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Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5051.
https://doi.org/10.1182/blood-2019-124384
Published: 2019
Journal Articles

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Larry D Cripe, MD, Katie J Sargent, RN, G. David Roodman, MD PhD, Hamid Sayar, MD MSc, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Rajasubramaniam Shanmugam, PhD, Adriana Rogozea, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3949.
https://doi.org/10.1182/blood-2018-99-111181
Published: 2018
Journal Articles

Characteristics, Treatment Patterns and Outcomes Among Newly Diagnosed Patients (pts) with Acute Myeloid Leukemia (AML) Who Present with Hyperleukocytosis: Findings from a Large International Patient Cohort

Maximilian Stahl, MD, Wei Wei, MD PhD, Pau Montesinos, MD PhD, Etienne Lengline, MD, Rory M Shallis, MD, Judith Neukirchen, MD, Vijaya R. Bhatt, MD, Mikkael A. Sekeres, MD MS, Amir T. Fathi, MD, Heiko Konig, MD PhD, Selina Luger, MD, Irum Khan, MBBS, Gail J. Roboz, MD, Thomas Cluzeau, MD PhD, David Martínez-Cuadron, MD, Emmanuel Raffoux, MD, Ulrich Germing, MD, Jayadev Manikkam Umakanthan, MBBS, Sudipto Mukherjee, MD PhD MPH, Andrew M. Brunner, MD, Adam M. Miller, BS, MD, Christine M. McMahon, MD, Ellen K. Ritchie, MD, Rebeca Rodríguez-Veiga, MD, Raphael Itzykson, MD PhD, Blanca Boluda, MD, Florence Rabian, MD, Mar Tormo, MD, Evelyn Gloria Acuna Cruz, MD, Emma Rabinovich, MD, Brendan Yoo, Nikolai A. Podoltsev, MD PhD, Steven D. Gore, MD, Amer M. Zeidan, MBBS, MHS
Journal: Blood
Blood (2018) 132 (Supplement 1): 4040.
https://doi.org/10.1182/blood-2018-99-112974
Published: 2018
Journal Articles

Outcomes of Patients with Newly-Diagnosed Acute Myeloid Leukemia and Hyperleukocytosis Who Did Not Undergo Intensive Chemotherapy: Results from a Large International Database

Rory M Shallis, MD, Maximilian Stahl, MD, Wei Wei, MD PhD, Pau Montesinos, MD PhD, Etienne Lengline, MD, Judith Neukirchen, MD, Vijaya R. Bhatt, MD, Mikkael A. Sekeres, MD MS, Amir T. Fathi, MD, Heiko Konig, MD PhD, Selina Luger, MD, Irum Khan, MBBS, Gail J. Roboz, MD, Thomas Cluzeau, MD PhD, David Martínez-Cuadron, MD, Emmanuel Raffoux, MD, Ulrich Germing, MD, Jayadev Manikkam Umakanthan, MBBS, Sudipto Mukherjee, MD PhD MPH, Andrew M. Brunner, MD, Adam M. Miller, BS, MD, Christine M. McMahon, MD, Ellen K. Ritchie, MD, Rebeca Rodríguez-Veiga, MD, Raphael Itzykson, MD PhD, Blanca Boluda, MD, Florence Rabian, MD, Mar Tormo, MD PhD, Evelyn Gloria Acuna Cruz, MD, Nikolai Podoltsev, MD PhD, Steven D. Gore, MD, Amer M. Zeidan, MBBS, MHS
Journal: Blood
Blood (2018) 132 (Supplement 1): 3999.
https://doi.org/10.1182/blood-2018-99-119755
Published: 2018
Journal Articles

Integrative Analysis of AML Cell Response to Cytarabine Reveals Synergistic Opportunities Centered on Cholesterol Metabolism

Fangli Chen, MD PhD, Xue Wu, PhD, Rogozea Adriana, Bin Guo, PhD, H. Scott Boswell, MD, George A. Calin, MD PhD, Mircea Ivan, MD PhD, Heiko Konig, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2631.
https://doi.org/10.1182/blood-2018-99-113634
Published: 2018
Journal Articles

A Single Institution Comparison of Treatment Outcomes of Adolescent and Young Adult (AYA) Patients with Acute Myeloid Leukemia (AML) Treated in Pediatric and Adult Settings

Vaibhav Agrawal, MD MBA, Jordyn Griffin, MD, Andrew O'Brien, MD, Robert P. Nelson, Jr., MD, Jodi L. Skiles, MD, Heiko Konig, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5859.
https://doi.org/10.1182/blood-2018-99-114189
Published: 2018
Journal Articles

Reduced Chemosensitivity of FLT3/ITD Mutated Cells to Cytarabine and Quizartinib Under Hypoxic Conditions

Heiko Konig, MD PhD, Adriana L Rogozea, Garrett H Kinnebrew, MD, Mircea Ivan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1579.
https://doi.org/10.1182/blood.V128.22.1579.1579
Published: 2016
Journal Articles

The Combination Of FLT3 Inhibition and Hypomethylation Confers Synergistic Anti-Leukemic Effects On FLT3/ITD Positive AML Cell Lines and Primary Cells

Heiko Konig, MD PhD, Mark Levis, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3965.
https://doi.org/10.1182/blood.V122.21.3965.3965
Published: 2013
Journal Articles

The Sal-Like 1 (SALL1) Protein is Highly Expressed in Primary Bone Marrow Cells Derived From Patients with Acute Myeloid Leukemia.

Heiko Konig, MD, PhD, Susan Kiefer, PhD, Lynn Robbins, Michael Rauchman, MD, Huda S. Salman, MD
Journal: Blood
Blood (2009) 114 (22): 1285.
https://doi.org/10.1182/blood.V114.22.1285.1285
Published: 2009
Journal Articles

The Polyamide-Chlorambucil Conjugate 1R-Chl Effectively Inhibits Proliferation and Induces Apoptosis in CML Progenitor Cells

Heiko Konig, MD, PhD, C. James Chou, PhD, Joel M. Gottesfeld, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2008) 112 (11): 5031.
https://doi.org/10.1182/blood.V112.11.5031.5031
Published: 2008