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Guy J. Leclerc, PhD
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Journal Articles

The NEDD8 Activating Enzyme Inhibitor Pevonedistat Induces ER Stress/UPR-Mediated Cell Death and Rebalances Homeostasis of Pro- and Anti-Apoptotic Proteins in Favor of Cell Death in Acute Lymphoblastic Leukemia Cells

Gilles M. Leclerc, PhD, Shuhua Zheng, BS, Guy J. Leclerc, PhD, Joanna DeSalvo, BSc, Ronan T. Swords, MDPhDFRCPI FRCPath, Julio C. Barredo, MD
Journal: Blood
Blood (2015) 126 (23): 1327.
https://doi.org/10.1182/blood.V126.23.1327.1327
Published: 2015
Journal Articles

BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

Guy J. Leclerc, PhD, Joanna DeSalvo, B.Sc., Gilles M. Leclerc, PhD, Theodore J. Lampidis, PhD, Julio C. Barredo, MD
Journal: Blood
Blood (2014) 124 (21): 916.
https://doi.org/10.1182/blood.V124.21.916.916
Published: 2014
Journal Articles

Histone Deacetylase Inhibitor Induces FPGS mRNA Expression in Childhood B-Precursor and T Acute Lymphoblastic Leukemia: Implication of Combination Therapy with Methotrexate To Enhance Cytotoxicity.

Guy J. Leclerc, PhD, Julio C. Barredo, M.D.
Journal: Blood
Blood (2007) 110 (11): 864.
https://doi.org/10.1182/blood.V110.11.864.864
Published: 2007
Journal Articles

TEL/AML1 and E2A/PBX1 Tranlsocations Lead to Altered Folylpoly-γ-Glutamate Synthetase (FPGS) Expression in ALL.

Julio C. Barredo, MD, Tingting Kinser, Guy J. Leclerc, PhD
Journal: Blood
Blood (2005) 106 (11): 539.
https://doi.org/10.1182/blood.V106.11.539.539
Published: 2005
Journal Articles

Differences in Folylpoly-γ-Glutamate Synthetase (FPGS) Expression in Childhood ALL Result from Cell Lineage of Origin and Presence of Non-Random Translocations.

Julio C. Barredo, MD, Sanja Altman-Hamandzic, Guy J. Leclerc, PhD
Journal: Blood
Blood (2004) 104 (11): 2087.
https://doi.org/10.1182/blood.V104.11.2087.2087
Published: 2004