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Journal Articles

Development of BAX 826, a Polysialylated Full-Length rFVIII with Significantly Improved PK Properties

Peter L. Turecek, PhD, Juergen Siekmann, PhD, Artur Mitterer, PhD, Michael Graninger, PhD, Gerald Schrenk, PhD, Peter Matthiessen, PhD, Hanspeter Rottensteiner, PhD, Werner Hoellriegl, DVM, Marietta Putz, MS, Hans Peter Schwarz, MD, Friedrich Scheiflinger, PhD

Blood (2015) 126 (23): 3536.

https://doi.org/10.1182/blood.V126.23.3536.3536

Published: 2015

Journal Articles

Preclinical Safety of Baxter's Recombinant ADAMTS13

Christina Piskernik, DVM, Barbara Dietrich, DVM, Susan Kubik, BSc, Tanja Ruthsatz, DVM, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, DVM

Blood (2012) 120 (21): 3381.

https://doi.org/10.1182/blood.V120.21.3381.3381

Published: 2012

Journal Articles

Preclinical Efficacy Testing of Baxter's Recombinant ADAMTS13 in a Mouse Model of TTP.

Alexandra Schiviz, DVM, Marlene Resch, DVM, Elisa Farnleitner, Hanspeter Rottensteiner, PhD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Werner Hoellriegl, PhD, Eva-Maria Muchitsch, DVM

Blood (2012) 120 (21): 2216.

https://doi.org/10.1182/blood.V120.21.2216.2216

Published: 2012

Journal Articles

Impact of Factor IXa Content On Function, Safety and Efficacy of Recombinant Factor IX Products.

Wilfried Auer, PhD, Hanspeter Rottensteiner, PhD, Gerald Schrenk, PhD, Werner Hoellriegl, PhD, Alexandra Schiviz, DVM, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Peter L Turecek, PhD, Eva-Maria Muchitsch, PhD

Blood (2012) 120 (21): 2233.

https://doi.org/10.1182/blood.V120.21.2233.2233

Published: 2012

Journal Articles

Preclinical Immunogenicity Assessment of Baxter‘s Longer-Acting FVIII Candidate BAX 855 Using Novel Preclinical Models,

Frank M Horling, PhD, Sandra Schwele, PhD, Christian Lubich, Rafi U Ahmad, PhD, Markus Weiller, PhD, Margit Spatzenegger, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2011) 118 (21): 3323.

https://doi.org/10.1182/blood.V118.21.3323.3323

Published: 2011

Journal Articles

Preclinical Immunogenicity Assessment of Baxter‘s Recombinant Factor VIIa,

Frank M Horling, PhD, Christine Lenk, Rafi Uddin Ahmad, PhD, Markus Weiller, PhD, Maria Schuster, DVM, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2011) 118 (21): 3327.

https://doi.org/10.1182/blood.V118.21.3327.3327

Published: 2011

Journal Articles

Safety of Baxter’s Longer Acting rFVIII (BAX 855) After Repeated Application in Rats and Cynomolgus Monkeys

Barbara Dietrich, DVM, Margit Spatzenegger, PhD, Reinhard Stidl, PhD, Martin Wolfsegger, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4345.

https://doi.org/10.1182/blood.V118.21.4345.4345

Published: 2011

Journal Articles

Pharmacokinetics of Baxter’s Longer Acting rFVIII (BAX 855) in Factor VIII Ko Mice, Rats and Cynomolgus Monkeys

Gerald Hoebarth, DVM, Susan Kubik, BSc, Martin Wolfsegger, PhD, John-Philip Lawo, Alfred Weber, PhD, Herbert Gritsch, Werner Hoellriegl, Alexandra Schiviz, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Peter L Turecek, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4346.

https://doi.org/10.1182/blood.V118.21.4346.4346

Published: 2011

Journal Articles

Efficacy of Baxter’s Longer Acting rFVIII (BAX 855) in Mouse Models of Hemophilia A

Alexandra Schiviz, Eder Barbara, John-Philip Lawo, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Peter L Turecek, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, Werner Hoellriegl

Blood (2011) 118 (21): 4350.

https://doi.org/10.1182/blood.V118.21.4350.4350

Published: 2011

Journal Articles

Preclinical Safety Pharmacology of Baxter’s Longer Acting rFVIII (BAX 855)

Barbara Dietrich, DVM, Susan Kubik, BSc, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4357.

https://doi.org/10.1182/blood.V118.21.4357.4357

Published: 2011

Journal Articles

Absorption, Metabolism, Distribution, and Excretion of Longer Acting rFVIII (BAX 855) Following Intravenous Administration to Rats

Reinhard Stidl, PhD, Juergen Siekmann, PhD, Sean M Culbertson, Tony Vinson, Antoni Kozlowski, Xiaoming Shen, Mary J Bossard, Hanspeter Rottensteiner, PhD, Barbara Dietrich, DVM, Chyung Cook, Peter L Turecek, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4358.

https://doi.org/10.1182/blood.V118.21.4358.4358

Published: 2011

Journal Articles

Deciphering of CD4 + T Cell Subsets Involved in Maintenance and Break of Immune Tolerance in a Humanized Mouse Model That Is Immune Tolerant to Human FVII

Christine Lenk, Markus Pasztorek, Markus Weiller, PhD, Rafi Uddin Ahmad, PhD, Hans Peter Schwarz, MD, Friedrich Scheiflinger, PhD, Birgit M Reipert, PhD, Maurus de la Rosa, PhD

Blood (2011) 118 (21): 2188.

https://doi.org/10.1182/blood.V118.21.2188.2188

Published: 2011

Journal Articles

Induction and Break of Immune Tolerance to Human FVIII in a HLA-DRB1*1501 Humanized Hemophilic Mouse Model

Katharina Nora Steinitz, PhD, Brigitte Binder, Christian Lubich, Rafi Uddin Ahmad, PhD, Markus Weiller, PhD, Maurus de la Rosa, PhD, Hans Peter Schwarz, MD, Friedrich Scheiflinger, PhD, Birgit M Reipert, PhD

Blood (2011) 118 (21): 2280.

https://doi.org/10.1182/blood.V118.21.2280.2280

Published: 2011

Journal Articles

Preclinical Safety of Baxter's Recombinant Factor IX

Barbara Dietrich, PhD, Susan Kubik, PhD, Wilfried Auer, PhD, Kuno Wuersch, PhD, Birgit Reipert, PhD, Frank Horling, PhD, Martin Wolfsegger, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 4654.

https://doi.org/10.1182/blood.V116.21.4654.4654

Published: 2010

Journal Articles

Single Dose Pharmacokinetics of a Recombinant FVIIa In Factor VIII KO Mice, Rats, and Cynomolgus Monkeys

Gerald Hoebarth, PhD, Susan Kubik, PhD, Martin Wolfsegger, PhD, John-Philip Lawo, PhD, Alfred Weber, PhD, Herbert Gritsch, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 4655.

https://doi.org/10.1182/blood.V116.21.4655.4655

Published: 2010

Journal Articles

Preclinical Efficacy Testing of Baxter's Recombinant FVIIa

Alexandra Schiviz, PhD, John-Philip Lawo, PhD, Marlene Resch, Peter Leidenmuehler, Bettina Bischetsrieder, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Werner Hoellriegl, PhD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 4659.

https://doi.org/10.1182/blood.V116.21.4659.4659

Published: 2010

Journal Articles

Toxico-Kinetics of Recombinant VWF In Non-Human Primates and Rabbits

Eva-Maria Muchitsch, PhD, Barbara Dietrich, PhD, Hanspeter Rottensteiner, PhD, Herbert Gritsch, Hartmut J. Ehrlich, MD, Peter Turecek, PhD, Hans Peter Schwarz, MD

Blood (2010) 116 (21): 1414.

https://doi.org/10.1182/blood.V116.21.1414.1414

Published: 2010

Journal Articles

Cleavage of Recombinant and Plasma-Derived VWF by Human ADAMTS13

Hanspeter Rottensteiner, PhD, Katalin Varadi, PhD, Susanne Vejda, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Peter Turecek, PhD

Blood (2010) 116 (21): 1415.

https://doi.org/10.1182/blood.V116.21.1415.1415

Published: 2010

Journal Articles

Preclinical Safety of Baxter's Recombinant Factor VIIa

Barbara Dietrich, PhD, Susan Kubik, PhD, Wilfried Auer, PhD, Birgit Reipert, PhD, Frank Horling, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 1417.

https://doi.org/10.1182/blood.V116.21.1417.1417

Published: 2010

Journal Articles

Agonist for Toll-Like Receptor (TLR) 9 Amplifies as Well as Inhibits the Differentiation of FVIII-Specific Memory B Cells into Antibody-Producing Plasma Cells in Vitro and in Vivo.

Peter Allacher, Christina Hausl, PhD, Aniko Ginta Pordes, Rafi Uddin Ahmad, PhD, Hartmut J Ehrlich, MD, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2008) 112 (11): 3382.

https://doi.org/10.1182/blood.V112.11.3382.3382

Published: 2008

NARROW

Development of BAX 826, a Polysialylated Full-Length rFVIII with Significantly Improved PK Properties

Preclinical Safety of Baxter's Recombinant ADAMTS13

Preclinical Efficacy Testing of Baxter's Recombinant ADAMTS13 in a Mouse Model of TTP.

Impact of Factor IXa Content On Function, Safety and Efficacy of Recombinant Factor IX Products.

Preclinical Immunogenicity Assessment of Baxter‘s Longer-Acting FVIII Candidate BAX 855 Using Novel Preclinical Models,

Preclinical Immunogenicity Assessment of Baxter‘s Recombinant Factor VIIa,

Safety of Baxter’s Longer Acting rFVIII (BAX 855) After Repeated Application in Rats and Cynomolgus Monkeys

Pharmacokinetics of Baxter’s Longer Acting rFVIII (BAX 855) in Factor VIII Ko Mice, Rats and Cynomolgus Monkeys

Efficacy of Baxter’s Longer Acting rFVIII (BAX 855) in Mouse Models of Hemophilia A

Preclinical Safety Pharmacology of Baxter’s Longer Acting rFVIII (BAX 855)

Absorption, Metabolism, Distribution, and Excretion of Longer Acting rFVIII (BAX 855) Following Intravenous Administration to Rats

Deciphering of CD4 + T Cell Subsets Involved in Maintenance and Break of Immune Tolerance in a Humanized Mouse Model That Is Immune Tolerant to Human FVII

Induction and Break of Immune Tolerance to Human FVIII in a HLA-DRB1*1501 Humanized Hemophilic Mouse Model

Preclinical Safety of Baxter's Recombinant Factor IX

Single Dose Pharmacokinetics of a Recombinant FVIIa In Factor VIII KO Mice, Rats, and Cynomolgus Monkeys

Preclinical Efficacy Testing of Baxter's Recombinant FVIIa

Toxico-Kinetics of Recombinant VWF In Non-Human Primates and Rabbits

Cleavage of Recombinant and Plasma-Derived VWF by Human ADAMTS13

Preclinical Safety of Baxter's Recombinant Factor VIIa

Agonist for Toll-Like Receptor (TLR) 9 Amplifies as Well as Inhibits the Differentiation of FVIII-Specific Memory B Cells into Antibody-Producing Plasma Cells in Vitro and in Vivo.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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