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Journal Articles

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, Kenichi Yoshida, MDPhD, Kana Nakatani, Yutarou Harata, Moe Higashitani, Yuri Ito, Yasuhiko Kamikubo, Yusuke Shiozawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, Hiroko Tanaka, BA, Ai Okada, Yasuhito Nannya, MD PhD, June Takeda, MD, Hiroo Ueno, MD PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Satoru Miyano, PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-134648
Published: 2020
Journal Articles

Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms

Hideki Makishima, MD PhD, Yasuhito Nannya, MD PhD, June Takeda, MD, Yukihide Momozawa, DVM,PhD, Ryunosuke Saiki, MD, Tetsuichi Yoshizato, MD PhD, Yoshiko Atsuta, MD PhD, Yuka Iijima-Yamashita, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Yasunobu Nagata, MD PhD, Yusuke Shiozawa, MD PhD, Makoto Onizuka, MD PhD, Kenichi Chiba, Hiroko Tanaka, Nobuyuki Kakiuchi, MD, Yotaro Ochi, MD, Hiroo Ueno, MD PhD, Hidehiro Itonaga, MD PhD, Yoshinobu Kanda, MD PhD, Masashi Sanada, MD, Ayana Kon, MD PhD, Yasushi Miyazaki, MD PhD, Keizo Horibe, MD PhD, Maria Creignou, Magnus Tobiasson, MD, Hisashi Tsurumi, MD PhD, Senji Kasahara, MD PhD, Chantana Polprasert, MD, Eva Hellstrom Lindberg, MD PhD, Akifumi Kondo Takaori, MD PhD, Toru Kiguchi, MD PhD, Mario Cazzola, MD, Fumihiko Matsuda, MD PhD, Kazuma Ohyashiki, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Torsten Haferlach, MD, Yoichiro Kamatani, MDPhD, Michiaki Kubo, MDPhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–40.
https://doi.org/10.1182/blood-2020-140174
Published: 2020
Journal Articles

DNA Methylation and Genetic Profiles in 320 Patients with Myelodysplastic Syndromes

Suguru Morimoto, Hideki Makishima, MD PhD, Yasunobu Nagata, MD PhD, Niroshan Nadarajah, Constance Baer, PhD, Tamara Alpermann, Genta Nagae, MD PhD, Yasuhito Nannya, MD PhD, Yasushi Miyazaki, MD PhD, Kenichi Yoshida, MD PhD, Tetsuichi Yoshizato, MD PhD, Masahiro Marshall Nakagawa, MDPhD, Ryosaku Inagaki, June Takeda, MD, Yoichi Fujii, MD, Yasuhide Takeuchi, MD, Hiroo Ueno, MD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Masashi Sanada, MD PhD, Satoru Miyano, PhD, Claudia Haferlach, MD, Wolfgang Kern, MD, Hiroyuki Aburatani, MD PhD, Torsten Haferlach, MD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1799.
https://doi.org/10.1182/blood-2018-99-116489
Published: 2018
Journal Articles

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD, PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, PhD, Nobutaka Kiyokawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Tomoya Isobe, MD, Masafumi Seki, MD,PhD, Shunsuke Kimura, MD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD PhD, Hiroyuki Tsukamoto, MD PhD, Dai Nishijima, PhD, Takao Deguchi, MD PhD, Kentaro Ohki, MD PhD, Atsushi Sato, MD, Hiroyuki Takahashi, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Takeshi Inukai, MD, Junko Takita, MD, PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4077.
https://doi.org/10.1182/blood-2018-99-115617
Published: 2018
Journal Articles

Clinical and Genetic Characteristics of Patients with Shwachman-Diamond Syndrome in Japan

Kenichiro Watanabe, MD PhD, Hirokazu Kanegane, MD PhD, Takayuki Hamabata, MD, Kagehiro Kozuki, MD, Katsutsugu Umeda, MD, PhD, Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Asahito Hama, Yusuke Okuno, MD PhD, Hideki Muramatsu, MD PhD, Yoshiyuki Takahashi, MD, PhD, Daisuke Hasegawa, MD PhD, Atsushi Manabe, MD PhD, Akira Ohara, MD, Masafumi Ito, MD PhD, Seishi Ogawa, MD PhD, Seiji Kojima, MD PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3862.
https://doi.org/10.1182/blood-2018-99-114313
Published: 2018
Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, MD, Masafumi Seki, MD, PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Yasuhito Nannya, MD PhD, Kentaro Ohki, MD PhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Akira Ohara, MD, Masashi Sanada, MD PhD, Mitsuteru Hiwatari, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Junko Takita, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4089.
https://doi.org/10.1182/blood-2018-99-111092
Published: 2018
Journal Articles

Novel and Significant Impact of Germline Variants Predisposed to Pathogenic Somatic Mutations and Loss of Heterozygosity (LOH) in Myelodysplastic Syndromes (MDS) and Clonal Hematopoiesis of Indeterminate Potential (CHIP)

Hideki Makishima, MD PhD, Tetsuichi Yoshizato, MD PhD, Yasuhito Nannya, MD PhD, Yasuhide Momozawa, PhD, Yoshiko Atsuta, MD PhD, Yusuke Shiozawa, MD, PhD, Yuka Iijima-Yamashita, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Hiromichi Suzuki, MD , PhD, June Takeda, MD, Yasunobu Nagata, Yusuke Sato, Nobuyuki Kakiuchi, MD, Makoto Onizuka, MD PhD, Keisuke Kataoka, MD PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Hiroo Ueno, MD, Masahiro Marshall Nakagawa, MDPhD, Hidehiro Itonaga, MD, PhD, Yoshinobu Kanda, MD PhD, Yasushi Miyazaki, MD PhD, Keizo Horibe, MD PhD, Masashi Sanada, MD PhD, Yoichiro Kamatani, MDPhD, Michiaki Kubo, MDPhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 108.
https://doi.org/10.1182/blood-2018-99-118833
Published: 2018
Journal Articles

Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, PhD, Kenichi Yoshida, MD PhD, Kazutaka Fukumura, PhD, Kana Nakatani, Yuki Noguchi, Saho Takasaki, Mina Noura, Yusuke Shiozawa, MD, PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Ai Okada, Yasuhito Nannya, MD PhD, June Takeda, MD, Hiroo Ueno, MD, Norio Shiba, MD PhD, Genki Yamato, MD PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Yasuhide Hayashi, MD PhD, Hiroyuki Mano, MD, PhD, Satoru Miyano, PhD, Yasuhiko Kamikubo, MD, PhD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2797.
https://doi.org/10.1182/blood-2018-99-111073
Published: 2018
Journal Articles

Genome-Wide Analysis of Non-Coding Alterations in Pan-Myeloid Cancers Using Whole Genome Sequencing

Yasuhito Nannya, MD PhD, Kenichi Yoshida, MD PhD, Lanying Zhao, MD, PhD, June Takeda, MD, Hiroo Ueno, MD, Tetsuichi Yoshizato, MD PhD, Akinori Yoda, PhD, Masahiro Nakagawa, MD PhD, Hideki Makishima, MD PhD, Hiroko Tanaka, BA, Nobuhiro Hiramoto, MD, Hideharu Muto, MD PhD, Shigeo Fuji, MDPhD, Chantana Polprasert, MD, Frederik Damm, MD, Kensuke Usuki, MD PhD, Masataka Taguchi, Shigeru Chiba, MD PhD, Shuichi Miyawaki, MD PhD, Lee-Yung Shih, MD, Hisashi Tsurumi, MD PhD, Senji Kasahara, MD PhD, Luca Malcovati, MD, Takayuki Ishikawa, Joop H. Jansen, Yasushi Miyazaki, MD PhD, Satoru Miyano, PhD, Mario Cazzola, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 103.
https://doi.org/10.1182/blood-2018-99-116250
Published: 2018
Journal Articles

Clinical Effect of Genetic Alterations in Pediatric Patients with B-Progenitor Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, M.S., Yusuke Shiozawa, MD , PhD, Yuichi Shiraishi, PhD, Tomomi Ishida, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD,PhD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Masafumi Seki, MD,PhD, Hiroko Tanaka, B.A., Kenichi Chiba, B.A., Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Koji Kato, MD, PhD, Toshihiko Imamura, MD, PhD, Satoru Miyano, PhD, Keizo Horibe, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3979.
https://doi.org/10.1182/blood.V130.Suppl_1.3979.3979
Published: 2017
Journal Articles

Molecular Pathogenesis of Progressive Refractoriness in MLL -Rearranged AML

Shinichi Kotani, Keisuke Kataoka, MD PhD, June Takeda, MD, Hiroo Ueno, MD, Yusuke Shiozawa, MD , PhD, Tetsuichi Yoshizato, MD,PhD, Ayana Kon, MD PhD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Akinori Yoda, PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Akifumi Takaori-Kondo, MD PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 474.
https://doi.org/10.1182/blood.V130.Suppl_1.474.474
Published: 2017
Journal Articles

The Epigenetic and Genetic Landscapes of Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, Masafumi Seki, MD,PhD, Tomoko Kawai, PhD, Kenichi Yoshida, MD PhD, Tomoya Isobe, Hiroo Ueno, MD, Yusuke Shiozawa, MD , PhD, Hiromichi Suzuki, MD , PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Kentaro Ohki, MD PhD, Motohiro Kato, MD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD, PhD, Toshihiko Imamura, MD, PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atushi Manabe, MD PhD, Keizo Horibe, Akira Ohara, MD, Masashi Sanada, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Yasuhide Hayashi, MD PhD, Satoru Miyano, PhD, Kenichiro Hata, MD PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1444.
https://doi.org/10.1182/blood.V130.Suppl_1.1444.1444
Published: 2017
Journal Articles

Whole-Genome Sequencing of Primary Central Nervous System Lymphoma and Diffuse Large B-Cell Lymphoma

Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Yusuke Okuno, MD PhD, Rie Nakamoto-Matsubara, MD PhD, Shunichi Koriyama, Tetsuichi Yoshizato, MD PhD, Yusuke Shiozawa, MD, Keisuke Kataoka, MD PhD, Hiroo Ueno, MD, June Takeda, MD, Hiroko Tanaka, BA, Azusa Hayano, Jumpei Homma, Junya Fukai, MD PhD, Koji Kajiwara, MD PhD, Makoto Ideguchi, MD PhD, Yoshihiro Komohara, MD PhD, Naoki Yajima, Naoto Tsuchiya, Masakazu Sano, Masayuki Nitta, MD PhD, Yoshihiro Muragaki, Mamiko Sakata-Yanagimoto, MD PhD, Yasuo Iwadate, MD PhD, Hiroaki Hondoh, MD PhD, Satoru Miyano, PhD, Shigeru Chiba, MD, PhD, Ryuya Yamanaka, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4112.
https://doi.org/10.1182/blood.V128.22.4112.4112
Published: 2016
Journal Articles

Molecular Heterogeneity in Peripheral T-Cell Lymphoma Not Otherwise Specified Revealed By Comprehensive Mutational Profiling

Yosaku Watatani, MD, Yasuharu Sato, MD PhD, Kenji Nishida, MD, Hiroaki Miyoshi, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Tanaka Hiroko, Hiroo Ueno, MD, Nobuyuki Kakiuchi, MD, Yusuke Shiozawa, MD, Tetsuichi Yoshizato, MD PhD, Kenichi Yoshida, MD PhD, Masashi Sanada, MD PhD, Satoru Miyano, PhD, Koichi Ohshima, MD PhD, Tadashi Yoshino, MD PhD, Seishi Ogawa, MD PhD, Keisuke Kataoka, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2927.
https://doi.org/10.1182/blood.V128.22.2927.2927
Published: 2016
Journal Articles

TAL1 Super Enhancer Aberration and Stil-TAL1 Fusion in Pediatric T Cell Acute Lymphoblastic Leukemia

Shunsuke Kimura, MD, Masafumi Seki, MD PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Hiromichi Suzuki, MD PhD, Keisuke Kataoka, MD PhD, Kentaro Ohki, MD PhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Nobutaka Kiyokawa, MD PhD, Masao Kobayashi, MD PhD, Atsushi Manabe, MD PhD, Akira Ohara, MD PhD, Yasuhide Hayashi, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1734.
https://doi.org/10.1182/blood.V128.22.1734.1734
Published: 2016
Journal Articles

VEGFA- a New Therapeutic Target in CNS Leukemia

Itaru Kato, MD, PhD, Yoko Nishinaka-Arai, PhD, Masahiro Nakamura, MD PhD, Ayse U. Akarca, BSc, Akira Niwa, MD, PhD, Hiroki Ozawa, Kenichi Yoshida, MD PhD, Makiko Mori, MD, Dapeng Wang, PhD, Hiroo Ueno, MD, Yusuke Shiozawa, MD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Rajeev Gupta, MD, PhD, Katsutsugu Umeda, MD PhD, Kenichiro Watanabe, MD PhD, Katsuyoshi Koh, MD PhD, Souichi Adachi, MD, PhD, Toshio Heike, MDPhD, Megumu K Saito, MD, PhD, Masashi Sanada, MD PhD, Seishi Ogawa, MD PhD, Teresa Marafioti, MD, Akira Watanabe, PhD, Tatsutoshi Nakahata, MD PhD, Tariq Enver, PhD
Journal: Blood
Blood (2016) 128 (22): 911.
https://doi.org/10.1182/blood.V128.22.911.911
Published: 2016
Journal Articles

Landscape of Driver Mutations and Their Clinical Impacts in Pediatric Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yuka Yamashita, MS, Yusuke Shiozawa, MD, Tomomi Ishida, Hiroyuki Tsukamoto, MD, Yuichi Shiraishi, PhD, Hiroko Tanaka, BA, Kenichi Chiba, BA, Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD PhD, Sadao Tokimasa, PhD MD, Junichi Hara, MD PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Keizo Horibe, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2016) 128 (22): 912.
https://doi.org/10.1182/blood.V128.22.912.912
Published: 2016
Journal Articles

Identifications of Highly Aggressive Phenotype with SPI1 Overexpression in Pediatric T Cell Acute Lymphoblastic Leukemia/Lymphoma

Masafumi Seki, MD PhD, Shunsuke Kimura, MD, Kenichi Yoshida, MD PhD, Tomoya Isobe, MD, Hiroo Ueno, MD, Hiromichi Suzuki, MD PhD, Yusuke Shiozawa, MD, Keisuke Kataoka, MD PhD, Yoichi Fujii, MD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Masatoshi Takagi, MD PhD, Atsushi Iwama, MD PhD, Kentaro Oki, MDPhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Hiroshi Moritake, MD PhD, Ryoji Kobayashi, MD PhD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Keizo Horibe, MD PhD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Akira Ohara, MD PhD, Masashi Sanada, MD PhD, Yasuhide Hayashi, MD PhD, Hiroyuki Mano, MDPhD, Satoru Miyano, PhD, Akira Oka, MD PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2016) 128 (22): 909.
https://doi.org/10.1182/blood.V128.22.909.909
Published: 2016
Journal Articles

Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Yuka Yamashita, MS, Masashi Sanada, MD PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Hiroko Tanaka, BA, Yuichi Shiraishi, MD PhD, Kenichi Chiba, BA, Toshihiko Imamura, MD PhD, Satoru Miyano, MD PhD, Koji Kato, MD PhD, Seiji Kojima, MD PhD, Seishi Ogawa, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1425.
https://doi.org/10.1182/blood.V126.23.1425.1425
Published: 2015
Journal Articles

Whole-Exome Analysis of Autoimmune Lymphoproliferative Syndrome-like Diseases

Masatoshi Takagi, MD PhD, Kohsuke Imai, MD PhD, Jinhua Piao, DDS, PhD, Motoy Yamashita, MD, Akihiro Hoshino, MD, Tsubasa Okano, MD, Hirokazu Kanegane, MD PhD, Hideki Muramatsu, MD PhD, Yusuke Okuno, MD PhD, Yuichi Shiraishi, MD PhD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Satoru Miyano, MD PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Seishi Ogawa, MD PhD, Yasuhide Hayashi, MD PhD, Seiji Kojima, MD PhD, Tomohiro Morio, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1022.
https://doi.org/10.1182/blood.V126.23.1022.1022
Published: 2015