadini, MD, James McCubrey, PhD, Alberto M. Martelli, MD

Blood (2008) 112 (11): 957.

https://doi.org/10.1182/blood.V112.11.957.957

Published: 2008

Journal Articles

Molecular and Functional Effects of the Novel MEK Inhibitor PD0325901 in Preclinical Models of Human Leukemias.

Michele Milella, MD, Maria Rosaria Ricciardi, PhD, Chiara Gregorj, PhD, Fabiana De Cave, PhD, Steven L. Abrams, BS, Linda S. Steelman, MS, Sabina Chiaretti, PhD, Marina Konopleva, MD, PhD, Maria Teresa Petrucci, MD, Francesco Cognetti, MD, Robert Foa, MD, PhD, Michael Andreeff, MD, PhD, James McCubrey, PhD, Agostino Tafuri, MD

Blood (2006) 108 (11): 254.

https://doi.org/10.1182/blood.V108.11.254.254

Published: 2006

Journal Articles

Raf Inhibitor BAY 43-9006 Induces Bim Dephosphorylation and Activates the Intracellular Apoptotic Pathway in AML.

Weiguo Zhang, MD, PhD, Marina Konopleva, MD, PhD, Teresa McQueen, BS, Jorje Cortes, MD, James McCubrey, PhD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 3367.

https://doi.org/10.1182/blood.V106.11.3367.3367

Published: 2005

Journal Articles

Mechanisms of Apoptosis Induction by BH3 Inhibitor ABT-737 in AML.

Michael Andreeff, MD, PhD, Rooha Contractor, Peter P. Ruvolo, PhD, Xingming Deng, MD, PhD, Ismael Samudio, PhD, Yue-Xi Shi, Teresa McQueen, BS, Rui-Yu Wang, MD, PhD, Wendy Schober, Xiaoyang Ling, PhD, Frank C. Marini, PhD, David Harris, Zeev Estrov, MD, James McCubrey, PhD, W. Stratford May, MD, PhD, Marina Konopleva, MD, PhD

Blood (2005) 106 (11): 244.

https://doi.org/10.1182/blood.V106.11.244.244

Published: 2005

NARROW

AMP-Dependent Kinase/mTOR Complex 1 Signaling In T-Cell Acute Lymphoblastic Leukemia: Therapeutical Implications

Dual Inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin with NVP-BEZ235 as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia.

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

The Glycogensynthase Kinase 3b (GSK-3β) Is Involved in Leukemic Transformation

Erucylphosphohomocholine, the First Intravenously Applicable Alkylphosphocholine, Induces Cell Cycle Arrest, Apoptosis, and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia.

PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic Leukemia Cells: A New Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia.

Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells-a Novel Therapeutic Approach for Leukemia Displaying Elevated Akt Signaling.

Molecular and Functional Effects of the Novel MEK Inhibitor PD0325901 in Preclinical Models of Human Leukemias.

Raf Inhibitor BAY 43-9006 Induces Bim Dephosphorylation and Activates the Intracellular Apoptotic Pathway in AML.

Mechanisms of Apoptosis Induction by BH3 Inhibitor ABT-737 in AML.

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American Society of Hematology

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American Society of Hematology

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