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Erik I Tucker, PhD
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Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-139948
Published: 2020
Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2433.
https://doi.org/10.1182/blood-2019-124999
Published: 2019
Journal Articles

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Michael Wallisch, PhD, Erik I Tucker, PhD, Christina U Lorentz, PhD, Jennifer Johnson, RLATG, Marschelle R Carris, BA, Owen JT McCarty, PhD, Monica T Hinds, PhD, András Gruber, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 236.
https://doi.org/10.1182/blood.V130.Suppl_1.236.236
Published: 2017
Journal Articles

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

Erik I Tucker, PhD, Brandon Markway, PhD, Michael Wallisch, PhD, Norah Green Verbout, PhD, Christina Lorentz, PhD, Marschelle Carris, Owen J.T. McCarty, PhD, Andras Gruber, MD
Journal: Blood
Blood (2016) 128 (22): 1390.
https://doi.org/10.1182/blood.V128.22.1390.1390
Published: 2016
Journal Articles

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Christina U Lorentz, PhD, Norah G Verbout, PhD, Zhiping Cao, Helen Liu, Owen J.T. McCarty, PhD, Erik I. Tucker, PhD, Andras Gruber, MD, Donna Van Winkle, PhD
Journal: Blood
Blood (2014) 124 (21): 2873.
https://doi.org/10.1182/blood.V124.21.2873.2873
Published: 2014
Journal Articles

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Michael Wallisch, PhD, Greisel Jennifer, BS, Erik I Tucker, PhD, Owen J.T. McCarty, PhD, Monica T Hinds, PhD, Sue Murray, Jeff Crosby, PhD, Brett P. Monia, PhD, Andras Gruber, MD
Journal: Blood
Blood (2014) 124 (21): 1485.
https://doi.org/10.1182/blood.V124.21.1485.1485
Published: 2014
Journal Articles

Rapid Interruption Of Occlusive Thrombus Formation By The Protein C Activator Enzyme EWE Thrombin (ProCase) In Primates

Erik I Tucker, PhD, Michael Wallisch, PhD, Philberta Y Leung, PhD, Andras Gruber, MD, Enrico Di Cera, MD, Norah G Verbout, PhD
Journal: Blood
Blood (2013) 122 (21): 202.
https://doi.org/10.1182/blood.V122.21.202.202
Published: 2013
Journal Articles

Antibodies to Human Factor XII with Antithrombotic Properties

Anton Matafonov, MD, Adam E. Gailani, Stephanie L. Grach, Philberta Y Leung, PhD, Qiufang Cheng, MD, Yipeng Geng, Owen J.T. McCarty, PhD, Erik I Tucker, PhD, Thomas Renne, MD, PhD, James H. Morrissey, PhD, Andras Gruber, MD, David Gailani, MD
Journal: Blood
Blood (2012) 120 (21): 1106.
https://doi.org/10.1182/blood.V120.21.1106.1106
Published: 2012
Journal Articles

FXII Promotes Coagulation in a FXI and FIX Independent Manner

Cristina Puy, PhD, Zoë C Wong, Erik I Tucker, PhD, Andras Gruber, MD, David Gailani, MD, Stephanie A. Smith, DVM, MS, Sharon H. Choi, MS, James H. Morrissey, PhD, Owen J.T. McCarty, PhD
Journal: Blood
Blood (2012) 120 (21): 3362.
https://doi.org/10.1182/blood.V120.21.3362.3362
Published: 2012
Journal Articles

Evidence for a Factor IX-Independent Role for Factor XI in Thrombin Generation

Anton Matafonov, MD, Qiufang Cheng, MD, Ingrid M. Verhamme, PhD, Obi Umunakwe, Erik I. Tucker, PhD, Mao-fu Sun, Andras Gruber, MD, David Gailani, MD
Journal: Blood
Blood (2011) 118 (21): 2244.
https://doi.org/10.1182/blood.V118.21.2244.2244
Published: 2011
Journal Articles

Apple Domain-Specific Anti-Factor XI Antibodies Inhibit Venous-Type Thrombosis with Improved Hemostatic Safety Profiles Compared to Enoxaparin in Primates

Erik I. Tucker, PhD, Ulla M Marzec, MS, Philberta Y Leung, PhD, Stephen R Hanson, PhD, Prof., Norah G Verbout, PhD, Sawan Hurst, MS, Owen J.T. McCarty, PhD, David Gailani, MD, Andras Gruber, MD
Journal: Blood
Blood (2011) 118 (21): 1173.
https://doi.org/10.1182/blood.V118.21.1173.1173
Published: 2011
Journal Articles

Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model

Erik I Tucker, PhD, Melani Helm, BS, Owen JT McCarty, PhD, Sawan Hurst, MS, David Gailani, MD, Andras Gruber, MD
Journal: Blood
Blood (2010) 116 (21): 820.
https://doi.org/10.1182/blood.V116.21.820.820
Published: 2010