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Journal Articles

Endothelial Colony-Forming Cells (ECFC) As an Autologous Model for Studying Endothelial Pathophysiology in Sickle Cell Anemia and Myeloproliferative Neoplasms

Stephanie Ospina-Prieto, PhD, Bruno K L Duarte, Jessica O F Guanaes, MSc, Fernando F. Costa, MD, PhD, Margareth C Ozelo, MD PhD

Blood (2018) 132 (Supplement 1): 74.

https://doi.org/10.1182/blood-2018-99-117218

Published: 2018

Journal Articles

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Pamela L. Brito, B.Sc, Flavia C. Leonardo, PhD, Raquel Costa, PhD, Raquel Soares, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3608.

https://doi.org/10.1182/blood-2018-99-118416

Published: 2018

Journal Articles

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

Lediana I. Miguel, M.Sc., Lidiane S. Torres, PhD, Wilson A. Ferreira, Jr., PhD, Fernanda C. Z. Fabris, B.Sc., Flavia C. Leonardo, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3610.

https://doi.org/10.1182/blood-2018-99-118974

Published: 2018

Journal Articles

A Single -195 C < G HBG1 Promoter Mediated By CRISPR/Cas9 Genome Editing Induces Fetal Hemoglobin Synthesis in Hudep-2

Priscila Keiko Matsumoto Martin, PhD, Dulcinéia Martins de Albuquerque, PhD, Carolina Lanaro, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Fernando F. Costa, MD, PhD

Blood (2018) 132 (Supplement 1): 3481.

https://doi.org/10.1182/blood-2018-99-118534

Published: 2018

Journal Articles

Benserazide As a Novel Fetal Hemoglobin Inducer: An Observational Study in Non-Carriers of Hemoglobin Disorders

Marina Erê A. H. P. Santos, BS, Felipe Vendrame, MSc, Alvaro Henrique Junqueira Tavares, BS, Leticia Marani, MSc, Paula C. de Azevedo, MD, Luiza G Piovesana, MD, Fernando F. Costa, MD, PhD, Kleber Yotsumoto Fertrin, MD PhD

Blood (2018) 132 (Supplement 1): 2345.

https://doi.org/10.1182/blood-2018-99-118997

Published: 2018

Journal Articles

Functional Analysis of the FOXO3 Gene on the Induction of Fetal Hemoglobin in K562 Cells

Flávia Peixoto Albuquerque, MD, Pedro Luis Franca-Neto, MSc, Rafael de Oliveira Franca, PhD, Aderson da Silva Araujo, PhD, Fernando F. Costa, MD, PhD, Marcos Bezerra, BSc, MSc, PhD, Antonio R. Lucena-Araujo, PhD

Blood (2018) 132 (Supplement 1): 2390.

https://doi.org/10.1182/blood-2018-99-111994

Published: 2018

Journal Articles

Exome Sequencing of Extreme Phenotypes Suggests Novel Candidate Genes As Modifiers of Leg Ulcer in Sickle Cell Anemia

Gabriela Queila de Carvalho Siqueira, Galina Ananina, PhD, Murilo Guimarães Borges, Bruno Batista de Souza, PhD, Iscia Teresinha Lopes Cendes, PhD, Fernando F. Costa, MD, PhD, Mônica Barbosa de Melo, PhD

Blood (2018) 132 (Supplement 1): 2351.

https://doi.org/10.1182/blood-2018-99-115192

Published: 2018

Journal Articles

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Hanan Chweih, M.Sc., Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Pamela L. Brito, B.Sc, Guilherme G.O. Barbosa, PhD, Flavia Garcia, PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2354.

https://doi.org/10.1182/blood-2018-99-118633

Published: 2018

Journal Articles

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Mariana Gonçalves Oliveira, M.Sc., Edson Antunes, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2362.

https://doi.org/10.1182/blood-2018-99-118813

Published: 2018

Journal Articles

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Lidiane S. Torres, PhD, Lediana I. Miguel, M.Sc., Merav E. Shaul, PhD, Zvi G. Fridlender, MD PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Sara T. Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2366.

https://doi.org/10.1182/blood-2018-99-118960

Published: 2018

Journal Articles

Proliferative Sickle Cell Retinopathy in SS and SC Hemoglobinopathies: Identification of New Candidate Genes

Sueli Matilde da Silva Costa, MD PhD, Mirta Tomie Ito, Bruno Batista Souza, PhD, Pedro Rodrigues Souza Cruz, PhD, Letícia de Carvalho Bapista, MD, Vinicius Mandolesi Rios, Marina Gonçalves Monteiro Viturino, Stephanie Ospina Pietro, PhD, Margareth C Ozelo, MD PhD, Fernando F. Costa, MD, PhD, Monica Barbosa Melo, MD PhD

Blood (2018) 132 (Supplement 1): 2368.

https://doi.org/10.1182/blood-2018-99-116312

Published: 2018

Journal Articles

Functional Properties of Hb S and Hb C in Stored Cpda-1 Red Blood Cells Concentrate — a Prospective Study

Susan Elisabeth Jorge, MMSc, PhD, Marcela Regina Grigoleto, BSc, Maria Lourdes Barjas Castro, MD PhD, Fernando F. Costa, MD, PhD, Maria de Fátima Sonati, MSc, PhD

Blood (2018) 132 (Supplement 1): 2548.

https://doi.org/10.1182/blood-2018-99-117298

Published: 2018

Journal Articles

CRISPR/Cas9 Unsettle PIP4K2A and α, β, and γ Globin Genes Expression

Danaê Malimpensa, BSc, Eliel Faber, MD, Marcus A.F. Corat, PhD, Marlous V.G. Lana, MSc, Bryan E. Strauss, PhD, Fernando F. Costa, MD, PhD, Susan Elisabeth Jorge, MMSc, PhD, Maria de Fátima Sonati, MSc, PhD

Blood (2018) 132 (Supplement 1): 2317.

https://doi.org/10.1182/blood-2018-99-117384

Published: 2018

Journal Articles

Aceruloplasminemia and Paroxysmal Nocturnal Hemoglobinuria Uncover Differential Expressions of Ceruloplasmin and Ferroportin in Immune Cells

Marina Borges, BSc,MSc, Marina Dal'Bó Pelegrini Campioni, BSc, Dulcinéia Martins de Albuquerque, PhD, Carolina Lanaro, PhD, Fernando F. Costa, MD, PhD, Kleber Yotsumoto Fertrin, MD PhD

Blood (2018) 132 (Supplement 1): 4895.

https://doi.org/10.1182/blood-2018-99-113485

Published: 2018

Journal Articles

Crosstalk between Mast Cells and Eosinophils Can Contribute to Pathophysiology of Sickle Cell Anemia

Myriam Salazar-Terreros, PhDMSc, Kleber Yotsumoto Fertrin, MD PhD, Fernando F. Costa, MD, PhD, Carla F. Franco-Penteado, PhD

Blood (2018) 132 (Supplement 1): 1070.

https://doi.org/10.1182/blood-2018-99-119029

Published: 2018

Journal Articles

Intravascular Hemolysis Leads to Priapism Phenotype: Experimental Evidence

Fabio H Silva, Beatriz Pereira Bossarino, Fabiano B Calmasini, PhD, Eduardo Costa Alexandre, PhD, Fernando F. Costa, MD, PhD

Blood (2018) 132 (Supplement 1): 1076.

https://doi.org/10.1182/blood-2018-99-115513

Published: 2018

Journal Articles

Elevated Levels of Hepatokine Angiopoietin-like 3 Correlate Paradoxically with Hypocholesterolemia and Hemolysis in Sickle Cell Anemia

Felipe Vendrame, MSc, Leticia Marani, MSc, Sara T. Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Kleber Yotsumoto Fertrin, MD PhD

Blood (2018) 132 (Supplement 1): 1069.

https://doi.org/10.1182/blood-2018-99-113851

Published: 2018

Journal Articles

The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis

Nicola Conran, PhD, Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Lediana I. Miguel, M.Sc., Flávia Costa Leonardo, PhD, Wilson A. Ferreira, Jr., PhD, Bo E. Hedlund, PhD, Howard L. Elford, PhD, Fernando F. Costa, MD, PhD

Blood (2018) 132 (Supplement 1): 1034.

https://doi.org/10.1182/blood-2018-99-119224

Published: 2018

Journal Articles

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Rafaela Mendonça, BS, Karla P.V Ferro, PhD, Flávia Costa Leonardo, PhD, Juliete A.F. Silva, PhD, Fernando Vieira Pericole, MD PhD, Sara T Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 2233.

https://doi.org/10.1182/blood.V130.Suppl_1.2233.2233

Published: 2017

Journal Articles

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Juliete A.F. Silva, PhD, Hanan Chweih, BSc, Erica M.F. Gotardo, PhD, Wilson A. Ferreira, Jr., PhD, Carla F. Franco-Penteado, B.Sc. PhD, Camila B. Almeida, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 3514.

https://doi.org/10.1182/blood.V130.Suppl_1.3514.3514

Published: 2017

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Endothelial Colony-Forming Cells (ECFC) As an Autologous Model for Studying Endothelial Pathophysiology in Sickle Cell Anemia and Myeloproliferative Neoplasms

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

A Single -195 C < G HBG1 Promoter Mediated By CRISPR/Cas9 Genome Editing Induces Fetal Hemoglobin Synthesis in Hudep-2

Benserazide As a Novel Fetal Hemoglobin Inducer: An Observational Study in Non-Carriers of Hemoglobin Disorders

Functional Analysis of the FOXO3 Gene on the Induction of Fetal Hemoglobin in K562 Cells

Exome Sequencing of Extreme Phenotypes Suggests Novel Candidate Genes As Modifiers of Leg Ulcer in Sickle Cell Anemia

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Proliferative Sickle Cell Retinopathy in SS and SC Hemoglobinopathies: Identification of New Candidate Genes

Functional Properties of Hb S and Hb C in Stored Cpda-1 Red Blood Cells Concentrate — a Prospective Study

CRISPR/Cas9 Unsettle PIP4K2A and α, β, and γ Globin Genes Expression

Aceruloplasminemia and Paroxysmal Nocturnal Hemoglobinuria Uncover Differential Expressions of Ceruloplasmin and Ferroportin in Immune Cells

Crosstalk between Mast Cells and Eosinophils Can Contribute to Pathophysiology of Sickle Cell Anemia

Intravascular Hemolysis Leads to Priapism Phenotype: Experimental Evidence

Elevated Levels of Hepatokine Angiopoietin-like 3 Correlate Paradoxically with Hypocholesterolemia and Hemolysis in Sickle Cell Anemia

The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

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