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A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics

Romane Durand, Géraldine Descamps, Céline Bellanger, Christelle Dousset, Sophie Maïga, Jean-Baptiste Alberge, Jennifer Derrien, Jonathan Cruard, Stéphane Minvielle, Nicoletta Libera Lilli, Catherine Godon, Yannick Le Bris, Benoit Tessoulin, Martine Amiot, Patricia Gomez-Bougie, Cyrille Touzeau, Philippe Moreau, David Chiron, Agnès Moreau-Aubry, Catherine Pellat-Deceunynck
Journal: Blood
Blood (2024) 143 (13): 1242–1258.
https://doi.org/10.1182/blood.2023021581
Published: 2024
Includes: Supplemental data
Journal Articles

TP53 CRISPR/Cas9 Reveals Strict BAX Dependence in the Response to BH3 Mimetic Targeting MCL1

Romane Durand, Domitille Costes-Tertrais, Geraldine Descamps, Christelle Dousset, Sophie Maïga, Jean-Baptiste Alberge, Elise Douillard, Jennifer Derrien, Celine Bellanger, David Chiron, Stephane Minvielle, Cyrille Touzeau, Philippe Moreau, Martine Amiot, Patricia Gomez-Bougie, Agnes Moreau-Aubry, Catherine Pellat-Deceunynck
Journal: Blood
Blood (2022) 140 (Supplement 1): 4198–4199.
https://doi.org/10.1182/blood-2022-155862
Published: 2022
Journal Articles

Inhibition of ATR Overcomes Chemotherapy Resistance in p53 Deficient Myeloma Cells

Louise Bouard, MDin training, Benoit Tessoulin, MD PhD, Géraldine Descamps, PhD, Cyrille Touzeau, MD PhD, Philippe Moreau, MD, Martine Amiot, PhD, Catherine Pellat-Deceunynck, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3109.
https://doi.org/10.1182/blood-2019-122547
Published: 2019
Journal Articles

Respective Place of Venetoclax and MCL1 BH3 Mimetics in Multiple Myeloma Treatment

Patricia Gomez-Bougie, PhD, Sophie Maïga, Benoit Tessoulin, MD, Jessie Bourcier, MD, Antoine Bonnet, MD, Géraldine Descamps, PhD, Carolane Seiller, Cyrille Touzeau, MD PhD, Philippe Moreau, Catherine Pellat-Deceunynck, PhD, Martine Amiot, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 953.
https://doi.org/10.1182/blood-2018-99-109987
Published: 2018
Journal Articles

The Oncolytic Measles Virus Preferentially Infects p53 Abnormal Myeloma Cells

Anne Lok, MD, Geraldine Descamps, PhD, Benoit Tessoulin, MD, Philippe Moreau, Steven Le Gouill, MD PhD, Frederic Tangy, PhD, Martine Amiot, Catherine Pellat-Deceunynck, PhD
Journal: Blood
Blood (2016) 128 (22): 310.
https://doi.org/10.1182/blood.V128.22.310.310
Published: 2016
Journal Articles

PRIMA-1 Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance

Benoît Tessoulin, Géraldine Descamps, Philippe Moreau, Sophie Maïga, Laurence Lodé, Catherine Godon, Séverine Marionneau-Lambot, Thibauld Oullier, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunynck
Journal: Blood
Blood (2014) 124 (10): 1626–1636.
https://doi.org/10.1182/blood-2014-01-548800
Published: 2014
Journal Articles

The p53 Reactivating Drug PRIMA-1Met Induces Apoptosis Of Myeloma Cells Via ROS Production

Benoit Tessoulin, Géraldine Descamps, PhD, Catherine Godon, Marie C Bene, PharmSciD, Philippe Moreau, MD, Steven Le Gouill, MD, PhD, Martine Amiot, PhD, Catherine Pellat-Deceunynck, PhD
Journal: Blood
Blood (2013) 122 (21): 131.
https://doi.org/10.1182/blood.V122.21.131.131
Published: 2013
Journal Articles

ABT-737 is highly effective against molecular subgroups of multiple myeloma

Linda Bodet, Patricia Gomez-Bougie, Cyrille Touzeau, Christelle Dousset, Géraldine Descamps, Sophie Maïga, Hervé Avet-Loiseau, Régis Bataille, Philippe Moreau, Steven Le Gouill, Catherine Pellat-Deceunynck, Martine Amiot
Journal: Blood
Blood (2011) 118 (14): 3901–3910.
https://doi.org/10.1182/blood-2010-11-317438
Published: 2011
Includes: Supplemental data
Journal Articles

A Humanized Anti-IGF-1R Monoclonal Antibody (AVE1642) Synergizes with Bortezomib To Induce Apoptosis in CD45neg Myeloma Cells.

Geraldine Descamps, PhD, Soraya Wuilleme-Toumi, MD, Patricia Gomez-Bougie, MD, PhD, Corinne Venot, PhD, Friedhelm Bladt Bladt, PhD, Regis Bataille, MD, PhD, Martine Amiot, PhD
Journal: Blood
Blood (2006) 108 (11): 845.
https://doi.org/10.1182/blood.V108.11.845.845
Published: 2006
Journal Articles

Identification and Hierarchy of Clonogenic Factors for Human Myeloma Cells: IL-6 for CD45+ Versus IL-6 and Growth Factors for CD45-.

Martine Amiot, PhD, Regis Bataille, MD, PhD, Madeleine Collette, Geraldine Descamps, Catherine Pellat-deceunynck, PhD
Journal: Blood
Blood (2005) 106 (11): 3407.
https://doi.org/10.1182/blood.V106.11.3407.3407
Published: 2005