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Isabel Ben Batalla, PhD
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Journal Articles

The Combination of AXL Inhibitor Bemcentinib and Low Dose Cytarabine Is Well Tolerated and Efficacious in Elderly Relapsed AML Patients: Update from the Ongoing BGBC003 Phase II Trial (NCT02488408)

Sonja Loges, MD PhD, Michael Heuser, Jörg Chromik, MD, Carlos Enrique Vigil, MD, Peter Paschka, MD, Francesca Re, MD, Nicola Di Renzo, MD, Roberto M. Lemoli, Daniele Giovanni Mattei, MD, Isabel Ben-Batalla, PhD, Monica Hellesoy, PhD, Katherine Lorens, MD, Joseph Birkett, PhD, Stuart McPherson, BSc, Jaya Nautiyal, PhD, David Micklem, PhD, Hani Gabra, MD PhD FRCPE, FRCP, James B. Lorens, PhD, Walter Fiedler, MD, Yesid Alvarado, MD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-136566
Published: 2020
Journal Articles

Durable Responses Observed in Elderly AML Patients Unfit for Intensive Chemotherapy with First-in Class Selective AXL Inhibitor Bemcentinib (BGB324) in Combination with LDAC: Phase II Open-Label Study

Sonja Loges, MD, PhD, Michael Heuser, MD, Jörg Chromik, MD, Carlos Enrique Vigil, MD, Peter Paschka, MD, Francesca Re, Nicola Di Renzo, MD, Roberto Massimo Lemoli, MD, Daniele Giovanni Mattei, MD, Isabel Ben Batalla, PhD, Monica Hellesoy, PhD, David Micklem, PhD, Robert J. Holt, PhD, James B. Lorens, PhD, Muhammad Shoaib, MD, Hassan Aly, MD PhD, Wouter Hanekom, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn T. Gjertsen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3943.
https://doi.org/10.1182/blood-2019-128683
Published: 2019
Journal Articles

Final Analysis of the Dose Escalation, Expansion and Biomarker Correlations in the Ph I/II Trial BGBC003 with the Selective Oral AXL Inhibitor Bemcentinib (BGB324) in Relapsed/Refractory AML and MDS

Sonja Loges, MD, PhD, Michael Heuser, MD, Joerg Chromik, Carlos E Vigil, MD, Peter Paschka, MD, Isabel Ben-Batalla, PhD, Nuray Akyüz, David Micklem, Robert Holt, Anthony Brown, James Lorens, Murray Yule, Maxim Kebenko, MD, Melanie Janning, Mascha Binder, MD, Walter Fiedler, MD, Jorge E. Cortes, MD, Bjorn Gjertsen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2672.
https://doi.org/10.1182/blood-2018-99-120380
Published: 2018
Journal Articles

Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

Janik Engelmann, Isabel Ben Batalla, PhD, Hanna Taipaleenmäki, PhD, Kristoffer Riecken, PhD, Victoria Gensch, Sarina Paesler, Nikolaus Berenbrok, Maria Elena Vargas, Jonas Waizenegger, MD, Boris Fehse, PhD, Klaus Pantel, MD, PhD, Ihab S Darwish, PhD, Somasekhar Bhamidipati, PhD, Esteban Masuda, PhD, Carsten Bokemeyer, MD, PhD, Eric Hesse, MD, PhD, Sonja Loges, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1922.
https://doi.org/10.1182/blood-2018-99-118273
Published: 2018
Journal Articles

Therapeutic Potential of Axl Blockade in BCR-ABL Negative Myeloproliferative Neoplasms (MPN)

Antonia Beitzen-Heineke, MD, Isabel Ben Batalla, PhD, Nikolaus Berenbrok, Sarina Paesler, Victoria Gensch, Gunhild von Amsberg, Philippe Schafhausen, MD, Kristoffer Riecken, PhD, Thomas Fischer, MD, Klaus Pantel, MD, PhD, Carsten Bokemeyer, MD, PhD, Sonja Loges, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3063.
https://doi.org/10.1182/blood-2018-99-118175
Published: 2018
Journal Articles

BET-Inhibition By JQ1 Promotes Proliferation and Self-Renewal Capacity of Hematopoietic Stem Cells

Mark Wroblewski, PhD, Marina Scheller-Wendorff, PhD, Raimund Bauer, PhD, Florian Udonta, Jara Schlichting, Lin Zhao, MD, Isabel Ben Batalla, PhD, Victoria Gensch, Marek Wanior, Hanna Taipaleenmäki, PhD, Simona Bolamperti, PhD, Zeynab Najafova, PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD PhD, Eric Hesse, MD PhD, Stefan Knapp, PhD, Steven Johnsen, PhD, Sonja Loges, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1900.
https://doi.org/10.1182/blood.V130.Suppl_1.1900.1900
Published: 2017
Journal Articles

BGB324 Inhibits BCR-ABL TKI-Resistant Chronic Myeloid Leukemia

Isabel Ben Batalla, PhD, Robert Erdmann, PhD, Heather Jørgensen, PhD, Rebecca Mitchell, Thomas Ernst, MD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Stephen Rankin, MD, Richard E. Clark, Prof MD, Steffen Koschmieder, MD, Alexander Schultze, MD, Subir Mitra, MD, Peter Vandenberghe, Prof MD PhD, Tim H. Brümmendorf, Prof MD, Peter Carmeliet, Prof MD PhD, Gudmundur Helgason, PhD, Andreas Hochhaus, MD, Klaus Pantel, Prof MD PhD, Carsten Bokemeyer, MD, Tessa L Holyoake, Prof PhD, Sonja Loges, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1569.
https://doi.org/10.1182/blood.V126.23.1569.1569
Published: 2015
Journal Articles

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

Robert Erdmann, PhDMSc, Heather Jorgensen, PhD, Isabel Ben-Batalla, PhD, Nils Kruse, PhD, David Micklem, PhD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Alexander Schultze, MD MSc, Mark Wroblewski, MSc, Mascha Binder, Miguel Cubas-Cordova, MSc, Tobias Hadlich, MD, Melanie Janning, MD MSc, Stefanie Sawall, Victoria Gensch, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, BSc, Jennifer Cassells, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MD, Steffen Koschmieder, MD, Peter Vandenberghe, MD PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD PhD, Tessa L. Holyoake, MD PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD, Sonja Loges, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4512.
https://doi.org/10.1182/blood.V124.21.4512.4512
Published: 2014