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Journal Articles

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Brady Trevisan, Martin Rodriguez, BSc, Sunil George, PhD, Shannon Lankford, Jordan E Shields, MS, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-140745

Published: 2020

Journal Articles

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Quan DM Pham, Martin Rodriguez, BSc, Ritu M Ramamurthy, Sunil George, PhD, Jorge Figueroa, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-140883

Published: 2020

Journal Articles

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Martin Rodriguez, BSc, Brady Trevisan, Sunil George, PhD, Ritu M Ramamurthy, Andrew Rabah, Jordan E Shields, MS, Denise Schwahn, DVM, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Michael Gautreaux, PhD, D.ABHI, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-140845

Published: 2020

Journal Articles

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

M. Graca Almeida-Porada, MD PhD, Sunil George, PhD, Alshaima Morsi, MD, Nadia El-Akabawy, MD, Jorge Figueroa, Jordan E Shields, MS, Diane Meares, Andrew M. Farland, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD

Blood (2017) 130 (Supplement 1): 361.

https://doi.org/10.1182/blood.V130.Suppl_1.361.361

Published: 2017

Journal Articles

Targeting T-Cell Malignancies with Chimeric Antigen Receptors Using Two Structurally Different Antigen Binding Domains Against CD5

Sunil S Raikar, MD, Lauren C Fleischer, Robert Moot, B.S., Na Yoon Paik, B.S., Kristopher Knight, B.S., Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2017) 130 (Supplement 1): 4462.

https://doi.org/10.1182/blood.V130.Suppl_1.4462.4462

Published: 2017

Journal Articles

Engineering CD5-Targeted Chimeric Antigen Receptors and Edited T Cells for the Treatment of T-Cell Leukemia

Lauren C Fleischer, Sunil S Raikar, MD, Robert Moot, B.S., Kristopher A Knight, B.S., Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2017) 130 (Supplement 1): 1914.

https://doi.org/10.1182/blood.V130.Suppl_1.1914.1914

Published: 2017

Journal Articles

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Philip Zakas, BS, Kristopher Knight, Ernest T Parker, BA, H. Trent Spencer, PhD, Eric Gaucher, PhD, Christopher B Doering, PhD

Blood (2015) 126 (23): 123.

https://doi.org/10.1182/blood.V126.23.123.123

Published: 2015

Journal Articles

Expanding the Ligand Binding Repertoire of Chimeric Antigen Receptors Using Lamprey Variable Lymphocyte Receptors

Robert Moot, BS, Sunil Raikar, MD, Lauren C Fleischer, BS, David McCarty, Melissa Querrey, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 3244.

https://doi.org/10.1182/blood.V126.23.3244.3244

Published: 2015

Journal Articles

Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a

Christopher B Doering, PhD, Gabriela Denning, PhD, Jordan E Shields, MS, William Swaney, Lilith Reeves, Punam Malik, MD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 4421.

https://doi.org/10.1182/blood.V126.23.4421.4421

Published: 2015

Journal Articles

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reginald Tran, BS, David R Myers, PhD, Jordan E Shields, MS, Byungwook Ahn, PhD, Yongzhi Qiu, PhD, Caroline Hansen, BS, Yumiko Sakurai, MSc, Robert Moot, BS, H. Trent Spencer, PhD, Christopher B Doering, PhD, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 4415.

https://doi.org/10.1182/blood.V126.23.4415.4415

Published: 2015

Journal Articles

Expansion and Bioengineering of Peripheral Blood-Derived Anti-Cancer Gd T Cells in Serum Free Media

Kathryn S Sutton, MD BS, Anindya Dasgupta, PhD, David McCarty, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 5553.

https://doi.org/10.1182/blood.V126.23.5553.5553

Published: 2015

Journal Articles

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

Harrison C. Brown, BBA, Jordan E Shields, Shangzhen Zhou, MD, J. Fraser Wright, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD

Blood (2013) 122 (21): 4210.

https://doi.org/10.1182/blood.V122.21.4210.4210

Published: 2013

Journal Articles

Development and Characterization of Recombinant Ovine Factor VIII

Philip M Zakas, Bagirath Gangadharan, MS, Graca Almeida-Porada, MD, PhD, Christopher D Porada, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD

Blood (2011) 118 (21): 1193.

https://doi.org/10.1182/blood.V118.21.1193.1193

Published: 2011

Journal Articles

Phenotypic Correction of Hemophilia A by Postnatal Intraperitoneal Transplantation of FVIII-Expressing MSC

Christopher Porada, PhD, Chad Sanada, Eason Kuo, Evan Colletti, Robert Moot, Christopher Doering, PhD, H. Trent Spencer, PhD, Graca Almeida-Porada, MD, PhD

Blood (2010) 116 (21): 249.

https://doi.org/10.1182/blood.V116.21.249.249

Published: 2010

Journal Articles

Development of a Novel Recombinant Factor VIII Product through Transgene Engineering and Lentiviral-Driven Expression

Keith W Kerstann, PhD, Pete Lollar, MD, H. Trent Spencer, PhD, Gabriela Denning, PhD, Lajos Baranyi, PhD, Robert Keefe, PhD, Boro Dropulic, MBA, PhD, Christopher B Doering, PhD

Blood (2008) 112 (11): 3072.

https://doi.org/10.1182/blood.V112.11.3072.3072

Published: 2008

Journal Articles

Humanized High-Expression Factor VIII Encoding Lentiviral Vectors Efficiently Drive High-Level FVIII Expression in Murine and Human Hematopoietic Cells

Christopher Doering, Ph.D., Gabriela Denning, Ph.D., Keith Kerstann, Ph.D., Bagirath Gangadharan, Robert Keefe, Ph.D., Boro Dropolic, Ph.D., H. Trent Spencer, PhD

Blood (2008) 112 (11): 3543.

https://doi.org/10.1182/blood.V112.11.3543.3543

Published: 2008

Journal Articles

High-Expression Porcine FVIII Driven by Erythroid-Specific Promoters for Lentiviral Vector-Mediated Gene Therapy

Nadia Sutherland, MD, Kerry L Dooriss, David A McCarty, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2008) 112 (11): 3544.

https://doi.org/10.1182/blood.V112.11.3544.3544

Published: 2008

Journal Articles

FVIII Tolerance Following Nonmyeloablative Transplantation of Hematopoietic Stem Cells Engineered To Encode a High-Expression Factor VIII Transgene in Hemophilia A Mice.

Lucienne M. Ide, BA, Bagirath Gangadharan, MS, Christopher Doering, PhD, H. Trent Spencer, PhD

Blood (2007) 110 (11): 2599.

https://doi.org/10.1182/blood.V110.11.2599.2599

Published: 2007

Journal Articles

Direct Comparison of Bioengineered Factor VIII Expression Constructs: Towards an Optimal Transgene for Gene Therapy of Hemophilia A.

Kerry L. Titus, Paul Lee, PhD, H. Trent Spencer, PhD, Christopher Doering, PhD

Blood (2006) 108 (11): 5477.

https://doi.org/10.1182/blood.V108.11.5477.5477

Published: 2006

Journal Articles

Marrow-Derived Stromal Cells as Gene Transfer Vehicles in a Murine Model of Hemophilia A.

Christopher B. Doering, PhD, Bagirath Gangadharan, MS, H. Trent Spencer, PhD

Blood (2006) 108 (11): 5489.

https://doi.org/10.1182/blood.V108.11.5489.5489

Published: 2006

NARROW

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

Targeting T-Cell Malignancies with Chimeric Antigen Receptors Using Two Structurally Different Antigen Binding Domains Against CD5

Engineering CD5-Targeted Chimeric Antigen Receptors and Edited T Cells for the Treatment of T-Cell Leukemia

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Expanding the Ligand Binding Repertoire of Chimeric Antigen Receptors Using Lamprey Variable Lymphocyte Receptors

Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Expansion and Bioengineering of Peripheral Blood-Derived Anti-Cancer Gd T Cells in Serum Free Media

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

Development and Characterization of Recombinant Ovine Factor VIII

Phenotypic Correction of Hemophilia A by Postnatal Intraperitoneal Transplantation of FVIII-Expressing MSC

Development of a Novel Recombinant Factor VIII Product through Transgene Engineering and Lentiviral-Driven Expression

Humanized High-Expression Factor VIII Encoding Lentiviral Vectors Efficiently Drive High-Level FVIII Expression in Murine and Human Hematopoietic Cells

High-Expression Porcine FVIII Driven by Erythroid-Specific Promoters for Lentiviral Vector-Mediated Gene Therapy

FVIII Tolerance Following Nonmyeloablative Transplantation of Hematopoietic Stem Cells Engineered To Encode a High-Expression Factor VIII Transgene in Hemophilia A Mice.

Direct Comparison of Bioengineered Factor VIII Expression Constructs: Towards an Optimal Transgene for Gene Therapy of Hemophilia A.

Marrow-Derived Stromal Cells as Gene Transfer Vehicles in a Murine Model of Hemophilia A.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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