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Journal Articles

Apobec Family Mutational Signatures Are Associated with Poor Prognosis Translocations in Multiple Myeloma

Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Lorenzo Melchor, PhD, Charlotte Pawlyn, MD, Martin F Kaiser, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David C Johnson, PhD, Ya-Wei Qiang, MD PhD, John Jones, MD, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 723.
https://doi.org/10.1182/blood.V124.21.723.723
Published: 2014
Journal Articles

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

Eileen M Boyle, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David C Johnson, PhD, Charlotte Pawlyn, MBBChir, John Jones, MD, Fabio Mirabella, PhD, Annamaria Brioli, Aneta Mikulasova, M.Sc., David A Cairns, PhD, Walter Gregory, PhD, Ana Quartilho, PhD, Mark T Drayson, MDPhD, Nigel Russell, Gordon Cook, MD PhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 637.
https://doi.org/10.1182/blood.V124.21.637.637
Published: 2014
Journal Articles

The Extent of Intra-Clonal Genetic Diversity within the Myeloma Clone Is a Predictive Biomarker of Progression and Outcome after Treatment

Lorenzo Melchor, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Christopher P Wardell, PhD, John Jones, MD, Martin F Kaiser, MD, Charlotte Pawlyn, MBBChir, David C Johnson, PhD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 640.
https://doi.org/10.1182/blood.V124.21.640.640
Published: 2014
Journal Articles

High Resolution Genome Wide DNA Methylation Analysis in a Large Trial Group Reveals a Novel Epigenetically Defined Subgroup of Myeloma Patients Characterized By Developmental Gene Hypermethylation

Martin F Kaiser, MD, Alexander Murison, PhD, Charlotte Pawlyn, MBBChir, Eileen M Boyle, MD, David C Johnson, PhD, Brian A Walker, PhD, Ping Wu, MBBS, MSc, Dil Begum, BSc, Nasrin Dahir, BSc, Christopher P Wardell, PhD, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2189.
https://doi.org/10.1182/blood.V124.21.2189.2189
Published: 2014
Journal Articles

The Spectrum of Epigenetic Mutations in Myeloma and Their Clinical Impact

Charlotte Pawlyn, MBBChir, Martin F Kaiser, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, David C Johnson, PhD, Lorenzo Melchor, PhD, Eileen M Boyle, MD, John Jones, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Gordon Cook, MD, Roger G Owen, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2194.
https://doi.org/10.1182/blood.V124.21.2194.2194
Published: 2014
Journal Articles

Rapid, Robust and Accessible Molecular Profiling of Biologically and Clinically Relevant Copy Number Alterations in Multiple Myeloma from Small Amounts of Tumor DNA

Martin F Kaiser, MD, Paula Proszek, MSc, Dil Begum, BSc, Nasrin Dahir, BSc, Brian A Walker, PhD, Suvi Savola, PhD, Eileen M Boyle, MD, David C Johnson, PhD, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5168.
https://doi.org/10.1182/blood.V124.21.5168.5168
Published: 2014
Journal Articles

High Throughput Genetic Profiling Using a Robust All-Molecular Diagnostic Approach Is Feasible to Specifically Identify a High Risk Group of Myeloma Patients

Martin F Kaiser, MD, Eileen M Boyle, MD, Brian A Walker, PhD, Charlotte Pawlyn, MBBChir, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David C Johnson, PhD, Suvi Savola, PhD, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 172.
https://doi.org/10.1182/blood.V124.21.172.172
Published: 2014
Journal Articles

Single-Cell Genetic Analysis Reveals The Genetic Composition Of Founder Clones, Phylogenetic Patterns Of Branching and Parallel Evolution, and Clonal Fluctuations Following Patient Treatment In Multiple Myeloma

Lorenzo Melchor, PhD, Annamaria Brioli, MD, Christopher P Wardell, PhD, Alexander Murison, PhD, Nicola E Potter, PhD, Martin F Kaiser, MD, Rosemary A Fryer, PhD, David C Johnson, PhD, Dil Begum, BSc, Sanna Hulkki, Gowri Vijayaraghavan, Ian Titley, PhD, Michele Cavo, MD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 398.
https://doi.org/10.1182/blood.V122.21.398.398
Published: 2013
Journal Articles

A Rapid and Robust Molecular Diagnostic Approach For Multiple Myeloma – Results From a Large Trial Cohort

Martin F. Kaiser, MD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David Gonzalez de Castro, PhD, Charlotte Pawlyn, MD, Annamaria Brioli, MD, Suvi Savola, PhD, Walter Gregory, PhD, Roger G. Owen, MD, Graham H. Jackson, MD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 3097.
https://doi.org/10.1182/blood.V122.21.3097.3097
Published: 2013
Journal Articles

MYC Translocations In Multiple Myeloma Involve Recruitment Of Enhancer Elements Resulting In Over-Expression and Decreased Overall Survival

Brian A Walker, PhD, Christopher P Wardell, PhD, Dil Begum, BSc, Nasrin Dahir, BSc, David C Johnson, PhD, Faith E Davies, MD, Gareth J Morgan, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 274.
https://doi.org/10.1182/blood.V122.21.274.274
Published: 2013