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Gerrit Jansen, PhD
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Journal Articles

Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells

Jacqueline Cloos, PhD, Godefridus J Peters, PhD, Marjon Al, BSc, Yehuda G Assaraf, PhD, Lixia Wang, PhD, Jack W. Singer, MD, Jorge E. Cortes, MD, Gert J. Ossenkoppele, MD PhD, Gerrit Jansen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3945.
https://doi.org/10.1182/blood-2018-99-114447
Published: 2018
Journal Articles

Marcks Marks Resistance to Proteasome Inhibitors: Exocytosis of Polyubiquitinated Proteins in Bortezomib-Resistant Leukemia Cells

Niels Franke, MD, Gertjan J.L. Kaspers, MD PhD, Yehuda G Assaraf, PhD, Johan Van Meerloo, MSc, Denise Niewerth, PhD, Terzah M. Horton, MD PhD, Wee Joo Chng, MD PhD, Chonglei Bi, B.S, Rene X. Menezes, PhD, Renée J. Musters, PhD, Pino J. Poddighe, PhD, Floortje Kessler, Serge Smeets, PhD, Bauke Ylstra, PhD, Sonja Zweegman, MD PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2015) 126 (23): 3712.
https://doi.org/10.1182/blood.V126.23.3712.3712
Published: 2015
Journal Articles

Spliceosome Inhibitor Meayamycin B As a Novel Potential Chemotherapeutic Agent in ALL and AML

Anna Wojtuszkiewicz, MSc, Yehuda G Assaraf, PhD, Gerrit Jansen, PhD, Kazunori Koide, PhD, Robert K. Bressin, Upamanyu Basu, Edwin Sonneveld, PhD, Elisa Giovannetti, PhD, Gertjan Kaspers, MD PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2014) 124 (21): 924.
https://doi.org/10.1182/blood.V124.21.924.924
Published: 2014
Journal Articles

The Novel Immunoproteasome Inhibitor PR-924: Anti-Leukemic Activity and Mechanisms Of Resistance

Denise Niewerth, MSc, Johan van Meerloo, MSc, Yehuda Assaraf, PhD, Gerrit Jansen, PhD, Tessa C Hendrickx, BSc, Christopher J. Kirk, Ph.D, Janet Anderl, MS, Sonja Zweegman, MD PhD, Jacqueline Cloos, PhD, Gertjan Kaspers, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3841.
https://doi.org/10.1182/blood.V122.21.3841.3841
Published: 2013
Journal Articles

Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutive PSMB5

Denise Niewerth, MSc, Niels Franke, MD, Gerrit Jansen, PhD, Yehuda Assaraf, PhD, Johan van Meerloo, MSc, Christopher J Kirk, PhD, Sonja Zweegman, MD, PhD, Gertjan J.L. Kaspers, MD, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2012) 120 (21): 1346.
https://doi.org/10.1182/blood.V120.21.1346.1346
Published: 2012
Journal Articles

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression

Denise Niewerth, MSc, Niels Franke, MD, Gerrit Jansen, PhD, Johan van Meerloo, MSc, Yehuda Assaraf, Prof, Christopher J Kirk, Elena T Chan, Sonja Zweegman, MD, PhD, Gertjan J. Kaspers, MD, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2011) 118 (21): 1513.
https://doi.org/10.1182/blood.V118.21.1513.1513
Published: 2011
Journal Articles

The Novel Proteasome Inhibitor 5-Amino-8-Hydroxyquinole (5AHQ) Overcomes Bortezomib Resistance in Malignant Hematological Cell Line Models Harboring Mutations in the PSMB5 Gene.

Niels E Franke, MD, MSc, Johan van Meerloo, B.ASc, Linda Slot, MSc, Xiaoming Li, PhD, Tabitha E Wood, PhD, Katarina Vojtekova, MSc, Sue Ellen Verbrugge, MSc, Gertjan Kaspers, MD, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2009) 114 (22): 940.
https://doi.org/10.1182/blood.V114.22.940.940
Published: 2009
Journal Articles

Acquired Resistance to Bortezomib in Human RPMI-8226 Multiple Myeloma Cells: Molecular Characterization, Cross-Resistance with Other Proteasome Inhibitors but Marked Sensitization to Glucocorticoids

Niels E Franke, MD, MSc, Gertjan L Kaspers, MD, PhD, Nynke van den Berg, Ina van Zantwijk, Katarina Vojtekova, MSc, Uzma Yaqub, BSc, Serge Smeets, MSc, Bauke Ylstra, PhD, Sonja Zweegman, MD, PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2008) 112 (11): 2640.
https://doi.org/10.1182/blood.V112.11.2640.2640
Published: 2008
Journal Articles

Acquisition of Mutations in the PSMB5 Gene during Chronic Exposure of Human Acute Lymphoblastic Leukemia CCRF-CEM Cells to the Proteasome Inhibitor Bortezomib

Niels E Franke, MD, MSc, Ruud Oerlemans, MSc, Ina van Zantwijk, Katarina Vojtekova, MSc, Gertjan L Kaspers, MD, PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2008) 112 (11): 2642.
https://doi.org/10.1182/blood.V112.11.2642.2642
Published: 2008
Journal Articles

Ex Vivo Activity of Bortezomib and Dexamethasone Combinations Against Childhood Acute Leukemia Cells.

Niels E. Franke, MD, Ina van Zantwijk, Gertjan J. Kaspers, MD,PhD, Josefien Vink, MSc, Dirk Reinhardt, MD,PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2007) 110 (11): 4205.
https://doi.org/10.1182/blood.V110.11.4205.4205
Published: 2007
Journal Articles

Molecular Mechanisms of Bortezomib Resistance in Acute Lymphoblastic Leukemia Cells in Comparison with Multiple Myeloma Cells.

Niels E. Franke, MD, Ruud Oerlemans, MSc, Sonja Zweegman, MD, PhD, Ina van Zantwijk, Gertjan J. Kaspers, MD, PhD, Gerrit Jansen, PhD, Jacqueline Cloos, PhD
Journal: Blood
Blood (2007) 110 (11): 3469.
https://doi.org/10.1182/blood.V110.11.3469.3469
Published: 2007
Journal Articles

Sensitization of Leukemic Cells for Glucocorticoids by Inhibition of NFκB Activity.

Jacqueline Cloos, PhD, Josefien Vink, MSc, Marjolein van Miltenburg, Ruud Oerlemans, MSc, Joost van der Heijden, MD, Ben A.C. Dijkmans, MD, PhD, Gerrit Jansen, PhD, Gertjan J.L. Kaspers, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 3395.
https://doi.org/10.1182/blood.V104.11.3395.3395
Published: 2004