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Journal Articles

Stat3 -/- Alloreactive Donor T Cells Reduce FAO but Increase Leakage of ROS in Response to PD-1 Signaling Triggered By Host-Tissue PD-L1, Leading to Prevention of Gvhd While Preserving GVL Effect

Xiaoqi Wang, MD, Shijie Yang, PhD, Yating Wang, PhD, Xiwei Wu, PhD, Martha Salas, Qingxiao Song, MD PhD, Hanjun Qin, Ubaydah Nasri, Arthur D. Riggs, PhD, Paul J Martin, MD, Xi Zhang, Defu Zeng, MD PhD

Blood (2019) 134 (Supplement_1): 198.

https://doi.org/10.1182/blood-2019-127228

Published: 2019

Journal Articles

Role of Donor-Derived CD19.CAR-T Cells in Treating Patients That Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation

Cheng Zhang, MD PhD, Lei Gao, Yao Liu, Li Gao, Pei-Yan Kong, Jun Liu, Ruihao Huang, Ying-Ying Ma, Defu Zeng, MD PhD, Qing-Hui Xiong, Wei-Ling Mei, Jia Liu, Peng-Fei Jiang, Xun Ye, De-Ping Han, Wei Cao, Xi Zhang

Blood (2019) 134 (Supplement_1): 4561.

https://doi.org/10.1182/blood-2019-128262

Published: 2019

Journal Articles

Combination Therapy of Allogeneic HSCT and In Vivo Activated iNKT Cells Prevents Acute Gvhd While Augmenting GVL Effect

Samuel Zeng, Qingxiao Song, MD PhD, Shanshan Tang, Xi Wang, PhD, Yuchen Wang, PhD, Defu Zeng, MD PhD, Lili Yang, PhD

Blood (2019) 134 (Supplement_1): 4439.

https://doi.org/10.1182/blood-2019-130826

Published: 2019

Journal Articles

Expansion of Th/Tc17 T Cells and Loss of CX3CR1 + Macrophages Play a Critical Role in the Pathogenesis of Steroid-Refractory Acute Intestinal Gvhd

Qingxiao Song, MD PhD, Xiaoning Wang, MD, Paul J Martin, MD, Yuanzhong Chen, MD PhD, Defu Zeng, MD PhD

Blood (2019) 134 (Supplement_1): 1925.

https://doi.org/10.1182/blood-2019-126261

Published: 2019

Journal Articles

Tissue-Resident PSGL1 lo CD4 + T Cells Interact with B Cells Via PD-1 and PD-L2 in Gvhd Target Tissues to Augment Autoimmune-like Chronic Gvhd

Xiaohui Kong, PhD, Deye Zeng, MD, Xiwei Wu, PhD, Shijie Yang, PhD, Bixin Wang, Qingxiao Song, MD PhD, Yongping Zhu, Martha Salas, Hanjun Qin, Ubaydah Nasri, Ryotaro Nakamura, MD, Paul J Martin, MD, Aimin Huang, Defu Zeng, MD PhD

Blood (2019) 134 (Supplement_1): 5607.

https://doi.org/10.1182/blood-2019-126315

Published: 2019

Journal Articles

Study on Use of CAR-T Cells in Allogeneic Hematopoietic Stem Cell Transplantation

Jun Liu, Xu Tan, Ma Ying-Ying, Wang Mai-Hong, Yao Liu, Gao Lei, Kong Peiyan, Cheng Zhang, MD PhD, Xi Zhang, Defu Zeng, MD

Blood (2018) 132 (Supplement 1): 5225.

https://doi.org/10.1182/blood-2018-99-114287

Published: 2018

Journal Articles

10-Day Low Dose Decitabine Regimen for Elderly Acute Myeloid Leukemia Patient Maintenance Treatment

Jia Liu, Kong Peiyan, Li Gao, Cheng Zhang, MD PhD, Yao Liu, Hongju Yan, Lidan Zhu, Shichun Gao, Gao Lei, Defu Zeng, MD, Xi Zhang

Blood (2018) 132 (Supplement 1): 5228.

https://doi.org/10.1182/blood-2018-99-115861

Published: 2018

Journal Articles

Stat3 Regulates Alloreactive T Cell Susceptibility Towards PD-L1-Mediated Tolerance Signaling, Gvhd and GVL Activity

Shijie Yang, PhD, Xiaoqi Wang, MD, Yuankun Zhang, PhD, Deye Zeng, MD, Qingxiao Song, MD, Paul J Martin, MD, Xi Zhang, Defu Zeng, MD

Blood (2018) 132 (Supplement 1): 3323.

https://doi.org/10.1182/blood-2018-99-119474

Published: 2018

Journal Articles

Tandem Autologous Hematopoietic Stem Cell Transplantation Treatment for Adult T-Cell Lymphoblastic Lymphoma: A Multiple Center Prospective Study in Southwestern China

Blood (2018) 132 (Supplement 1): 5747.

https://doi.org/10.1182/blood-2018-99-115705

Published: 2018

Journal Articles

Efficacy of Low-Dose Decitabine in the Early Relapse of AML/MDS after Allogeneic Hematopoietic Stem Cell Transplantation

Xu Guo-Fa, Chen Ting, Liu Huanfeng, Lin Shijia, Lei Gao, Cheng Zhang, MD PhD, Yao Liu, Xi Zhang, Defu Zeng, MD, Kong Peiyan

Blood (2018) 132 (Supplement 1): 5739.

https://doi.org/10.1182/blood-2018-99-115659

Published: 2018

Journal Articles

Neutralizing IL-2 Early after HCT Specifically Prevents Expansion of Donor GM-CSF-Producing CD4 + T Cells That Initiate Acute Gut Gvhd

Qingxiao Song, MD, Xiaoning Wang, MD, Paul J Martin, MD, Yuanzhong Chen, MD PhD, Defu Zeng, MD

Blood (2018) 132 (Supplement 1): 2030.

https://doi.org/10.1182/blood-2018-99-119966

Published: 2018

Journal Articles

Decitabine Combined with FB3 As Conditional Regimen for Elderly Acute Myeloid Leukemia Patient with Allogeneic Hematopoietic Stem Cell Transplantation

Shichun Gao, Jia Liu, Kong Peiyan, Li Gao, Cheng Zhang, MD PhD, Yao Liu, Hongju Yan, Lidan Zhu, Defu Zeng, MD, Lei Gao, Xi Zhang

Blood (2018) 132 (Supplement 1): 2108.

https://doi.org/10.1182/blood-2018-99-115926

Published: 2018

Journal Articles

Sirolimus Is Effective in Refractory Immune Thrombocytopenia: Results of an Open-Label Prospective Multicenter Trial in China

Blood (2017) 130 (Supplement 1): 4728.

https://doi.org/10.1182/blood.V130.Suppl_1.4728.4728

Published: 2017

Journal Articles

PD-L1/CD80 and PD-L1/PD-1 Signaling Reciprocally Regulate Alloreactive CD8 + T Cell Glycolysis, Proliferation, Apoptosis and Gvhd-Inducing Capacity

Kaniel M. Cassady, BS, Jian Zhou, MD PhD, Art Riggs, PhD, Defu Zeng, MD

Blood (2015) 126 (23): 4282.

https://doi.org/10.1182/blood.V126.23.4282.4282

Published: 2015

Journal Articles

Extrafollicular CD4 + T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation

Ruishu Deng, MD PhD, Christian Hurtz, PhD, Chanyu Yue, PhD, Gang Xiao, PhD, Hua Yu, PhD, Markus Muschen, MDPhD, Stephen J. Forman, MD, Paul J. Martin, MD, Defu Zeng, MD

Blood (2015) 126 (23): 1875.

https://doi.org/10.1182/blood.V126.23.1875.1875

Published: 2015

Journal Articles

Host Tissue PD-L1 Separates GVL Effect from Gvhd after Temporary Depletion of Donor CD4 + T Cells Early after HCT

Xiong Ni, MD, Qingxiao Song, MD, Ruishu Deng, MD PhD, Hua Jin, BS, Kaniel M. Cassady, BS, Mingfeng Zhang, PhD, Stephen J. Forman, MD, Paul J. Martin, MD, Jianmin Wang, MD PhD, Defu Zeng, MD

Blood (2015) 126 (23): 1882.

https://doi.org/10.1182/blood.V126.23.1882.1882

Published: 2015

Journal Articles

B7H1/B7.1 Interaction Alleviate Acute Gvhd in a PD-1 Dependent Manner

Ruishu Deng, MDPhD, Kaniel Cassady, Xiaofan Li, MDPhD, Sheng Yao, PhD, Mingfeng Zhang, PhD, Jeremy Racine, PhD, Jeffrey Lin, Lieping Chen, MDPhD, Defu Zeng, MD

Blood (2014) 124 (21): 2423.

https://doi.org/10.1182/blood.V124.21.2423.2423

Published: 2014

Journal Articles

Host Natural Killer T Cells Regulate Allogeneic Donor CD8 + T Cell Expression of Homing and Chemokine Receptors and Tissue Migration

Nainong Li, MD PhD, Jingwei Lou, MD PhD, Jeremy Racine, PhD, Stephen J. Forman, MD, Defu Zeng, MD

Blood (2014) 124 (21): 5804.

https://doi.org/10.1182/blood.V124.21.5804.5804

Published: 2014

Journal Articles

Antibodies from Donor B Cells Are Not Required for Initiating but Required for Persisting Scleroderma in Chronic Gvhd

Hua Jin, MD, Xiong Ni, MD, Ruishu Deng, MDPhD, James Young, PhD, Heather F Johnston, PhD, Qifa Liu, MD, Defu Zeng, MD

Blood (2014) 124 (21): 3817.

https://doi.org/10.1182/blood.V124.21.3817.3817

Published: 2014

Journal Articles

Oral Administration of Ibrutinib Is Ineffective at Preventing Scleroderma in Chronic Gvhd in Two Preclinical Mouse Models

Yajing Xu, MD, Heather F Johnston, PhD, Stephen J. Forman, MD, Defu Zeng, MD

Blood (2014) 124 (21): 3818.

https://doi.org/10.1182/blood.V124.21.3818.3818

Published: 2014

NARROW

Stat3 -/- Alloreactive Donor T Cells Reduce FAO but Increase Leakage of ROS in Response to PD-1 Signaling Triggered By Host-Tissue PD-L1, Leading to Prevention of Gvhd While Preserving GVL Effect

Role of Donor-Derived CD19.CAR-T Cells in Treating Patients That Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation

Combination Therapy of Allogeneic HSCT and In Vivo Activated iNKT Cells Prevents Acute Gvhd While Augmenting GVL Effect

Expansion of Th/Tc17 T Cells and Loss of CX3CR1 + Macrophages Play a Critical Role in the Pathogenesis of Steroid-Refractory Acute Intestinal Gvhd

Tissue-Resident PSGL1 lo CD4 + T Cells Interact with B Cells Via PD-1 and PD-L2 in Gvhd Target Tissues to Augment Autoimmune-like Chronic Gvhd

Study on Use of CAR-T Cells in Allogeneic Hematopoietic Stem Cell Transplantation

10-Day Low Dose Decitabine Regimen for Elderly Acute Myeloid Leukemia Patient Maintenance Treatment

Stat3 Regulates Alloreactive T Cell Susceptibility Towards PD-L1-Mediated Tolerance Signaling, Gvhd and GVL Activity

Tandem Autologous Hematopoietic Stem Cell Transplantation Treatment for Adult T-Cell Lymphoblastic Lymphoma: A Multiple Center Prospective Study in Southwestern China

Efficacy of Low-Dose Decitabine in the Early Relapse of AML/MDS after Allogeneic Hematopoietic Stem Cell Transplantation

Neutralizing IL-2 Early after HCT Specifically Prevents Expansion of Donor GM-CSF-Producing CD4 + T Cells That Initiate Acute Gut Gvhd

Decitabine Combined with FB3 As Conditional Regimen for Elderly Acute Myeloid Leukemia Patient with Allogeneic Hematopoietic Stem Cell Transplantation

Sirolimus Is Effective in Refractory Immune Thrombocytopenia: Results of an Open-Label Prospective Multicenter Trial in China

PD-L1/CD80 and PD-L1/PD-1 Signaling Reciprocally Regulate Alloreactive CD8 + T Cell Glycolysis, Proliferation, Apoptosis and Gvhd-Inducing Capacity

Extrafollicular CD4 + T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation

Host Tissue PD-L1 Separates GVL Effect from Gvhd after Temporary Depletion of Donor CD4 + T Cells Early after HCT

B7H1/B7.1 Interaction Alleviate Acute Gvhd in a PD-1 Dependent Manner

Host Natural Killer T Cells Regulate Allogeneic Donor CD8 + T Cell Expression of Homing and Chemokine Receptors and Tissue Migration

Antibodies from Donor B Cells Are Not Required for Initiating but Required for Persisting Scleroderma in Chronic Gvhd

Oral Administration of Ibrutinib Is Ineffective at Preventing Scleroderma in Chronic Gvhd in Two Preclinical Mouse Models

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American Society of Hematology

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ASH Publications

American Society of Hematology

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