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Journal Articles

NPM-ALK Upregulates Jab1/Csn5 through STAT3 Activation in Anaplastic Large Cell Lymphoma: A Novel Function of NPM-ALK That Contributes to PD1/PD-L1 Immune Checkpoint Regulation

Elias Drakos, MD PhD Prof., Konstantina Stathopoulou, MSc., Lingxiao Li, PhD, Daniel Bilbao, Vasiliki Leventaki, Pedro Farrajota Neves Da Silva, MD, Vasileios Atsaves, PhD, Anders Österborg, MD PhD, L. Jeffrey Medeiros, MD, Francisco Vega, MD PhD, Jonathan H. Schatz, MD, Francois Claret, PhD, George Z. Rassidakis, MD PhD Prof.

Blood (2019) 134 (Supplement_1): 2796.

https://doi.org/10.1182/blood-2019-130457

Published: 2019

Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

Mohammad Hojjat-Farsangi, MSc,PhD, Amineh Ghaderi, MSc, AmirHossein Daneshmanesh, MD PhD, Jemina Lehto, MSc, Ali Moshfegh, MSc,PhD, Parviz Kokhaei, MSc,PhD, Jan Vågberg, MSc,PhD, Elisabeth Olsson, MSc,PhD, Charlotta Löfberg, MSc,PhD, Charlotta Carina Norström, MSc,PhD, Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Håkan Mellstedt, MD PhD Prof.

Blood (2019) 134 (Supplement_1): 2565.

https://doi.org/10.1182/blood-2019-126801

Published: 2019

Journal Articles

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Håkan Mellstedt, MD PhD Prof., Amineh Ghaderi, MSc, Johanna Aschan, MSc, Fariba Mozaffari, MSc,PhD, Ali Moshfegh, MSc,PhD, Birgitta Sander, MD PhD Prof., Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Mohammad Hojjat-Farsangi, MSc,PhD

Blood (2019) 134 (Supplement_1): 5312.

https://doi.org/10.1182/blood-2019-129773

Published: 2019

Journal Articles

Encouraging Outcomes with Intensive Chemotherapy for Patients with Primary Mediastinal B-Cell Lymphoma - a Swedish Lymphoma Register Study

Tove Wästerlid, MD PhD, George Z. Rassidakis, MD PhD Prof., Birgitta Sander, MD PhD Prof., Karin E. Smedby, MD PhD

Blood (2019) 134 (Supplement_1): 1618.

https://doi.org/10.1182/blood-2019-122819

Published: 2019

Journal Articles

Nutlin-3A, an MDM2 Antagonist, Induces p53-Dependent Cell Cycle Arrest and Apoptosis in Hodgkin Lymphoma (HL).

Elias Drakos, MD, Athanasios Thomaides, MD, Jiang Li, MD,PhD, Marina Konopleva, MD,PhD, L. Jeffrey Medeiros, MD, Michael Andreeff, MD,PhD, George Z. Rassidakis, MD,PhD

Blood (2006) 108 (11): 2506.

https://doi.org/10.1182/blood.V108.11.2506.2506

Published: 2006

Journal Articles

Overexpression of CXCR4 in Acute Myeloid Leukemia Predicts Adverse Overall and Progression-Free Survival Independently of FLT3 Gene Mutation.

Sergej Konoplev, MD, PhD, George Z. Rassidakis, MD,PhD, Elihu H. Estey, MD, Hagop M. Kantarjian, MD, Xuelin Huang, PhD, Lianchun Xiao, Michael Andreeff, MD,PhD, Marina Konopleva, MD,PhD, L. Jeffrey Medeiros, MD

Blood (2006) 108 (11): 1890.

https://doi.org/10.1182/blood.V108.11.1890.1890

Published: 2006

Journal Articles

NPM-ALK Promotes Cell Cycle Progression through Activation of JNK and c-Jun in Anaplastic Large Cell Lymphoma.

Vasiliki Leventaki, MD, Elias Drakos, MD, Megan Lim, MD, Kojo S. Elenitoba-Johnson, MD, Francois-Xavier Claret, PhD, L. Jeffrey Medeiros, MD, George Z. Rassidakis, MD,PhD

Blood (2006) 108 (11): 2057.

https://doi.org/10.1182/blood.V108.11.2057.2057

Published: 2006

Journal Articles

Differential Expression of the Homeobox Gene MIXL1 in Non Hodgkin (NHL) and Hodgkin Lymphomas (HL).

Elias Drakos, MD, George Z. Rassidakis, MD, PhD, Wei Guo, PhD, L. Jeffrey Medeiros, MD, Lalitha Nagarajan, PhD

Blood (2005) 106 (11): 3014.

https://doi.org/10.1182/blood.V106.11.3014.3014

Published: 2005

Journal Articles

Heat Shock Protein 90 (HSP90) Inhibition by the Small Molecule 17-AAG Induces Cell Cycle Arrest and Apoptosis in Anaplastic Large Cell Lymphoma (ALCL) Irrespective of ALK Expression: Role of Akt, ERK and ALK Kinases in the Molecular Mechanisms of 17-AAG Anti-Tumor Activity.

Georgios V. Georgakis, MD, Yang Li, MS, George Z. Rassidakis, MD, PhD, Felipe Samaniego, MD, L. Jeffrey Medeiros, MD, Anas Younes, MD

Blood (2005) 106 (11): 2811.

https://doi.org/10.1182/blood.V106.11.2811.2811

Published: 2005

Journal Articles

Inhibition of AKT/mTOR Signaling Pathway Induces Cell Cycle Arrest and Apoptosis in Acute Myelogenous Leukemia.

Weina Chen, MD, PhD, Ioannis Grammatikakis, BS, Jiang Li, MD, Vassiliki Leventaki, MD, L. Jeffrey Medeiros, MD, George Z. Rassidakis, MD, PhD

Blood (2005) 106 (11): 2355.

https://doi.org/10.1182/blood.V106.11.2355.2355

Published: 2005

Journal Articles

Inhibition of AKT/mTOR Signaling Induces Cell Cycle Arrest and Apoptosis in Mantle Cell Lymphoma.

Evangelia Peponi, MD, Elias Drakos, MD, Guadalupe Reyes, PhD, Vassiliki Leventaki, MD, L. Jeffrey Medeiros, MD, George Z. Rassidakis, MD, PhD

Blood (2005) 106 (11): 2415.

https://doi.org/10.1182/blood.V106.11.2415.2415

Published: 2005

Journal Articles

cJun Is Phosphorylated at Ser73 and Contributes to Cell Cycle Progression in Anaplastic Large Cell Lymphoma.

Vassiliki Leventaki, MD, Elias Drakos, MD, Francois-Xavier Claret, PhD, L. Jeffrey Medeiros, MD, George Z. Rassidakis, MD, PhD

Blood (2005) 106 (11): 2620.

https://doi.org/10.1182/blood.V106.11.2620.2620

Published: 2005

Journal Articles

Activation of mTOR Signaling Pathway Contributes to Tumoral Cell Survival in ALK-Positive Anaplastic Large Cell Lymphoma.

Francisco Vega, MD, PhD, L. Jeffrey Medeiros, MD, Coralyn Atwell, BS, Jeong Hee Cho, MD, PhD, Ling Tian, PhD, Francois-Xavier Claret, PhD, George Z. Rassidakis, MD, PhD

Blood (2005) 106 (11): 2419.

https://doi.org/10.1182/blood.V106.11.2419.2419

Published: 2005

Journal Articles

Heat Shock Protein 90 (HSP90) Is Overexpressed in Primary and Cultured Hodgkin Lymphoma (HL) Cells: Role of Therapeutic Targeting Using the Small Molecule Inhibitor 17-AAG.

Georgios V. Georgakis, MD, Yang Li, MS, George Z. Rassidakis, MD, PhD, L. Jeffrey Medeiros, MD, Anas Younes, MD

Blood (2005) 106 (11): 2422.

https://doi.org/10.1182/blood.V106.11.2422.2422

Published: 2005

Journal Articles

cDNA Microarray Analysis of Genes Associated with NPM-ALK Overexpression in Anaplastic Large Cell Lymphomas.

Megan S. Lim4, MD PhD, G. Christopher Fillmore4, PhD, Stephen D. Jenson4, BSc, Richard A. Friedman, PhD, Jonathan A. Schumacher4, Bsc, Sherrie L. Perkins4, MD PhD, George Z. Rassidakis, MD, L. Jeffrey Medeiros, MD, Mitchell S. Cairo, MD, Kojo S.J. Elenitoba-Johnson4

Blood (2004) 104 (11): 2269.

https://doi.org/10.1182/blood.V104.11.2269.2269

Published: 2004

Journal Articles

TCL1 Expression in B-Cell Tumors Is Dynamically Regulated by Maturation Stage, Proliferation, and the Follicular Microenvironment.

Marco Herling, MD, Ryuji Kobayashi, PhD, Kaushali A. Patel, MS, Kong Chao Chang, MD, Ellen Schlette, MD, George Z. Rassidakis, MD, L. Jeffrey Medeiros, MD, Dan Jones, MD, PhD

Blood (2004) 104 (11): 4333.

https://doi.org/10.1182/blood.V104.11.4333.4333

Published: 2004

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NPM-ALK Upregulates Jab1/Csn5 through STAT3 Activation in Anaplastic Large Cell Lymphoma: A Novel Function of NPM-ALK That Contributes to PD1/PD-L1 Immune Checkpoint Regulation

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Encouraging Outcomes with Intensive Chemotherapy for Patients with Primary Mediastinal B-Cell Lymphoma - a Swedish Lymphoma Register Study

Nutlin-3A, an MDM2 Antagonist, Induces p53-Dependent Cell Cycle Arrest and Apoptosis in Hodgkin Lymphoma (HL).

Overexpression of CXCR4 in Acute Myeloid Leukemia Predicts Adverse Overall and Progression-Free Survival Independently of FLT3 Gene Mutation.

NPM-ALK Promotes Cell Cycle Progression through Activation of JNK and c-Jun in Anaplastic Large Cell Lymphoma.

Differential Expression of the Homeobox Gene MIXL1 in Non Hodgkin (NHL) and Hodgkin Lymphomas (HL).

Heat Shock Protein 90 (HSP90) Inhibition by the Small Molecule 17-AAG Induces Cell Cycle Arrest and Apoptosis in Anaplastic Large Cell Lymphoma (ALCL) Irrespective of ALK Expression: Role of Akt, ERK and ALK Kinases in the Molecular Mechanisms of 17-AAG Anti-Tumor Activity.

Inhibition of AKT/mTOR Signaling Pathway Induces Cell Cycle Arrest and Apoptosis in Acute Myelogenous Leukemia.

Inhibition of AKT/mTOR Signaling Induces Cell Cycle Arrest and Apoptosis in Mantle Cell Lymphoma.

cJun Is Phosphorylated at Ser73 and Contributes to Cell Cycle Progression in Anaplastic Large Cell Lymphoma.

Activation of mTOR Signaling Pathway Contributes to Tumoral Cell Survival in ALK-Positive Anaplastic Large Cell Lymphoma.

Heat Shock Protein 90 (HSP90) Is Overexpressed in Primary and Cultured Hodgkin Lymphoma (HL) Cells: Role of Therapeutic Targeting Using the Small Molecule Inhibitor 17-AAG.

cDNA Microarray Analysis of Genes Associated with NPM-ALK Overexpression in Anaplastic Large Cell Lymphomas.

TCL1 Expression in B-Cell Tumors Is Dynamically Regulated by Maturation Stage, Proliferation, and the Follicular Microenvironment.

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